Review
Oncology
Quan Liu, Xian Zhang, Jun Zhang
Summary: Breast cancer remains a major health concern for women worldwide. Exosomes, with their ability to transfer various substances and reshape recipient cell function, have emerged as promising candidates for nano-medicine in breast cancer treatment. Nanoparticle-based platforms constructed from exosomes offer advantages such as low immune response, minimal adverse effects, prolonged circulation, and easy modification, providing a new approach for precise and efficient breast cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ling'ao Meng, Kedong Song, Shenglong Li, Yue Kang
Summary: Breast cancer has become the most common cancer, surpassing lung cancer. Traditional chemotherapy brings significant side effects and often leads to drug resistance. Exosomes, small extracellular vesicles derived from the cell membrane and involved in various biological activities, show potential for breast cancer treatment.
Review
Biochemistry & Molecular Biology
Zeyi Lu, Yuanlei Chen, Wenqin Luo, Lifeng Ding, Huan Wang, Yang Li, Bo wen Yang, Liangliang Ren, Qining Zheng, Haiyun Xie, Ruyue Wang, Chenhao Yu, Yudong Lin, Zhenwei Zhou, Liqun Xia, Gonghui Li
Summary: This review article discusses the important role of exosomes in drug resistance. By transferring bioactive cargoes, exosomes can modulate the response of tumor cells to drugs, thereby affecting treatment outcomes. Exosomes also have the potential to serve as biomarkers in liquid biopsy for the diagnosis and treatment of genitourinary cancers.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Oncology
Jiongjia Cheng, Xiaofeng Wang, Xuechun Yuan, Guangxiang Liu, Qian Chu
Summary: Cancer-derived exosomes have emerged as stable reservoirs for potential biomarkers in non-invasive cancer diagnosis. Exosomal proteins play pivotal roles in tumor development and progression through multiple signaling pathways. Furthermore, exosomal proteins have practical applications in detecting and monitoring several solid-tumor cancers.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Mohd Mughees, Krishna Kumar, Saima Wajid
Summary: Exosomes play a potential role in breast cancer therapy and serve as important drug carriers. In BC cells, exosomes can assist in the efficient targeted delivery of therapeutic substances, including proteins, nucleic acid, and anti-cancer drugs. The properties of exosomes as an efficient delivery system show promise for future exploration and potential use in other forms of cancer as well.
JOURNAL OF DRUG TARGETING
(2021)
Review
Oncology
Ameneh Jafari, Amirhesam Babajani, Meghdad Abdollahpour-Alitappeh, Nayebali Ahmadi, Mostafa Rezaei-Tavirani
Summary: Exosomes, originating from various types of cells, are crucial in cell-to-cell communication and cancer progression. Their unique biogenesis, low immunogenicity, and ability to target tumor cells make them attractive for cancer therapy. Understanding the molecular mechanisms of exosomes' involvement in tumorigenesis is crucial for developing next-generation cancer therapeutics.
Article
Pharmacology & Pharmacy
Nurdan Sena Degirmenci, Merve Uslu, Oguz Kaan Krbas, Fikrettin Sahin, Evren Onay Uar
Summary: Exosomes, as natural vesicle nanocarriers, have the advantages of biocompatibility, natural form, high stability, and low toxicity. Loading chemotherapeutic drugs into exosomes derived from non-cancerous cells can enhance the effectiveness of drug treatment without interfering with the drug's mechanism of action.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaohui Zhang, Jiapo Wang, Na Liu, Weimin Wu, Hong Li, Wen Lu, Xiaoqing Guo
Summary: The therapeutic efficacy of umbilical cord blood-derived M1 macrophage exosomes loaded with cisplatin (CIS) in ovarian cancer and platinum resistance was investigated. It was found that M1exoCIS could reduce CIS resistance, inhibit tumor growth, and have lower toxicity.
MOLECULAR PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Cynthia Mark, Jin Sun Lee, Xiaojiang Cui, Yuan Yuan
Summary: Antibody drug conjugates (ADCs) combine monoclonal antibodies with cytotoxic drugs for selective delivery to cancer cells, optimizing treatment effectiveness. ADC research has significantly impacted breast cancer management, providing valuable options. However, important questions remain, such as drug sequencing and overcoming resistance mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Wen Tian, Xiaoying Niu, Feifei Feng, Xin Wang, Jiaqiang Wang, Weitao Yao, Peng Zhang
Summary: Osteosarcoma, the most common malignant bone sarcoma in children, is hindered by chemotherapy drugs resistance. Exosomal miRNAs play an important role in the occurrence, development, and drug resistance of osteosarcoma. Exploration of exosome biogenesis and role of exosomal miRNAs provides new strategies and targets for understanding the pathogenesis of osteosarcoma and overcoming drug resistance. Engineering modification of exosomes enhances their targeting ability, making them more effective in delivering cargos to recipient cells. This review focuses on the mechanisms of exosomal miRNAs in osteosarcoma and their potential as tumor biomarkers, as well as recent advances in the clinical application of engineering exosomes to overcome chemotherapy resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Chuanyun Li, Tong Zhou, Jing Chen, Rong Li, Huan Chen, Shumin Luo, Dexi Chen, Cao Cai, Weihua Li
Summary: Exosomal miRNAs play a critical role in regulating genes and their altered expression is associated with almost all human cancers. They modulate processes that interfere with cancer immunity and microenvironment, and significantly impact tumor growth, invasion, metastasis, angiogenesis, and drug resistance. Understanding the detailed mechanisms of miRNAs in cancer development could contribute to both cancer treatment and prevention of malignant diseases. This review highlights recent advances in cancer-derived exosomal miRNAs, including their sorting and delivery mechanisms, as well as their potential as diagnostic and prognostic markers and in detecting cancer resistance to therapeutic agents.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Hyosuk Kim, Eun Hye Kim, Gijung Kwak, Sung-Gil Chi, Sun Hwa Kim, Yoosoo Yang
Summary: Exosomes are nanovesicles secreted by cells that can mediate intercellular communication and serve as promising drug delivery vehicles due to their stability, biocompatibility, and targeting abilities. They can carry therapeutic signaling molecules from specific cell types, impacting cancer treatment significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Hyosuk Kim, Hochung Jang, Haeun Cho, Jiwon Choi, Kwang Yeon Hwang, Yeonho Choi, Sun Hwa Kim, Yoosoo Yang
Summary: Exosomes derived from various sources can serve as efficient drug delivery carriers, extending drug half-life and increasing release stability by encapsulating drugs, and possessing natural advantages such as high biocompatibility and low immunogenicity.
Article
Oncology
Chun Liu, Chenxi Hu, Ting Chen, Yanting Jiang, Xin Zhang, Hongyu Liu, Yuan Wang, Zhi Li, Kaiyuan Hui, Xiaodong Jiang
Summary: This study identified plasma exosomal lnc-SNAPC5-3:4 as a potential biomarker for monitoring the efficacy of anlotinib.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Lei Yin, Xiaotian Liu, Xuejun Shao, Tao Feng, Jun Xu, Qi Wang, Shenghao Hua
Summary: Exosomes play a crucial role in lung cancer metastasis by promoting various processes such as cell proliferation, angiogenesis, and immune evasion. They are also being explored as potential therapeutic drug carriers and predictive biomarkers for diagnosing, prognosis, and anti-tumor drug resistance in lung cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)