Article
Biochemistry & Molecular Biology
Sun-Hye Choi, Kyung-Jong Won, Rami Lee, Han-Sung Cho, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study demonstrates that gintonin promotes wound healing by enhancing migration and proliferation of skin cells, as well as increasing vascular endothelial growth factor release, possibly through activation of LPA receptors and downstream signaling pathways involving VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Edward J. Calabrese, Gaurav Dhawan, Rachna Kapoor, Evgenios Agathokleous, Vittorio Calabrese
Summary: This article investigates the commonly observed hormetic dose responses in dermal wound healing, specifically focusing on cell viability, proliferation, and migration of human keratinocytes in in vitro studies. Hormetic responses can be induced by a wide range of substances, including endogenous agents, drugs, and plant derived extracts. The findings suggest that hormesis plays a fundamental role in wound healing and has important implications for agent screening, evaluation, and clinical strategies.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Lei Qiang, Seungwon Yang, Yan-Hong Cui, Yu-Ying He
Summary: The study found that inhibiting epidermal cell autophagy impairs wound healing in mice, affecting processes such as keratinocyte proliferation, immune cell infiltration, and dermal tissue formation. TNF induces CCL2 transcription through the autophagy-AMPK-BRAF-MAPK1/3/ERK-AP1 pathway, influencing keratinocyte migration and proliferation, and activating dermal fibroblasts.
Article
Pharmacology & Pharmacy
Saeed Ali Alsareii, Nasser A. N. Alzerwi, Mansour Yousef Alasmari, Abdulrahman Manaa Alamri, Mater H. Mahnashi, Ibrahim Ahmed Shaikh, Chetan Savant, Preeti V. Kulkarni, Arun K. Shettar, Joy H. Hoskeri, Vijay Kumbar
Summary: M. zapota extract exhibits antibacterial and antioxidant properties that enhance wound healing. In vitro and in vivo experiments demonstrated that M. zapota extract accelerates wound contraction, epithelization, collagen proliferation, and cell migration. These findings highlight the significant wound-healing potential of M. zapota extract.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ihsan Safwan Kamarazaman, Nor Azah Mohamad Ali, Fauziah Abdullah, Nazrin Che Saad, Aida Azlina Ali, Salfarina Ramli, Pornchai Rojsitthisak, Hasseri Halim
Summary: This study investigated the wound healing and antioxidant properties of ethanolic extract of Baeckea frutescens leaves. The extract was found to promote cell proliferation and migration, and exhibited strong antioxidant activity. Phytochemical analysis revealed the presence of saponins, flavonoids, tannins, and steroids in the extract, which may contribute to its antioxidant and wound healing properties.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Review
Multidisciplinary Sciences
Akshay Hegde, Akhil S. H. P. Ananthan, Chinmayi Kashyap, Subhasri Ghosh
Summary: Skin, as a protective barrier, has the ability to rapidly heal itself due to the presence of resident stem cells and progenitors that are activated during trauma. The role of keratinocytes and keratinocyte stem cells in wound healing, along with cytoskeletal dynamics, are crucial for maintaining tissue integrity and responding to environmental cues during the healing process.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2021)
Article
Cell Biology
Jia Ma, Jing Huang, Jinli Sun, Yanfeng Zhou, Xiaoyuan Ji, Daoxia Guo, Chang Liu, Jiyu Li, Jiye Zhang, Haiyun Song
Summary: The organic selenium compound SeMC showed high sensitivity in inhibiting A549 lung adenocarcinoma cells, inducing synergistic lethality when combined with chemotherapeutics. SeMC promoted lipid peroxidation and increased ROS generation in cancer cells. The in vivo efficacy of combination therapy was significantly enhanced by hydrogel-mediated drug delivery.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Francesca Rossi, Giada Magni, Francesca Tatini, Martina Banchelli, Federica Cherchi, Michele Rossi, Elisabetta Coppi, Anna Maria Pugliese, Duccio Rossi degl'Innocenti, Domenico Alfieri, Francesco S. Pavone, Roberto Pini, Paolo Matteini
Summary: Studies have shown that blue LED light can be used to modulate the metabolism and proliferation of human fibroblasts and play a significant role in wound healing, particularly in co-cultures of fibroblasts and keratinocytes.
Article
Biology
Yu Yamanoi, Jing Lei, Yasunori Takayama, Shigekuni Hosogi, Yoshinori Marunaka, Makoto Tominaga
Summary: The chloride channel anoctamin1 is activated by calcium influx through transient receptor potential vanilloid 3 (TRPV3), leading to chloride influx and enhancement of wound healing in keratinocytes.
COMMUNICATIONS BIOLOGY
(2023)
Article
Engineering, Multidisciplinary
Jiahui He, Zhenlong Li, Jiaxin Wang, Tongyang Li, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a multifunctional hydrogel with antibacterial, antioxidant, self-healing, and conductive properties. The hydrogel is capable of releasing nitric oxide (NO) under near-infrared (NIR) laser irradiation, which promotes the healing of diabetic wounds.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Chemistry, Medicinal
Raquel Costa, Luis Costa, Ilda Rodrigues, Catarina Meireles, Raquel Soares, Paula Tamagnini, Rita Mota
Summary: The study suggests that Cyanoflan is a promising biopolymer for innovative applications in skin wound healing, as it does not affect cell viability, apoptosis, migration, or induce oxidative or inflammatory reactions.
Article
Nanoscience & Nanotechnology
Shen Guo, Yikun Ren, Rong Chang, Yuanmeng He, Dan Zhang, Fangxia Guan, Minghao Yao
Summary: An injectable hydrogel material with excellent injectability, self-healing ability, and tissue-adhesiveness was designed and fabricated. It showed antioxidative, antibacterial, and hemostatic abilities, and could effectively stop bleeding and promote wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Hui Xin Wong, Chin Chiat Lee, Paul Chi-Lui Ho
Summary: This study compared the relevance of different wound healing models in keratinocytes and fibroblasts interaction physiologically. The conditioned media and transwell co-cultures models were found to be more suitable than co-cultures for wound healing research, as they better simulate layered tissue constructs and paracrine interactions in the physiological environment.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Cell Biology
Pattawika Lertpatipanpong, Chanin Sillapachaiyaporn, Garam Oh, Yeong-Hun Kang, Cheol-Yong Hwang, Seung Joon Baek
Summary: Cold atmospheric microwave plasma (CAMP) is a promising therapeutic option for skin infection and wound treatment, and it promotes wound healing through regulating cellular migration, invasion, gene expression, and signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Engineering, Environmental
Mengzhen Zhang, Xinyun Zhai, Tengfei Ma, Yongkang Huang, Chunhua Yan, Yaping Du
Summary: Ce-CNDs, fabricated by a simple hydrothermal method, exhibit superior antioxidant property and good biocompatibility. With unique photoluminescence and antibacterial property, Ce-CNDs possess the potential to accelerate wound healing and serve as an integrated nanoplatform for optical imaging and treatment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Sadia Anjum, Hamile Ali, Faiza Naseer, Maisa S. Abduh, Halima Qadir, Salik Kakar, Yasir Waheed, Tahir Ahmad
Summary: This study demonstrates that avocado and papaya fruit juices can reduce the accumulation of cadmium in the liver, kidney, and hippocampal tissues, and upregulate the expression of antioxidant enzymes while reducing lipid peroxidation. Compared to avocado, papaya has a stronger potential for improving memory and learning, as well as reducing lipid peroxidation in various tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi
Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem
Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif
Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song
Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy
Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen
Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano
Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz
Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao
Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams
Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk
Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)