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Biochemistry & Molecular Biology
Quanwei Li, Jianzhao Liao, Weijin Chen, Kai Zhang, Hongji Li, Feiyang Ma, Hui Zhang, Qingyue Han, Jianying Guo, Ying Li, Lianmei Hu, Jiaqiang Pan, Zhaoxin Tang
Summary: The study investigated the effect of NAC combined with insulin treatment on diabetic nephropathy, showing that NAC attenuated ferroptosis in DN by activating the SIRT3-SOD2-Gpx4 signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
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Cell Biology
Wanpeng Wang, Ran Yu, Caixia Wu, Qingju Li, Jiajia Chen, Yao Xiao, Haoyu Chen, Jian Song, Mingyue Ji, Zhi Zuo
Summary: The study reveals that berberine effectively inhibits kidney damage induced by iodine-based contrast agents, and exerts its protective effects through the modulation of Akt/Foxo3a/Nrf2 signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
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Pharmacology & Pharmacy
Zhou Guo, Jiamin Lin, Kai Sun, Jiayou Guo, Xudong Yao, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Fengjing Guo
Summary: The study confirmed the occurrence of ferroptosis in chondrocytes under inflammatory conditions, with inhibition of chondrocyte ferroptosis alleviating chondrocyte destruction. Erastin-induced chondrocyte ferroptosis stimulated increased MMP13 expression and decreased collagen II expression. DFO suppressed chondrocyte ferroptosis and promoted activation of the Nrf2 antioxidant system, essential for chondrocyte protection, suggesting DFO injection as a potential new OA treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qiong-Yi Zhang, Shao-Cong Han, Rong-Ping Huang, Man-Ya Jiang, Chang-Yu Yan, Xi-You Li, Yu-Jiao Zhan, Xiao-Min Li, Yi-Fang Li, Hiroshi Kurihara, Rui-Rong Tan, Wei-Xi Li, Rong-Rong He
Summary: This study demonstrates that CPP can alleviate liver pathological damage caused by oxidative stress, and its antioxidant activity may depend on the enhancement of GPx and SOD and the increase of GSH levels. Furthermore, CPP combats liver injury by regulating the expression of HO-1 and NQO1, promoting the translocation of Nrf2, and inhibiting its degradation through binding with Keap1.
Article
Immunology
Qiwen Yu, Sanyang Chen, Hongwei Tang, Xiaodan Zhang, Ruolin Tao, Zhiping Yan, Jihua Shi, Wenzhi Guo, Shuijun Zhang
Summary: Veratric acid (VA) has protective effects against liver ischemia/reperfusion (I/R) injury by activating the Nrf2 signaling pathway, leading to increased expression of Nrf2, HO-1, and NQO-1 proteins, which helps alleviate oxidative stress and apoptosis, thus reducing liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinke Zhang, Mengcheng Li, Tianrui Zhao, Jianxin Cao, Yaping Liu, Yongpeng Wang, Yifen Wang, Guiguang Cheng
Summary: This study found that E Se tea, enriched in dihydrochalcones, has a protective effect on acetaminophen-induced acute liver injury by reducing inflammation and oxidative stress, and upregulating antioxidant genes.
Article
Biochemistry & Molecular Biology
Fengpei Zhang, Hui Xu, Yuan Yuan, Haichen Huang, Xiaoping Wu, Junli Zhang, Junsheng Fu
Summary: This study demonstrated that Lyophyllum decastes fruiting body polysaccharide (LDFP) protects against CCl4-induced acute liver injury in mice by activating the Nrf2 pathway, reducing inflammatory response, and improving antioxidant status in the liver.
Article
Pharmacology & Pharmacy
Jianqiang Hu, Wenjing Gu, Ning Ma, Xiaoye Fan, Xinxin Ci
Summary: Evidence suggests that Nrf2 activation has renal protective effects on cisplatin-induced acute kidney injury, potentially by inhibiting lipid peroxide-mediated ferroptosis. Leonurine activates the Nrf2 pathway and protects against cisplatin-induced acute kidney injury by inhibiting ferroptosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Leyi Ma, Fan Wu, Qingqing Shao, Guang Chen, Lijun Xu, Fuer Lu
Summary: This study demonstrated that baicalin can treat diabetic nephropathy (DN) by alleviating oxidative stress and inflammation, and its underlying mechanisms are associated with the activation of Nrf2-mediated antioxidant signaling pathway and the inhibition of MAPK-mediated inflammatory signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Ruifeng Jiang, Jun Ge, Juanru Zhao, Xiaohui Yan
Summary: Calycosin, as the major active component of Radix astragali, can prevent the cytotoxicity induced by high glucose in renal tubular epithelial cells through regulation of the SIRT-3/SOD2 pathway, suggesting its potential as a candidate for the treatment of diabetic nephropathy.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Liangcai Hou, Genchun Wang, Xiong Zhang, Fan Lu, Jingting Xu, Zhou Guo, Jiamin Lin, Zehang Zheng, Haigang Liu, Yanjun Hou, Kai Sun, Fengjing Guo
Summary: This study found that MitoQ activated the NRF2 pathway, reducing cartilage degradation and inflammation. Additionally, MitoQ increased the expression of glutathione peroxidase 4, decreasing oxidative stress levels.
Article
Biochemistry & Molecular Biology
Lina Xing, Hengjiang Guo, Sixuan Meng, Bingbing Zhu, Ji Fang, Jiebo Huang, Junliang Chen, Yunman Wang, Li Wang, Xingmei Yao, Hao Wang
Summary: Klotho activates the Nrf2 signaling pathway to inhibit oxidative stress and apoptosis induced by high glucose, thus protecting podocytes. This protective effect may be targeted by activating Nrf2 for the treatment of diabetic nephropathy (DN).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Critical Care Medicine
Yulin Li, Minfei Yang, Lutao Xie, Gongping Zhang, Jiefeng Xu, Shanxiang Xu
Summary: The present study found that Sulforaphane (SFN), known as the activator of the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway, produced effective postresuscitation lung protection through alleviating lung pyroptosis. SFN reduced lung injury score, improved oxidative imbalance, decreased pyroptosis-related proinflammatory cytokines, downregulated pyroptosis-related proteins, and activated the Nrf2/HO-1 pathway.
Article
Agriculture, Multidisciplinary
Yonger Chen, Shumin Zhu, Zongwen Chen, Ying Liu, Chaoying Pei, Haiyang Huang, Shaozhen Hou, Weimin Ning, Jian Liang
Summary: This study investigates the protective effect of GA on DSS-induced SLI in mice and its mechanism. The results show that GA can attenuate hepatic pathological damage, decrease liver parameters and cytokine levels, and increase antioxidant enzyme activities. Moreover, GA alleviates ferroptosis in DSS-induced liver injury and activates the Nrf2-Gpx4 signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Li-Wei Liu, Yu Xie, Guan-Qun Li, Tao Zhang, Yu-Hang Sui, Zhong-Jie Zhao, Yang-Yang Zhang, Wen-Bo Yang, Xing-Long Geng, Dong-Bo Xue, Hua Chen, Yong-Wei Wang, Tian-Qi Lu, Li-Ren Shang, Zhi-Bo Li, Le Li, Bei Sun
Summary: Gut microbiota dysbiosis exacerbates acute pancreatitis, and the use of fecal microbiota transplantation could potentially reduce tissue damage and inflammation.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)