Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs

Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning

(2020) Anisha K. Nigam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer

(2019) Stephanie A. Bien et al.   HUMAN GENETICS

Interactive Tree Of Life (iTOL) v4: recent updates and new developments

(2019) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies

(2019) Sook Wah Yee et al.   PLoS Genetics

A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis

(2019) Sara Brin Rosenthal et al.   Scientific Reports

The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease

(2018) Sanjay K. Nigam   Annual Review of Pharmacology and Toxicology

The systems biology of uric acid transporters

(2018) Sanjay K. Nigam et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes

(2018) Georg Sager et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut–liver–kidney axis

(2017) Kevin T. Bush et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

(2017) Tao Long et al.   NATURE GENETICS

Expression Atlas: gene and protein expression across multiple studies and organisms

(2017) Irene Papatheodorou et al.   NUCLEIC ACIDS RESEARCH

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Clustal Omega for making accurate alignments of many protein sequences

(2017) Fabian Sievers et al.   PROTEIN SCIENCE

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes

(2017) Wei Wu et al.   Scientific Reports

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipocalin 2 and lipocalin 2 receptor in neuron-glia interactions following injury

(2016) Chia Wan-Jie et al.   Frontiers in Cellular Neuroscience

A critical role of solute carrier 22a14 in sperm motility and male fertility in mice

(2016) Shin-ya Maruyama et al.   Scientific Reports

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

Role of OAT4 in Uptake of Estriol Precursor 16α-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus

(2015) Masatoshi Tomi et al.   ENDOCRINOLOGY

Genetics of human metabolism: an update

(2015) Gabi Kastenmüller et al.   HUMAN MOLECULAR GENETICS

CCTOP: a Consensus Constrained TOPology prediction web server

(2015) László Dobson et al.   NUCLEIC ACIDS RESEARCH

The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective

(2015) Sanjay K. Nigam et al.   PHYSIOLOGICAL REVIEWS

Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs

(2015) Christopher Zhu et al.   PLoS One

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Single-nucleotide polymorphisms in SLC22A23 are associated with ulcerative colitis in a Canadian white cohort

(2014) Alejandra Serrano León et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease

(2013) Hirofumi Yano et al.   Clinical and Experimental Nephrology

A Common Variant of Organic Anion Transporter 4 (OAT4/SLC22A11) Gene Is Associated with Renal Underexcretion Type Gout

(2013) Masayuki Sakiyama et al.   Drug Metabolism and Pharmacokinetics

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Transporter Classification Database

(2013) Milton H. Saier et al.   NUCLEIC ACIDS RESEARCH

BioV Suite - a collection of programs for the study of transport protein evolution

(2012) Vamsee S. Reddy et al.   FEBS Journal

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Ergothioneine; antioxidant potential, physiological function and role in disease

(2011) Irwin K. Cheah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lipocalin-2 (24p3/Neutrophil Gelatinase-associated Lipocalin (NGAL)) Receptor Is Expressed in Distal Nephron and Mediates Protein Endocytosis

(2011) Christian Langelueddecke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1)

(2011) William R. Wikoff et al.   JOURNAL OF PROTEOME RESEARCH

Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23

(2011) Katie M. Bennett et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Remote Communication through Solute Carriers and ATP Binding Cassette Drug Transporter Pathways: An Update on the Remote Sensing and Signaling Hypothesis

(2011) W. Wu et al.   MOLECULAR PHARMACOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

A Novel Transporter of SLC22 Family Specifically Transports Prostaglandins and Co-localizes with 15-Hydroxyprostaglandin Dehydrogenase in Renal Proximal Tubules

(2010) Katsuko Shiraya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of polymorphisms in predicted target sites for micro RNAs differentially expressed in endometriosis

(2010) Z. Z. Zhao et al.   MOLECULAR HUMAN REPRODUCTION

Genome-wide association study of antipsychotic-induced QTc interval prolongation

(2010) K Åberg et al.   PHARMACOGENOMICS JOURNAL

Smoking and smoking cessation in disadvantaged women: Assessing genetic contributions

(2009) George R. Uhl et al.   DRUG AND ALCOHOL DEPENDENCE

Toward a Systems Level Understanding of Organic Anion and Other Multispecific Drug Transporters: A Remote Sensing and Signaling Hypothesis

(2009) S.-Y. Ahn et al.   MOLECULAR PHARMACOLOGY

Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members

(2009) Wei Wu et al.   PHYSIOLOGICAL GENOMICS

Molecular Genetics of Successful Smoking Cessation

(2008) George R. Uhl et al.   ARCHIVES OF GENERAL PSYCHIATRY

Functional and Immunochemical Characterization of a Novel Organic Anion Transporter Oat8 (Slc22a9) in Rat Renal Collecting Duct

(2008) Hirokazu Yokoyama et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Identification of a New Urate and High Affinity Nicotinate Transporter, hOAT10 (SLC22A13)

(2008) Andrew Bahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple organic anion transporters contribute to net renal excretion of uric acid

(2008) Satish A. Eraly et al.   PHYSIOLOGICAL GENOMICS

Expression patterns of the organic cation/carnitine transporter family in adult murine brain

(2007) Anne Marie Lamhonwah et al.   BRAIN & DEVELOPMENT