☆ 4.7 Article

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium

BRITISH JOURNAL OF CANCER (2016)

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BRITISH JOURNAL OF CANCER
卷 115, 期 1, 页码 95-101

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SPRINGERNATURE
DOI: 10.1038/bjc.2016.153

关键词

recreational physical activity; inactivity; epithelial ovarian cancer; mortality risk; survival

类别

Oncology

资金

  1. NIH/NCI [R01CA095023, R01CA126841]
  2. Roswell Park Alliance Foundation
  3. Interdisciplinary Training Grant in Cancer Epidemiology [R25CA113951]
  4. U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729]
  5. National Health & Medical Research Council of Australia
  6. Cancer Councils of New South Wales, Victoria, Queensland, South Australia and Tasmania
  7. Cancer Foundation of Western Australia
  8. National Health and Medical Research Council of Australia [199600, 400281]
  9. National Institutes of Health [R01-CA074850, R01-CA080742, R01-CA112523, R01-CA87538, R01-CA122443, P30-CA15083, P50-CA136393, R01-CA54419, P50-CA105009]
  10. U.S. National Institutes of Health [R01-CA58598, N01-CN-55424, N01-PC-67001]
  11. Ministry of Health, Labour and Welfare
  12. National Cancer Institute, Bethesda, MD [R01-CA61107]
  13. Danish Cancer Society, Copenhagen, Denmark [94 222 52]
  14. Mermaid I project
  15. Mayo Foundation
  16. Minnesota Ovarian Cancer Alliance
  17. Fred C. and Katherine B. Andersen Foundation
  18. Department of Defense [W81XWH-10-1-02802]
  19. National Cancer Institute [NIH-K07 CA095666, R01-CA83918, NIH-K22-CA138563, P30-CA072720]
  20. Cancer Institute of New Jersey
  21. NCI CCSG award [P30-CA008748]
  22. California Cancer Research Program [00-01389V-20170, 2II0200]
  23. [5T32CA108456]
  24. [R01 CA188900]
  25. [DOD: DAMD17-02-1-0669]
  26. [NCI: K07-CA080668]
  27. [R01-CA95023]
  28. [P50-CA159981]
  29. [R01-CA126841]
  30. [P01CA17054]
  31. [P30CA14089]
  32. [R01CA61132]
  33. [N01PC67010]
  34. [R03CA113148]
  35. [R03CA115195]
  36. [N01CN025403]

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Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR = 1.34, 95% CI: 1.18-1.52) and without (HR = 1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

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