3D Structure and Function of Glycosyltransferases Involved in N-glycan Maturation

Glycoengineering of HEK293 cells to produce high-mannose-type N-glycan structures

(2019) Wei-Wei Ren et al.   JOURNAL OF BIOCHEMISTRY

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells

(2019) Yoshiki Narimatsu et al.   MOLECULAR CELL

Bisecting GlcNAc Is a General Suppressor of Terminal Modification of N-glycan

(2019) Miyako Nakano et al.   MOLECULAR & CELLULAR PROTEOMICS

Emerging structural insights into glycosyltransferase-mediated synthesis of glycans

(2019) Kelley W. Moremen et al.   Nature Chemical Biology

N-GlycositeAtlas: a database resource for mass spectrometry-based human N-linked glycoprotein and glycosylation site mapping

(2019) Shisheng Sun et al.   Clinical Proteomics

Neural functions of bisecting GlcNAc

(2018) Yasuhiko Kizuka et al.   GLYCOCONJUGATE JOURNAL

HumanN-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite

(2018) Renuka Kadirvelraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis

(2018) Barnali Biswas et al.   Scientific Reports

Multiple sclerosis and cognition: synaptic failure and network dysfunction

(2018) Massimiliano Di Filippo et al.   NATURE REVIEWS NEUROSCIENCE

Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V

(2018) Masamichi Nagae et al.   Nature Communications

Core fucose is essential glycosylation for CD14-dependent Toll-like receptor 4 and Toll-like receptor 2 signalling in macrophages

(2018) Kotarosumitomo Nakayama et al.   JOURNAL OF BIOCHEMISTRY

Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling

(2017) Junko Iijima et al.   GLYCOBIOLOGY

Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations

(2017) Brian J McMillan et al.   GLYCOBIOLOGY

The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer

(2017) Heba Allam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1

(2017) Zhijie Li et al.   Nature Chemical Biology

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation

(2017) W-F Chiang et al.   ONCOGENE

Structural, mutagenic and in silico studies of xyloglucan fucosylation in Arabidopsis thaliana suggest a water-mediated mechanism

(2017) Breeanna R. Urbanowicz et al.   PLANT JOURNAL

Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities

(2017) Joan Teyra et al.   STRUCTURE

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

(2017) Masahiro Okada et al.   Cell Reports

Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice

(2016) Laura Feldcamp et al.   BEHAVIOURAL BRAIN RESEARCH

Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease

(2016) Hironobu Fujii et al.   GASTROENTEROLOGY

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Expression ofN-Acetylglucosaminyltransferase III Suppresses α2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to α2,6-Sialylation Levels

(2016) Jishun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

(2016) Jessika Valero-González et al.   Nature Chemical Biology

Structure ofArabidopsis thalianaFUT1 Reveals a Variant of the GT-B Class Fold and Provides Insight into Xyloglucan Fucosylation

(2016) Joana Rocha et al.   PLANT CELL

Carbohydrate-binding domain of the POMGnT1 stem region modulatesO-mannosylation sites of α-dystroglycan

(2016) Naoyuki Kuwabara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients

(2016) Reto S. Kohler et al.   Oncotarget

Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis

(2016) Haik Mkhikian et al.   eLife

Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins

(2016) Masamichi Nagae et al.   Scientific Reports

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions

(2015) Y. Kizuka et al.   BIOCHEMICAL JOURNAL

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

(2015) Y. Kizuka et al.   EMBO Molecular Medicine

Symbol Nomenclature for Graphical Representations of Glycans

(2015) Ajit Varki et al.   GLYCOBIOLOGY

Loss of α1,6-Fucosyltransferase Decreases Hippocampal Long Term Potentiation

(2015) Wei Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurons and Glia Modify Receptor Protein-tyrosine Phosphatase ζ (RPTPζ)/Phosphacan with Cell-specificO-Mannosyl Glycans in the Developing Brain

(2015) Chrissa A. Dwyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Core Fucosylation of IgG B Cell Receptor Is Required for Antigen Recognition and Antibody Production

(2015) Wenzhe Li et al.   JOURNAL OF IMMUNOLOGY

Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer

(2015) S Carvalho et al.   ONCOGENE

Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers

(2015) Rio Honma et al.   ONCOLOGY

GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain

(2015) Hung-Hsiang Huang et al.   eLife

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors

(2014) Diego O. Croci et al.   CELL

Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL3) regulates cellular N‐glycosylation

(2014) Matthias Voss et al.   EMBO JOURNAL

Epigenetic Regulation of a Brain-specific GlycosyltransferaseN-Acetylglucosaminyltransferase-IX (GnT-IX) by Specific Chromatin Modifiers

(2014) Yasuhiko Kizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycomic Analysis of Membrane Glycoproteins with Bisecting Glycosylation from Ovarian Cancer Tissues Reveals Novel Structures and Functions

(2014) Heba Allam et al.   JOURNAL OF PROTEOME RESEARCH

Specific Glycosylation of Membrane Proteins in Epithelial Ovarian Cancer Cell Lines: Glycan Structures Reflect Gene Expression and DNA Methylation Status

(2014) Merrina Anugraham et al.   MOLECULAR & CELLULAR PROTEOMICS

Donor Assists Acceptor Binding and Catalysis of Human α1,6-Fucosyltransferase

(2013) Miriam P. Kötzler et al.   ACS Chemical Biology

Structural and biochemical characterization of O-mannose-linked human natural killer-1 glycan expressed on phosphacan in developing mouse brains

(2013) J. Morise et al.   GLYCOBIOLOGY

Structure-function relationships of membrane-associated GT-B glycosyltransferases

(2013) D. Albesa-Jove et al.   GLYCOBIOLOGY

Loss of Branched O-Mannosyl Glycans in Astrocytes Accelerates Remyelination

(2013) K. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

The carbohydrate-active enzymes database (CAZy) in 2013

(2013) Vincent Lombard et al.   NUCLEIC ACIDS RESEARCH

Structures of NodZ α1,6-fucosyltransferase in complex with GDP and GDP-fucose

(2012) Krzysztof Brzezinski et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Complex N-Glycans Are Essential, but Core 1 and 2 Mucin O-Glycans, O-Fucose Glycans, and NOTCH1 Are Dispensable, for Mammalian Spermatogenesis1

(2012) Frank Batista et al.   BIOLOGY OF REPRODUCTION

Human Prostate Cancer in a Clinically Relevant Xenograft Mouse Model: Identification of β(1,6)-Branched Oligosaccharides as a Marker of Tumor Progression

(2012) Tobias Lange et al.   CLINICAL CANCER RESEARCH

Structure of human POFUT2: insights into thrombospondin type 1 repeat fold andO-fucosylation

(2012) Chun-I Chen et al.   EMBO JOURNAL

Developmental Expression of the Neuron-specificN-Acetylglucosaminyltransferase Vb (GnT-Vb/IX) and Identification of Itsin VivoGlycan Products in Comparison with Those of Its Paralog, GnT-V

(2012) Jin Kyu Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles ofN-Acetylglucosaminyltransferase III in Epithelial-to-Mesenchymal Transition Induced by Transforming Growth Factor β1 (TGF-β1) in Epithelial Cell Lines

(2012) Qingsong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensitivity of Heterozygous α1,6-Fucosyltransferase Knock-out Mice to Cigarette Smoke-induced Emphysema

(2012) Congxiao Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Bisecting GlcNAc and Core Fucosylation on Conformational Properties of Biantennary Complex-Type N-Glycans in Solution

(2012) Wataru Nishima et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss and Recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation Is a Mechanism Involved in Epithelial-Mesenchymal-Epithelial Transitions

(2012) Salomé S. Pinho et al.   PLoS One

Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer

(2012) C.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycomic Analyses of Mouse Models of Congenital Muscular Dystrophy

(2011) Stephanie H. Stalnaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD133 ProteinN-Glycosylation Processing Contributes to Cell Surface Recognition of the Primitive Cell Marker AC133 Epitope

(2011) Anthony B. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport

(2011) Kazuaki Ohtsubo et al.   NATURE MEDICINE

The Bisecting GlcNAc on N-Glycans Inhibits Growth Factor Signaling and Retards Mammary Tumor Progression

(2010) Y. Song et al.   CANCER RESEARCH

A testis-specific regulator of complex and hybrid N-glycan synthesis

(2010) Hung-Hsiang Huang et al.   JOURNAL OF CELL BIOLOGY

O-glycosylation pattern of CD24 from mouse brain

(2009) Christina Bleckmann et al.   BIOLOGICAL CHEMISTRY

Comparison of the substrate specificities and catalytic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX)

(2009) Gerardo Alvarez-Manilla et al.   GLYCOBIOLOGY

Protective effect of N-glycan bisecting GlcNAc residues on  -amyloid production in Alzheimer's disease

(2009) K. Akasaka-Manya et al.   GLYCOBIOLOGY

Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice

(2009) Shinji Takamatsu et al.   GLYCOBIOLOGY

Functional roles of N-glycans in cell signaling and cell adhesion in cancer

(2008) Yan-Yang Zhao et al.   CANCER SCIENCE

Branched N-glycans regulate the biological functions of integrins and cadherins

(2008) Yanyang Zhao et al.   FEBS Journal

Golgi  -mannosidase II cleaves two sugars sequentially in the same catalytic site

(2008) N. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry

Beta N-acetylglucosaminyltransferase V (Mgat5) deficiency reduces the depression-like phenotype in mice

(2007) L. Soleimani et al.   GENES BRAIN AND BEHAVIOR