Article
Biochemistry & Molecular Biology
Shuang Wang, Yingce Zheng, Shengzi Jin, Yunwei Fu, Yun Liu
Summary: Dioscin exerts a renoprotective effect by reducing oxidative injury, apoptosis, and ferroptosis in the kidneys through the Nrf2/HO-1 signaling pathway, providing new insights into the prevention of acute kidney injury.
Article
Pharmacology & Pharmacy
Yan Li, Ke Li, Weihao Zhao, Haodong Wang, Xiaodong Xue, Xianghui Chen, Wantao Li, Peihao Xu, Kexin Wang, Pengfei Liu, Xuefei Tian, Rongguo Fu
Summary: This study found that valproic acid (VPA) prevents cisplatin-induced renal injury through regulating glutathione peroxidase 4 (GPX4) and inhibiting ferroptosis. This suggests that inhibiting ferroptosis through VPA is a viable treatment for cisplatin-induced acute kidney injury.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiming Gong, Tengfang Lai, Liudan Liang, Yan Jiang, Fahui Liu
Summary: The study reveals that CX3CL1 inhibition can alleviate kidney damage in Cis-AKI patients. This therapeutic effect is achieved by mitigating ferroptosis, reducing intracellular iron overload, decreasing oxidative stress, and improving mitochondrial dysfunction.
MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Huiyue Qi, Fei Deng, Yinghuai Wang, Hao Zhang, Yashpal S. S. Kanwar, Yingbo Dai
Summary: In this study, it was found that supplementation of myo-inositol attenuated cisplatin-induced injury and regulated the process of ferroptosis by promoting CHIP-mediated ubiquitination of NOX4. These findings suggest that myo-inositol may have potential benefits in the treatment of cisplatin-induced acute kidney injury.
Article
Biochemistry & Molecular Biology
Zebin Deng, Yilong Wang, Jiachen Liu, Hao Zhang, Lizhi Zhou, Hao Zhao, Yachun Han, Shu Yan, Zheng Dong, Yinhuai Wang, Yingbo Dai, Fei Deng
Summary: This study identified WW domain binding protein-2 (WBP2) as a potential modulator of acute kidney injury (AKI) and cisplatin-induced AKI (CP-AKI) through bioinformatics analysis. WBP2 was found to be downregulated in CP-AKI and was shown to decelerate ferroptosis to alleviate CP-AKI. Mechanistically, WBP2 interacted with glutathione peroxidase 4 (GPX4) to inhibit ferroptosis. Additionally, WBP2 competed with heat shock cognate protein 70 (HSC70) for binding with GPX4, leading to the deceleration of chaperon-mediated autophagy of GPX4. Overall, this study provides novel insights into the modulation of ferroptosis in cisplatin-related nephropathy and highlights the beneficial role of WBP2 in CP-AKI.
Article
Medicine, Research & Experimental
Minling Pan, Zhen Wang, Yiyi Wang, Xianqin Jiang, Yali Fan, Fanghua Gong, Yunpeng Sun, Dezhong Wang
Summary: Ferroptosis is a crucial process in AKI that can lead to CKD and ESRD. Celastrol, an active ingredient of Tripterygium wilfordii, has anti-inflammatory and anti-cancer effects. This study found that celastrol protected against cisplatin-induced AKI by reducing inflammation, oxidative stress, renal iron accumulation, and ferroptosis. Mechanistic analysis revealed that celastrol upregulated GPX4 via Nrf2, alleviating ferroptosis and reducing LDH release, intracellular iron accumulation, and lipid peroxidation. These findings suggest the potential use of celastrol for treating AKI associated with ferroptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xue Yang, Shihui Dong, Yun Fan, Yuanyuan Xia, Fan Yang, Zhaohong Chen, Dacheng Chen, Mingchao Zhang, Dandan Liang, Caihong Zeng
Summary: This study investigates the role of Kruppel-like factor 15 (KLF15) in acute kidney injury (AKI). The results show that KLF15 expression is reduced in AKI mice and its knockout exacerbates folic acid-induced ferroptosis and kidney injury. Further experiments reveal that KLF15 stabilizes nuclear factor erythroid 2-related factor 2 (NRF2) protein and increases glutathione peroxidase 4 (GPX4) level, thus attenuating ferroptosis. These findings demonstrate the important role of KLF15 in modulating ferroptosis in AKI and suggest it as a potential therapeutic target for AKI treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kranti A. Mapuskar, Casey F. Pulliam, Diana Zepeda-Orozco, Benjamin R. Griffin, Muhammad Furqan, Douglas R. Spitz, Bryan G. Allen
Summary: This review discusses the mechanisms underlying chemotherapy-induced kidney injury, focusing on the role of Nrf2 in cancer therapy and its redox regulation in cisplatin-induced kidney injury. Understanding the redox regulation of Nrf2 in cisplatin-induced kidney injury holds significant promise for developing novel therapeutic interventions and enhancing the safety and efficacy of cancer treatment.
Article
Pharmacology & Pharmacy
Ning Ma, Zhentong Wei, Jianqiang Hu, Wenjing Gu, Xinxin Ci
Summary: The study demonstrated that farrerol effectively inhibited cisplatin-induced inflammation and renal fibrosis by activating Nrf2 and PINK1/Parkin-mediated mitophagy, providing a potential novel therapeutic target for CKD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qisheng Lin, Shu Li, Haijiao Jin, Hong Cai, Xuying Zhu, Yuanting Yang, Jingkui Wu, Chaojun Qi, Xinghua Shao, Jialin Li, Kaiqi Zhang, Wenyan Zhou, Minfang Zhang, Jiayi Cheng, Leyi Gu, Shan Mou, Zhaohui Ni
Summary: This study investigated the mechanism by which mitophagy protects against ferroptosis in cisplatin-induced acute kidney injury. The results showed aggravated iron accumulation, lipid peroxidation, and ferroptosis in mice lacking BNIP3, Pink1, or Park2. Additionally, the synthetic antioxidant ferroptosis inhibitor, Ferrstatin-1, rescued the effects of mitophagy inhibition.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Weihuang Qiu, Sheng An, Tingjie Wang, Jiaxin Li, Binmei Yu, Zhenhua Zeng, Zhongqing Chen, Bo Lin, Xianzhong Lin, Youguang Gao
Summary: This study finds that ferroptosis exacerbates sepsis-induced acute kidney injury. Melatonin can suppress ferroptosis and alleviate kidney injury by upregulating the Nrf2/HO-1 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiaojiao Fan, Xinyue Xu, Yuting Li, Lingge Zhang, Mengqiu Miao, Yujia Niu, Yue Zhang, Aihua Zhang, Zhanjun Jia, Mengqiu Wu
Summary: A novel compound, 84-B10, was found to protect against cisplatin-induced acute kidney injury by restoring mitochondrial homeostasis and inhibiting mtROS-induced ferroptosis. This suggests the potential use of 84-B10 in preventing and treating cisplatin nephrotoxicity.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Food Science & Technology
Wenyue Qiu, Xinting Zhang, Xiaoyue Pang, Jianjia Huang, Shuilian Zhou, Rongmei Wang, Zhaoxin Tang, Rongsheng Su
Summary: The study demonstrated that asiatic acid could alleviate LPS-induced acute kidney injury in broilers by targeting regulation of the Nrf2 pathway, inhibiting oxidative stress and ferroptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Yingrong Ye, Yichun Chen, Hanpeng Wu, Yiwu Fu, Youpeng Sun, Xia Wang, Peixuan Li, Zhikai Wu, Jingjing Wang, Zhengtao Yang, Ershun Zhou
Summary: Methylmercury is a highly toxic form of mercury that poses a risk for kidney impairment in humans. This study investigated whether ferroptosis, a metabolic cell death pathway, is involved in methylmercury-induced acute kidney injury in mice. The results suggested that ferroptosis and the NF-kappa B/NLRP3/MAPK/Nrf2 pathways are implicated in methylmercury-induced kidney injury. These findings provide a theoretical basis and reference for future research on the prevention and treatment of methylmercury-induced kidney injury.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoyan Meng, Wenjing Huang, Weiwei Mo, Tingting Shu, Haoqiang Yang, Haibo Ning
Summary: ADAMTS-13 alleviates ferroptosis in cisplatin-induced acute kidney injury, improving renal function and tubular damage. Ferroptosis inhibitor Fer-1 partially reverses cisplatin-induced AKI, while iron supplement Fe exacerbates this effect. ADAMTS-13 alleviates inflammatory response and oxidative stress in cisplatin-induced AKI mice, acting through regulating the Nrf2 signaling pathway to inhibit ferroptosis.
Article
Environmental Sciences
Kun Yan, Tianhua Hou, Laiyu Zhu, Xinxin Ci, Liping Peng
Summary: This study identified the role of ferroptosis in PM2.5-induced acute lung injury, revealing a novel mechanism involving the AMPK-Beclin1 pathway and System Xc-. The findings provide new insight into the toxicological effects of PM2.5 on respiratory problems.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoye Fan, Tingting Dong, Kun Yan, Xinxin Ci, Liping Peng
Summary: The increasing abundance of PM2.5 in the environment has increased susceptibility to AECOPD. This study evaluated the role of NOX4/Nrf2 redox imbalance on AECOPD induced by PM2.5-CS exposure and found that PM2.5 exacerbates cytotoxicity by enhancing NOX4/Nrf2 redox imbalance-mediated mitophagy. Restoring the NOX4/Nrf2 redox balance can alleviate this cytotoxicity and ameliorate AECOPD.
Article
Pharmacology & Pharmacy
Tingting Dong, Xiaoye Fan, Nan Zheng, Kun Yan, Tianhua Hou, Liping Peng, Xinxin Ci
Summary: The Nrf2 signaling pathway and tectoridin have a protective role in PM2.5-induced lung injury by regulating ferroptosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Xiaoling Hong, Ning Ma, Danjie Li, Mengwen Zhang, Wenqiuzi Dong, Jie Huang, Xinxin Ci, Songling Zhang
Summary: Dissemination of ovarian cancer cells can lead to poor prognosis. This study identified UBE2E2 as an upregulated protein in ovarian cancer and showed that it is associated with poor prognosis. UBE2E2 was found to promote ovarian cancer cell migration, epithelial-mesenchymal transition (EMT), and metastasis through the activation of the Nrf2-p62-Snail signaling pathway. The deletion of UBE2E2 reduced tumorigenicity and metastasis in mice models. These findings provide novel therapeutic targets for preventing ovarian cancer metastasis.
CELL DEATH & DISEASE
(2023)