期刊
MATERIALS LETTERS
卷 261, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.matlet.2019.127151
关键词
Photo-responsive; Flower-like micelle; Drug delivery; Polymers; Biomaterials
资金
- National Natural Science Fundation of China [31670979, 51273034]
- Science and Technology Program of Sichuan Province [2018GZ0460, 2019YFS0132]
The photo-responsive ABA amphiphilic triblock copolymers polylactide-block-poly(ethylene glycol)-block-polylactide with o-nitrobenzyl esters as the photocleavable block-linker (defined as PLA-NB-PEG-NB-PLA), were prepared by controlled ring-opening polymerization (ROP) of D, L-lactide (D, L-LA) using two o-nitrobenzyl groups terminated polyethylene glycol as initiator. Flower-like micelles formed after these copolymers were dissolved in aqueous solution. Introduction of shortened PEG and PLA chains, although resulting in the reduction of micelle sizes, would bring about higher photolysis rate and loading efficiency of DOX. The flower-like micelles showed excellent photocleavage properties, thereby, burst release of DOX could be induced after UV irradiation, which will have potential application in biomedical materials. (C) 2019 Elsevier B.V. All rights reserved.
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