Mechanism of hypertension and proteinuria during angiogenesis inhibition

Targeting the Endothelin Axis with Atrasentan, in combination with IFN-alpha, in metastatic renal cell carcinoma

(2012) G Groenewegen et al.   BRITISH JOURNAL OF CANCER

Intravitreal aflibercept injection for neovascular (wet) age-related macular degeneration

(2012) Matthew Ohr et al.   EXPERT OPINION ON PHARMACOTHERAPY

Linking Placental Ischemia and Hypertension in Preeclampsia

(2012) Eric M. George et al.   HYPERTENSION

Bevacizumab for Retinopathy of Prematurity

(2012) Michael W. Stewart   OPHTHALMOLOGY

Endothelin: Key Mediator of Hypertension in Preeclampsia

(2011) E. M. George et al.   AMERICAN JOURNAL OF HYPERTENSION

Bevacizumab-Induced Hypertension

(2011) Kostas N. Syrigos et al.   BIODRUGS

Vascular Endothelial Growth Factor (VEGF), VEGF Receptors and Their Inhibitors for Antiangiogenic Tumor Therapy

(2011) Satoru Takahashi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Alteration of Nitric Oxide Gas on Gene Expression of Endothelin-1 and Endothelial Nitric Oxide Synthase by a Time-and Dose-Dependent Manner in Human Endothelial Cells

(2011) Yi-Hao Weng   CHINESE JOURNAL OF PHYSIOLOGY

Contrary Effects of the Receptor Tyrosine Kinase Inhibitor Vandetanib on Constitutive and Flow-Stimulated Nitric Oxide Elaboration in Humans

(2011) Erica L. Mayer et al.   HYPERTENSION

The Vascular Endothelial Growth Factor Receptor Inhibitor Sunitinib Causes a Preeclampsia-Like Syndrome With Activation of the Endothelin System

(2011) Mariëtte H.W. Kappers et al.   HYPERTENSION

Sunitinib-Induced Systemic Vasoconstriction in Swine Is Endothelin Mediated and Does Not Involve Nitric Oxide or Oxidative Stress

(2011) Mariëtte H.W. Kappers et al.   HYPERTENSION

Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression

(2011) Mariëtte H. W. Kappers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Angiogenic balance and diagnosis of pre-eclampsia: selecting the right VEGF receptor

(2011) V Jha et al.   JOURNAL OF HUMAN HYPERTENSION

Proteinuria and hypertension with tyrosine kinase inhibitors

(2011) Praveen Kandula et al.   KIDNEY INTERNATIONAL

Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial

(2011) Brian I Rini et al.   LANCET

Posterior reversible encephalopathy syndrome induced by anti-VEGF agents

(2011) Camille Tlemsani et al.   Targeted Oncology

Targeting the endothelin axis in prostate carcinoma

(2011) Álvaro Pinto et al.   TUMOR BIOLOGY

Sunitinib-induced reduction in skin microvascular density is a reversible phenomenon

(2010) M. P. de Boer et al.   ANNALS OF ONCOLOGY

Reduction in skin microvascular density and changes in vessel morphology in patients treated with sunitinib

(2010) Astrid A.M. van der Veldt et al.   ANTI-CANCER DRUGS

Endothelin—Biology and disease

(2010) Al-karim Khimji et al.   CELLULAR SIGNALLING

Rapid Development of Hypertension and Proteinuria with Cediranib, an Oral Vascular Endothelial Growth Factor Receptor Inhibitor

(2010) E. S. Robinson et al.   Clinical Journal of the American Society of Nephrology

Sorafenib: a clinical and pharmacologic review

(2010) Renuka Iyer et al.   EXPERT OPINION ON PHARMACOTHERAPY

Suppression of the Nitric Oxide Pathway in Metastatic Renal Cell Carcinoma Patients Receiving Vascular Endothelial Growth Factor–Signaling Inhibitors

(2010) Emily S. Robinson et al.   HYPERTENSION

Hypertension Induced by the Tyrosine Kinase Inhibitor Sunitinib Is Associated With Increased Circulating Endothelin-1 Levels

(2010) Mariëtte H.W. Kappers et al.   HYPERTENSION

Mononuclear Phagocyte System Depletion Blocks Interstitial Tonicity-Responsive Enhancer Binding Protein/Vascular Endothelial Growth Factor C Expression and Induces Salt-Sensitive Hypertension in Rats

(2010) Agnes Machnik et al.   HYPERTENSION

Glomerular Disturbances in Preeclampsia: Disruption Between Glomerular Endothelium and Podocyte Symbiosis

(2010) Daniel E. Henao et al.   HYPERTENSION IN PREGNANCY

Clinical Course of Advanced Non–Small-Cell Lung Cancer Patients Experiencing Hypertension During Treatment With Bevacizumab in Combination With Carboplatin and Paclitaxel on ECOG 4599

(2010) Suzanne E. Dahlberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Bevacizumab Increases Risk for Severe Proteinuria in Cancer Patients

(2010) S. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Initial Assessment, Surveillance, and Management of Blood Pressure in Patients Receiving Vascular Endothelial Growth Factor Signaling Pathway Inhibitors

(2010) Michael L. Maitland et al.   JNCI-Journal of the National Cancer Institute

Nephrotoxicities Associated with the Use of Tyrosine Kinase Inhibitors: A Single-Center Experience and Review of the Literature

(2010) Kenar D. Jhaveri et al.   NEPHRON CLINICAL PRACTICE

Hypertension Induced by Vascular Endothelial Growth Factor Signaling Pathway Inhibition: Mechanisms and Potential Use as a Biomarker

(2010) Emily S. Robinson et al.   SEMINARS IN NEPHROLOGY

Renal Effects of Anti-angiogenesis Therapy: Update for the Internist

(2009) Faina Gurevich et al.   AMERICAN JOURNAL OF MEDICINE

Vascular endothelial growth factor receptor inhibitor enhances dietary salt-induced hypertension in Sprague-Dawley rats

(2009) Jian-Wei Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma

(2009) P. Bono et al.   ANNALS OF ONCOLOGY

Management of hypertension in angiogenesis inhibitor-treated patients

(2009) H. Izzedine et al.   ANNALS OF ONCOLOGY

Ambulatory Monitoring Detects Sorafenib-Induced Blood Pressure Elevations on the First Day of Treatment

(2009) M. L. Maitland et al.   CLINICAL CANCER RESEARCH

Vascular Endothelial Growth Factor Receptor 2 Controls Blood Pressure by Regulating Nitric Oxide Synthase Expression

(2009) Carie S. Facemire et al.   HYPERTENSION

Vascular Endothelial Growth Factor Inhibitors and Hypertension

(2009) Joey P. Granger   HYPERTENSION

Role of Endothelin in Mediating Soluble fms-Like Tyrosine Kinase 1–Induced Hypertension in Pregnant Rats

(2009) Sydney R. Murphy et al.   HYPERTENSION

ETA Receptor Blockade With Atrasentan Prevents Hypertension With the Multitargeted Tyrosine Kinase Inhibitor ABT-869 in Telemetry-instrumented Rats

(2009) Patricia N Banfor et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cardiovascular and renal toxicity during angiogenesis inhibition: clinical and mechanistic aspects

(2009) Mariëtte HW Kappers et al.   JOURNAL OF HYPERTENSION

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

Biomarkers of response and resistance to antiangiogenic therapy

(2009) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

An overview of small-molecule inhibitors of VEGFR signaling

(2009) S. Percy Ivy et al.   Nature Reviews Clinical Oncology

Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with first-line bevacizumab

(2008) M. Scartozzi et al.   ANNALS OF ONCOLOGY

Nitric Oxide, Tetrahydrobiopterin, Oxidative Stress, and Endothelial Dysfunction in Hypertension

(2008) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Distinct modulation of the endothelin-1 pathway in iNOS−/− and eNOS−/− miceThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.

(2008) Julie Labonté et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Hypertension and Rarefaction during Treatment with Telatinib, a Small Molecule Angiogenesis Inhibitor

(2008) N. Steeghs et al.   CLINICAL CANCER RESEARCH

Role of Endothelin-1 in Clinical Hypertension

(2008) Neeraj Dhaun et al.   HYPERTENSION

Preeclampsia Pathogenesis

(2008) S. Ananth Karumanchi et al.   HYPERTENSION

The endothelin axis in cancer

(2008) Anna Bagnato et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Preeclampsia-like Syndrome Characterized by Reversible Hypertension and Proteinuria Induced by the Multitargeted Kinase Inhibitors Sunitinib and Sorafenib

(2008) T. V. Patel et al.   JNCI-Journal of the National Cancer Institute

Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib

(2008) G. Bollee et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

VEGF Inhibition and Renal Thrombotic Microangiopathy

(2008) Vera Eremina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation

(2007) J.-J. Mourad et al.   ANNALS OF ONCOLOGY