Article
Oncology
Lihong Mei, Zhihua Zhang, Xushuo Li, Ying Yang, Ruixue Qi
Summary: This study aimed to explore potential metabolomics biomarkers for predicting the efficiency of chemo-immunotherapy in NSCLC patients. Metabolomics profiling analyses using GC-MS identified seven key metabolites, including pyruvate, threonine, alanine, urea, oxalate, elaidic acid, and glutamate, which were associated with the chemo-immunotherapy response. Pathway analyses revealed that urea cycle, glucose-alanine cycle, glycine and serine metabolism, alanine metabolism, and glutamate metabolism were the key metabolic pathways involved.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Daniela Madama, Rosana Martins, Ana S. Pires, Maria F. Botelho, Marco G. Alves, Ana M. Abrantes, Carlos R. Cordeiro
Summary: Lung cancer is a significant burden globally, with late-stage diagnosis and low survival rates posing challenges. Interest in noninvasively collected samples and metabolomics as a growing area of study for lung cancer is increasing. More consistent and systematized studies are needed to identify metabolic biomarkers and pathways associated with tumor progression, relapse, and therapy resistance.
Article
Cell Biology
Zhenzhen Hui, Jiali Zhang, Yulin Ren, Xiaoling Li, Cihui Yan, Wenwen Yu, Tao Wang, Shanshan Xiao, Yulong Chen, Ran Zhang, Feng Wei, Jian You, Xiubao Ren
Summary: The study found that the synergistic increase of B cells and CD4(+) T cells is associated with positive therapeutic response in neoadjuvant chemoimmunotherapy. B cell IgG subclasses IgG1 and IgG3 play critical roles in anti-tumor immune responses in tumor lesions, and this process is driven by increased IL-21 secretion by infiltrated T follicular helper (Tfh) cells after neoadjuvant chemoimmunotherapy.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Huaiyuan Zhang, Ziyuan Xu
Summary: Immunotherapy for non-small cell lung cancer (NSCLC) has made significant progress in the past two decades. However, cure and survival rates for NSCLC patients remain low. Therefore, investigating the connection between the gut microbiota (GM) and NSCLC immunotherapy outcomes, particularly the gut-lung axis (GLA), is crucial. Promising GM-based therapeutic strategies have shown potential in improving the effectiveness and reducing toxicity of immunotherapy in NSCLC patients, advancing the utilization of microbiota precision medicine.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Patricia Rich, R. Brian Mitchell, Eric Schaefer, Paul R. Walker, John W. Dubay, Jason Boyd, David Oubre, Ray Page, Mazen Khalil, Suman Sinha, Scott Boniol, Hafez Halawani, Edgardo S. Santos, Warren Brenner, James M. Orsini, Emily Pauli, Jonathan Goldberg, Andrea Veatch, Mitchell Haut, Bassam Ghabach, Savita Bidyasar, Maria Quejada, Waseemullah Khan, Kan Huang, Linda Traylor, Wallace Akerley
Summary: Blood-based HIC proteomic testing provides clinically meaningful information for immunotherapy treatment decision in NSCLC independent of PD-L1 levels. Results showed that HIC-H patients had longer overall survival compared to HIC-C patients across different treatment regimens, recommending against using ICI therapy alone for HIC-C patients regardless of their PD-L1 expression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Andrea De Giglio, Marta Aprile, Alessandro Di Federico, Francesca Sperandi, Barbara Melotti, Francesco Gelsomino, Andrea Ardizzoni
Summary: This retrospective study analyzed metastatic NSCLC patients treated with upfront CT-ICI and found that baseline steroid administration was associated with poorer survival outcomes, while intercurrent steroid administration did not reach a significant value. This suggests that the use of baseline steroids may have a detrimental effect on survival outcomes in NSCLC patients treated with CT-ICI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Maja Sutic, Ana Vukic, Jurica Baranasic, Asta Foersti, Feda Dzubur, Miroslav Samarzija, Marko Jakopovic, Luka Brcic, Jelena Knezevic
Summary: Lung cancer is the leading cause of cancer-related deaths globally, with most patients still being diagnosed at an advanced stage despite screening efforts for high-risk populations. In the past decade, management of lung cancer has significantly progressed towards personalized treatments, with molecular biomarkers playing a crucial role in prognosis and predicting therapy response. Non-small cell lung cancer, being the most common type, is the primary focus for discussion on promising new biomarkers in clinical management.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Mariana Brandao, Valerie Durieux, Masa Auprih, Alessandra Fozza, Nicolas Dauby, Francesco Cuccia, Sandrine Aspeslagh, Marthe Verhaert, Niccolo Giaj-Levra
Summary: Lung cancer is the most common non-AIDS defining cancer among people living with HIV. Data on the effectiveness and safety of radiotherapy and systemic regimens, including immuno-therapy, for these patients are limited. A systematic search of the literature identified 21 publications, including 513 PLWH with non-small cell lung cancer (NSCLC). Chemotherapy showed variable response rates (17%-83%) with substantial hematological toxicity. Single-agent immunotherapy had response rates between 13% and 50%, with acceptable toxicity profiles. Tyrosine kinase inhibitors showed partial response and long overall survival. Radiotherapy had high response rates (55%-100%) but pneumonitis occurred in 18% of patients. Larger studies are needed to confirm these findings and more data is needed regarding the long-term efficacy and safety of treatments, especially immunotherapy, among PLWH.
Review
Biochemistry & Molecular Biology
Agnieszka Rybarczyk-Kasiuchnicz, Rodryg Ramlau, Katarzyna Stencel
Summary: Lung cancer is a common malignant neoplasm that may progress to metastasize to the central nervous system, affecting the prognosis unfavorably. The discovery of EGFR-activating mutations and ALK rearrangements in lung adenocarcinoma patients has led to the introduction of small-molecule tyrosine kinase inhibitors for advanced-stage treatment. These inhibitors target different pathways to improve progression-free survival in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Li-Chung Chiu, Shu-Min Lin, Yu-Lun Lo, Scott Chih-Hsi Kuo, Cheng-Ta Yang, Ping-Chih Hsu
Summary: Early-stage NSCLC patients face high risks of recurrence and death even after surgery, with limited improvements from traditional treatments like chemotherapy and radiation. Immunotherapies, including immune checkpoint inhibitors and cancer vaccination, have shown potential in improving survival rates and are being actively researched in clinical trials.
Editorial Material
Biochemistry & Molecular Biology
Joshua R. Veatch, Sylvain Simon, Stanley R. Riddell
Summary: Preliminary results from a phase 1 trial suggest promising anti-tumor activity of tumor-infiltrating-lymphocyte therapy in patients with advanced non-small-cell lung cancer.
Article
Oncology
Geoffroy Bilger, Nicolas Girard, Helene Doubre, Matteo Giaj Levra, Etienne Giroux-Leprieur, Frederique Giraud, Chantal Decroisette, Matthieu Carton, Marie Ange Massiani
Summary: This study analyzed the characteristics of patients with controlled disease who discontinued ICI treatment after at least 18 months. The results showed that 50% of patients stopped ICI treatment, mainly due to prescriber choice or toxicity. After a median follow-up of 21 months from treatment discontinuation, 33% of patients experienced tumor progression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Oncology
Lin Zhang, Weihao Lin, Fengwei Tan, Ning Li, Qi Xue, Shugeng Gao, Yibo Gao, Jie He
Summary: This study provides an overview of the clinical trials on Sintilimab for non-small cell lung cancer (NSCLC) conducted in China, showing its effectiveness and tolerability, but further research is needed.
BIOMARKER RESEARCH
(2022)
Article
Oncology
Marie Wislez, Julien Mazieres, Armelle Lavole, Gerard Zalcman, Olivier Carre, Thomas Egenod, Raffaele Caliandro, Catherine Dubos-Arvis, Gaelle Jeannin, Olivier Molinier, Marie-Ange Massiani, Alexandra Langlais, Franck Morin, Francoise Le Pimpec Barthes, Laurent Brouchet, Jalal Assouad, Bernard Milleron, Diane Damotte, Martine Antoine, Virginie Westeel
Summary: This study assessed the feasibility of neoadjuvant durvalumab for early-stage resectable non-small-cell lung cancer. The results showed that this treatment approach resulted in a high complete resection rate and some pathological response. However, the unexpectedly high postoperative mortality rate led to the premature termination of the study.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Biagio Ricciuti, Greg Jones, Mariano Severgnini, Joao Alessi, Gonzalo Recondo, Marissa Lawrence, Tim Forshew, Christine Lydon, Mizuki Nishino, Michael Cheng, Mark Awad
Summary: In patients with advanced NSCLC, changes in ctDNA levels after pembrolizumab treatment may predict treatment response before radiological assessment. Early decreases in ctDNA corresponded with clinical benefit, suggesting a potential role for ctDNA as an early pharmacodynamic biomarker of response or resistance to immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Francesca Romana Ponziani, Antonio Nesci, Camilla Caputo, Lucia Salvatore, Anna Picca, Federica Del Chierico, Francesco Paroni Sterbini, Emanuele Marzetti, Angela Di Giorgio, Luca Santoro, Lorenza Putignani, Antonio Gasbarrini, Angelo Santoliquido, Maurizio Pompili
Summary: This study finds a high prevalence of lower extremity arterial disease (LEAD) in patients with primary biliary cholangitis (PBC), and it is associated with inflammatory markers and alterations in the gut-liver axis.
LIVER INTERNATIONAL
(2023)
Review
Immunology
Antonia Piazzesi, Lorenza Putignani
Summary: This article reviews the impact of helminths and gut microbiota on childhood development and pediatric diseases, and discusses how helminths enact changes in their host through gut microbes. The modifications of gut microbiota induced by helminths are of great importance in overcoming parasitic infections and treating inflammatory diseases. Deepening the understanding of helminth-microbiota interactions may lead to novel and more effective therapeutic strategies for childhood disorders.
PARASITE IMMUNOLOGY
(2023)
Article
Food Science & Technology
Vicky Caponigro, Federico Marini, Amalia G. M. Scannell, Aoife A. Gowen
Summary: This study compares the efficacy of Raman, FT-NIR, and FT-MIR spectral imaging techniques in quantifying lactose concentration in dried whole milk on different metallic surfaces. The results demonstrate that spectral imaging can rapidly quantify lactose concentration without the need for standard references.
Article
Chemistry, Multidisciplinary
Martina Foschi, Valerio Di Maria, Angelo Antonio D'Archivio, Federico Marini, Alessandra Biancolillo
Summary: In recent years, legumes have gained popularity among consumers due to their nutritional benefits. However, the valuable Italian lentils, often produced in smaller communities, can be subject to fraud as expired lentils may be sold alongside edible ones. This study aims to develop a non-destructive method using RGB imaging and SPORT-LDA classifier to classify Italian lentils according to their harvest year, origin, and detect expiration. The SPORT-LDA models achieved an average classification accuracy of around 88% for geographical origin and an overall accuracy of 90% for expiration detection.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Organic
Sarah R. Moor, James R. Howard, Brenden T. Herrera, Matthew S. McVeigh, Federico Marini, Adrian T. Keatinge-Clay, Eric V. Anslyn
Summary: Characterization of chiral molecules in solution is essential for measuring reaction success. Distinguishing between chiral molecules with multiple stereocenters using optical techniques is challenging. This study presents a technique using circular dichroism spectra and multivariate regression models to predict the speciation of 3-hydroxy-2-methylbutanoic acid stereoisomers, allowing for rapid and accurate determination of enantiomeric excess and diastereomeric excess without chiral chromatography.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Biochemistry & Molecular Biology
Antonella Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta, Gabriele Ruffolo, Pierangelo Cifelli, Federico Marini, Cristian Ripoli, Eleonora Palma, Claudio Grassi, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Summary: Down syndrome (DS) is associated with Alzheimer's disease (AD) and brain insulin resistance. The KYCCSRK peptide has shown potential for improving insulin signaling in DS and reducing AD-like neuropathology in mice.
Article
Biochemistry & Molecular Biology
Lucrezia Laterza, Lorenza Putignani, Carlo Romano Settanni, Valentina Petito, Simone Varca, Flavio De Maio, Gabriele Macari, Valerio Guarrasi, Elisa Gremese, Barbara Tolusso, Giulia Wlderk, Maria Antonia Pirro, Caterina Fanali, Franco Scaldaferri, Laura Turchini, Valeria Amatucci, Maurizio Sanguinetti, Antonio Gasbarrini
Summary: This study investigated the effectiveness of gut microbiota modulation for enhancing recovery after COVID-19. A pilot interventional study was conducted with twenty recently recovered COVID-19 patients to explore the impact of a mixed probiotic containing Lactobacilli, Bifidobacteria, and Streptococcus thermophilus on gastrointestinal symptoms, inflammation, intestinal barrier integrity, and gut microbiota profile. Various markers and computational algorithms were utilized to evaluate the outcomes before and after 8 weeks of probiotic supplementation. The results showed a significant reduction in inflammatory markers and an increase in Bifidobacteria at T-1, indicating potential anti-inflammatory effects and the influence of probiotics on gut microbiota composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Chemistry, Multidisciplinary
Federico Marini, Alessandra Biancolillo
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
Maurizio Muscaritoli, Alessandra Modena, Matteo Valerio, Paolo Marchetti, Roberto Magarotto, Silvia Quadrini, Filomena Narducci, Giuseppe Tonini, Teresa Grassani, Luigi Cavanna, Camilla Di Nunzio, Chiara Citterio, Marcella Occelli, Antonia Strippoli, Bruno Chiurazzi, Antonio Frassoldati, Giuseppe Altavilla, Antonio Lucenti, Fabrizio Nicolis, Stefania Gori
Summary: Malnutrition and cachexia in cancer patients have a negative impact on treatment, outcomes, quality of life, and survival. However, the risk of malnutrition and cachexia is still overlooked in cancer patients. A study revealed that 51% of patients already had nutritional deficiencies at their first oncology visit. These findings emphasize the importance of proactive, early management of malnutrition in cancer patients.
Article
Health Care Sciences & Services
Daniele Marinelli, Giulio Ravoni, Maria Fusilli, Emilia Colpani, Marco Filetti, Daniele Santini, Giampiero Porzio, Raffaele Giusti
Summary: This study examined time to death and rates of palliative sedation in home palliative care for patients with advanced cancer. The results showed that Eastern Cooperative Oncology Group performance status, sex, and anticancer treatment significantly influenced survival time. Among the cohort, 38% of patients received home palliative sedation for refractory symptoms, primarily delirium and dyspnoea.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Letter
Health Care Sciences & Services
Raffaele Giusti, Giulio Ravoni, Giampiero Porzio
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Chemistry, Medicinal
Alessandra Biancolillo, Claudia Scappaticci, Martina Foschi, Claudia Rossini, Federico Marini
Summary: Counterfeit or substandard drugs are a growing concern, particularly during the COVID-19 pandemic, and analytical chemistry plays a crucial role in detecting and addressing this issue. This study focuses on developing a NIR-based tool for quantifying dexamethasone in excipient mixtures. Two regression strategies were tested, with the second strategy (SPORT) proving to be the most accurate, achieving an R-pred(2) of 0.9044 and an RMSEP of 450 mg/kg on external mixtures. The Variable Importance in Projection (VIP) was used to interpret the results and identify the most influential spectral regions in the SPORT model.
Letter
Health Care Sciences & Services
Giulio Ravoni, Maria Fusilli, Giulia Parretti, Emilia Colpani, Giampiero Porzio, Giuseppe Spinelli, Daniele Marinelli, Raffaele Giusti
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Medicine, General & Internal
Melissa Bersanelli, Elena Verzoni, Alessio Cortellini, Raffaele Giusti, Lorenzo Calvetti, Paola Ermacora, Marilena Di Napoli, Annamaria Catino, Valentina Guadalupi, Giorgia Guaitoli, Vieri Scotti, Francesca Mazzoni, Antonello Veccia, Pamela Francesca Guglielmini, Fabiana Perrone, Marco Maruzzo, Ernesto Rossi, Chiara Casadei, Vincenzo Montesarchio, Francesco Grossi, Mimma Rizzo, Maria Grazia Travagliato Liboria, Manlio Mencoboni, Fable Zustovich, Lucia Fratino, Caterina Accettura, Saverio Cinieri, Andrea Camerini, Mariella Soraru, Paolo Andrea Zucali, Serena Ricciardi, Antonio Russo, Giorgia Negrini, Maria Chiara Banzi, Gaetano Lacidogna, Giuseppe Fornarini, Letizia Laera, Claudia Mucciarini, Matteo Santoni, Claudia Mosillo, Andrea Bonetti, Lucia Longo, Donata Sartori, Editta Baldini, Michele Guida, Mauro Iannopollo, Roberto Bordonaro, Maria Francesca Morelli, Pierosandro Tagliaferri, Massimiliano Spada, Anna Ceribelli, Rosa Rita Silva, Franco Nole, Giordano Beretta, Petros Giovanis, Daniele Santini, Stefano Luzi Fedeli, Oriano Nanni, Evaristo Maiello, Roberto Labianca, Carmine Pinto, Alberto Clemente, Michele Tognetto, Ugo De Giorgi, Sandro Pignata, Massimo Di Maio, Sebastiano Buti, Diana Giannarelli
Summary: The INVIDIa-2 study found that influenza vaccination has a positive impact on the outcomes of advanced cancer patients receiving immune checkpoint inhibitor therapy. The vaccination was associated with improved overall survival, progression-free survival, and disease-control rate. These findings support the recommendation of vaccination in cancer patients and suggest a potential synergy between antiviral and antitumor immunity. Rating: 8/10.
Article
Chemistry, Analytical
Andrea Cerrato, Alessandra Biancolillo, Giuseppe Cannazza, Chiara Cavaliere, Cinzia Citti, Aldo Lagana, Federico Marini, Massimo Montanari, Carmela Maria Montone, Roberta Paris, Nino Virzi, Anna Laura Capriotti
Summary: This study conducted a comprehensive analysis of industrial hemp samples from different regions in Italy and different cultivars using metabolomics. The study found that cannabinoids, flavonoids, and phenolic acids play a key role in differentiating hemp samples and determining their biological activities.
ANALYTICA CHIMICA ACTA
(2023)