Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade

(2013) Jennifer Vandooren et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Matrix Metalloproteinase Inhibitors: A Review on Bioanalytical Methods, Pharmacokinetics and Metabolism

(2012) Xu Wang et al.   CURRENT DRUG METABOLISM

The involvement of oxidants and NF-κB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells

(2012) Dror Ben-David et al.   INFLAMMATION RESEARCH

Mouse video endoscopy: A novel method in the preclinical development of Inflammatory Bowel Disease therapies

(2012) G Lyng et al.   INFLAMMATORY BOWEL DISEASES

Fecal MMP-9

(2012) Anita Annaházi et al.   INFLAMMATORY BOWEL DISEASES

Proinflammatory cytokines induce crosstalk between colonic epithelial cells and subepithelial myofibroblasts: Implication in intestinal fibrosis

(2012) Ioannis Drygiannakis et al.   Journal of Crohns & Colitis

Ulcerative colitis

(2012) Ingrid Ordás et al.   LANCET

The validation of matrix metalloproteinase-9 mRNA gene expression as a predictor of outcome in patients with metastatic gastric cancer

(2011) S.-E. Al-Batran et al.   ANNALS OF ONCOLOGY

Matrix Metalloproteinase-9 Is Associated with Relapse and Prognosis of Patients with Colorectal Cancer

(2011) Dake Chu et al.   ANNALS OF SURGICAL ONCOLOGY

Gastric cancer — The role of matrix metalloproteinases in tumor progression

(2011) Marta Łukaszewicz-Zając et al.   CLINICA CHIMICA ACTA

Intestinal Inflammation and Cancer

(2011) Thomas A. Ullman et al.   GASTROENTEROLOGY

Pharmacological intervention studies using mouse models of the inflammatory bowel diseases

(2011) Iurii Koboziev et al.   INFLAMMATORY BOWEL DISEASES

Prognostic impact of MMP-2 and MMP-9 expression in pathologic stage IA non-small cell lung cancer

(2011) Wenlong Shao et al.   JOURNAL OF SURGICAL ONCOLOGY

Matrix metalloprotease-9 induces transforming growth factor-β1 production in airway epithelium via activation of epidermal growth factor receptors

(2011) Diahn-Warng Perng et al.   LIFE SCIENCES

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis

(2011) Sigrun Thorsteinsdottir et al.   Nature Reviews Gastroenterology & Hepatology

The Behavior of Matrix Metalloproteinase-9 in Lymphocytic Colitis, Collagenous Colitis and Ulcerative Colitis

(2011) Gábor Lakatos et al.   PATHOLOGY & ONCOLOGY RESEARCH

Silymarin Targets β-Catenin Signaling in Blocking Migration/Invasion of Human Melanoma Cells

(2011) Mudit Vaid et al.   PLoS One

Interleukin 17A Promotes Hepatocellular Carcinoma Metastasis via NF-kB Induced Matrix Metalloproteinases 2 and 9 Expression

(2011) Jian Li et al.   PLoS One

Matrix Metalloproteinase-9 Is a Prognostic Marker to Predict Survival of Patients Who Underwent Surgery Due to Rectal Carcinoma

(2011) Saulius Svagzdys et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Physiology and pathophysiology of matrix metalloproteases

(2010) T. Klein et al.   AMINO ACIDS

Expression of Matrix Metalloproteinase-9 mRNA and Vascular Endothelial Growth Factor Protein in Gastric Carcinoma and Its Relationship to Its Pathological Features and Prognosis

(2010) Qiong Yang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Targeting MMP-9, uPAR and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells

(2010) A K Nalla et al.   CANCER GENE THERAPY

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

(2010) Chrisostomi Gialeli et al.   FEBS Journal

Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo

(2010) A. Beliveau et al.   GENES & DEVELOPMENT

Anti-TNF-α agents in the treatment of immune-mediated inflammatory diseases: mechanisms of action and pitfalls

(2010) Léia CR Silva et al.   Immunotherapy

Jekyll and Hyde: the role of the microenvironment on the progression of cancer

(2010) Michael Allen et al.   JOURNAL OF PATHOLOGY

Urokinase Plasminogen Activator Receptor and/or Matrix Metalloproteinase-9 Inhibition Induces Apoptosis Signaling through Lipid Rafts in Glioblastoma Xenograft Cells

(2010) C. Chetty et al.   MOLECULAR CANCER THERAPEUTICS

Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis

(2009) Pallavi Garg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions

(2009) Elena I. Deryugina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix metalloproteinases: Evolution, gene regulation and functional analysis in mouse models

(2009) Miriam Fanjul-Fernández et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics

(2009) David Rodríguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MMP-9 (Gelatinase B) Expression is Associated With Disease-Free Survival and Disease-Specific Survival in Colorectal Cancer Patients

(2009) Riyad Bendardaf et al.   CANCER INVESTIGATION

Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activationin Vivoand Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway

(2009) Veronica C. Ardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer

(2009) Roopali Roy et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY

Integration of the β-Catenin-Dependent Wnt Pathway with Integrin Signaling through the Adaptor Molecule Grb2

(2009) Steve P. Crampton et al.   PLoS One

Functional genetic mouse models: promising tools for investigation of the proteolytic internet

(2008) Achim Krüger   BIOLOGICAL CHEMISTRY

Matrix Metalloproteinase-9 Is Required for Tumor Vasculogenesis but Not for Angiogenesis: Role of Bone Marrow-Derived Myelomonocytic Cells

(2008) G-One Ahn et al.   CANCER CELL

Effect of Ablation or Inhibition of Stromal Matrix Metalloproteinase-9 on Lung Metastasis in a Breast Cancer Model Is Dependent on Genetic Background

(2008) M. D. Martin et al.   CANCER RESEARCH

Spontaneous and cytokine induced expression and activity of matrix metalloproteinases in human colonic epithelium

(2008) G. Pedersen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Elevated circulatory MMP-2 and MMP-9 levels and activities in patients with rheumatoid arthritis and systemic lupus erythematosus

(2008) Yih-Hsin Chang et al.   CLINICAL BIOCHEMISTRY

VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis

(2008) Lukas J.A.C. Hawinkels et al.   EUROPEAN JOURNAL OF CANCER

Exposure to pro-inflammatory cytokines upregulates MMP-9 synthesis by mesenchymal stem cells-derived osteoprogenitors

(2008) D. Ben David et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Distinct Functionality of Tumor Cell-Derived Gelatinases during Formation of Liver Metastases

(2008) M. Gerg et al.   MOLECULAR CANCER RESEARCH