Article
Multidisciplinary Sciences
Marie-Anne Goyette, Islam E. Elkholi, Chloe Apcher, Hellen Kuasne, Carla Rothlin, William J. Muller, Darren E. Richard, Morag Park, Jean-Philippe Gratton, Jean-Francois Cote
Summary: Inhibition of Axl leads to reduction of hypoxia-induced EMT, invasion, and cytokine production, creating a favorable environment for immunotherapy and reducing metastatic burden in HER2(+) breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Da-Liang Ou, Chia-Wei Chen, Chia-Lang Hsu, Chih-Hung Chung, Zi-Rui Feng, Bin-Shyun Lee, Ann-Lii Cheng, Muh-Hwa Yang, Chiun Hsu
Summary: Regorafenib may enhance antitumor immunity by modulating macrophage polarization independently of its anti-angiogenic effects. It enhances the antitumor effects of antigen-specific T cells and shows synergistic effects with anti-PD1 by affecting multiple immune-related pathways in the tumor microenvironment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Jie Zhang, Zhujiang Dai, Cheng Yan, Daorong Wang, Dong Tang
Summary: Phosphatidylserine (PS) targeted therapy plays a crucial role in cancer immunotherapy by inhibiting tumor growth, enhancing immunity, and offering new perspectives for future therapies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Ji Eun Won, Youngseon Byeon, Tae In Wi, Chan Mi Lee, Ju Hyeong Lee, Tae Heung Kang, Jeong-Won Lee, YoungJoo Lee, Yeong-Min Park, Hee Dong Han
Summary: Poly(lactic-co-glycolic acid) nanoparticles have been developed as a potential combination approach for cancer immunotherapy, showing promising effects in enhancing immune responses and inhibiting tumor growth.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Engineering, Biomedical
Chunxiang Feng, Zhiyong Xiong, Cheng Wang, Wen Xiao, Haibing Xiao, Kairu Xie, Ke Chen, Huageng Liang, Xiaoping Zhang, Hongmei Yang
Summary: The novel exosome-based drug delivery system designed in this study effectively degrades high molecular weight hyaluronan and modifies the immune microenvironment, reducing tumor cell metastasis.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Ruxia Han, Qingya Liu, Yi Lu, Jinrong Peng, Meng Pan, GuiHua Wang, Wen Chen, Yao Xiao, ChengLi Yang, Zhiyong Qian
Summary: A tumor microenvironment-responsive drug delivery system was constructed and combined with doxorubicin for tumor therapy. The system effectively utilized the advantages of photothermal effect to kill tumor cells, release of DOX, and ICD effect to activate host immune response against tumors.
Article
Gastroenterology & Hepatology
Wei-Feng Hong, Yu-Jun Gu, Na Wang, Jie Xia, Heng-Yu Zhou, Ke Zhan, Ming-Xiang Cheng, Ying Cai
Summary: This study identified key immune-relevant genes in the HCC microenvironment which may play a crucial role in cancer development and progression. By analyzing immune-related genetic changes, the study provides insights into potential therapeutic targets and molecular mechanisms underlying HCC. Additionally, the immune-related risk score model demonstrated strong discriminating power in predicting immune checkpoint genes and infiltration of immune cells in HCC.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Oncology
Li Xia, Enming Tian, Mingcheng Yu, Chenglong Liu, Lian Shen, Yafei Huang, Zhongen Wu, Jinlong Tian, Ker Yu, Yonghui Wang, Qiong Xie, Di Zhu
Summary: The study designed a RORγt agonist that enhances the antitumor immune response of PD-1. The agonist increased the migration of CD8(+) T cells and MoDCs in tumors, thereby promoting tumor infiltration. This study provides insights into the mechanism of RORγt agonists in immunotherapy and offers a strategy to improve the efficacy of PD-1 antibodies in cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Huan He, Qibin Liao, Chen Zhao, Cuisong Zhu, Meiqi Feng, Zhuoqun Liu, Lang Jiang, Linxia Zhang, Xiangqing Ding, Min Yuan, Xiaoyan Zhang, Jianqing Xu
Summary: The study demonstrates that hypoxia-inducible HiTA-CAR-T cells exhibit high tumor cytotoxicity and activity while showing low on-target toxicity to normal tissues. The HiTA system represents a significant improvement in transgene expression, providing a promising approach for designing CAR-T cells targeting various tumor antigens.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Rui Tang, Hongye He, Xiaohong Lin, Nianhong Wu, Li Wan, Qiaoqi Chen, Yaqin Hu, Chen Cheng, Yuting Cao, Xun Guo, Ying Zhou, Xialin Xiong, Min Zheng, Qi Wang, Faqi Li, Yang Zhou, Pan Li
Summary: Combining high-intensity focused ultrasound (HIFU) with immunomodulation can effectively treat solid tumors and stimulate anti-tumor immune response to inhibit tumor recurrence and metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Dongqiang Zeng, Jiani Wu, Huiyan Luo, Yong Li, Jian Xiao, Jianjun Peng, Zilan Ye, Rui Zhou, Yunfang Yu, Gaofeng Wang, Na Huang, Jianhua Wu, Xiaoxiang Rong, Li Sun, Huiying Sun, Wenjun Qiu, Yichen Xue, Jianping Bin, Yulin Liao, Nailin Li, Min Shi, Kyoung-Mee Kim, Wangjun Liao
Summary: This study established the predictive value of TMEscore in patients with mGC and identified associations between TMEscore and mutations, metabolic pathways, and epigenetic features through multi-omics data analysis. These findings suggest that exploration of TME in gastric cancer data could be beneficial for precision immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Won Suk Lee, Dong Sung Kim, Jeong Hun Kim, Yoonki Heo, Hannah Yang, Eun-Jin Go, Jin Hyoung Kim, Seung Joon Lee, Byung Cheol Ahn, Jung Sun Yum, Hong Jae Chon, Chan Kim
Summary: The TLR2/3 agonist, L-pampo, was found to enhance antitumor immunity and improve the efficacy of immune checkpoint blockade, showing potential value in the treatment of patients with advanced cancers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Maulasri Bhatta, Gautam N. Shenoy, Jenni L. Loyall, Brian D. Gray, Meghana Bapardekar, Alexis Conway, Hans Minderman, Raymond J. Kelleher Jr, Beatriz M. Carreno, Gerald Linette, Leonard D. Shultz, Kunle Odunsi, Sathy Balu-Iyer, Koon Yan Pak, Richard B. Bankert
Summary: The study demonstrated that ExoBlock has high avidity for binding to PS, significantly blocking the immunosuppressive activity of human ovarian tumor and melanoma-associated exosomes in vitro. Additionally, ExoBlock enhanced T cell-mediated tumor suppression in both the X-mouse and OTX models, leading to reduction in tumor burden, metastasis, and circulating PS+ exosomes in tumor-bearing mice. These results suggest that targeting exosomal PS in TMEs using ExoBlock is a promising strategy to enhance antitumor T-cell responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Meng-Ling Ye, Si-Qi Li, Yi-Xin Yin, Ke-Zhi Li, Ji-Lin Li, Bang-Li Hu
Summary: Cancer stem cells play crucial roles in colorectal cancer tumorigenesis and treatment response. This study found that the mRNA stemness index (mRNAsi) was associated with the clinical outcome in colorectal cancer (CRC) patients. A stemness-related classification based on mRNAsi scores and RNA sequence data was introduced and showed promise as a prognostic predictor for CRC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Xu Wang, Tao Zhou, Xingyi Chen, Yu Wang, Yushi Ding, Haoyang Tu, Shengyang Gao, Haoyu Wang, Xinying Tang, Yong Yang
Summary: Our study identifies ZNF207 as an immunosuppressive target in HCC, promoting HCC progression by regulating CD8(+) T cell infiltration and exhaustion. Mechanistically, ZNF207 is involved in the MAPK-chemokine C-X3-C-motif ligand axis and the regulation of indoleamine 2,3-dioxygenase 1 levels, leading to CD8(+) T cell exhaustion. Silencing ZNF207 could be beneficial for anti-PD1 combination therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Chen Zhao, Yu Zhang, Aleksander S. Popel
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Adam C. Mirando, Raquel Lima e Silva, Zenny Chu, Peter A. Campochiaro, Niranjan B. Pandey, Aleksander S. Popel
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Hanwen Wang, Huilin Ma, Richard J. Sove, Leisha A. Emens, Aleksander S. Popel
Summary: This study introduces a modular quantitative systems pharmacology (QSP) platform for predicting immunotherapy efficacy and identifying predictive biomarkers. Virtual clinical trials were conducted using a virtual patient cohort generated by the model, with retrospective analysis and model validation based on clinical trial data.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Chang Gong, Alvaro Ruiz-Martinez, Holly Kimko, Aleksander S. Popel
Summary: The study aims to develop a platform that combines the strengths of QSP and ABM models to create a cancer development model in the context of anti-cancer immunity and immune checkpoint inhibition therapy, which can be applied in virtual clinical trials and biomarker discovery.
Article
Mathematical & Computational Biology
Yu Zhang, Christopher D. Kontos, Brian H. Annex, Aleksander S. Popel
Summary: The Ang-Tie signaling pathway plays a crucial role in vascular growth and stability, with dysregulation leading to vascular dysfunction and various diseases. A mechanistic computational model has been developed to understand the complex molecular mechanisms of this pathway and predict potential therapeutic strategies for inflammatory endothelial cells.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2021)
Article
Oncology
Haoyang Mi, Shamilene Sivagnanam, Courtney B. Betts, Shannon M. Liudahl, Elizabeth M. Jaffee, Lisa M. Coussens, Aleksander S. Popel
Summary: Quantitative image analysis of PDAC specimens reveals intertumoral and intratumoral heterogeneity of immune populations and identifies spatial immune architectures that are significantly associated with disease prognosis.
Review
Pharmacology & Pharmacy
Natsuki Furukawa, Vered Stearns, Cesar A. Santa-Maria, Aleksander S. Popel
Summary: Compared to other subtypes of breast cancer, there are limited targeted therapy options for triple-negative breast cancer (TNBC). Research has shown that not only cancer cells, but also stromal cells and immune cells in the tumor microenvironment (TME) play significant roles in the progression of TNBC. Therefore, understanding the components of the TME and the interactions between different cell populations is critical.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Oncology
Mehdi Nikfar, Haoyang Mi, Chang Gong, Holly Kimko, Aleksander S. Popel
Summary: This study introduces a new approach to quantitatively validate the performance of a hybrid spatio-temporal method called spatial quantitative systems pharmacology (spQSP). The study uses a compartmental QSP model and a spatial agent-based model to simulate the effect of anti-PD-1 therapy on tumor growth dynamics and intratumoral heterogeneity. Four spatial metrics and the ratio of cancer cells to immune cells are used to categorize the tumor microenvironment and evaluate the efficacy of the treatment. The results of this study can facilitate future research on specific cancer types, different therapeutics, and immunopathological samples.
Article
Oncology
Hanwen Wang, Theinmozhi Arulraj, Holly Kimko, Aleksander S. Popel
Summary: QSP models can be used to generate virtual patients and predict drug response. This study used immunogenomic data and pharmacokinetic data to generate virtual patients for non-small cell lung cancer (NSCLC) and predicted clinical response to PD-L1 inhibition.
NPJ PRECISION ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Theinmozhi Arulraj, Hanwen Wang, Leisha A. Emens, Cesar A. Santa-Maria, Aleksander S. Popel
Summary: This study developed a quantitative systems pharmacology model based on transcriptome information to predict and identify response to anti-PD-1 therapy in patients with triple-negative breast cancer. The results suggest that certain features can serve as biomarkers individually or in combination to predict treatment response and guide potential therapeutic strategies.
Article
Mathematical & Computational Biology
Min Song, Youli Wang, Brian H. Annex, Aleksander S. Popel
Summary: Inflammatory cytokine mediated responses play an important role in the development of diseases associated with angiogenesis. However, targeting angiogenesis as a strategy has shown limited effectiveness, possibly due to the interdependent role between inflammation and angiogenesis. This study focuses on IL-6-mediated intracellular signaling in endothelial cells and develops a computational model to quantitatively characterize its effects. The model predicts the dose-dependency of IL-6 classic and trans-signaling induced responses and identifies influential species and parameters in modulating downstream signals. Overall, the model provides insights into IL-6 signaling in endothelial cells and can be used to identify potential targets for modulating angiogenesis.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2023)
Article
Pharmacology & Pharmacy
Alberto Ippolito, Hanwen Wang, Yu Zhang, Vahideh Vakil, Hojjat Bazzazi, Aleksander S. Popel
Summary: Conditionally activated molecules, such as Probody therapeutics, are investigated for their potential to improve antitumoral response while reducing systemic toxicity. This study used a quantitative systems pharmacology model to evaluate the effectiveness and targeting specificity of an anti-PD-L1 Probody therapeutic compared to the non-modified antibody. The results suggest that optimizing the design parameters of the Probody therapeutic can increase its efficacy.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2023)
Article
Oncology
Adam C. Mirando, Akash Patil, Christine I. Rafie, Brian J. Christmas, Niranjan B. Pandey, Vered Stearns, Elizabeth M. Jaffee, Evanthia T. Roussos Torres, Aleksander S. Popel
Article
Multidisciplinary Sciences
Spyros K. Stamatelos, Akanksha Bhargava, Eugene Kim, Aleksander S. Popel, Arvind P. Pathak
SCIENTIFIC REPORTS
(2019)
