Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Review
Pharmacology & Pharmacy
Meran Keshawa Ediriweera
Summary: Histone acetylation is a crucial epigenetic event and continues to be an area of great interest in biochemical research. The balance between histone acetyltransferases (HATs) and histone deacetylases (HDACs) is disrupted in various human cancers. Histone deacetylase inhibitors (HDACi) have shown promising results in restoring dysregulated histone acetylation profiles and are considered as potential anti-cancer therapeutics. Recent studies have identified odd-chain fatty acids as novel HDACi, further expanding the understanding of fatty acids in cancer therapy.
DRUG DISCOVERY TODAY
(2023)
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Yu Liu, Xinyi Shen, Mingchang Pang, Zhen Sun, Yongjiang Qian, Wenxin Xue, Zhongqun Wang, Lihua Li
Summary: Atherosclerosis (AS) is the leading cause of death in cardiovascular diseases, and Sirt3, an important histone deacetylase, plays a crucial role in the development and regression of AS by deacetylating mitochondrial proteins in blood vessels and participating in various metabolic activities. Medical research targeting Sirt3 is also actively underway, aiming to provide new insights and intervention strategies for AS.
Review
Biochemistry & Molecular Biology
Sonali Bahl, Edward Seto
Summary: Histone deacetylases (HDACs) are enzymes that regulate cellular processes by removing acetyl groups from proteins. HDAC activities are regulated by various mechanisms, including posttranslational modifications like reversible phosphorylation. Dysregulation of HDACs can contribute to disease development, making it important to understand how reversible phosphorylation affects their functions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Agronomy
Seung Hee Eom, Tae Kyung Hyun
Summary: In this study, 20 HDAC genes were identified in the Brassica rapa genome, with segmental duplicated paralogs and tandem duplicated paralogs present in the BraHDAC family. The expression patterns of paralogous gene pairs suggest functional divergence, and BraHDA3 is suggested to encode a functional HDAC enzyme that can be inhibited by SAHA.
Review
Pharmacology & Pharmacy
Yuan Meng, Juan Du, Ning Liu, Yuanyuan Qiang, Lifei Xiao, Xiaobing Lan, Lin Ma, Jiamei Yang, Jianqiang Yu, Guangyuan Lu
Summary: Depression is a serious mental illness with multiple causes. Previous studies have shown that it is influenced by environmental and genetic factors. This review explores the relationship between histone deacetylases (HDACs) and depression, and discusses the potential therapeutic use of HDAC inhibitors (HDACis) in treating depression.
JOURNAL OF DRUG TARGETING
(2023)
Review
Medicine, General & Internal
Dimitrios Goutas, Stamatios Theocharis, Gerasimos Tsourouflis
Summary: HDACs play important roles in tumorigenesis and tumor progression, showing potential as therapeutic targets in cancer treatment. However, their clinical significance as biomarkers in cancer is not fully elucidated. This study aims to emphasize the clinical significance of HDAC isoform expression in different tumor types and their correlations with clinicopathological parameters and patient outcomes.
Article
Multidisciplinary Sciences
Sharath Chandra Gaddelapati, Najla M. Albishi, Ramesh Kumar Dhandapani, Subba Reddy Palli
Summary: This study identified 10 genes coding for HDACs in the yellow fever mosquito and determined their role in larval development using RNA interference. The findings suggest that HDAC3 plays a crucial role in larval development and knockdown of HDAC3 leads to larval death and affects midgut size.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Obstetrics & Gynecology
Marina Ilicic, Tamas Zakar, Amy Gregson, Waleed M. Hussein, Roger Smith, Jonathan W. Paul
Summary: The article summarizes the crucial role of myometrial phenotypic transformation during pregnancy to facilitate childbirth, and the involvement of protein acetylation in this process. Studies show that histone deacetylase inhibitors have significant relaxation effects on pregnant human myometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Tinghui Shao, Yujia Xue, Mingming Fang
Summary: The study investigated the transcriptional regulation mechanism of Clca2 in cardiac fibrosis, revealing that the Twist1-HDAC1 complex can suppress the expression of Clca2 in cardiac fibroblasts, potentially leading to FMyT and cardiac fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Fabian B. Kraft, Maria Hanl, Felix Feller, Linda Schaeker-Huebner, Finn K. Hansen
Summary: Histone deacetylases (HDACs) are important for gene regulation, cell growth, and cell movement. FDA-approved HDAC inhibitors have shown efficacy in treating certain types of lymphomas and myeloma, but they also have many side effects. This study focuses on developing prodrugs of HDAC inhibitors that can be released specifically in the target tissue. The researchers synthesized prodrugs with photo-cleavable protecting groups and demonstrated their effectiveness in inhibiting HDAC activity and proliferation in cancer cells upon light activation.
Article
Chemistry, Multidisciplinary
He-ming Huang, Shi-jie Fan, Xiao-ru Zhou, Yan-jun Liu, Xiao Li, Li-ping Liao, Jing Huang, Cui-cui Shi, Liang Yu, Rong Fu, Jian-gao Fan, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li
Summary: Givinostat demonstrated therapeutic potential in treating nonalcoholic steatohepatitis (NASH) by alleviating inflammation and attenuating hepatic fibrosis, as shown in both in vivo and in vitro studies.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Genetics & Heredity
Jingjing Pu, Amit Sharma, Jian Hou, Ingo G. H. Schmidt-Wolf
Summary: With increasing knowledge about histone modifications and its role in disease conditions like cancer and neurodegeneration, histone deacetylase 6 (HDAC6) is considered to be at the forefront of research advancing clinical translation in these areas.
Article
Oncology
Saheed A. A. Ayodeji, Bin Bao, Emily A. A. Teslow, Lisa A. A. Polin, Greg Dyson, Aliccia Bollig-Fischer, Charlie Fehl
Summary: The study reveals a pathway in triple-negative breast cancer (TNBC) models where hyperglycemic conditions activate cancer stem cell (CSC) expansion. Targeting this pathway could potentially reduce hyperglycemia-driven breast cancer risk.
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Naoyuki Taniguchi, Yuki Ohkawa, Kento Maeda, Yoichiro Harada, Masamichi Nagae, Yasuhiko Kizuka, Hideyuki Ihara, Yoshitaka Ikeda
Summary: Cancer-related changes in glycans on cell surface proteins are regulated by glycosyltransferases and related genes, which play key roles in cancer metastasis and invasion. The significance of EMT and N-glycan branching glycosyltransferases needs to be reconsidered for potential therapeutic strategies. Specific glycosyltransferases involved in EMT or MET pathways may be difficult to define due to their roles in intermediate states.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Misuzu Hashimoto, Akiyoshi Fukamizu, Tsutomu Nakagawa, Yasuhiko Kizuka
Summary: PRMT1 is crucial for the development of neurons, astrocytes, and oligodendrocytes, requiring further investigation. The relevance of PRMT1 in neurodegenerative diseases will continue to be a hot topic.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Review
Biochemistry & Molecular Biology
Yoichiro Harada, Yuki Ohkawa, Kento Maeda, Naoyuki Taniguchi
Summary: The endoplasmic reticulum (ER) contains multiple quality control systems (QCS) that shape the glycoproteome of eukaryotic cells. One of these systems, glycan QCS, plays a crucial role in ensuring proper glycoprotein folding while also potentially increasing the risk of overall hypoglycosylation, leading to protein misfolding and cellular stress response activation.
Editorial Material
Biochemistry & Molecular Biology
Naoyuki Taniguchi, Kento Maeda, Masato Kitano
Summary: This commentary discusses a highly cited paper by Yasuhisa Kono which focused on the mechanism of hydroxylamine autooxidation in the assay of superoxide dismutase activity. Kono's work contributed to the development and progress in enzyme assay systems.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Motoko Takahashi, Yoshihiro Hasegawa, Kento Maeda, Masato Kitano, Naoyuki Taniguchi
Summary: Glycosylation of cell surface receptors plays a crucial role in regulating signal transduction. This review focuses on the role of glycosyltransferases involved in N-glycan modification, specifically the effects of branching and elongation on signaling by cell surface receptors. The review also discusses the involvement of these enzymes in EMT/MET programs related to differentiation, cancer development, progression, and therapy resistance.
GLYCOCONJUGATE JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Tetsuya Hirata, Atsushi Kobayashi, Tamio Furuse, Ikuko Yamada, Masaru Tamura, Hiroyuki Tomita, Yuko Tokoro, Akinori Ninomiya, Yoshitaka Fujihara, Masahito Ikawa, Yusuke Maeda, Yoshiko Murakami, Yasuhiko Kizuka, Taroh Kinoshita
Summary: The GPI-GalNAc side chain is essential for the functions of GPI-APs in mammals, particularly in bone and the brain. Knocking out the initiation enzyme PGAP4 in mice leads to various phenotypes and increased vulnerability to prion diseases, highlighting the protective roles of the GalNAc side chain.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Reina F. Osuka, Tetsuya Hirata, Masamichi Nagae, Miyako Nakano, Hiroyuki Shibata, Ryo Okamoto, Yasuhiko Kizuka
Summary: The N-terminal domain of N-acetylglucosaminyltransferase-V (GnT-V) is crucial for efficient glycosylation and plays a key role in the recognition of glycoprotein substrates. This study revealed that the N domain interacts directly with the substrate polypeptide, providing new insights into the mechanism of substrate-selective biosynthesis of N-glycans.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Biographical-Item
Biochemistry & Molecular Biology
Naoyuki Taniguchi, Ernesto Carafoli
Summary: This article expresses gratitude and admiration for Dr. William Lennarz for his contributions and accomplishments in the field of life science during his tenure as Editor-in-Chief of Biochemical and Biophysical Research Communications.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kiyotaka Kondo, Yoichiro Harada, Miyako Nakano, Takehiro Suzuki, Tomoko Fukushige, Ken Hanzawa, Hirokazu Yagi, Koichi Takagi, Keiko Mizuno, Yasuhide Miyamoto, Naoyuki Taniguchi, Koichi Kato, Takuro Kanekura, Naoshi Dohmae, Kentaro Machida, Ikuro Maruyama, Hiromasa Inoue
Summary: Protein N-glycosylation in lung cancer sEVs may potentially reflect the histology of lung cancers.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yuriko Tachida, Saori Miura, Yui Muto, Hiroyuki Takuwa, Naruhiko Sahara, Akihiro Shindo, Yukio Matsuba, Takashi Saito, Naoyuki Taniguchi, Yasushi Kawaguchi, Hidekazu Tomimoto, Takaomi Saido, Shinobu Kitazume
Summary: The deposition of amyloid P in blood vessels of the brain is commonly observed in Alzheimer's disease patients. However, it is difficult to examine the contribution of cerebral amyloid angiopathy (CAA) to the pathogenesis of Alzheimer's disease in mouse models. Based on biochemical analyses, the researchers hypothesized that endothelial APP expression would be lower in rodents and subsequently generated mice that express human WT APP in endothelial cells. The mice showed increased levels of serum A beta and soluble APP, indicating the crucial role of endothelial APP in blood A beta levels. Crossing these mice with a specific APP knock-in mouse model led to an expanded CAA pathology.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Dermatology
Kota Tachibana, Yuki Ohkawa, Noriko Kanto, Kento Maeda, Shuichi Ohe, Taiki Isei, Yoichiro Harada, Naoyuki Taniguchi
Summary: Glycan expression plays an important role in melanoma cells, and the ectopic expression of keratan sulfate (KS) can enhance the invasiveness and adhesion capabilities of melanoma cells, as well as stimulate the phosphorylation of paxillin, contributing to the development of malignant phenotypes.
JOURNAL OF DERMATOLOGY
(2022)
Article
Biology
Tetsuya Hirata, Misaki Takata, Yuko Tokoro, Miyako Nakano, Yasuhiko Kizuka
Summary: The activity of GnT-V in cells is regulated by changing the maturity of cellular N-glycans. Altering the glycosylation state affects the secretion and protein level of GnT-V, which in turn impacts its promotion of cancer growth and malignancy.
COMMUNICATIONS BIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Naoyuki Taniguchi
JOURNAL OF BIOCHEMISTRY
(2022)
Article
Oncology
Amrita K. Cheema, Yaoxiang Li, Mary Ventimiglia, Keith Kowalczyk, Ryan Hankins, Gaurav Bandi, Einsley-Marie Janowski, Scott Grindrod, Alejandro Villagra, Anatoly Dritschilo
Summary: Radiotherapy is an effective treatment for cancers, which can be used alone or in combination with surgery and chemotherapy. It can cause DNA damage and activate innate immune response, leading to cell cycle arrest, cell death, and immune stimulation.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Reina F. Osuka, Masamichi Nagae, Akito Ohuchi, Shiho Ohno, Yoshiki Yamaguchi, Yasuhiko Kizuka
Summary: In this study, it was found through molecular dynamics simulations and biochemical experiments that residues outside the catalytic pocket of GnT-V are likely involved in the recognition of the core part of N-glycan. Additionally, the simulation suggested that UDP binding affects the orientation of the acceptor due to conformational changes. These findings provide new insights into how GnT-V recognizes its glycoprotein substrates.