Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

The role of extracellular vesicles in cancer microenvironment and metastasis: myths and challenges

(2019) Fabrice Lucien et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Protein composition reflects extracellular vesicle heterogeneity

(2019) Tatyana Vagner et al.   PROTEOMICS

Microbe-Host Communication by Small RNAs in Extracellular Vesicles: Vehicles for Transkingdom RNA Transportation

(2019) Heon-Jin Lee   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Extracellular Vesicle as a Source of Alzheimer’s Biomarkers: Opportunities and Challenges

(2019) Seongju Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8+ T cells

(2019) Sjoerd T.T. Schetters et al.   Acta Biomaterialia

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

Dietary Bovine Milk Exosomes Elicit Changes in Bacterial Communities in C57BL/6 Mice

(2019) Fang Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

B cell superantigens in the human intestinal microbiota

(2019) Jeffrey J. Bunker et al.   Science Translational Medicine

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

(2018) Kassem Makki et al.   Cell Host & Microbe

Apoptotic vesicles: deathly players in cancer-associated coagulation

(2018) Morad-Remy Muhsin-Sharafaldine et al.   IMMUNOLOGY AND CELL BIOLOGY

Variation in candidate TBI biomarker genes are associated with gross neurological outcomes after severe TBI

(2018) Nicole Osier et al.   JOURNAL OF NEUROTRAUMA

Extracellular vesicles and microvascular pathology: decoding the active dialogue

(2018) Elham Hosseini Beheshti et al.   MICROCIRCULATION

Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses

(2018) Mario Codemo et al.   mBio

Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

(2018) Xiaogang Wang et al.   Nature Communications

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease

(2018) M.K. Seo et al.   JOURNAL OF DAIRY SCIENCE

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles

(2018) Min-Hye Kim et al.   Allergy Asthma & Immunology Research

Staphylococcus aureus -derived extracellular vesicles induce monocyte recruitment by activating human dermal microvascular endothelial cells in vitro

(2018) Jihye Kim et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

(2018) Joeri Tulkens et al.   GUT

The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from Staphylococcus aureus

(2018) Katja Schlatterer et al.   mBio

Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria

(2018) Elizabeth A. Kennedy et al.   Frontiers in Physiology

Infrared spectroscopic characterization of monocytic microvesicles (microparticles) released upon lipopolysaccharide stimulation

(2017) Joonsup Lee et al.   FASEB JOURNAL

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

(2017) Gera Goverse et al.   JOURNAL OF IMMUNOLOGY

Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia

(2017) Dionne Tannetta et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The inhibitory impacts of Lactobacillus rhamnosus GG-derived extracellular vesicles on the growth of hepatic cancer cells

(2017) Elham Behzadi et al.   MICROBIAL PATHOGENESIS

Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake

(2017) Kinsley C. French et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

In Silico Analysis of the Small Molecule Content of Outer Membrane Vesicles Produced by Bacteroides thetaiotaomicron Indicates an Extensive Metabolic Link between Microbe and Host

(2017) William A. Bryant et al.   Frontiers in Microbiology

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

(2017) Jessica D. Cecil et al.   Frontiers in Immunology

Detrimental Impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and Immune Homeostasis: An Overview

(2017) Claire Immediato Daïen et al.   Frontiers in Immunology

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Mechanisms of outer membrane vesicle entry into host cells

(2016) Eloise J. O'Donoghue et al.   CELLULAR MICROBIOLOGY

Extracellular vesicle–derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression

(2016) Jung-Hwan Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients

(2016) Anna Zinger et al.   Multiple Sclerosis Journal

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms

(2016) Lynne Turnbull et al.   Nature Communications

Exosomes confer pro-survival signals to alter the phenotype of prostate cells in their surrounding environment

(2016) Elham Hosseini-Beheshti et al.   Oncotarget

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

(2016) Jian Tan et al.   Cell Reports

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles

(2016) Katja Koeppen et al.   PLoS Pathogens

Activation of Immune and Defense Responses in the Intestinal Mucosa by Outer Membrane Vesicles of Commensal and Probiotic Escherichia coli Strains

(2016) María José Fábrega et al.   Frontiers in Microbiology

Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients

(2016) Anna Zinger et al.   Multiple Sclerosis Journal

Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content

(2016) Natalia Tiberti et al.   Scientific Reports

Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems

(2015) Khalid Al-Nedawi et al.   FASEB JOURNAL

Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi

(2015) Lisa Brown et al.   NATURE REVIEWS MICROBIOLOGY

The role of extracellular vesicles in placental vascular complications

(2015) Anat Aharon   THROMBOSIS RESEARCH

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Immuno-analysis of microparticles: probing at the limits of detection

(2015) Sharissa L. Latham et al.   Scientific Reports

Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle

(2015) Youngwoo Choi et al.   Scientific Reports

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

(2015) Angélica T. Vieira et al.   Arthritis & Rheumatology

Outer-Inner Membrane Vesicles Naturally Secreted by Gram-Negative Pathogenic Bacteria

(2015) Carla Pérez-Cruz et al.   PLoS One

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling

(2014) Aaron T. Irving et al.   Cell Host & Microbe

Extracellular vesicles and reproduction–promotion of successful pregnancy

(2014) Dionne Tannetta et al.   Cellular & Molecular Immunology

Maternal–fetal cellular trafficking

(2014) Cerine Jeanty et al.   CURRENT OPINION IN PEDIATRICS

Endothelial Microparticles Interact with and Support the Proliferation of T Cells

(2014) Julie Wheway et al.   JOURNAL OF IMMUNOLOGY

Production, Fate and Pathogenicity of Plasma Microparticles in Murine Cerebral Malaria

(2014) Fatima El-Assaad et al.   PLoS Pathogens

Innate and Adaptive Immune Interactions at the Fetal–Maternal Interface in Healthy Human Pregnancy and Pre-Eclampsia

(2014) Peter Hsu et al.   Frontiers in Immunology

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Role of microparticles in sepsis

(2012) V.L. Reid et al.   BRITISH JOURNAL OF ANAESTHESIA

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

(2012) Yue Shen et al.   Cell Host & Microbe

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration

(2012) S. B. Walters et al.   JOURNAL OF IMMUNOLOGY

Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer

(2012) Weiguang Chen et al.   PLoS One

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Microparticles and their emerging role in cancer multidrug resistance

(2011) J. Gong et al.   CANCER TREATMENT REVIEWS

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microvesiculation and cell interactions at the brain–endothelial interface in cerebral malaria pathogenesis

(2010) Valéry Combes et al.   PROGRESS IN NEUROBIOLOGY

Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions

(2010) Ronan Jambou et al.   PLoS Pathogens

Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

(2010) Kevin N. Couper et al.   PLoS Pathogens

B Cell Activation by Outer Membrane Vesicles—A Novel Virulence Mechanism

(2010) Maria Laura A. Perez Vidakovics et al.   PLoS Pathogens

Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium

(2009) Dorothée Faille et al.   FASEB JOURNAL

Systemic Increase in the Ratio between Foxp3+ and IL-17-Producing CD4+ T Cells in Healthy Pregnancy but Not in Preeclampsia

(2009) B. Santner-Nanan et al.   JOURNAL OF IMMUNOLOGY

Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function

(2009) M. Hedlund et al.   JOURNAL OF IMMUNOLOGY

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells

(2009) M Bebawy et al.   LEUKEMIA

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Proteomics in gram-negative bacterial outer membrane vesicles

(2008) Eun-Young Lee et al.   MASS SPECTROMETRY REVIEWS

Protection against cerebral malaria by the low-molecular-weight thiol pantethine

(2008) M.-F. Penet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

(2008) J. E. Mold et al.   SCIENCE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Itinerant exosomes: emerging roles in cell and tissue polarity

(2008) Aparna Lakkaraju et al.   TRENDS IN CELL BIOLOGY