Transfer and Vascular Effect of Endothelin Receptor Antagonists in the Human Placenta

Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia

(2019) Emilie Hitzerd et al.   CURRENT PHARMACEUTICAL DESIGN

Endothelin receptor antagonism during preeclampsia: a matter of timing?

(2019) Emilie Hitzerd et al.   CLINICAL SCIENCE

Placental effects and transfer of sildenafil in healthy and preeclamptic conditions

(2019) Emilie Hitzerd et al.   EBioMedicine

The Endothelin System: A Critical Player in the Pathophysiology of Preeclampsia

(2018) Joey P. Granger et al.   CURRENT HYPERTENSION REPORTS

Effect of bosentan therapy in persistent pulmonary hypertension of the newborn

(2018) Gunlawadee Maneenil et al.   Pediatrics and Neonatology

A Review of Systemic Corticosteroid Use in Pregnancy and the Risk of Select Pregnancy and Birth Outcomes

(2017) Gretchen Bandoli et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Microvascular endothelial cells from preeclamptic women exhibit altered expression of angiogenic and vasopressor factors

(2016) Dennis K. Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Association Studies Suggest a Key Role for Endothelin-1 in the Pathogenesis of Preeclampsia and the Accompanying Renin–Angiotensin–Aldosterone System SuppressionNovelty and Significance

(2015) Koen Verdonk et al.   HYPERTENSION

Hypertension in an Animal Model of HELLP Syndrome is Associated With Activation of Endothelin 1

(2015) Rachael Morris et al.   Reproductive Sciences

Macitentan for the treatment of pulmonary arterial hypertension

(2014) Namita Sood   EXPERT OPINION ON PHARMACOTHERAPY

Distinct ETA Receptor Binding Mode of Macitentan As Determined by Site Directed Mutagenesis

(2014) John Gatfield et al.   PLoS One

The (pro)renin receptor blocker handle region peptide upregulates endothelium-derived contractile factors in aliskiren-treated diabetic transgenic (mREN2)27 rats

(2013) Wendy W. Batenburg et al.   JOURNAL OF HYPERTENSION

Macitentan and Morbidity and Mortality in Pulmonary Arterial Hypertension

(2013) Tomás Pulido et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypertension in Pregnancy

(2013)   OBSTETRICS AND GYNECOLOGY

Pharmacokinetics of Macitentan in Caucasian and Japanese Subjects: The Influence of Ethnicity and Sex

(2013) Shirin Bruderer et al.   PHARMACOLOGY

An Evaluation of Reproductive and Developmental Toxicity of Sitaxentan (Thelin) in Rats

(2012) David M. Cross et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Mechanism of hypertension and proteinuria during angiogenesis inhibition

(2012) Stephanie Lankhorst et al.   JOURNAL OF HYPERTENSION

The Human Placental Perfusion Model: A Systematic Review and Development of a Model to Predict In Vivo Transfer of Therapeutic Drugs

(2011) J R Hutson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The relationship between circulating endothelin-1, soluble fms-like tyrosine kinase-1 and soluble endoglin in preeclampsia

(2011) P K Aggarwal et al.   JOURNAL OF HUMAN HYPERTENSION

Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice

(2010) Barbara Baragatti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Are Early and Late Preeclampsia Distinct Subclasses of the Disease—What Does the Placenta Reveal?

(2010) J. L. van der Merwe et al.   HYPERTENSION IN PREGNANCY

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET

Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism

(2009) Louis-Bruno Ruest et al.   DEVELOPMENTAL BIOLOGY

Hypertension in Response to Autoantibodies to the Angiotensin II Type I Receptor (AT1-AA) in Pregnant Rats

(2009) Babbette LaMarca et al.   HYPERTENSION

Role of Endothelin in Mediating Soluble fms-Like Tyrosine Kinase 1–Induced Hypertension in Pregnant Rats

(2009) Sydney R. Murphy et al.   HYPERTENSION

Pharmacokinetics and Safety of Ambrisentan in Combination With Sildenafil in Healthy Volunteers

(2008) Rebecca Spence et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

(2008) M. Iglarz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS