Boron nitride (10BN) a prospective material for treatment of cancer by boron neutron capture therapy (BNCT)

Highly water dispersible (BN)-B-10 has been synthesized using solvothermal method at relatively low temperature. Structural and morphological analysis of (BN)-B-10 has been done. Cytotoxicity analysis on normal (HEK-293) and cancer (HeLa, MCF-7) cells showed that (BN)-B-10 is relatively less toxic and produces insignificant oxygen species. Promising BNCT antitumor effect was observed in (BN)-B-10 treated HeLa cells. The thermal neutron fluence of similar to 6.3 x 10(12)/cm(2) resulted in almost 50% cell killing of BN treated HeLa cells. (C) 2019 Elsevier B.V. All rights reserved.