Article
Pharmacology & Pharmacy
Federica Conti, Giovanni Luca Romano, Chiara Maria Eandi, Mario Damiano Toro, Robert Rejdak, Giulia Di Benedetto, Francesca Lazzara, Renato Bernardini, Filippo Drago, Giuseppina Cantarella, Claudio Bucolo
Summary: The study demonstrated that brimonidine effectively protected the function of RGCs in mouse eyes and regulated the inflammatory biomarkers induced by retinal ischemia reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Giovanni Luca Romano, Lucia Gozzo, Oriana Maria Maurel, Serena Di Martino, Valentina Riolo, Vincenzo Micale, Filippo Drago, Claudio Bucolo
Summary: The topical ocular administration of FLX was found to have a neuroprotective effect in a mouse model of acute retinal damage, as it counteracted the damage of retinal ganglion cells and preserved retinal function. FLX treatment also reduced the production of pro-inflammatory molecules elicited by retinal injury. Further studies are needed to support the use of FLX as a neuroprotective agent in retinal degenerative diseases.
Article
Ophthalmology
Kaibao Ji, Zongyuan Li, Yiming Lei, Wanxin Xu, Lingyi Ouyang, Tao He, Yiqiao Xing
Summary: The study demonstrated that resveratrol can mitigate retinal ischemic injury induced RGC loss and retinal function impairment by inhibiting the HIF-1a/VEGF and p38/p53 pathways while activating the PI3K/Akt pathway.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Abduqodir H. Toychiev, Khulan Batsuuri, Miduturu Srinivas
Summary: The study revealed an increase in Cx43 expression and GJ coupling in retinal astrocytes during retinal ischemia/reperfusion injury, leading to exacerbate RGC loss. Deleting astrocytic Cx43 improved neuronal survival in acute ischemia, while pharmacological inhibition of GJ coupling provided neuroprotection in the injury condition.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Zongyuan Li, Feijia Xie, Ning Yang, Jiayi Yang, Jinyuan Luo, Dihao Hua, Tao He, Yiqiao Xing
Summary: The study demonstrated that overexpression of KLF7 can prevent the loss of RGCs and preserve electrophysiological function. Additionally, overexpression of KLF7 can ameliorate retinal dysfunction after RIR injury and improve the visual acuity of mice. The activation of Akt pathway and the suppression of the mitochondrial apoptotic pathway contribute to the neuroprotection of KLF7.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Min Zhang, Jiayi Yang, Kaibao Ji, Xuejun He, Tao He, Yiqiao Xing
Summary: Inhibition of p66Shc expression can protect retinal ganglion cells (RGCs) from ischemia-induced apoptosis and preserve retinal function by acting through the Akt pathway.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sven Schnichels, Maximilian Schultheiss, Patricia Klemm, Matthias Blak, Thoralf Herrmann, Marion Melchinger, Karl-Ulrich Bartz-Schmidt, Marina Loescher, Guenther Zeck, Martin Stehphan Spitzer, Jose Hurst
Summary: This study investigated the neuroprotective effects of Cyclosporine A (CsA) on rat retinas, showing that a concentration of 9 μg/mL CsA had significant neuroprotective effects on retinal ganglion cells under hypoxic conditions without negative effects. Further in vivo studies are warranted to explore the potential of local CsA treatment for hypoxic retinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Deokho Lee, Yohei Tomita, Yukihiro Miwa, Ari Shinojima, Norimitsu Ban, Shintaro Yamaguchi, Ken Nishioka, Kazuno Negishi, Jun Yoshino, Toshihide Kurihara
Summary: The study suggests that NMN administration offers protection against retinal ischemia/reperfusion injury by suppressing inflammation, protecting retinal neuronal cells, and activating the antioxidant pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Yi
Summary: This study demonstrates that bergenin attenuates myocardial apoptosis and oxidative damage induced by MI/R through the SIRT1 signaling pathway. Bergenin significantly reduces cardiomyocyte apoptosis and ROS production, and improves cardiac function in vitro and in vivo.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Raquel Boia, Paul A. N. Dias, Caridad Galindo-Romero, Hugo D. Ferreira, Ines D. Aires, Manuel Vidal-Sanz, Marta Agudo-Barriuso, Rui Bernardes, Paulo F. Santos, Herminio C. de Sousa, Antonio Francisco Ambrosio, Mara E. M. Braga, Ana Raquel Santiago
Summary: The use of PCL implants loaded with selective A3R agonists has shown to effectively protect RGCs and improve their function, although it does not prevent retinal thinning due to transient ischemia.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Ophthalmology
Jing Xu, Yuyan Guo, Qiong Liu, Hui Yang, Ming Ma, Jian Yu, Linjiang Chen, Chunlian Ou, Xiaohui Liu, Jing Wu
Summary: In this study, it was found that PGB can protect RGCs from apoptosis induced by RIR injury by activating the Akt/GSK3/3//3-catenin pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Panagiotis Chronopoulos, Caroline Manicam, Jenia Kouchek Zadeh, Panagiotis Laspas, Johanna Charlotte Unkrig, Marie Luise Goebel, Aytan Musayeva, Norbert Pfeiffer, Matthias Oelze, Andreas Daiber, Huige Li, Ning Xia, Adrian Gericke
Summary: This study demonstrates that resveratrol has a protective effect against ischemia-reperfusion injury in the murine retina, reducing the loss of retinal ganglion cells and endothelial dysfunction of retinal blood vessels. This protective effect may be achieved by suppressing upregulation of nitric oxide synthase 2 and alleviating nitro-oxidative stress.
Article
Neurosciences
Siyu Zeng, Lei Du, Guojing Lu, Yiqiao Xing
Summary: In this study, it was found that cellular repressor of E1A-stimulated genes (CREG) protected retinal ganglion cells (RGCs) from ischemia-reperfusion injury (RIRI) by activating the Akt signaling pathway and regulating apoptotic proteins. CREG also improved retinal function and visual acuity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stefanie Scheid, Max Goeller, Wolfgang Baar, Jakob Wollborn, Hartmut Buerkle, Gunther Schlunck, Wolf Lagreze, Ulrich Goebel, Felix Ulbrich
Summary: This study found that both inhalative and intravenous administration of H2S can reduce neuronal cell death caused by neuronal ischemia-reperfusion injury, and the mechanism involves the mitogen-activated protein kinase (MAPK) ERK1/2 pathway to inhibit apoptosis and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Fei Yao, Xuan Zhang, Xueyan Yao, Xiaohua Ren, Xiaobo Xia, Jian Jiang, Lexi Ding
Summary: This study revealed that activation of PPAR alpha by FA can promote RGC survival, alleviate thinning of the ganglion cell complex, and reduce the latency of positive waves in FVEPs after IR injury. Additionally, FA treatment significantly increased the expression of endogenous PPAR alpha and suppressed GFAP and COX2 expression.
FRONTIERS IN MEDICINE
(2021)
Article
Peripheral Vascular Disease
Dihao Hua, Yishuang Xu, Xiangbing Zeng, Ning Yang, Mengnan Jiang, Xiao Zhang, Jiayi Yang, Tao He, Yiqiao Xing
MICROVASCULAR RESEARCH
(2020)
Article
Ophthalmology
Zongyuan Li, Feijia Xie, Ning Yang, Jiayi Yang, Jinyuan Luo, Dihao Hua, Tao He, Yiqiao Xing
Summary: The study demonstrated that overexpression of KLF7 can prevent the loss of RGCs and preserve electrophysiological function. Additionally, overexpression of KLF7 can ameliorate retinal dysfunction after RIR injury and improve the visual acuity of mice. The activation of Akt pathway and the suppression of the mitochondrial apoptotic pathway contribute to the neuroprotection of KLF7.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Medicine, General & Internal
Ning Yang, Yiqiao Xing, Qiuya Zhao, Siyu Zeng, Juan Yang, Lei Du
Summary: This study compared the efficacy, safety, and recurrence rates of PRF grafts and LCAs in pterygium excision. The results showed that PRF grafts had shorter surgery times, lower recurrence rates, and fewer complications. Therefore, PRF grafts are a simple, effective method for pterygium management.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Ophthalmology
Ningzhi Zhang, Wenye Cao, Xuejun He, Yiqiao Xing, Ning Yang
Summary: This study evaluated the use of methanol as a preservation treatment for further immunostaining of the retina. Results showed that cold methanol can serve as an effective medium for long-term storage of fixed retinas, which is useful for further research.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ning Yang, Siyu Zeng, Juan Yang, Guojing Lu, Lei Du
Summary: This study evaluated the effectiveness of platelet-rich fibrin (PRF) membrane transplantation for the treatment of large idiopathic macular holes (MHs). The results showed that all patients achieved closure of the MHs and had significant improvements in visual acuity and foveal avascular zone. This indicates that PRF transplantation is an effective and safe technique for the treatment of large MHs.
CURRENT EYE RESEARCH
(2022)
Article
Ophthalmology
Ning Yang, Juan Yang, Xuejun He, Wenxi Zhang, Yiqiao Xing
Summary: This study identified dysregulated long noncoding RNAs (lncRNAs) associated with retinal ganglion cell (RGC) injury and explored their potential regulatory functions, along with the molecular mechanisms underlying their regulation. The analysis revealed a co-expression network between DE lncRNAs and DE mRNAs enriched in inflammatory and immune-related pathways, indicating their involvement in RGC injury. Additionally, a regulatory network involving lncRNA-TF-mRNA was constructed, providing insight into the pathogenesis of RGC injury and potential directions for further research in neurodegenerative diseases.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Ophthalmology
Ningzhi Zhang, Xuejun He, Yiqiao Xing, Ning Yang
Summary: This review summarizes the progress and current status of research on type-specific susceptibility of RGCs. It also highlights current limitations and possible directions for future research in this field.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Review
Cell Biology
Ningzhi Zhang, Wenye Cao, Xuejun He, Yiqiao Xing, Ning Yang
Summary: This article provides an overview of the role of long non-coding RNAs (lncRNAs) in retinal ganglion cell (RGC) apoptosis and summarizes the current limitations and future prospects of research in this area.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Medicine, General & Internal
Xuejun He, Ningzhi Zhang, Wenye Cao, Yiqiao Xing, Ning Yang
Summary: Advancements in high-throughput sequencing (HTS) technology have provided new insights into the etiology, signaling pathways, and biomarkers of ocular diseases, aiding in improving their diagnosis and research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Ophthalmology
Wenye Cao, Ningzhi Zhang, Xuejun He, Yiqiao Xing, Ning Yang
Summary: This review summarizes the current knowledge about the expression and regulatory functions of long non-coding RNAs (lncRNAs) related to the progression of pathological retinal neovascularization (RNV). The study found that lncRNA MEG3 attenuates RNV, while other lncRNAs such as MALAT1, MIAT, ANRIL, HOTAIR, HOTTIP, and SNHG16 play a promoting role in the pathological progression of RNV. Targeting lncRNAs may be a new therapeutic approach in the future for attenuating RNV progression and treating RNV-related retinal diseases.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Xuejun He, Wenye Cao, Zhiyi Wang, Ningzhi Zhang, Kexin Xu, Lu Yu, Yiqiao Xing, Ning Yang
Summary: This meta-analysis aimed to explore the efficacy and safety of the combination of tissue plasminogen activator (TPA) and anti-vascular endothelial growth factor (anti-VEGF) drugs for submacular hemorrhage (SMH) treatment. The results showed that this drug combination significantly improved best-corrected visual acuity (BCVA) and reduced foveal thickness (FT), with a high level of safety.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Kexin Xu, Lu Yu, Zhiyi Wang, Pei Lin, Ningzhi Zhang, Yiqiao Xing, Ning Yang
Summary: Gene therapy has shown promising results in the treatment of optic nerve injury (ONI), with a focus on preventing neurodegenerative diseases and protecting retinal ganglion cells (RGCs) and axons. The eye is an ideal target for gene therapy due to its accessibility and immune privilege. However, challenges such as misalignment, AAV immunogenicity, time, and cost still need to be addressed before clinical trials can be conducted.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Ningzhi Zhang, Zhiyi Wang, Pei Lin, Yiqiao Xing, Ning Yang
Summary: Retinal ganglion cells (RGCs) are the projection neurons of the retina that transmit external visual information to the brain. Pathological changes in RGCs are closely related to various retinal degenerative diseases. Whole-mount retinal immunostaining is commonly used to evaluate the development and pathology of the retina. To ensure reliable and reproducible experimental results, the use of an effective preserving medium is crucial.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Review
Neurosciences
Duan Chen, Sen Miao, Xuemei Chen, Zhiyi Wang, Pei Lin, Ningzhi Zhang, Ning Yang
Summary: Glaucoma is a leading cause of irreversible blindness worldwide, and understanding the molecular mechanisms and potential therapeutic targets, such as ferroptosis and pyroptosis, in the pathogenesis of glaucoma is of great importance for its prevention and treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biology
Ning Yang, Xuejun He, Ningzhi Zhang, Yiqiao Xing
Summary: KH902 demonstrates significant inhibition on retinal hypoxia and neovascularization, reducing the expression of VEGF and Gal-1 without causing damage to neuroretinal structure. These findings suggest that KH902 may be a potential treatment for other neovascular ocular diseases.
ARCHIVES OF BIOLOGICAL SCIENCES
(2021)