Exosomes transmit T790M mutation‐induced resistance in EGFR‐mutant NSCLC by activating PI3K/AKT signalling pathway

High ratio of T790M to EGFR activating mutations correlate with the osimertinib response in non-small-cell lung cancer

(2018) Ryo Ariyasu et al.   LUNG CANCER

Exosomes derived from mesenchymal non-small cell lung cancer cells promote chemoresistance

(2017) Richard J. Lobb et al.   INTERNATIONAL JOURNAL OF CANCER

The role of exosomes and miRNAs in drug-resistance of cancer cells

(2017) Duc-Hiep Bach et al.   INTERNATIONAL JOURNAL OF CANCER

Cisplatin-resistant lung cancer cell–derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100–5p-dependent manner

(2017) Xiaobing Qin et al.   International Journal of Nanomedicine

Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

(2017) Feng Wei et al.   Molecular Cancer

Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer

(2017) Tony S. Mok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

(2016) Le Qu et al.   CANCER CELL

The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes

(2016) Shu Wen Wen et al.   CANCER RESEARCH

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

(2016) Jill E. Larsen et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

(2016) Aaron N Hata et al.   NATURE MEDICINE

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

(2016) Chi Lam Au Yeung et al.   Nature Communications

Downregulation of miR-522 suppresses proliferation and metastasis of non-small cell lung cancer cells by directly targeting DENN/MADD domain containing 2D

(2016) Tianze Zhang et al.   Scientific Reports

Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials

(2015) James Chih-Hsin Yang et al.   LANCET ONCOLOGY

PTEN and PI3K/AKT in non-small-cell lung cancer

(2015) Cristina Pérez-Ramírez et al.   PHARMACOGENOMICS

Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles

(2015) Diana Sousa et al.   TRENDS IN MOLECULAR MEDICINE

Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222

(2015) Dan-dan Yu et al.   TUMOR BIOLOGY

miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type

(2015) Jiayu Li et al.   Oncotarget

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

(2014) Claudia Fumarola et al.   BIOCHEMICAL PHARMACOLOGY

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells

(2014) J. Wang et al.   BLOOD

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs

(2014) Wei-xian Chen et al.   PLoS One

Exosomes - Structure, Biogenesis and Biological Role in Non-Small-Cell Lung Cancer

(2014) M. Frydrychowicz et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers

(2013) H. A. Yu et al.   CLINICAL CANCER RESEARCH

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study

(2011) Caicun Zhou et al.   LANCET ONCOLOGY

Integrated Profiling of MicroRNAs and mRNAs: MicroRNAs Located on Xq27.3 Associate with Clear Cell Renal Cell Carcinoma

(2011) Liang Zhou et al.   PLoS One

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

(2011) L. V. Sequist et al.   Science Translational Medicine

DEGseq: an R package for identifying differentially expressed genes from RNA-seq data

(2009) Likun Wang et al.   BIOINFORMATICS

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

(2009) Tony S. Mok et al.   NEW ENGLAND JOURNAL OF MEDICINE