Article
Engineering, Electrical & Electronic
Mayumi Otoba Uno, Shigeru Morita, Mariko Omori, Kansei Yoshimura
Summary: This study presents pressure-sensing double-ply yarns that can be used as a platform for soft and flexible electronic devices. The sensor yarns are sensitive to compressive and tensile strains but insensitive to free bending.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Biochemistry & Molecular Biology
Melis Ercelik, Cagla Tekin, Fatma Nur Parin, Busra Mutlu, Hazal Yilmaz Dogan, Gulcin Tezcan, Secil Ak Aksoy, Melisa Gurbuz, Kenan Yildirim, Ahmet Bekar, Hasan Kocaeli, Mevlut Ozgur Taskapilioglu, Pinar Eser, Berrin Tunca
Summary: Glioblastoma is prone to recur after surgical treatment, requiring local therapeutic strategies. This study developed a nanofiber-based therapy using Oleuropein, rutin, and Temozolomide against recurrent GB cells. The results demonstrated that the nanofiber webs effectively controlled the release of Oleuropein and Temozolomide, suppressing the growth and migration of GB cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Jincheng Gu, Shinichi Yagi, Jie Meng, Yubing Dong, Chen Qian, Defang Zhao, Alesh Kumar, Ting Xu, Agnese Lucchetti, Huaizhong Xu
Summary: Co-axial electro-centrifugal spinning (ECS) technology enables the large-scale production of core-sheath nanofibers and solves the nozzle clogging issue, making it applicable for controlled drug release.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Physical
Wen Yu, Xiang Li, Jianxin He, Yuankun Chen, Linya Qi, Pingping Yuan, Kangkang Ou, Fan Liu, Yuman Zhou, Xiaohong Qin
Summary: In this study, nanofiber yarn loaded with a high-efficiency antibacterial agent was prepared using electrospinning technology. The nanofiber fabric showed over 99.99% antibacterial rate against Escherichia coli and Staphylococcus aureus, which remained above 99.99% even after ten washes, demonstrating high antibacterial activity and excellent durability.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Raul Cazorla-Luna, Roberto Ruiz-Caro, Maria-Dolores Veiga, R. Karl Malcolm, Dimitrios A. Lamprou
Summary: Electrospinning is a cutting-edge technology for producing nanofibers and microfibers by applying high voltage to polymer solutions or melts, with potential applications in drug delivery systems and tissue engineering. Recent years have witnessed a growing interest in utilizing electrospinning technology for the treatment and prevention of diseases related to women's sexual and reproductive health.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Xuejiao Tao, Yuman Zhou, Kun Qi, Chaozhong Guo, Yunling Dai, Jianxin He, Zhao Dai
Summary: Flexible wearable textile triboelectric generators can convert mechanical energy into electrical energy to power wearable electronic products. They are small, lightweight, and exhibit excellent durability and electrical performance. The generators can drive low-consumption electronic devices, demonstrating potential for flexible self-powered electronic devices and intelligent textiles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Qiao Yang, Jianfeng Li, Weiwei Su, Liu Yu, Ting Li, Yongdi Wang, Kairui Zhang, Yaobin Wu, Ling Wang
Summary: This study presents an electrospinning approach to fabricate aligned poly (epsilon-caprolactone) nanofiber yarns that integrate with nano- and micro-scale structure to mimic the hierarchical structure of native tendon tissue. These aligned nanofiber yarns demonstrated good in vitro biocompatibility and the ability to induce 3D cellular alignment and elongation of tendon stem/progenitor cells. Furthermore, they showed potential in promoting tenogenic differentiation and tendon repair in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hamta Majd, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar
Summary: This research utilized a novel core-sheath pressurised gyration technique to create antibacterial fibre patches, demonstrating a biphasic delivery system suitable for wound-dressing applications. The study investigated the effect of operating parameters on fibre morphology, the influence of core-sheath structure and drug loading, successfully encapsulating TEHCL.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Polymer Science
Renatha Jiffrin, Saiful Izwan Abd Razak, Mohamad Ikhwan Jamaludin, Amir Syahir Amir Hamzah, Muadz Ahmad Mazian, Muhammad Azan Tamar Jaya, Mohammed Z. Nasrullah, Mohammed Majrashi, Abdulrahman Theyab, Ahmed A. Aldarmahi, Zuhier Awan, Mohamed M. Abdel-Daim, Abul Kalam Azad
Summary: Electrospinning is a promising method for creating nanofiber membranes that can release drugs over time. These nanofiber composites have a large surface area to volume ratio, which aids in cell binding, drug loading, and mass transfer processes.
Article
Materials Science, Textiles
Zhichao Yang, Shuqiang Liu, Jingjing Li, Gaihong Wu, Man Zhang, Fu Li, Lu Jia, Yujing Zhang, Huimin Li, Xia Liu, Jingjing Zhao, Huiqin Zhang, Shiyu Li
Summary: In this study, a new drug-loading system for core-spun surgical sutures was constructed to improve the clinical applicability of surgical sutures. By adjusting the composition ratio of different materials in the shell, the release rate and release cycle of the suture were regulated, providing a new idea for the study of new antibacterial surgical sutures.
FIBERS AND POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Xiaowen Han, Mingda Zhao, Ruiling Xu, Yaping Zou, Yuxiang Wang, Jie Liang, Qing Jiang, Yong Sun, Yujiang Fan, Xingdong Zhang
Summary: Synchronous control of disease and regeneration progression is necessary for lesioned tissue after surgery, and therapeutic and regenerative scaffolds need to be developed. Electrospun hyaluronic acid derivative nanofiber membranes can promote the potential regeneration of injured skin tissues and achieve therapeutic effects when incorporated with drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Manufacturing
Zhen Zeng, Baowei Hao, Daiqi Li, Deshan Cheng, Guangming Cai, Xin Wang
Summary: In this study, a novel and simple spinning strategy was proposed to fabricate spandex/CNT cotton yarns with good performance, which could be dyed into different colors through a concise dyeing process to become sensors. The sensor exhibited good sensitivity, broad sensing range, excellent durability, and abrasion resistance, and could be successfully integrated into textiles. The weavable and dyeable core-spun yarn provided a feasible approach for industrial-scale production of wearable sensors.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2021)
Article
Cell Biology
Liang-Ju Ning, Ya-Jing Zhang, Yan-Jing Zhang, Min Zhu, Wei Ding, Yan-Lin Jiang, Yi Zhang, Jing-Cong Luo, Ting-Wu Qin
Summary: A new decellularized tendon hydrogel from Macaca mulatta was developed in this study, which was found to promote proliferation, migration, and tenogenic differentiation of tendon-derived stem cells. The retained nanofibrous structure and bioactive factors make this hydrogel a promising candidate for tendon regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Rong Tan, Xiong Yang, Haojian Lu, Liu Yang, Tieshan Zhang, Jiaqi Miao, Yu Feng, Yajing Shen
Summary: This study presents a degradable millirobot based on nanofibers that can work in the alimentary tract. The robot can programmatically release different drugs in response to variations in acidic physiological concentrations. The multi-legged design allows effective locomotion in harsh in-body environments. In a rabbit model, the robot demonstrated locomotion abilities, desired-region anchoring, and stepwise drug release.
Review
Materials Science, Biomaterials
Aszad Alam, Rounik Karmakar, Aravind Kumar Rengan, Mudrika Khandelwal
Summary: Drug delivery and delivery systems play a crucial role in medical research, and nanofibers have proven to be significant in achieving controlled release of drugs at specific sites. This review explores the materials, techniques, modifications, drug release, applications, and challenges of nanofiber-based drug delivery systems. It highlights the potential of these systems in stimuli-responsive and dual drug delivery.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Biomedical
Shaohua Wu, Ye Qi, Wen Shi, Mitchell Kuss, Shaojuan Chen, Bin Duan
Summary: This study developed conductive PPDO/CNT composite nanofiber yarns, demonstrating their potential for nerve regeneration applications. The PPDO/CNT NYs showed excellent mechanical properties and biocompatibility, and were able to promote cell differentiation and maturation through electrical stimulation.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Textiles
Li Chang, Chuanfen Wu, Pengfei Lan, Bing Bai, Liang Jiang, Shaojuan Chen, Stephen Jerrams, Jianwei Ma
Summary: Blends of polypropylene and styrene-ethylene/butylene-styrene copolymer were successfully used to produce elastic melt-blown nonwovens with high elongation and elastic recovery, while maintaining fine fiber diameters and good filtration properties. The blends displayed a co-continuous structure when the ratio of SEBS to PP was similar, showing good spinnability during rheological and thermal properties tests.
TEXTILE RESEARCH JOURNAL
(2022)
Article
Chemistry, Applied
Fang Zhou, Congjing Cui, Shibin Sun, Shaohua Wu, Shaojuan Chen, Jianwei Ma, Chang Ming Li
Summary: A multifunctional bilayer membrane with antibacterial, anti-inflammatory, and effective cell contact guide functions was designed and fabricated using electrospinning. The outer layer exhibited great antibacterial activity, while the inner layer provided anti-inflammatory and cell contact guide functions. The membrane showed obvious inhibitory effects against E. coli and S. aureus and was non-cytotoxic to fibroblasts.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Congjing Cui, Shibin Sun, Xueyan Li, Shaojuan Chen, Shaohua Wu, Fang Zhou, Jianwei Ma
Summary: This study successfully optimized the structure and drug release characteristics of a nanofibrous membrane, resulting in controlled release of ciprofloxacin and exhibiting good antibacterial properties and biocompatibility. The findings of this research are of great significance for promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Li Chang, Yanfen Zhou, Kun Dai, Liang Jiang, Stephen Jerrams, Jianwei Ma, Shaojuan Chen
Summary: An elastic masterbatch and elastic melt blown nonwovens were prepared using SEBS and PP blend. The study investigated the phase separation morphology, rheological properties, and crystal structure of the elastic masterbatch. Results showed that a compatible structure was achieved in the blend, with SEBS network structure restricting the crystallization of PP. The study also examined the relationship between process parameters and properties of the elastic nonwoven, finding that air pressure and DCD affected fiber diameter and bonding, with DCD having a greater impact on elastic recovery.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Manufacturing
Mengsi Liu, Yaping Sheng, Chenggang Huang, Yanfen Zhou, Liang Jiang, Mingwei Tian, Shaojuan Chen, Stephen Jerrams, Fenglei Zhou, Jianyong Yu
Summary: In this study, elastomeric fiber based strain sensors incorporating graphene and carbon nanotubes were fabricated via coaxial wet spinning. The solution etched fiber based strain sensors achieved a significant improvement in obtaining a high maximum gauge factor and capability of working over a wide strain range. The strain sensor showed excellent durability and was used to monitor physiological movements with fast and accurate responses.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2023)
Article
Engineering, Biomedical
Jiangyu Cai, Jiao Liu, Junjie Xu, Yufeng Li, Ting Zheng, Tianlun Zhang, Kang Han, Shaojuan Chen, Jia Jiang, Shaohua Wu, Jinzhong Zhao
Summary: In this study, innovative nano-micro fibrous woven scaffolds with tendon-like structure and high-strength mechanical properties were fabricated for the treatment of large-size tendon injury. These scaffolds showed improved cell adhesion, elongation, proliferation, and maintained tenocyte phenotype. In vivo experiments demonstrated that the scaffold facilitated Achilles tendon regeneration with improved structure and biomechanical properties.
Article
Materials Science, Biomaterials
Shibin Sun, Qifan Yuan, Xueyan Li, Xueqin Wang, Shaohua Wu, Shaojuan Chen, Jianwei Ma, Fang Zhou
Summary: This study developed curcumin functionalized composite fibers with pH real-time monitoring, antibacterial, and anti-inflammatory properties, which showed great potential for the treatment of wound infection.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Polymer Science
Ye Qi, Conger Wang, Qiuyu Wang, Fang Zhou, Tao Li, Bo Wang, Weidong Su, Dawei Shang, Shaohua Wu
Summary: The study reports on a simple, quick, and cost-effective method to produce nanofiber-constructed yarns (NYs) using a combination of electrospinning, hand winding, and stretching post-treatment. The NYs demonstrated improved surface hydrophilicity and wettability with increasing silk fibroin (SF) content. Cells were able to sense and respond to the nanofibrous morphology and orientation of the NYs and SF promoted cell growth and proliferation. This research provides a simple and feasible method for fabricating PCL/SF NYs and NY-based biotextiles with great potential for tissue engineering and regenerative medicine applications.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Engineering, Biomedical
Yiran Li, Qi Meng, Shaojuan Chen, Peixue Ling, Mitchell A. Kuss, Bin Duan, Shaohua Wu
Summary: Surgical sutures play a vital role in the closure and healing of damaged tissues and organs. Recent advancements in multiple disciplines have led to the development of innovative surgical sutures with humanization and multi-functionalization. This review summarizes the materials, fabrication strategies, structures, functionalizations, and commercial products of surgical sutures, and discusses the challenges and future prospects in the field.
ACTA BIOMATERIALIA
(2023)
Article
Agricultural Engineering
Yiran Li, Hui Zhao, Tao Li, Dawei Shang, Limin Wu, Ning Guan, Shaohua Wu
Summary: A novel two-step modification strategy was used to functionalize commonly used cotton fibers into highly effective antibacterial fibers. These fibers demonstrated high antibacterial sustainability and durability, while maintaining low cost. By blending only 10% of these functionalized fibers into nonwoven fabrics, strong antibacterial efficiency was achieved without compromising cytocompatibility. This study presents a simple and cost-effective technique for fabricating advanced functional textiles that can be widely applied in daily lives.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Engineering, Biomedical
Shaohua Wu, Yiran Li, Shaojuan Chen, Huiyuan Zhai, Peixue Ling
Summary: This study developed a simple and cost-effective technique roadmap for generating high performance PLLA nanofiber-constructed yarns or threads with controllable structures. By combining a modified electrospinning method with traditional textile processes such as hot stretching, twisting, and plying, PLLA ENYs with adjustable morphology, structure, and tensile properties were successfully fabricated. The study investigated the effects of different treatments on the alignment and crystallinity of the fibers, as well as the enhancements in tensile properties.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
