pH-triggered sustained drug release of multilayer encapsulation system with hollow mesoporous silica nanoparticles/chitosan/polyacrylic acid

Chitosan is one of the most important and commonly used pH stimuli-responsive polymer. However, the drug burst release when the pH values are in the sensitive range of CS makes the release of the drug unsustainable. To address this problem, the multilayer encapsulation of hollow mesoporous silica nanoparticles with chitosan and polyacrylic acid as outmost layer (SiO2@CS@PAA), is reported. The morphology and structure of the SiO2@CS@PAA are characterized and the release behaviors of drugs in different pH release medium are also studied. The results suggested that the decoration of PAA could reduce the burst release of drugs with pH-sensitivity. (C) 2019 Elsevier B.V. All rights reserved.