Article
Biochemistry & Molecular Biology
Xiaojie Liang, Yajun Wang, Yuekun Li, Wei An, Xinru He, Yanzhen Chen, Zhigang Shi, Jun He, Ru Wan
Summary: This study evaluated the effects of salt-alkaline stress on metabolite accumulation in the salt-tolerant Ningqi1 wolfberry fruits and identified diverse metabolites affected by the stress. The results showed that soil salt-alkaline stress enhanced metabolite accumulation in wolfberry fruits, with an increase in amino acids, alkaloids, organic acids, and polyphenols contents, and a decrease in nucleic acids, lipids, hydroxycinnamoyl derivatives, organic acids, derivatives, and vitamins contents. Thirteen salt-responsive metabolites were identified as potential biomarkers for salt-alkaline stress tolerance in wolfberry. The study also revealed that reductions in lipids and chlorogenic acids, up-regulation of abscisic acid, and accumulation of polyamines are essential mechanisms for salt-alkaline stress tolerance in Ningqi1 wolfberry. Overall, this study provides important metabolic insights into salt-alkaline stress tolerance and key metabolite biomarkers for improving wolfberry tolerance to salt-alkaline stress.
Article
Medicine, General & Internal
Jiangbo Song, Lian Liu, Zhiquan Li, Ting Mao, Jianfei Zhang, Lei Zhou, Xin Chen, Yunzhu Shang, Tao Sun, Yuxin Luo, Yu Jiang, Duan Tan, Xiaoling Tong, Fangyin Dai
Summary: This study presents a promising animal model for investigating the pathogenesis of PD and conducting drug screening. Treatment with L-dopa and carbidopa, as well as administration of Lycium barbarum polysaccharide, showed positive effects on motor ability, dopamine level, and oxidative damage in the silkworm PD model.
Article
Food Science & Technology
Cristiane de Freitas Rodrigues, Jean Ramos Boldori, Marcell Valandro Soares, Sabrina Somacal, Tatiana Emanuelli, Aryele Izaguirry, Francielli Weber Santos Cibin, Paula Rossini Augusti, Cristiane Casagrande Denardin
Summary: Goji berry juice exerts toxic effects on Caenorhabditis elegans, promoting premature aging. Further studies in mammals are needed before its consumption can be recommended.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yinhong Niu, Jiale Liao, Haitao Zhou, Chih-chen Wang, Lei Wang, Yanli Fan
Summary: Lycium barbarum leaf flavonoid extracts have anti-aging and redox-modulating effects, which can alleviate oxidative stress-induced damage in cells and upregulate antioxidant enzyme activity and gene expression through the MAPK signaling pathway.
Article
Plant Sciences
Fan Wang, Kuo Zhang, Mengying Zhai, Xin Lin, Yuxuan Hu, Lijin Feng, Jingyu Yang, Hongjian Yu, Chunfu Wu
Summary: LBP significantly improves ethanol-induced cognitive impairment in mice by promoting hippocampal neurogenesis and reducing oxidative stress.
Article
Biochemistry & Molecular Biology
Yanjun Ju, Yujie Wang, Lei Ma, Lu Kang, Hejiang Liu, Xue Ma, Duoyong Zhao
Summary: This study analyzed the effects of variety, geographical origin, and harvest season on the accumulation of polyphenols in Lycium barbarum using advanced chromatography and mass spectrometry techniques. The antioxidant activities of fruit extracts from different regions were also evaluated. Results showed significant differences in polyphenolic contents and antioxidant activities depending on geographical origin, variety, and harvest season. The study provided scientific guidance for the application of polyphenols from different L. barbarum varieties and origins.
Review
Food Science & Technology
Hao Liu, Bo Cui, Zheng Zhang
Summary: This article reviews the effective actions of the main bioactive compounds in Lycium barbarum fruits in reducing blood glucose and other complications of diabetes, discusses their possible metabolism in the pathogenesis of diabetes, and explains the basic mechanism of regulation of blood glucose. It provides reliable evidence for the beneficial effects of Lycium barbarum fruits in treating diabetes.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Wen Xie, Yuan-Yuan Huang, Hua-Guo Chen, Xin Zhou
Summary: In this study, Lycium barbarum polysaccharide (LBP) showed significant protective effects against lead-induced kidney damage in mice by alleviating renal pathological damages and improving related biochemical indicators. LBP treatment also increased the weight and feed intake of mice with lead toxicity. The optimal dose of LBP for protecting kidneys from lead toxicity was found to be a medium dose.
Article
Plant Sciences
Yolanda Gonzalez-Garcia, Claribel Cardenas-Alvarez, Gregorio Cadenas-Pliego, Adalberto Benavides-Mendoza, Marcelino Cabrera-de-la-Fuente, Alberto Sandoval-Rangel, Jesus Valdes-Reyna, Antonio Juarez-Maldonado
Summary: The study found that saline stress reduces the content of chlorophyll, lycopene, and beta-carotene in bell pepper leaves, but increases the activity of certain enzymes. Meanwhile, nanoparticles have shown to increase the content of bioactive compounds in bell pepper fruits to some extent.
Review
Chemistry, Medicinal
Yali Niu, Guoheng Zhang, Xiaojia Sun, Shikun He, Guorui Dou
Summary: Oxidative stress caused by imbalanced production of reactive species and reduced antioxidant activity can lead to ocular diseases. Lycium barbarum polysaccharides (LBPs) are complex polysaccharides extracted from the fruit of L. barbarum, which have remarkable antioxidant effects and are relatively safe. Recent research has focused on the antioxidant mechanisms of LBPs and their potential applications in various ocular diseases.
Article
Biochemistry & Molecular Biology
Katarzyna Rajkowska, Anna Otlewska, Natalia Broncel, Alina Kunicka-Styczynska
Summary: This study compares the microbial diversity and content of bioactive compounds in dried goji berries available on the Polish market to those of the most highly valued goji berries from the Ningxia region in China. The content of phenols, flavonoids, and carotenoids were determined, as well as the antioxidant capacities of the fruits. The highest quality was demonstrated by naturally dried fruits from the Ningxia region. These berries were characterized by a high content of polyphenols and high antioxidant activity, as well as high microbial quality. The lowest antioxidant capacity was shown by goji berries cultivated in Poland. However, they contained a high amount of carotenoids. The highest microbial contamination was found in the goji berries available in Poland (>10(6) CFU/g), which is important in terms of consumer safety. Despite the widely accepted benefits of consuming goji berries, both the country of cultivation and the preservation method may influence their composition, bioactivity, and microbial quality.
Article
Biochemistry & Molecular Biology
Yanfeng Peng, Linlin Zhao, Ke Hu, Yongjing Yang, Jin Ma, Yuqing Zhai, Yan Jiang, Dejun Zhang
Summary: The study aims to investigate the anti-fatigue effect of Lycium barbarum polysaccharide (LBP) during exercise and develop an anti-fatigue effervescent tablet. Animal experiments show that LBP and the effervescent tablet significantly increase endurance, improve biochemical markers, and enhance antioxidant capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Chongde Sun, Yilong Liu, Liuhuan Zhan, Gina R. Rayat, Jianbo Xiao, Huamin Jiang, Xian Li, Kunsong Chen
Summary: Consumption of fruits with natural antioxidants may have positive effects on preventing and treating diabetes, helping to lower blood glucose levels. Bioactive compounds in various fruits, such as phenolic compounds, polysaccharides, and vitamin C, have been found to exhibit anti-diabetic activities.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Food Science & Technology
Letizia Poggioni, Marco Romi, Massimo Guarnieri, Giampiero Cai, Claudio Cantini
Summary: This study investigated the relationship between the functional constituents and environmental factors in goji berries grown in central Italy. The results showed that goji berries harvested at the beginning of the fruiting season had the highest flavonoids content and antioxidant power, while those harvested in September had the highest total polyphenols and zeaxanthin contents.
Article
Chemistry, Organic
Hui Chen, Jiang-Bo Kong, Li Zhang, Hui-Hui Wang, Yan-Gang Cao, Meng-Nan Zeng, Meng Li, Yan-Jun Sun, Kun Du, Gui-Min Xue, Ya Wu, Xiao-Ke Zheng, Wei-Sheng Feng
Summary: Three tetrahydroquinoline alkaloids with a unique structure were isolated from the fruits of Lycium barbarum, and compounds 1 and 3 showed neuroprotective activity by inhibiting apoptosis in PC12 cells.
Article
Medicine, General & Internal
Chiung-Ju Hsu, Hsin-An Hou, Chang-Ping Lin, Yi-Jui Lee, Wen-Fang Hsu, Po-Ting Yeh
Summary: Intraocular lymphoma patients were divided into two groups to receive different protocols of intravitreal methotrexate injections. The study found that there was no statistically significant difference in overall survival and progression-free survival between the two groups. A new protocol with reduced frequency of injections showed promising results and decreased incidence of keratitis.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Ophthalmology
Wen-Yi Wang, Chang-Hao Yang, Ta-Ching Chen, Yi-Ting Hsieh, Tzyy-Chang Ho, Chung-May Yang, Fang-Yu Liu, Tso-Ting Lai
Summary: The study investigated the changes in branching neovascular networks (BNN) in patients with polypoidal choroidal vasculopathy (PCV) who received combined photodynamic therapy (PDT) and anti-vascular endothelial growth factor (anti-VEGF) therapy using optical coherence tomography angiography (OCTA). The results showed that BNN initially regressed but enlarged at 6 months after therapy. Patients with continuous BNN regression had thicker choroid at baseline. OCTA can be used for follow-up evaluations of PCV patients.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Shwu-Jiuan Sheu, Chang-Hao Yang, Chi-Chun Lai, Pei-Chang Wu, Shih-Jen Chen
Summary: The study evaluated the efficacy of a treat-and-extend approach using intravitreal aflibercept injections for patients with center-involved DME. The results showed favorable clinical outcomes at week 52 with minimal treatment burden.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
I-Wen Lai, Chang-Ping Lin, Yi -Ting Hsieh, Po -Ting Yeh
Summary: This study aimed to assess ocular sarcoidosis in Taiwan through a retrospective review of 364 patients. The majority of patients presented with panuveitis and posterior uveitis. Overall, proper treatment led to good visual outcomes, with females and poor initial vision identified as risk factors for poor outcomes.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Ophthalmology
Li-Wei Chan, Yu-Chi Sung, Dung-Chi Wu, Chien-Yu Chen, Chang-Hao Yang, Chung-May Yang, Pei-Lung Chen, Ta-Ching Chen
Summary: This study investigated the relationship between different CYP4V2 disease-causing variants and disease severity in Bietti crystalline dystrophy. A novel severity prediction score was applied for grouping and analysis. The results demonstrated that more severe variants led to a higher severity prediction score and faster disease progression. The establishment of a severity index could be helpful in identifying treatment strategies for patients with BCD.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Review
Ophthalmology
Cheng-Kuo Cheng, Shih-Jen Chen, Jiann-Torng Chen, Lee-Jen Chen, San-Ni Chen, Wen-Lu Chen, Sheng-Min Hsu, Chien-Hsiung Lai, Shwu-Jiuan Sheu, Pei-Chang Wu, Wei-Chi Wu, Wen-Chuan Wu, Chung-May Yang, Ling Yeung, Ta-Ching Chen, Chang-Hao Yang
Summary: The treat-and-extend approach with anti-VEGF agents is an effective strategy to manage neovascular age-related macular degeneration (nAMD), aiming to maximize visual acuity benefits while minimizing treatment burden. Treatment intervals can be extended or shortened based on patient response, and discontinuation of treatment with regular monitoring may be considered for stable disease.
Article
Medicine, General & Internal
Cheng-Han Chen, Yu-Ting Tsao, Po-Ting Yeh, Yu-Hsiang Liao, Yi-Tzu Lee, Wan-Ting Liao, Yung-Chih Wang, Ching-Fen Shen, Chao-Min Cheng
Summary: Early detection of microorganisms is crucial for infectious disease management, but traditional culture methods are time-consuming. The MTT-PMS assay can rapidly measure metabolic activity in live cells and detect common bacterial pathogens.
Article
Ophthalmology
Yun Hsia, Cheng-Yung Lee, Tzyy-Chang Ho, Chang-Hao Yang, Chung-May Yang
Summary: This study aimed to investigate the development, evolution, outcomes, and prognostic factors of lamellar macular hole (LMH) in highly myopic patients. The study identified four different traction-related LMH developmental processes with varying evolution and outcomes. LMHs caused by foveal thinning induced by epiretinal membranes were associated with the worst visual outcomes.
Article
Ophthalmology
Tso-Ting Lai, Chung-May Yang, Yi-Ting Hsieh, Po-Ting Yeh, Ching-Wen Huang, Chia-Ying Tsai
Summary: The purpose of this study was to evaluate the rate and time to complete vascularization in premature infants and explore associated factors. The findings showed that lower birth weight, presence of retinopathy of prematurity (ROP), and antivascular endothelial growth factor therapy may delay complete vascularization. These results can contribute to a better understanding and management of persistent avascular retina in preterm infants.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Yu-Ting Su, Yi-Jun Chen, Chang-Ping Lin, Yi-Ting Hsieh, Chung-May Yang, Angelique Chiu-Ang, Po-Ting Yeh
Summary: This retrospective cohort study aimed to explore the clinical features and outcomes of cytomegalovirus retinitis (CMVR) in patients with HIV and non-HIV. The study found that CMVR patients without HIV had higher mortality and recurrence rates, and risk factors for poor visual outcome included poor initial visual acuity, retinal detachment, and a high plasma cytomegalovirus titer.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Oncology
Chieh-Lung Cheng, Po-Ting Yeh, Wei-Quan Fang, Wei-Li Ma, Hsin-An Hou, Cheng-Hong Tsai, Chang-Ping Lin, Hwei-Fang Tien
Summary: This study reports the long-term outcomes of patients with vitreoretinal lymphoma (VRL) using a combination therapy. The study found that the combination therapy was effective and well tolerated. However, further intensive consolidation strategies are needed to effectively prevent CNS/systemic relapse.
Review
Ophthalmology
Chun-Ju Lin, Ning-Yi Hsia, De-Kuang Hwang, Yih-Shiou Hwang, Yo-Chen Chang, Yung-Ray Hsu, Po-Ting Yeh, Chang-Ping Lin, Alan Y. Hsu, Mao-Wang Ho, Shwu-Jiuan Sheu
Summary: There is a lack of guidelines for managing tubercular uveitis (TBU) in Taiwan. In response, an evidence-based consensus was proposed by the Taiwan Ocular Inflammation Society, which involved a meeting of ophthalmologists and an infection disease expert. The consensus covered nomenclature, assessment and diagnosis, and treatment of TBU. A literature review informed the consensus statements and recommendations, providing an algorithmic approach to diagnosing and managing TBU.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Pei-Chung Tsai, Ming -Hui Cheng, Bo-Hsun Peng, Jwo-Huei Jou, Yun-Hsin Cheng, Yi-Chen Ku, Hsin-Ya Chiu, Ming -Li Chou, Po -Ting Yeh
Summary: Projectors and large TV screens are commonly used in modern teaching, but there are concerns about the potential eye hazards of eLearning. A quantitative study was conducted to determine the permissible viewing time for using projectors and large TV screens. Surprisingly, the large TV screens were found to be more eye-friendly and could allow for a longer viewing time, likely due to their higher resolution. Two dilemmas were observed in eLearning, with those sitting in the front experiencing higher illuminance and shorter viewing time, while those in the back requiring a larger font size for clear visibility. Using orange text on a black background was suggested to ensure both viewing clarity and a longer permissible viewing time. These findings can help educators and e-display users apply display tools safely.
Article
Biochemistry & Molecular Biology
Chao-Wen Lin, Yi-Chun Cheng, Chang-Hao Yang, Hsien-Sung Huang
Summary: This study found that extended exposure to white or blue light can promote the expression of the Angelman syndrome-related gene UBE3A in the retina but not in the visual cortex. Additionally, it was observed that this light exposure caused changes in the chromatin structure of the Ube3a promoter, which further impacted gene expression.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Ophthalmology
Yi-Chen Sun, Kai-Feng Hung, Tzu-Yun Li, Yu-An Chang, Po-Ting Yeh, Fung-Rong Hu
Summary: This study aimed to investigate the role of transmembrane mucins in blocking fluorescein ingress to the corneal epithelium and their deficiency in contributing to corneal fluorescein punctate staining in dry eyes. The results showed that decreased expression of mucin1 was associated with fluorescein punctate staining in the superficial corneal epithelial cells. Upregulation of mucin1 and mucin16 hindered intracellular fluorescence ingress, while downregulation of mucin1 and mucin16 enhanced fluorescence ingress in human corneal epithelial cells (HCECs) after fluorescein staining.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
