Correction
Chemistry, Multidisciplinary
Ang Gao, Xian-li Hu, Madiha Saeed, Bin-fan Chen, Ya-ping Li, Hai-jun Yu
Summary: A correction to this paper has been published and can be accessed through a link at the top of the paper.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Karishma Dhuri, Ravinder Reddy Gaddam, Ajit Vikram, Frank J. Slack, Raman Bahal
Summary: miR-155 is overexpressed in lymphomas and leukemias, and chemically modified triplex PNAs show superior therapeutic efficacy in targeting miR-155. Anti-miR-155 targeting is validated through gene expression, Western blot analysis, and cell viability studies. These findings suggest the potential of next-generation triplex PNAs for targeting other miRNAs in cancer therapy.
Review
Biochemistry & Molecular Biology
Mohsen Karami Fath, Kimiya Babakhaniyan, Maryam Zokaei, Azadeh Yaghoubian, Sadaf Akbari, Mahdieh Khorsandi, Asma Soofi, Mohsen Nabi-Afjadi, Hamidreza Zalpoor, Fateme Jalalifar, Ali Azargoonjahromi, Zahra Payandeh, Armina Alagheband Bahrami
Summary: This study reviews the applications of therapeutic peptides and targeting ligands in cancer therapy. Therapeutic peptides show promise as targeted drug delivery systems due to their specificity and modifiability.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Review
Chemistry, Medicinal
Valentina Foglizzo, Serena Marchio
Summary: The evolution of nanomedicine involves redesigning carriers to create new therapeutic and diagnostic platforms. Bacteriophage research has shown potential in drug and gene delivery, with the ability to display specific molecular determinants on their surface. Phages can be used as carriers for imaging molecules and therapeutics, and their genetic material can be manipulated for gene therapy purposes. They hold promise as anticancer agents with the potential for systemic administration and modulation of their immunogenic profile for vaccine production in immuno-oncology.
Review
Engineering, Biomedical
Qian-Ni Ye, Yue Wang, Song Shen, Cong-Fei Xu, Jun Wang
Summary: Considerable breakthroughs have been made in the treatment of malignant tumors using antibody drugs, but challenges such as instability in vivo, poor tumor penetration, and limited response rate remain. Biomaterials-based delivery systems have been reported to enhance the efficacy of antibody drugs in recent years. The integration of biomaterials with therapeutic antibodies shows promise in enhancing cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Manu Smriti Singh, Srinivas Ramishetti, Dalit Landesman-Milo, Meir Goldsmith, Sushmita Chatterjee, Ramesh Palakuri, Dan Peer
Summary: LNPs encapsulating siRNAs demonstrate efficient tumor targeting and gene silencing in ovarian cancer cells, showing promising potential for the treatment of advanced ovarian cancer.
Review
Engineering, Biomedical
Faisal Raza, Lauren Evans, Mahzad Motallebi, Hajra Zafar, Miguel Pereira-Silva, Kalsoom Saleem, Diana Peixoto, Abbas Rahdar, Esmaeel Sharifi, Francisco Veiga, Clare Hoskins, Ana Claudia Paiva-Santos
Summary: Pancreatic cancer is a challenging and often considered incurable disease. Liposomes have shown promise as future drug delivery systems for pancreatic cancer treatment due to their versatility, ease of fabrication, and modification. This review explores the various mechanisms of liposomes in treating pancreatic cancer, including chemotherapy, targeted therapy, mRNA therapy, immunotherapy, and photothermal therapy. Although multifunctional liposomal formulations have shown pre-clinical success, none have been clinically approved for pancreatic cancer. This review sheds light on the progress made so far and provides insights for future liposomal therapy and improved patient outcomes.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Yasamin Ghahramani, Marzieh Mokhberi, Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Fatemeh Fallahi Nezhad, Wei-Hung Chiang, Ahmad Gholami, Chin Wei Lai
Summary: The use of asymmetric nanoparticle anticancer agents is discussed in relation to the treatment of cancer using bioinspired and biomimetic materials.
Review
Pharmacology & Pharmacy
Jeongrae Kim, Yongwhan Choi, Dong-Hwee Kim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: This review summarizes recent advances in the use of injectable hydrogels for combination immunotherapy in treating tumors. Injectable hydrogels, with their biocompatibility, degradability, and controllable properties, can effectively encapsulate various immunotherapeutic agents and elicit antitumor immune responses. The review also discusses the application of injectable hydrogels in chemoimmunotherapy, photoimmunotherapy, and radioimmunotherapy.
Review
Instruments & Instrumentation
Mayur Aalhate, Srushti Mahajan, Hoshiyar Singh, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, and early-stage non-metastatic cases have a high cure rate. However, there is a high risk of recurrence with endocrine therapy. Nanomedicine, which improves drug delivery and reduces toxicity, has become a promising approach for breast cancer treatment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Asma Ghaemi, Masoume Vakili-Azghandi, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: Gene therapy has the potential to prevent or treat various genetic or acquired diseases by regulating gene and protein expression. Effective delivery systems are needed to ensure successful gene therapy, and oral delivery approaches show promise in treating diseases such as inflammatory bowel disease and cancer. This review provides an update on the development of oral gene delivery techniques for gene therapy and vaccination purposes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Rouba D. Al Bostami, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: Cancer therapies have made significant advancements in the past decade, but there are still barriers to their success. Nanomedicines that deliver multiple drugs and genes simultaneously have shown improved effectiveness and synergistic effects. However, the development of co-delivery systems faces limitations and challenges and requires a better understanding of the therapeutic agent ratio and heterogeneity of cancer cells.
Article
Chemistry, Physical
Giacomo Reina, Cristian Gabellini, Maria Maranska, Fabian Grote, Shan Min Chin, Lucas Jacquemin, Francois Berger, Paola Posocco, Siegfried Eigler, Alberto Bianco
Summary: Gene therapy has become a forefront treatment for various diseases. However, the clinical application of graphene oxide as a gene vector is limited due to the lack of homogeneity in different synthetic methods. In this study, a new class of graphene oxide called oxo-G was prepared with controlled size and surface chemistry. After functionalization, oxo-G was able to efficiently complex siRNA and induce gene silencing in vitro at doses more than 20 times lower than previous graphene-based materials. This work aims to inspire further development of oxo-G materials for biomedical applications, with the hope that oxo-G can be considered as an alternative candidate for future in vivo gene silencing.
Article
Medicine, Research & Experimental
Yu Chen, Shi-Hang Xiong, Fei Li, Xiang-Jun Kong, De-Fang Ouyang, Ying Zheng, Hua Yu, Yuan-Jia Hu
Summary: This study analyzed the advancements in therapeutic siRNA delivery technology from a patent perspective. A total of 11,509 patent documents were collected and analyzed, and the overall patent landscape was presented from temporal, spatial, organizational, and technological dimensions. The findings provide a basis for decision-making for researchers and developers in the field.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Biochemistry & Molecular Biology
Giulia Della Pelle, Nina Kostevsek
Summary: Gene therapy has the potential to be a significant advancement in 21st-century medicine. Using the body's cells as drug delivery systems offers a unique approach, with red blood cells as a potential candidate due to their abundance and potential cost-effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Elham Sameiyan, Parirokh Lavaee, Mohammad Ramezani, Mona Alibolandi, Zahra Khoshbin, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: A simple electrochemical sensing platform has been developed for the detection of aflatoxin B-1. This method showed enhanced sensitivity and selectivity, and can be applied to measure various toxins by substituting the proper aptamers and complementary strands.
Article
Chemistry, Analytical
Sedighe Khaksari, Amir Reza Ameri, Seyed Mohammad Taghdisi, Mahya Sabet, Seyed Mohammad Javad Ghaani Bami, Khalil Abnous, Seyed Ali Mousavi Shaegh
Summary: This paper presents a novel microfluidic electrochemical aptasensor for the determination of A549 cells. The sensor utilizes a target-induced structure switching mode to selectively and sensitively detect A549 cells. It has a wide linear dynamic range and a low detection limit, making it suitable for analysis in complex matrices.
Article
Pharmacology & Pharmacy
Tahoora Ghasemzadeh, Maliheh Hasannia, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Negar Nekooei, Mohammad Ramezani, Mona Alibolandi
Summary: The study designed and fabricated targeted nanobubbles with high encapsulation efficiency and sustained drug release. The decorated nanobubbles showed enhanced cellular uptake and cytotoxicity in MUC1-overexpressing cells. In vivo experiments demonstrated superior therapeutic efficacy and survival rate of the modified nanobubbles, and the echogenic capability was demonstrated through ultrasonic imaging.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Chemistry, Applied
Zahra Khoshbin, Marzieh Moeenfard, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: A simple aptasensor embedded in a micropipette tip is developed for label-free monitoring of acrylamide. The aptasensor utilizes the formation of a triple-helix molecular switch structure to induce the aggregation of gold nanoparticles. A smartphone imaging readout strategy enables the quantification of acrylamide based on the color change of the solution inside the micropipette tip. This aptasensor shows good selectivity and can successfully quantify acrylamide in various food samples.
Article
Chemistry, Medicinal
Elham Moradi, TaranehSadat Zavvar, Mona Alibolandi, Mohammad Ramezani, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: We evaluated DNA nanocarriers composed of multiple repeats of AS1411 and FOXM1 aptamers for targeted epirubicin delivery to breast cancer cells. The nanocarriers showed characteristics of being safe, stable, efficient epirubicin loading, pH-dependent drug release, and tumor-targeting ability in vitro and in vivo. The complex of the nanocarrier carrying epirubicin exhibited higher entry and cytotoxicity in target cells, higher therapeutic effect, and tumor drug accumulation compared to epirubicin alone.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Spectroscopy
Hamed Zahraee, Zahra Khoshbin, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: In this study, a sensitive fluorescent method was developed using a hybrid structure of three aptamer strands and SYBR Green I (SGI) fluorescent dye for the detection of tobramycin (TOB) drug. The collapse of the hybridized aptamer skeleton to single strands due to preferential binding of aptamers to TOB resulted in the reduction of SGI molecules and quenching of the fluorescence response. The developed aptasensor showed superior target specificity with a detection limit of 0.153 pM and a wide linear dynamic range.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Sedighe Khaksari, Khalil Abnous, Farzin Hadizadeh, Mohammad Ramezani, Seyed Mohammad Taghdisi, Seyed Ali Mousavi Shaegh
Summary: Extracellular vesicles (EVs) are membrane-enclosed vesicles secreted from mammalian cells, which act as multi-component delivery vehicles for intercellular communications. Probing circulating EVs has great potential for early diagnostics of diseases, and biosensors have attracted attention in the identification of EVs due to their simplicity and portability. Amplification strategies, including various detection modalities and microfluidic systems, are essential for detecting the extremely low concentrations of EVs in bodily fluids at early stages of a disease.
Article
Chemistry, Analytical
Zahra Khoshbin, Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Parirokh Lavaee, Ali Khakshour Abdolabadi, Khalil Abnous
Summary: A simple colorimetric strategy was developed for the monitoring of lead ion (Pb2+) using gold nanoparticles (AuNPs) regulated by aptamer strands. The aptamers masked the surface of AuNPs, preventing their peroxidase-like activity and the oxidation of TMB. The aptamer-Pb2+ complex, formed by adding Pb2+, released the aptamer from the AuNPs surface, enabling the oxidation of TMB and resulting in a color change from colorless to blue. The aptasensor showed a linear concentration range of 0.2 to 200 nM and a LOD of 0.056 nM for Pb2+ detection, successfully monitoring Pb2+ in drinking water, milk, and human serum, making it suitable for various applications.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Medicinal
Salimeh Mirzaei, Zahra Khademi, Reza Zolfaghari, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: In this study, a dual-targeting delivery system using mesoporous silica nanoparticles with hollow structures (HMSNs) was developed for specific delivery of epirubicin (EPI) to cancer cells and introducing a H+-triggered bubble generating nanosystem (BGNS). The results demonstrated that this system showed promising anti-cancer effects and reduced off-target effects.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Alizadeh, Elnaz Yaghoobi, Maryam Imanimoghadam, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: Using nanocarriers for targeted drug delivery can reduce side effects and improve therapeutic efficacy. This study developed nanoparticles that target mucin-1 and successfully demonstrated their effectiveness in targeting cancer cells.
JOURNAL OF DRUG TARGETING
(2023)
Article
Chemistry, Analytical
Masoomeh Esmaelpourfarkhani, Noor Mohammad Danesh, Mohammad Ramezani, Mona Alibolandi, Ali Khakshour Abdolabadi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: To combat drug trafficking and abuse, it is necessary to develop a sensing method for cocaine detection. This study proposes a label-free and simple split aptamer-based fluorescent aptasensor, which utilizes the N-methyl mesoporphyrin IX (NMM)/G-quadruplex system as a fluorescent indicator for cocaine detection. The working principle of the aptasensor is based on the formation of a split G-quadruplex structure in the presence of cocaine, leading to an increase in the emission intensity of fluorescence. Under optimized conditions, the designed fluorescent aptasensor exhibits a useful linear concentration range (50 pM to 25 nM) and a limit of detection (16 pM). The potential application of the designed aptasensor is demonstrated by successfully detecting cocaine in spiked human serum samples, with satisfying recoveries.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Ghasem Anbiaee, Zahra Khoshbin, Hamed Zahraee, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: Developing cost-effective smart sensing tools with ultrahigh sensitivity for food safety insurance is highly important. Aptamer-based biosensors powered by recycling signal amplification strategies, such as target recycling supported by enzymes, have shown great potential in achieving signal amplification. Exonucleases, as superior biocatalysts, simplify the amplification process and exhibit outstanding selectivity and sensitivity, making them promising sensing tools for label-free, ease-of-use, cost-effective, and real-time diagnosis of diverse targets. This article summarizes the achievements and perspectives in aptasensor design for qualitative monitoring of diverse targets using exonucleases for signal amplification.
Article
Chemistry, Analytical
Monireh Bolourinezhad, Majid Rezayi, Zahra Meshkat, Saman Soleimanpour, Majid Mojarrad, Farkhonde Zibadi, Seyed Hamid Aghaee-Bakhtiari, Seyed Mohammad Taghdisi
Summary: This study developed a rapid and accurate biosensor for detecting SARS-CoV-2. It utilized MXene nanosheets and carbon platinum to amplify the signal upon hybridization reaction. The biosensor showed a limit of detection of 0.4 aM and demonstrated high accuracy and sensitivity in clinical samples.
Review
Materials Science, Biomaterials
Ali Aliabadi, Maliheh Hasannia, Masoume Vakili-Azghandi, Fatemeh Araste, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: The formation of polymeric micelles via self-assembly is a versatile approach for improving the solubility and permeability of hydrophobic drugs. Polymer-based micelles have advantages in terms of size, morphology, and scalability. Various techniques have been employed to synthesize copolymers that can self-assemble into well-defined micellar structures with tunable drug release patterns. This review summarizes important polymerization techniques and recent achievements in the field of drug delivery using micellar systems, and proposes new visions for designing and synthesizing potent amphiphilic polymers.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Biomaterials
Ali Aliabadi, Maliheh Hasannia, Masoume Vakili-Azghandi, Fatemeh Araste, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: Polymeric micelles formed through self-assembly of amphiphilic polymers in aqueous environments have been explored as a versatile platform for enhancing the solubility and permeability of hydrophobic drugs. Compared to other self-assembly-based vehicles, polymeric micelles commonly have smaller size, spherical morphology, and simpler scale-up process. The synthesis of various amphiphilic polymers using different polymerization techniques has led to the development of smart copolymers that can form micelles, load therapeutics, and respond to external stimuli. This review summarizes important polymerization techniques and recent achievements in the field of drug delivery using micellar systems, and proposes new visions for the design and synthesis of innovative amphiphilic polymers for drug delivery applications. ROP, ATRP, RAFT, and combined methods were employed for copolymer synthesis, resulting in copolymers with proficiency of self-assembly into micellar structures.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)