More Than One HMG-CoA Lyase: The Classical Mitochondrial Enzyme Plus the Peroxisomal and the Cytosolic Ones

p53 β-hydroxybutyrylation attenuates p53 activity

(2019) Kun Liu et al.   Cell Death & Disease

Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency

(2019) Kim L Ho et al.   CARDIOVASCULAR RESEARCH

Gene expression across mammalian organ development

(2019) Margarida Cardoso-Moreira et al.   NATURE

A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart

(2019) Desiree Abdurrachim et al.   Scientific Reports

Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms

(2019) Huajun Yang et al.   Frontiers in Neurology

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

(2019) Chia-Wei Cheng et al.   CELL

The specific molecular architecture of plant 3-hydroxy-3-methylglutaryl-CoA lyase

(2019) Andréa Hemmerlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ketone bodies as epigenetic modifiers

(2018) Hai-Bin Ruan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution

(2018) Jeramiah J. Smith et al.   NATURE GENETICS

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

(2018) Young-min Han et al.   MOLECULAR CELL

Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis

(2018) Patrycja Puchalska et al.   Cell Metabolism

HMGCLL1 is a predictive biomarker for deep molecular response to imatinib therapy in chronic myeloid leukemia

(2018) Jong-Ho Park et al.   LEUKEMIA

Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species

(2017) Mary Board et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: Clinical presentation and outcome in a series of 37 patients

(2017) Sarah Catharina Grünert et al.   MOLECULAR GENETICS AND METABOLISM

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Transcriptional landscape of human cancers

(2017) Mengyuan Li et al.   Oncotarget

Inactivation of HMGCL promotes proliferation and metastasis of nasopharyngeal carcinoma by suppressing oxidative stress

(2017) Wenqi Luo et al.   Scientific Reports

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

(2016) Kenneth C. Bedi et al.   CIRCULATION

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

HESX1mutations in patients with congenital hypopituitarism: variable phenotypes with the same genotype

(2016) Qing Fang et al.   CLINICAL ENDOCRINOLOGY

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms

(2016) Lavanya B. Achanta et al.   NEUROCHEMICAL RESEARCH

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

The sea lamprey meiotic map improves resolution of ancient vertebrate genome duplications

(2015) Jeramiah J. Smith et al.   GENOME RESEARCH

Protection of Hypoglycemia-Induced Neuronal Death by β-Hydroxybutyrate Involves the Preservation of Energy Levels and Decreased Production of Reactive Oxygen Species

(2015) Alberto Julio-Amilpas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

(2015) Hee-Bum Kang et al.   MOLECULAR CELL

Induction of a Proinflammatory Response in Cortical Astrocytes by the Major Metabolites Accumulating in HMG-CoA Lyase Deficiency: the Role of ERK Signaling Pathway in Cytokine Release

(2015) Carolina Gonçalves Fernandes et al.   MOLECULAR NEUROBIOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Mitochondrial Encephalopathy With Lactic Acidosis and Stroke-like Episodes (MELAS) May Respond to Adjunctive Ketogenic Diet

(2014) Claude Steriade et al.   PEDIATRIC NEUROLOGY

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages

(2014) Mahbubur Rahman et al.   Nature Communications

Identification and Characterization of an Extramitochondrial Human 3-Hydroxy-3-methylglutaryl-CoA Lyase

(2012) Christa Montgomery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol

(2012) María Arnedo et al.   JOURNAL OF LIPID RESEARCH

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Influence of multiple cysteines on human 3-hydroxy-3-methylglutaryl-CoA lyase activity and formation of inter-subunit adducts

(2011) Christa Montgomery et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Evidence for intron length conservation in a set of mammalian genes associated with embryonic development

(2011) Cathal Seoighe et al.   BMC BIOINFORMATICS

Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway

(2011) Beatriz Puisac et al.   MOLECULAR BIOLOGY REPORTS

Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria

(2010) Beatriz Puisac et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Ten novelHMGCLmutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria

(2009) Sebastián Menao et al.   HUMAN MUTATION

3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: Initial presentation in a young adult

(2009) S. Reimão et al.   JOURNAL OF INHERITED METABOLIC DISEASE

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Rapidly regulated genes are intron poor

(2008) Daniel C. Jeffares et al.   TRENDS IN GENETICS