Sodium butyrate inhibits migration and induces AMPK‐mTOR pathway‐dependent autophagy and ROS‐mediated apoptosis via the miR‐139‐5p/Bmi‐1 axis in human bladder cancer cells

Targeting autophagy using natural compounds for cancer prevention and therapy

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Sodium Butyrate Inhibits Colorectal Cancer Cell Migration by Downregulating Bmi-1 Through Enhanced miR-200c Expression

(2018) Zhiyao Xu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of apoptosis by caspase inhibitor Z-VAD-FMK improves cryotolerance of in vitro derived bovine embryos

(2018) Maria Elena Pero et al.   THERIOGENOLOGY

Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo

(2018) Kangmao Huang et al.   Cell Death & Disease

Evaluation of Z-VAD-FMK as an anti-apoptotic drug to prevent granulosa cell apoptosis and follicular death after human ovarian tissue transplantation

(2018) Maïté Fransolet et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The HDAC3–SMARCA4–miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma

(2018) Narendra Bharathy et al.   Science Signaling

Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends

(2017) Sebastien Antoni et al.   EUROPEAN UROLOGY

Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment

(2017) Vahid Salimi et al.   Lipids in Health and Disease

EMT: Present and future in clinical oncology

(2017) Patricia G. Santamaria et al.   Molecular Oncology

MicroRNA-139-5p inhibits bladder cancer proliferation and self-renewal by targeting the Bmi1 oncogene

(2017) Hongbo Luo et al.   TUMOR BIOLOGY

Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy

(2017) Ling-Li Huang et al.   Oncology Letters

Bladder cancer

(2017) Oner Sanli et al.   Nature Reviews Disease Primers

Inhibition of BMI1 induces autophagy-mediated necroptosis

(2016) Anindya Dey et al.   Autophagy

Dual tumor-suppressorsmiR-139-5pandmiR-139-3ptargetingmatrix metalloprotease 11in bladder cancer

(2016) Masaya Yonemori et al.   CANCER SCIENCE

HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia

(2016) T.-H. Lai et al.   CLINICAL CANCER RESEARCH

Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa–pT1 Urothelial Carcinoma of the Bladder: Which Patients Benefit from the Instillation?

(2016) Richard J. Sylvester et al.   EUROPEAN UROLOGY

Gender and Bladder Cancer: A Collaborative Review of Etiology, Biology, and Outcomes

(2016) Jakub Dobruch et al.   EUROPEAN UROLOGY

Bladder cancer

(2016) Ashish M Kamat et al.   LANCET

miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1

(2016) Nibedita Patel et al.   LIFE SCIENCES

Closing the Gender Gap: Can We Improve Bladder Cancer Survival in Women? - A Systematic Review of Diagnosis, Treatment and Outcomes

(2016) Frances Burge et al.   UROLOGIA INTERNATIONALIS

Gender-related differences in urothelial carcinoma of the bladder: a population-based study from the Swedish National Registry of Urinary Bladder Cancer

(2016) Andreas Thorstenson et al.   Scandinavian Journal of Urology

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mucoadhesive polyacrylamide nanogel as a potential hydrophobic drug carrier for intravesical bladder cancer therapy

(2015) Shengjie Lu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacologic agents targeting autophagy

(2015) Helin Vakifahmetoglu-Norberg et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

HDAC Inhibitors Target HDAC5, Upregulate MicroRNA-125a-5p, and Induce Apoptosis in Breast Cancer Cells

(2015) Tsung-Hua Hsieh et al.   MOLECULAR THERAPY

MiR-139-5p: promising biomarker for cancer

(2015) He-da Zhang et al.   TUMOR BIOLOGY

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

WIPI-Mediated Autophagy and Longevity

(2015) Mona Grimmel et al.   Cells

Neuronal autophagy: Going the distance to the axon

(2014) Zhenyu Yue et al.   Autophagy

Defining and Treating the Spectrum of Intermediate Risk Nonmuscle Invasive Bladder Cancer

(2014) Ashish M. Kamat et al.   JOURNAL OF UROLOGY

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

The ZEB1 Transcription Factor Acts in a Negative Feedback Loop with miR200 Downstream of Ras and Rb1 to Regulate Bmi1 Expression

(2013) Yongqing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells

(2013) Dhanir Tailor et al.   MITOCHONDRION

Complex regulation of autophagy in cancer – Integrated approaches to discover the networks that hold a double-edged sword

(2013) János Kubisch et al.   SEMINARS IN CANCER BIOLOGY

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells

(2013) P Cheng et al.   Cell Death & Disease

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis

(2012) Tiejun Zhang et al.   Autophagy

Regulation of PINK1-Parkin-mediated mitophagy

(2011) Wolfdieter Springer et al.   Autophagy

Apoptosis of bladder cancer by sodium butyrate and cisplatin

(2011) Takuo Maruyama et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNAs as potential cancer therapeutics

(2009) P Trang et al.   ONCOGENE