Review
Biochemistry & Molecular Biology
Anshul Sharma, Hae-Jeung Lee
Summary: Inflammation plays a crucial role in the development of various chronic diseases. Bilberry, despite receiving little attention, possesses anti-inflammatory properties. This review summarizes the phytochemical composition of bilberry and its preclinical and clinical studies regarding anti-inflammatory effects. Studies from 2007 to the present demonstrate that bilberry exhibits anti-inflammatory activity by reducing the expression of inflammatory markers and modulating specific signaling pathways. Clinical studies show that bilberry supplementation in various forms can effectively reduce inflammatory markers in patients with metabolic disorders. Therefore, bilberry holds promise as a preventive and therapeutic agent for chronic inflammatory disorders.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Medicinal
Vahideh Behrouz, Golbon Sohrab, Mehdi Hedayati, Meghdad Sedaghat
Summary: This study shows that daily administration of 30 mg crocin supplement to patients with type 2 diabetes mellitus reduces the concentrations of hs-CRP, TNF-alpha, and NF-kappa B which are involved in the pathogenesis of complications of T2DM.
PHYTOTHERAPY RESEARCH
(2021)
Article
Hematology
Marco Orlandi, Stefano Masi, Devina Bhowruth, Yago Leira, Georgios Georgiopoulos, Derek Yellon, Aroon Hingorani, Scott T. Chiesa, Derek J. Hausenloy, John Deanfield, Francesco D'Aiuto
Summary: The study showed that remote ischemic preconditioning (RIPC) can prevent acute endothelial dysfunction in patients with periodontitis following exposure to an acute inflammatory stimulus by modulating inflammation and oxidation processes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Food Science & Technology
De Santis Stefania, M. L. Clodoveo, M. Cariello, G. D'Amato, C. Franchini, M. F. Faienza, F. Corbo
Summary: Obesity is a major public health challenge with a multifactorial etiology, but it is preventable. Studies have shown that dietary polyphenols can modulate gene expression related to obesity, aiding in the fight against obesity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Food Science & Technology
Jinhan Yang, Lin Zhang, Tong Wang, Jiajia Zhang, Mingyue Li, Xiaoxia Jin, Xiaoqiong Tan, Gaoyang Wang, Fenghong Zhao, Yaping Jin
Summary: Our study investigated the effects of combined treatment with 1,2-dichloroethane (1,2-DCE) and high dose ethanol on liver and the mechanisms. The findings revealed that the combined treatment synergistically upregulated CYP2E1 levels, leading to liver damage through oxidative stress. It also triggered inflammasome activation and inflammatory responses, and resulted in insufficient protection from antioxidant defense systems.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Julie E. A. Hunt, Mariana O. C. Coelho, Sean Buxton, Rachel Butcher, Daniel Foran, Daniel Rowland, William Gurton, Heather Macrae, Louise Jones, Kyle S. Gapper, Ralph J. F. Manders, David G. King
Summary: The study showed that consuming NZBC extract can significantly accelerate the recovery of muscle damage post-exercise, alleviate muscle soreness, and improve muscle function recovery speed.
Article
Food Science & Technology
Ivan Cruz-Chamorro, Nuria Alvarez-Sanchez, Ana Isabel Alvarez-Rios, Guillermo Santos-Sanchez, Justo Pedroche, Francisco Millan, Cecilio Carrera Sanchez, Maria Soledad Fernandez-Pachon, Maria Carmen Millan-Linares, Alicia Martinez-Lopez, Patricia Judith Lardone, Ignacio Bejarano, Juan Miguel Guerrero, Antonio Carrillo-Vico
Summary: This study aimed to evaluate the safety and efficacy of a beverage containing Lupinus angustifolius protein hydrolysates (LPHs) on the immune, oxidative, and metabolic status of healthy subjects. The results showed that LPHb ingestion was safe and effective in enhancing the anti-/pro-inflammatory response of PBMCs and improving cellular antioxidant capacity. Additionally, LPHb was found to reduce the LDL-C/HDL-C atherogenic index and serum total cholesterol levels, especially in the male cohort.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Veterinary Sciences
Katie D. Mauro, Michele P. Lambert, M. Anna Kowalska, Vincent J. Thawley, Mortimer Poncz, Cynthia M. Otto
Summary: This pilot clinical trial evaluated the safety and effect of 2-O, 3-O desulfated heparin (ODSH) in dogs with septic peritonitis. The results showed no adverse effects of ODSH administration and some dogs survived to discharge. A larger randomized controlled trial is needed to further assess the efficacy of ODSH in the treatment of septic peritonitis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Maryam Ershad, Mark K. Shigenaga, Brian Bandy
Summary: Excessive dietary fat and bile acids can harm intestinal barrier integrity and promote inflammation, while dietary polyphenols found in berries may offer protection to intestinal epithelial cells exposed to fat. Anthocyanin-rich bilberry extract and resveratrol can help reduce oxidative stress and inflammation in intestinal cells, potentially preventing barrier dysfunction caused by high-fat diets.
Article
Food Science & Technology
Gudrun Pahlke, Katarina Ahlberg, Anne Oertel, Theresa Janson-Schaffer, Stephanie Grabher, Hans-Peter Mock, Andrea Matros, Doris Marko
Summary: The study found that cyanidin 3-O-glucoside (Cy-3-glc) and cyanidin 3-O-sambubioside (Cy-3-sam) were the most potent in terms of antioxidant properties and protection against hydrogen peroxide-induced reactive oxygen species levels.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Medicine, General & Internal
Piyush Sharma, Raj Kumar Yadav, Rajesh Khadgawat, Rima Dada
Summary: This study examines the efficacy of 12 weeks of yoga-based lifestyle intervention with standard care on the expression of genes related to oxidative stress, inflammation, and aging in obese adults. The results suggest a positive impact of yoga-based intervention on the expression of aging-related genes in obesity, although this benefit was not evident till week 12.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Myunghee Kim, Hyeyoon Eo, Josephine Gahyun Lim, Hyunjung Lim, Yunsook Lim
Summary: This meta-analysis found that dietary vitamin E supplementation can attenuate exercise-induced muscle damage, especially when the supplementation is less than 500 IU.
Article
Chemistry, Medicinal
Hoda Zahedi, Mohammad Javad Hosseinzadeh-Attar, Mahdi Shadnoush, Amirhossein Sahebkar, Bahareh Barkhidarian, Omid Sadeghi, Atabak Najafi, Saeed Hosseini, Mostafa Qorbani, Arezoo Ahmadi, Seyed Hossein Ardehali, Abdolreza Norouzy
Summary: The study showed that short-term supplementation with curcuminoids can significantly reduce inflammation levels, improve clinical outcomes, and enhance nutritional status in patients with TBI.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Branislav Kura, Maria Szantova, Tyler W. LeBaron, Viliam Mojto, Miroslav Barancik, Barbara Szeiffova Bacova, Barbora Kalocayova, Matus Sykora, Ludmila Okruhlicova, Narcisa Tribulova, Anna Gvozdjakova, Zuzana Sumbalova, Jarmila Kucharska, Xenia Faktorova, Martina Jakabovicova, Zuzana Durkovicova, Jan Macutek, Michaela Koscova, Jan Slezak
Summary: This study suggests that molecular hydrogen has positive effects on non-alcoholic fatty liver disease, including lowering weight and body mass index. Moreover, hydrogen-rich water has no significant impact on liver function and can improve lipid profile and lactate dehydrogenase levels. The mild increase of certain biomarkers may indicate the hormetic effects of molecular hydrogen. Further research is needed to explore its preventive and therapeutic potential.
Article
Food Science & Technology
Laleh Karimzadeh, Vahideh Behrouz, Golbon Sohrab, Mehdi Hedayati, Golpar Emami
Summary: This study suggests that daily consumption of beetroot juice can reduce the concentrations of inflammatory markers, including IL-6, TNF-alpha, and NF-kappa B, in patients with type 2 diabetes.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Cell Biology
Xuebin Gao, Yongdui Ruan, Xuan Zhu, Xiaozhuan Lin, Yan Xin, Xiang Li, Meiqing Mai, Honghui Guo
Summary: Nonalcoholic steatohepatitis (NASH) is the inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) that can lead to liver fibrosis and cirrhosis. Research showed that deoxycholic acid (DCA) induces an inflammatory response in steatotic hepatocytes by inhibiting PINK1-mediated mitophagy and activating the NLRP3 inflammasome, leading to pyroptosis.
Review
Biochemistry & Molecular Biology
Xiang Li, Yan Xin, Yuqian Mo, Pavel Marozik, Taiping He, Honghui Guo
Summary: This article reviews the research progress of phytosterols as a molecular regulator of cholesterol and the mechanism of action for this pharmacological effect. Phytosterols can reduce cholesterol absorption, regulate cholesterol metabolism, and significantly lower the plasma concentration of total cholesterol and triglycerides.
Article
Nutrition & Dietetics
Xin Dai, Si Liu, Lokyu Cheng, Ting Huang, Honghui Guo, Dongliang Wang, Min Xia, Wenhua Ling, Yunjun Xiao
Summary: Betaine supplementation reduces plasma SAH levels and protects against SAHH-deficiency-promoted atherosclerosis by inhibiting inflammation and smooth muscle cell proliferation and migration.
Article
Cardiac & Cardiovascular Systems
Xin Dai, Si Liu, Lokyu Cheng, Ting Huang, Honghui Guo, Dongliang Wang, Min Xia, Wenhua Ling, Yunjun Xiao
Summary: This study reveals a correlation between SAHH deficiency and atherosclerotic calcification, and elucidates a new mechanism in which epigenetic upregulation of H19 and AMPK inhibition concurrently contribute to SAHH deficiency-promoted Runx2-dependent atherosclerotic calcification.
CIRCULATION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Xuan Zhu, Xiaozhuan Lin, Peiwen Zhang, Yongji Liu, Wenhua Ling, Honghui Guo
Summary: The study revealed that the activation of NLRP3 inflammasome is significantly increased in NAFLD patients, but can be markedly suppressed by anthocyanins.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Xiaozhuan Lin, Meiqing Mai, Taiping He, Hairong Huang, Peiwen Zhang, Enqin Xia, Honghui Guo
Summary: The research found that UDCA treatment has a significant effect on reducing serum levels of ALT and GGT in NASH patients, but has no significant impact on physical characteristics or liver histology.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Chemistry, Applied
Hui Tang, Pao Li, Lin Chen, Jin-Kui Ma, Hong-Hui Guo, Xiao-Chen Huang, Rui-Min Zhong, Si-Qun Jing, Li-Wen Jiang
Summary: This study investigated the formation mechanism of flavor compounds in stinky tofu brine, and identified phenol, p-cresol, indole, and 3-methylindole as the key flavor substances. Associated bacteria and enzymes played significant roles in the formation of these flavor compounds.
Review
Biochemistry & Molecular Biology
Mengliu Luo, Meiqing Mai, Wanhan Song, Qianhua Yuan, Xiaoling Feng, Enqin Xia, Honghui Guo
Summary: This article discusses the relationship between aging and health issues, exploring the importance of delaying organ or tissue aging and improving physiological function in reducing the risk of age-related diseases. It also emphasizes the importance of consuming colorful plant foods to increase lifespan, particularly highlighting the potential anti-aging effects of certain phytochemicals found in dark-colored plant foods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Xiang Li, Xuan Zhu, Xiaozhuan Lin, Mengliu Luo, Yunjun Xiao, Yongdui Ruan, Honghui Guo
Summary: This study demonstrates that stigmasterol (STG) has a protective effect in mice with NAFLD progressing to steatohepatitis. STG reduces hepatic cholesterol accumulation and inflammation, increases bile acid content in the intestines, enhances the alternative pathway for bile acid synthesis, and improves gut microbiota diversity.
JOURNAL OF NUTRITION
(2023)
Article
Food Science & Technology
Xiaozhuan Lin, Xuan Zhu, Yan Xin, Peiwen Zhang, Yunjun Xiao, Taiping He, Honghui Guo
Summary: Intermittent fasting shows potential in alleviating NASH by regulating gut microbiota and bile acids metabolism. It can reduce body weight, insulin resistance, hepatic steatosis, and inflammation, while reshaping gut microbiota and promoting bile acid excretion.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiang Li, Lei Zhou, Yuying Zheng, Taiping He, Honghui Guo, Jiangbin Li, Jingjing Zhang
Summary: Feeding adult zebrafish with egg yolk powder for 30 days can simulate the pathology of human nonalcoholic fatty liver disease.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xuebin Gao, Xiaozhuan Lin, Yan Xin, Xuan Zhu, Xiang Li, Ming Chen, Zhigang Huang, Honghui Guo
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder globally. A study found that high dietary cholesterol intake accelerates the progression of NAFLD and induces liver inflammation in mice. Additionally, certain bacterial species in the gut microbiota were found to be positively correlated with the content of unconjugated bile acids in the liver. High dietary cholesterol alters gut microbiota composition and bile acid metabolism, promoting the development of NASH.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Wanhan Song, Qianhua Yuan, Ya Wang, Meiqing Mai, Mengliu Luo, Honghui Guo
Summary: This study investigated the relationship between anthocyanin intake and obesity-related inflammatory markers. The findings showed that anthocyanin supplementation can significantly reduce plasma concentrations of inflammatory markers, such as C-reactive protein, tumor necrosis factor alpha, and interleukin-6. Additionally, anthocyanin intake had a stronger effect on CRP and IL-6 concentrations in overweight or dyslipidemic individuals, and after 8 to 12 weeks of intervention on plasma IL-6 and TNF-alpha.
NUTRITION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Meiqing Mai, Ya Wang, Mengliu Luo, Zhongxia Li, Di Wang, Yongdui Ruan, Honghui Guo
Summary: This study suggests that silibinin may hold therapeutic potential for NASH by alleviating pyroptosis and inhibiting NLRP3 inflammasome activation.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2023)
Article
Chemistry, Analytical
Xuan Zhu, En-Qin Xia, Yu-Guo Liu, Wei-Qiao Li, Yan Xin, Xiao-Zhuan Lin, Pavel Marozik, Hong-Hui Guo
Summary: A green extraction method coupled with ultra-high performance liquid chromatography-mass spectrometry was developed to simultaneously determine bile acids (BAs) in ileal contents and fecal samples. The study found that cholic acid was the dominant BA in both samples of high-fat and high-cholesterol diet-induced obese mice, with higher concentrations of hydrophobic BAs observed in obese mice. The proposed method can be used for similar samples of bile acids analysis in patients with obesity.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.