期刊
MACROMOLECULAR BIOSCIENCE
卷 20, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201900328
关键词
burn injuries; core-shell nanofibers; electrospinning; silk fibroin; wound healing
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes for Health Research (CIHR)
- Canada Foundation for Innovation (CFI)
- 4M Biotech Inc.
- European Union Framework Programme for Research and Innovation HORIZON 2020 [668983-FoReCaST]
- American Heart Association [19TPA34850188]
- Brigham Research Institute
Burn injuries represent a major life-threatening event that impacts the quality of life of patients, and places enormous demands on the global healthcare systems. This study introduces the fabrication and characterization of a novel wound dressing made of core-shell hyaluronic acid-silk fibroin/zinc oxide (ZO) nanofibers for treatment of burn injuries. The core-shell configuration enables loading ZO-an antibacterial agent-in the core of nanofibers, which in return improves the sustained release of the drug and maintains its bioactivity. Successful formation of core-shell nanofibers and loading of zinc oxide are confirmed by transmission electron microscopy, Fourier-transform infrared spectroscopy, and energy dispersive X-ray. The antibacterial activity of the dressings are examined against Escherichia coli and Staphylococcus aureus and it is shown that addition of ZO improves the antibacterial property of the dressing in a dose-dependent fashion. However, in vitro cytotoxicity studies show that high concentration of ZO (>3 wt%) is toxic to the cells. In vivo studies indicate that the wound dressings loaded with ZO (3 wt%) substantially improves the wound healing procedure and significantly reduces the inflammatory response at the wound site. Overall, the dressing introduced herein holds great promise for the management of burn injuries.
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