Article
Chemistry, Physical
Zejun Xu, Guiting Liu, Li Zheng, Jun Wu
Summary: A hydrogel with enhanced antimicrobial and antioxidant properties (CMGFC) was developed to accelerate diabetic wound healing. The CMGFC hydrogel showed high antibacterial efficiency and strong ROS scavenging ability, protecting cells from oxidative stress. In vivo results demonstrated reduced inflammatory responses, enhanced angiogenesis, and improved wound healing with the CMGFC hydrogel.
Article
Chemistry, Applied
Yajie Zhong, Farzad Seidi, Yilin Wang, Ling Zheng, Yongcan Jin, Huining Xiao
Summary: An injectable self-healing hydrogel with inherent antibacterial activity was developed by forming dynamic covalent bonds between boronic acid and catechol groups in quaternized chitosan, along with encapsulating EGCG. The hydrogels showed excellent dual functions of antibacterial and antioxidant properties, and demonstrated good biocompatibility and contact-active antibacterial activity. In vivo evaluation showed the hydrogels' regenerative wound healing performance, highlighting their potential as novel wound dressings for wound management.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Saeed Ali Alsareii, Javed Ahmad, Ahmad Umar, Mohammad Zaki Ahmad, Abdul Aleem Mohammed, Alamri Abdulrahman Manaa, Mansour Yousef AlAsmari, Abdulhadi Mohamed Elbashir
Summary: More than 5 million people require medical attention annually due to burn-related injuries. This study evaluates the wound healing potential of chitosan gel containing hesperetin for burn wounds.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hengji Zhao, Yushu Zhang, Chao Zhou, Chunling Zhang, Bo Liu
Summary: Natural polysaccharide-based hydrogels provide effective skin protection during trauma and exhibit good antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Ziqiang Zhou, Xuejuan Zhang, Lijun Xu, Huangjie Lu, Yuying Chen, Chuanbin Wu, Ping Hu
Summary: In this study, a novel hydrogel was designed as a wound dressing material for diabetic wounds. The hydrogel showed good biocompatibility and enhanced wound healing in diabetic rats.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Pengpeng Deng, Lichao Yao, Juanjuan Chen, Zhigang Tang, Jinping Zhou
Summary: AC hydrogels can accelerate wound healing, with self-healing, low swelling rate, biocompatibility, and excellent hemostatic effect. They also show outstanding antibacterial activity and can be used for designing multifunctional dressings.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Wei Han, Chen Chen, Kuan Yang, Haibo Wang, Honggang Xia, Yu Zhao, Yun Teng, Gengchao Feng, Yong Mei Chen
Summary: Injectable and self-healing hydrogel with inherent antibacterial and antioxidant bioactivities, based on hyaluronic acid and chitosan, is prepared. This versatile hydrogel can serve as a functional wound dressing with multiple capabilities, including injectability, self-healing, antibacterial activity, and antioxidation. It shows excellent wound healing effects in a rat skin full-thickness incision model, promoting angiogenesis, granulation tissue formation, and collagen disposition. This study offers a promising alternative for treating chronic non-healing wounds without relying on antibiotics or antioxidant agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yuhang Liu, Anwei Zhou, Yiping Zhang, Zihan Tian, Xiao Cheng, Ya Gao, Xinyuan Zhou, Xiaotong Wu, Kerong Chen, Xinghai Ning
Summary: A photoactive self-healing hydrogel called Macropatch has been developed to promote wound healing by protecting the wound from further injury, sealing organ bleeding, and preventing bacterial infections under visible light irradiation. The hydrogel exhibits good self-healing capability, mechanical strength, tissue adhesiveness, and visible light-induced antibacterial activity, leading to a fast recovery of bacteria-infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Dongying Zhang, Qianqian Ouyang, Zhang Hu, Sitong Lu, Weiyan Quan, Puwang Li, Yu Chen, Sidong Li
Summary: Chitosan-based thermosensitive hydrogels incorporating integral active oyster peptide microspheres were studied for wound healing applications with promising results in accelerating cell migration and promoting fast wound healing in a mouse model. Safety evaluation demonstrated the biocompatibility of the hydrogel, indicating its potential as a medical dressing for wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Miao Zhang, Xiaoni Qiao, Wenwei Han, Tianze Jiang, Fei Liu, Xia Zhao
Summary: A novel composite hydrogel was fabricated, promoting cell proliferation and migration for wound healing, while also exhibiting significant antibacterial activity. This study highlights the potential of marine carbohydrate composite hydrogels in wound care management.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Shunxian Ji, Yushuang Zhao, Xinrang Zhai, Lu Wang, Huali Luo, Zhiyong Xu, Wei Dong, Bingbing Wu, Wei Wei
Summary: This study designed a double-crosslinked hydrogel for wound dressing using photocrosslinkable gelatin methacryloyl (GelMA) and sulfhydrylated chitosan (CS-SH). The resulting hydrogels showed a highly porous inner structure, enhanced mechanical properties, and moisture retention capacity. In vitro studies showed no cytotoxicity and promoted cell proliferation. The double-crosslinked hydrogel also exhibited antibacterial properties and accelerated full-thickness skin defect healing in animal experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Chuang Li, Tao Jiang, Cong Zhou, Ankang Jiang, Cuifen Lu, Guichun Yang, Junqi Nie, Feiyi Wang, Xiaofan Yang, Zhenbing Chen
Summary: Promoting the healing of diabetic wounds is a major challenge, but Chitosan-based POSS-PEG hybrid hydrogels show excellent healing properties with strong mechanical strength, self-healing efficiency, cytocompatibility, and antibacterial properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Lifeng Zhang, Jiali Yang, Wencong Liu, Qiteng Ding, Shuwen Sun, Shuai Zhang, Ning Wang, Yue Wang, Siyu Xi, Chunyu Liu, Chuanbo Ding, Changtian Li
Summary: This study reported a hydrogel dressing (PCA) based on L-arginine conjugated chitosan (CA) and aldehyde functionalized polysaccharides of Phellinus igniarius (OPPI) for wound repair in diabetes. PCA showed good antioxidant, antibacterial, and safety properties, and effectively promoted wound healing by promoting epithelial formation, collagen deposition, and enhancing angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Medicinal
Maria Silvia Gurgel Assis, Taciane Cristina Fernandes Pedrosa, Fernanda Segurasse de Moraes, Tamires Guedes Caldeira, Gislaine Ribeiro Pereira, Jacqueline de Souza, Andre Luis Morais Ruela
Summary: Acyclovir, an antiviral drug, has low oral bioavailability and is often used to treat herpes simplex encephalitis, which has a poor prognosis with high mortality and permanent sequelae. Research has focused on improving drug bioavailability through novel drug delivery systems, such as nanotechnology-based systems, to enhance the effectiveness of acyclovir in treating the disease.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Bruno Cesar Correa Salles, Krissia Caroline Leme, Marcelo Aparecido da Silva, Claudia Quintino da Rocha, Marcelo M. P. Tangerina, Wagner Vilegas, Sonia A. Figueiredo, Stella Maris da Silveira Duarte, Maria Rita Rodrigues, Fernanda Borges de Araujo Paula
Summary: The study evaluated the effects of flavonoids from Passiflora edulis leaves on diabetes-induced complications in rats. Analysis revealed the presence of various flavonoids, and treatment with the extract showed improvements in blood glucose, lipid levels, and platelet aggregation in diabetic rats. The findings suggest that C-glycosides in the extract may be beneficial for diabetes-related complications.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Food Science & Technology
Mariana Araujo Vieira do Carmo, Marina Fidelis, Pollyanna Francielli de Oliveira, Lais Quellen Feitoza, Marcos Jose Marques, Eric Batista Ferreira, Won Young Oh, Fereidoon Shahidi, Jarkko Hellstrom, Leonardo Augusto Almeida, Romulo Dias Novaes, Daniel Granato, Luciana Azevedo
Summary: The study demonstrated that Jabuticaba seed extract (LJE) may provide chemopreventive protection against colon cancer development by reducing inflammation and increasing proapoptotic pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Francois Isnaldo Dias Caldeira, Bruna Cardoso, Leonardo de Souza Carvalho, Eric Batista Ferreira, Suzane Cristina Pigossi, Larissa Santana Rodriguez
Summary: This study evaluated health-related quality of life, sleep quality, and sleepiness index in dentistry students at a university in Southeast Brazil. The results showed that dentistry students had poor indicators of quality of life, especially in the domains of body pain, vitality, general health perception, and limitations due to emotional and social aspects. Differences in sleep quality were also observed when related to demographic factors and academic performance.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2022)
Article
Education & Educational Research
Eric Batista Ferreira, Frederico Augusto Toti
Summary: This study analyzed trends and characteristics of Brazilian journals over a seven-year period, identifying different groups of journals based on impact, and uncovering asymmetry in Brazilian publications.
SCIENCE & EDUCATION
(2022)
Article
Pharmacology & Pharmacy
Cintia Oliveira Alves, Romulo Dias Novaes, Maria Tereza Carneiro Paschoal Bernardes, Reggiani Vilela Goncalves, Laila Pereira da Silva, Sandra Barbosa Neder Agostini, Gislaine Ribeiro Pereira, Flavia Chiva Carvalho
Summary: This study evaluated two MTX-loaded liquid crystals (C1CH and C1CHCE) as topical treatments for psoriasis. The results showed that these liquid crystals exhibited significant immunomodulatory effects and induced skin remodeling. They also reduced inflammation and regulated the activity of cytokines and enzymes associated with psoriasis.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Juciane de Abreu Ribeiro Pereira, Maria de Fatima Piccolo Barcelos, Eduardo Valerio Villas Boas, Roberta Hilsdorf Piccoli, Janina de Sales Guilarducci, Rafaela Correa Pereira, Jose Rodrigo Pauli, Eric Batista Ferreira, Michel Cardoso de Angelis-Pereira, Dennys Esper Cintra
Summary: This study found that the combination of yacon flour and yogurt with two strains of probiotics had positive effects on metabolic parameters, inflammatory and insulin signaling proteins in diet-induced obese mice. The combination resulted in decreased body weight, fasting glucose, and triacylglycerol levels, as well as reduced fat accumulation. Additionally, it decreased inflammatory markers and improved insulin signaling. These findings suggest that the use of prebiotics and probiotics in food can counteract obesity-associated inflammation and improve insulin resistance in the short term.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Genetics & Heredity
Larissa Vilela Nascimento, Francisco Lotufo Neto, Dalmo Antonio Ribeiro Moreira, Virginia Braga Cerutti, Helena Strelow Thurow, Gisele Medeiros Bastos, Eric Batista Ferreira, Rosario Dominguez Crespo Hirata, Mario Hiroyuki Hirata
Summary: The study found that short-term treatment with antidepressant drugs increased DNA methylation in KCNE1 and SCN5A promoters, potentially leading to ECG alterations in psychiatric patients, which were correlated with patient age and drug doses.
Article
Environmental Sciences
Wanderson Roberto da Silva, Patricia Angelica Teixeira, Joao Maroco, Eric Batista Ferreira, Micaela Aparecida Teodoro, Juliana Alvares Duarte Bonini Campos
Summary: This study examines the relationship between attention to body shape, social physique anxiety, and personal characteristics, and evaluates their correlation with body composition. The results show that greater attention to body shape is associated with higher expectations of negative physical evaluation and lower comfort with physical presentation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biotechnology & Applied Microbiology
Alessandra Oliveira Silva, Jessyca Milene Ribeiro, Talita Barbara Patrocinio, Gabriel Estevam Amorim, Antonio Alves Pereira-Junior, Marilene Lopes Angelo, Fernanda Borges de Araujo Paula, Nelma de Mello Silva Oliveira, Silvia Graciela Ruginsk, Jose Antunes-Rodrigues, Lucila Leico Kagohara Elias, Marcos Vinicios Salles Dias, Larissa Helena Torres, Carla Speroni Ceron
Summary: This study investigated the ameliorative effects of kefir on anxiety-like behavior induced by chronic unpredictable stress (CUS) in mice. Results showed that kefir improved the anxiety-like behavior by modulating brain-derived neurotrophic factor (BDNF) and corticosterone levels, and increased the antioxidant defense in the heart and kidney of mice.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Mathematics
Eric B. Ferreira, Fernanda L. Valadares, Caros P. Silva
Summary: Dairy consumption in Brazil is influenced by factors such as family income, consumer profile, eating habits, and cultural beliefs. The most consumed cheeses in Brazil are Mucareala, Minas cheese, Requeijao, Prato, and Parmesao. However, the popularity of cheeses on Twitter does not necessarily reflect preference. Through a tournament bracket experiment carried out on Instagram, the preferred cheeses in Brazil were found to be Parmesao, Mucarela, Prato, and Coalho. Future research should focus on developing inferential statistics for tournament bracket experiments.
Article
Pharmacology & Pharmacy
Sandra Barbosa Neder Agostini, Victor Lima de Sousa Machado, Luciano Sindra Virtuoso, Denismar Alves Nogueira, Gislaine Ribeiro Pereira, Flavia Chiva Carvalho
Summary: This study evaluated the effect of NaCl concentration on the physicochemical properties of polyelectrolyte complexes (PECs) based on chitosan and hypromellose loaded with methotrexate. The results showed that increasing NaCl concentration can decrease particle size and polydispersity index (PdI) without affecting drug entrapment efficiency (EE) and drug release.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mario Henrique Souza Simoes, Bruno Cesar Correa Salles, Stella Maris da Silveira Duarte, Marcelo Aparecido da Silva, Andre Luiz Machado Viana, Gabriel de Oliveira Isaac de Moraes, Sonia Aparecida Figueiredo, Eric Batista Ferreira, Maria Rita Rodrigues, Fernanda Borges de Araujo Paula
Summary: This study evaluated the antioxidant potential of Coffea arabica Linen (L.) leaf extract and its effects on platelet aggregation in dyslipidemic rats. The results demonstrated that the extract showed antioxidant activity and reduced platelet aggregation without affecting liver and kidney function.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Mathematics
Gabriel Baldasso, Ricardo M. Salgado, Eric B. Ferreira
Summary: The analysis of tweets from former Presidents Obama and Trump on Twitter revealed a group with high retweet/like ratio for Obama's tweets and a group with high response/retweet ratio for Trump's tweets. The K-Means and Fuzzy C-Means algorithms showed different results for Obama’s tweets but high similarity in the results for Trump’s tweets.
