Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice
出版年份 2020 全文链接
标题
Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice
作者
关键词
-
出版物
MOLECULAR AND CELLULAR BIOLOGY
Volume 40, Issue 6, Pages -
出版商
American Society for Microbiology
发表日期
2020-01-09
DOI
10.1128/mcb.00467-19
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis
- (2019) Christopher M. Henstridge et al. NATURE REVIEWS NEUROSCIENCE
- Inflammatory mechanisms in neurodegeneration
- (2019) Michael R. Nichols et al. JOURNAL OF NEUROCHEMISTRY
- Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice
- (2019) Yoko Yagishita et al. JOURNAL OF ENDOCRINOLOGY
- The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
- (2019) Amaia M Arranz et al. LANCET NEUROLOGY
- A Unifying Hypothesis for Alzheimer’s Disease: From Plaques to Neurodegeneration
- (2019) Frances A. Edwards TRENDS IN NEUROSCIENCES
- Microglial subtypes: diversity within the microglial community
- (2019) Vassilis Stratoulias et al. EMBO JOURNAL
- Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
- (2018) Aleksandra Deczkowska et al. CELL
- Protective Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate on Aβ1-42-Induced Cognitive Deficit, Oxidative Stress, Inflammation, and Apoptosis in Mice
- (2018) Fabiana Morroni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
- (2018) Masayuki Yamamoto et al. PHYSIOLOGICAL REVIEWS
- Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy
- (2018) Ana I. Rojo et al. Redox Biology
- Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer’s disease
- (2018) Priscilla Youssef et al. Scientific Reports
- Metabolomic changes in the mouse retina after optic nerve injury
- (2018) Kota Sato et al. Scientific Reports
- The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice
- (2017) Chika Higashi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease
- (2017) Caterina Branca et al. HUMAN MOLECULAR GENETICS
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice
- (2017) Takuma Suzuki et al. MOLECULAR AND CELLULAR BIOLOGY
- Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress
- (2017) Yoko Yagishita et al. Cell Reports
- NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology
- (2017) Ana I. Rojo et al. Redox Biology
- Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
- (2017) Erika Castillo et al. Scientific Reports
- Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease
- (2016) Isabel Lastres-Becker et al. ANTIOXIDANTS & REDOX SIGNALING
- Pitfalls in the analysis of the physiological antioxidant glutathione (GSH) and its disulfide (GSSG) in biological samples: An elephant in the room
- (2016) Daniela Giustarini et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
- (2016) Eri H. Kobayashi et al. Nature Communications
- The Keap1–Nrf2 system and diabetes mellitus
- (2015) Akira Uruno et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response
- (2015) Ryota Saito et al. MOLECULAR AND CELLULAR BIOLOGY
- Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy
- (2015) Gururaj Joshi et al. NEUROBIOLOGY OF AGING
- Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2
- (2015) Karen F.S. Bell et al. Nature Communications
- The Role of Oxidative Stress in Neurodegenerative Diseases
- (2015) Geon Ha Kim et al. Experimental Neurobiology
- Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease
- (2014) Fabiana Morroni et al. BRAIN RESEARCH
- Single App knock-in mouse models of Alzheimer's disease
- (2014) Takashi Saito et al. NATURE NEUROSCIENCE
- Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?
- (2014) Torbjörn Persson et al. Oxidative Medicine and Cellular Longevity
- Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
- (2014) Scott J. Webster et al. Frontiers in Genetics
- Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice
- (2013) Hiroyuki Muramatsu et al. GENES TO CELLS
- A new LC–MS/MS method for the clinical determination of reduced and oxidized glutathione from whole blood
- (2013) Tereza Moore et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1
- (2013) Toshiaki Fukutomi et al. MOLECULAR AND CELLULAR BIOLOGY
- Neuronal activity regulates astrocytic Nrf2 signaling
- (2013) A. Habas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functions of plasmalogen lipids in health and disease
- (2012) Nancy E. Braverman et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
- (2012) Kai Takaya et al. FREE RADICAL BIOLOGY AND MEDICINE
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Stimulation of phagocytosis by sulforaphane
- (2011) Hiroyuki Suganuma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Elevation of glutathione as a therapeutic strategy in Alzheimer disease
- (2011) Chava B. Pocernich et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Dynamics of Nrf2 and Keap1 in ARE-MediatedNQO1Expression by Wasabi 6-(Methylsulfinyl)hexyl Isothiocyanate
- (2011) De-Xing Hou et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Alzheimer's disease
- (2011) Clive Ballard et al. LANCET
- Embryonic Lethality and Fetal Liver Apoptosis in Mice Lacking All Three Small Maf Proteins
- (2011) H. Yamazaki et al. MOLECULAR AND CELLULAR BIOLOGY
- Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation
- (2011) Hidemi Yoshida et al. NEUROSCIENCE RESEARCH
- Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex
- (2010) Mubeen A. Ansari et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1
- (2010) K. Taguchi et al. MOLECULAR AND CELLULAR BIOLOGY
- Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
- (2010) G. P. Sykiotis et al. Science Signaling
- Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease
- (2009) Magali Dumont et al. JOURNAL OF NEUROCHEMISTRY
- Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription
- (2009) Lichuan Yang et al. PLoS One
- Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
- (2009) K. Kanninen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione
- (2008) Francesc X. Soriano et al. JOURNAL OF NEUROCHEMISTRY
- Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
- (2008) Katja Kanninen et al. MOLECULAR AND CELLULAR NEUROSCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started