Poly-Arginine Peptide-18 (R18) Reduces Brain Injury and Improves Functional Outcomes in a Nonhuman Primate Stroke Model

Poly-arginine Peptide R18D Reduces Neuroinflammation and Functional Deficits Following Traumatic Brain Injury in the Long-Evans Rat

(2019) Li Shan Chiu et al.   International Journal of Peptide Research and Therapeutics

Poly-Arginine Peptides R18 and R18D Improve Functional Outcomes After Endothelin-1-Induced Stroke in the Sprague Dawley Rat

(2019) Bruno P Meloni et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

(2019) Bruce C V Campbell et al.   LANCET

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

(2018) Raul G. Nogueira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies

(2018) Diego Milani et al.   PLoS One

Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

(2018) Adam B. Edwards et al.   Molecular Brain

Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics

(2018) Gabriella MacDougall et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat

(2017) Diego Milani et al.   NEUROSCIENCE RESEARCH

A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP

(2017) Lan-Hui Li et al.   PLoS One

Reconsidering Neuroprotection in the Reperfusion Era

(2017) Sean I. Savitz et al.   STROKE

Translational Stroke Research

(2017) Francesca Bosetti et al.   STROKE

Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat stroke model

(2016) Diego Milani et al.   BMC NEUROSCIENCE

Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety, Tolerability, and Pharmacokinetics of a Single Escalating Dose and Repeated Doses of CN-105 in Healthy Adult Subjects

(2016) Jeffrey T. Guptill et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic Mechanisms

(2016) Gabriella MacDougall et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Acute endovascular recanalization therapy comes of age

(2016) Alejandro A. Rabinstein   Nature Reviews Neurology

Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke

(2016) Yi Yang et al.   PEPTIDES

Inhibition ofN-Methyl-d-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential

(2015) John Marshall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poly-Arginine and Arginine-Rich Peptides are Neuroprotective in Stroke Models

(2015) Bruno P Meloni et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

(2015) Bruno P. Meloni et al.   PHARMACOLOGY & THERAPEUTICS

Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo

(2015) Sofie Stalmans et al.   PLoS One

Collapsin Response Mediator Protein 2 (CRMP2) Interacts withN-Methyl-d-aspartate (NMDA) Receptor and Na+/Ca2+Exchanger and Regulates Their Functional Activity

(2014) Tatiana Brustovetsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Transduction of 11 Poly-arginine Peptide in an Ischemic Lesion of Mouse Brain

(2014) Yuki Gotanda et al.   Journal of Stroke & Cerebrovascular Diseases

The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity

(2014) Agustin García-Caballero et al.   NEURON

Identification of multifunctional peptides from human milk

(2014) Santi M. Mandal et al.   PEPTIDES

The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Cultures

(2013) Bruno P. Meloni et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cell-Penetrating Peptide-Mediated Therapeutic Molecule Delivery into the Central Nervous System

(2013) Li-Li Zou et al.   Current Neuropharmacology

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

(2013) Ashley L Hilchie et al.   Nature Chemical Biology

Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway

(2013) Qin Gu et al.   NEUROCHEMISTRY INTERNATIONAL

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Michael D Hill et al.   LANCET NEUROLOGY

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

(2012) Douglas J. Cook et al.   NATURE

Nonhuman Primate Models of Stroke for Translational Neuroprotection Research

(2012) Douglas J. Cook et al.   Neurotherapeutics

Neuroprotection by Freezing Ischemic Penumbra Evolution Without Cerebral Blood Flow Augmentation With a Postsynaptic Density-95 Protein Inhibitor

(2011) Bernt T. Bråtane et al.   STROKE

Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand

(2008) F. X. Soriano et al.   JOURNAL OF NEUROSCIENCE

Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

(2008) Hong-Shuo Sun et al.   STROKE