Article
Cell Biology
Qiang Guo, Xiaoxiao Zhu, Ran Wei, Lin Zhao, Zhen Zhang, Xunqiang Yin, Yunhong Zhang, Chu Chu, Bin Wang, Xia Li
Summary: The study demonstrated that miR-130b-3p regulates the polarization of M1 macrophages by inhibiting IRF1, thus affecting inflammation. The miR-130b-3p/IRF1 pathway may be a potential target for regulating macrophage polarization.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Engineering, Environmental
Kai Wang, Ruonan Dong, Jiezhang Tang, Huichen Li, Juanli Dang, Zhaoxiang Zhang, Zhou Yu, Baolin Guo, Chenggang Yi
Summary: This study developed a self-healing hydrogel capable of stably releasing exosomes to enhance diabetic wound healing. Through the synergistic effect of exosome release and M2 macrophage polarization, it accelerated angiogenesis and wound healing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Xuebo Wei, Zhiyong Liao, Liangliang Yang, Fangfang Wu, Shaodong Chen, Chuxiao Shao, Xin Wang, Keshen Xiao, Jian Xiao, Ke Xu, Da Sun, Hongyu Zhang
Summary: The study found that phosphorus magnesium fiber (PMF), as a novel nanoscale functional material, can accelerate wound healing. PMF releases magnesium ions into wounds, which promote wound closure and regulate macrophage polarization. This research provides insights for the potential use of PMF in wound healing and tissue regeneration.
APPLIED MATERIALS TODAY
(2023)
Review
Emergency Medicine
Xingqian Wu, Wenjie He, Xingrui Mu, Ye Liu, Junyu Deng, Yiqiu Liu, Xuqiang Nie
Summary: This article reviews the functions of macrophages in diabetic wound healing, the relationship between dysregulated macrophage phenotypes and diabetic wound healing, and the mechanism of macrophage polarization. New therapeutic drugs targeting phagocyte polarization may provide a new strategy for promoting the healing of chronic diabetic wounds.
Article
Medicine, Research & Experimental
Yuxi Wu, Xiaoying Wu, Jiahuan Wang, Sifan Chen, Hongxing Chen, Jing Liu, Tingting Zeng, Mengdie Hu, Ying Liang, Kan Sun, Chuan Yang, Li Yan, Meng Ren
Summary: The enrichment of long noncoding RNA upregulated in diabetic skin (lnc-URIDS) in fibroblast-derived extracellular vesicles (Fib-EVs) was induced by high glucose, facilitating the transfer of lnc-URIDS to primary rat epidermal keratinocytes and increasing the expression of matrix metalloproteinase-9. Mechanistically, lnc-URIDS binding to YTH domain family protein-2 enhanced its degradation in the lysosomes, resulting in increased translational activity of matrix metalloproteinase-9 mRNA and ultimately leading to collagen degradation for diabetic wound healing.
LABORATORY INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Javier Larrasa-Alonso, Maria Villalba-Orero, Carlos Marti-Gomez, Paula Ortiz-Sanchez, Marina M. Lopez-Olaneta, M. Ascension Rey-Martin, Fatima Sanchez-Cabo, Francois McNicoll, Michaela Muller-McNicoll, Pablo Garcia-Pavia, Enrique Lara-Pezzi
Summary: RBP SRSF4 plays a critical role in the heart, with its loss of expression leading to cardiac hypertrophy, diastolic dysfunction, and abnormal repolarization. The mechanism involves downregulation of GAS5 and subsequent elevation of GR transcriptional activity. These findings may contribute to the development of new therapeutic approaches for cardiac hypertrophy and myocardial pathology in patients with Cushing syndrome.
CIRCULATION RESEARCH
(2021)
Article
Engineering, Biomedical
Georgios Theocharidis, Sahar Rahmani, Sangmin Lee, Zhuqing Li, Antonio Lobao, Konstantinos Kounas, Xanthi-Lida Katopodi, Peng Wang, Salina Moon, Ioannis S. Vlachos, Monika Niewczas, David Mooney, Aristidis Veves
Summary: This study investigates the efficacy of calcium-crosslinked alginate dressings in treating diabetic foot ulcers. The results show that alginate dressings can serve as a delivery platform for primary macrophages and their secretome, accelerating wound healing.
Article
Chemistry, Multidisciplinary
Hao Xia, Ze Dong, Qi Tang, Rongjian Ding, Yimeng Bai, Ke Zhou, Lihuang Wu, Lili Hao, Yiyan He, Jun Yang, Hongli Mao, Zhongwei Gu
Summary: Excessive inflammation, bacterial infection, and blocked angiogenesis pose challenges to diabetic wound healing. This study presents a novel approach using a glycopeptide-based hydrogel to regulate the pH microenvironment in diabetic wound sites. The hydrogel demonstrates anti-inflammatory effects and promotes angiogenesis, leading to effective diabetic wound repair and skin regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Cell Biology
Qing Zhao, Gaozong Pang, Lin Yang, Shu Chen, Ruiyao Xu, Wei Shao
Summary: Long noncoding RNAs (lncRNAs) play important regulatory roles in the human body, maintaining immune balance and participating in various physiological and pathological processes. Studies have revealed that lncRNAs can regulate immune responses, immune cell development, and inflammatory diseases with distinct regulatory mechanisms, highlighting their potential as diagnostic biomarkers and therapeutic targets.
Article
Biochemistry & Molecular Biology
Kai Hu, Yan Xu, Xiaoxiao Li, Pan Du, Yichi Lu, Guozhong Lyu
Summary: This study found that Nr-CWS can enhance macrophage physiological activities, polarize macrophages towards M2, and increase the expression of healing-promoting cytokines. Furthermore, Nr-CWS can accelerate wound healing.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lan Pang, Qian Liao, Liang Zou, Chen Zhang, Xin Nie, Zhiwen Yi, Chaomei Fu, Jinming Zhang
Summary: This study isolated and characterized two glycoproteins from the medicinal insect Periplaneta americana. The glycoproteins showed potential in promoting wound healing, as evidenced by their anti-inflammatory effects and ability to accelerate wound healing in diabetic mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Zhipeng Zhou, Tuo Deng, Maixian Tao, Lisha Lin, Luyun Sun, Xuemei Song, Dongxiu Gao, Jixing Li, Zhongjuan Wang, Xingzi Wang, Jinpeng Li, Zexiu Jiang, Lan Luo, Lian Yang, Mingyi Wu
Summary: Diabetic foot ulcers (DFUs) are a severe and rapidly growing diabetic complication. A natural adhesive from snail mucus has been discovered to promote skin wound healing. A double-network hydrogel biomaterial composed of snail glycosaminoglycan (AFG) and methacrylated gelatin (GelMA) was developed, which exhibited strong tissue adhesion, anti-inflammatory activity, and biocompatibility. The AFG/GelMA hydrogel effectively promoted chronic wound healing.
Article
Biochemistry & Molecular Biology
Bo Li, Yue Zhou, Jing Chen, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, Changlong Bi
Summary: Aberrant expressions of lncRNA H19 and miR-29b have been implicated in the complications of diabetes mellitus, specifically in diabetic foot ulcer (DFU). Upregulation of lncRNA H19 in DFU tissues competitively binds to miR-29b, leading to increased expression of FBN1, which enhances fibroblast proliferation and migration while inhibiting apoptosis, ultimately facilitating wound healing in DFU.
Article
Engineering, Biomedical
Yuhang Jiang, Wentao Zhao, Shuangshuang Xu, Jingjing Wei, Fernando Lopez Lasaosa, Yiyan He, Hongli Mao, Rosa Maria Bolea Bailo, Deling Kong, Zhongwei Gu
Summary: Research has shown that mannose-decorated globular lysine dendrimers (MGLDs) can elicit anti-inflammatory activity by targeting and reprogramming macrophages, which may be beneficial in the therapy of injuries and inflammation.
Article
Engineering, Environmental
Na Xu, Yuanping Gao, Zheng Li, Yu Chen, Menglong Liu, Jiezhi Jia, Rui Zeng, Gaoxing Luo, Jiangfeng Li, Yunlong Yu
Summary: Diabetic wound management faces challenges due to immune disorders. Targeted regulation of macrophage polarization could be a useful approach. The synthesized composite hydrogel showed good mechanical properties and antibacterial capacity, and promoted wound healing through anti-inflammation and pro-angiogenesis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Plant Sciences
Lan Zhang, Zheng Zhang, Golam Jalal Ahammed, Xiaorong Wang, Huihan Fang, Peng Yan, Li-Ping Zhang, Shibei Ge, Jianyu Fu, Wen-Yan Han, Xin Li
Summary: 24-epibrassinolide (EBR) can improve tea resistance against the fungal pathogen Colletotrichum fructicola by inducing lignin synthesis in tea leaves.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Environmental Sciences
Wenxun Dong, Yanjun Zhang, Liping Zhang, Ningyue Chen, Yixuan Zou, Yaodong Du, Jiaming Liu
Summary: This study focuses on the impact of the Three Gorges Dam on flood season discharge after its full operation in 2009. A hydrological model was used to reconstruct the daily discharge from 2003 to 2018 at five downstream stations. The results show that the dam has an impact on the maximum 1-day discharge, maximum 30-day runoff, and coefficient of variation of daily discharge.
Correction
Plant Sciences
Jiawei Li, Yucong Ma, Mengdie Hu, Yulu Zhao, Bin Liu, Chunmei Wang, Min Zhang, Liping Zhang, Xinlei Yang, Guojun Mu
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Environmental Sciences
Guiyang Wu, Jie Chen, Xinyan Shi, Jong-Suk Kim, Jun Xia, Liping Zhang
Summary: This study investigates changes in meteorological and hydrological drought conditions in 8,655 watersheds globally under 1.5-3.0 degrees C warmer climates. The results show that, except for certain regions, both meteorological and hydrological drought conditions would be relieved in warmer climates due to increased precipitation. However, the severity of drought conditions would increase during the propagation from meteorological to hydrological droughts, with more severe conditions occurring first and then being relieved with rising temperatures. Efforts to slow down global warming are crucial to suppress the deterioration of drought conditions during propagation.
Article
Engineering, Environmental
Song Liu, Dunxian She, Liping Zhang, Jun Xia
Summary: This study proposes a time- and signature-domain Bayesian inference framework for calibration of hydrological models, which aims to improve the efficiency of Approximate Bayesian Computation (ABC) in solving model calibration problems. Information redundancy analysis (IRA) and discriminatory power analysis (DPA) are used to obtain a set of approximately sufficient signatures. The framework is tested on a rainfall-runoff model for the Ren River basin in China, and the results show that utilizing relevant signatures can enhance the quality of Bayesian model calibration and reduce predictive uncertainty.
STOCHASTIC ENVIRONMENTAL RESEARCH AND RISK ASSESSMENT
(2023)
Article
Environmental Sciences
Zichen Wang, Liping Zhang, Guofeng Sun, Wei Zhou, Jing Sheng, Xiaomei Ye, Ademola O. Olaniran, E. B. Gueguim Kana
Summary: This study analyzed the adsorption characteristics of biogas slurry ammonium nitrogen by farmland soil and investigated the relationship between soil properties and adsorption capacity. The findings provide valuable insights for the safe application of biogas slurry in agriculture.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Mathematics, Applied
Shouqiang Du, Jingjing Sun, Shengqun Niu, Liping Zhang
Summary: In this paper, a new type of stochastic absolute value equations involving absolute values of variables is proposed. By utilizing an equivalence relation and expected value formulation, the solution conditions for the equations are given. The discrete minimization problem is solved by a smoothing gradient method. Numerical results and discussions are presented.
JOURNAL OF APPLIED MATHEMATICS AND COMPUTING
(2023)
Article
Environmental Sciences
Peng Yan, Zhenhao Zou, Xin Li, Liping Zhang, Lan Zhang, Jianyu Fu, Han Wenyan
Summary: This study found that biochar can significantly reduce the distribution of the pesticide imidacloprid in plants, soil, and groundwater, thus decreasing its potential harm to plants and groundwater. Biochar treatments increased the immobilization of imidacloprid in soil.
Article
Engineering, Civil
Song Liu, Dunxian She, Liping Zhang, Jun Xia, Senlin Chen, Gangsheng Wang
Summary: Quantifying and reducing errors and uncertainties in high-resolution gridded precipitation products is essential for accurate hydrological modeling. This study evaluates and merges six gridded precipitation products using formal Bayesian inference schemes and develops a predictability signature to optimize the merging process. The findings show that Bayesian total error analysis provides more realistic parameter estimates and tighter predictive intervals, and the predictability signature improves the accuracy of hydrologic simulations by merging precipitation measurements.
JOURNAL OF HYDROLOGY
(2022)
Article
Surgery
Maggie M. Hodges, Melissa L. DeSouza, Kevin M. Reavis, Daniel Davila Bradley, Christy M. Dunst
Summary: The clinical significance of multiple rapid swallows (MRS) during high-resolution manometry (HRM) prior to fundoplication is limited, and the response to MRS is not significantly associated with dysphagia after surgery. When using a tailored approach, standard HRM metrics can effectively predict post-operative dysphagia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Green & Sustainable Science & Technology
Xiao Li, Liping Zhang, Sidong Zeng, Zhenyu Tang, Lina Liu, Qin Zhang, Zhengyang Tang, Xiaojun Hua
Summary: Accurate monthly runoff prediction is significant for flood control and water resources management. This study used machine learning models with multi-variable input to predict monthly runoff and selected multiple circulation and meteorological indexes as explanatory variables. The results showed that the multi-input machine learning models performed well at two hydrological stations and provided better predictability compared to traditional statistical models with univariate input.
Article
Environmental Sciences
Xin-rong Pan, Lei Chen, Li-ping Zhang, Jian-e Zuo
Summary: Rainfall runoff and combined sewer overflow contribute to the occurrence and distribution of antibiotic resistance genes (ARGs). Multidrug resistance genes are the most abundant ARG types, positively correlated with chemical organic demand (COD) and bacterial abundance. Nanoparticles may also play a role in the spread and transformation of ARGs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Mathematics, Applied
Liping Zhang, Defeng Sun, Zhenting Luan
Summary: This paper introduces the tensor complementarity problem and its applications in various fields. By analyzing the structure, a monotone tensor complementarity problem is proposed along with the properties of its solution set, and the conditions for feasibility are given. Furthermore, a regularized smoothing Newton method is proposed to solve the problem, and its global convergence and superlinear convergence are proven.
SCIENCE CHINA-MATHEMATICS
(2023)
Article
Surgery
Kunying Li, Taomei Lian, Qiang Liang, Liping Zhang, Ying Chen, Jiwei Liu, Jiaping Qian, Xin Liu
Summary: This study suggests that the use of a high-frequency electric knife, saccular dilatation, and cryotherapy is feasible and effective for interventional therapy for cicatricial constriction, with good outcomes and few complications.
Review
Engineering, Manufacturing
Zhuang Guo, Weiqiang Zheng, Liping Zhang, Fei Li
Summary: This study proposes a directional transport device for bulk rod materials and analyzes its working principle and feasibility using the discrete element method. Through orthogonal combination tests, the optimal parameter combination is obtained and verified by experiments. This study is of great significance in the design of material conveying systems for sand fixation equipment.
INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING
(2023)