Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS

An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis

(2015) Smita Matkar et al.   CANCER CELL

Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7

(2015) Wen Tan et al.   Evidence-based Complementary and Alternative Medicine

Protective autophagy promotes the resistance of HER2-positive breast cancer cells to lapatinib

(2015) Suning Chen et al.   TUMOR BIOLOGY

Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus

(2014) Zheng Li et al.   Evidence-based Complementary and Alternative Medicine

Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway

(2014) Juan Xie et al.   TUMOR BIOLOGY

ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors

(2014) S Mohanty et al.   Cell Death & Disease

RON confers lapatinib resistance in HER2-positive breast cancer cells

(2013) Quanren Wang et al.   CANCER LETTERS

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

(2013) Junfang Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lapatinib as a component of neoadjuvant therapy for HER2-positive operable breast cancer (NSABP protocol B-41): an open-label, randomised phase 3 trial

(2013) André Robidoux et al.   LANCET ONCOLOGY

Enhanced PI3K p110  Signaling Confers Acquired Lapatinib Resistance That Can Be Effectively Reversed by a p110 -Selective PI3K Inhibitor

(2013) S. W. Brady et al.   MOLECULAR CANCER THERAPEUTICS

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

3,5,3′-Triiodothyronine (T3) stimulates cell proliferation through the activation of the PI3K/Akt pathway and reactive oxygen species (ROS) production in chick embryo hepatocytes

(2012) Davide Gnocchi et al.   STEROIDS

Mechanism of the Nrf2/Keap1/ARE signaling system

(2011) V. O. Tkachev et al.   BIOCHEMISTRY-MOSCOW

Berberine Suppresses the TPA-Induced MMP-1 and MMP-9 Expressions Through the Inhibition of PKC-α in Breast Cancer Cells

(2011) Sangmin Kim et al.   JOURNAL OF SURGICAL RESEARCH

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

Resistance to HER2 inhibitors: Is addition better than substitution? Rationale for the hypothetical concept of drug sedimentation

(2010) Mario Campone et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Disruption of Nrf2 Enhances the Upregulation of Nuclear Factor-kappaB Activity, Tumor Necrosis Factor-α, and Matrix Metalloproteinase-9 after Spinal Cord Injury in Mice

(2010) Lei Mao et al.   MEDIATORS OF INFLAMMATION

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

(2009) L. Liu et al.   CANCER RESEARCH

Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations

(2009) Jun Tang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells

(2008) Jing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

(2008) C.-l. Dai et al.   CANCER RESEARCH

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice

(2008) Ying Ji Li et al.   CLINICAL IMMUNOLOGY

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

(2008) Mohsen Imanshahidi et al.   PHYTOTHERAPY RESEARCH

Berberine Diminishes the Side Population and ABCG2 Transporter Expression in MCF-7 Breast Cancer Cells

(2008) Jong Kim et al.   PLANTA MEDICA

Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-κB in primary cultured rat hippocampal neurons

(2008) Ming Zhang et al.   TOXICOLOGY LETTERS