Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting
出版年份 2020 全文链接
标题
Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting
作者
关键词
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出版物
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 24, Issue 2, Pages 91-100
出版商
Informa UK Limited
发表日期
2020-01-31
DOI
10.1080/14728222.2020.1724285
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Migraine-provoking substances evoke periorbital allodynia in mice
- (2019) Francesco De Logu et al. JOURNAL OF HEADACHE AND PAIN
- Gepants for the treatment of migraine
- (2019) Andrea Negro et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models
- (2019) Amanda Avona et al. JOURNAL OF NEUROSCIENCE
- Eptinezumab for prevention of chronic migraine: A randomized phase 2b clinical trial
- (2019) David W Dodick et al. CEPHALALGIA
- Long-term safety and tolerability of erenumab: Three-plus year results from a five-year open-label extension study in episodic migraine
- (2019) Messoud Ashina et al. CEPHALALGIA
- Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls
- (2019) Katharina Kamm et al. CEPHALALGIA
- Ischemic Stroke Associated With Calcitonin Gene-Related Peptide Inhibitor Therapy for Migraine: A Case Report
- (2019) Stephen Aradi et al. Journal of Stroke & Cerebrovascular Diseases
- Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised, phase 3, double-blind, placebo-controlled trial
- (2019) Robert Croop et al. LANCET
- Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine
- (2019) Richard B. Lipton et al. NEW ENGLAND JOURNAL OF MEDICINE
- Fremanezumab for the preventive treatment of migraine in adults
- (2019) Luana Lionetto et al. Expert Review of Clinical Pharmacology
- Safety and tolerability of ubrogepant following intermittent, high-frequency dosing: Randomized, placebo-controlled trial in healthy adults
- (2019) Peter J Goadsby et al. CEPHALALGIA
- Effect of Ubrogepant vs Placebo on Pain and the Most Bothersome Associated Symptom in the Acute Treatment of Migraine
- (2019) Richard B. Lipton et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system
- (2019) Jacob C. A. Edvinsson et al. JOURNAL OF HEADACHE AND PAIN
- Ubrogepant for the Treatment of Migraine
- (2019) David W. Dodick et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and safety of galcanezumab for the prevention of episodic migraine: Results of the EVOLVE-2 Phase 3 randomized controlled clinical trial
- (2018) Vladimir Skljarevski et al. CEPHALALGIA
- Efficacy and safety of erenumab (AMG334) in chronic migraine patients with prior preventive treatment failure: A subgroup analysis of a randomized, double-blind, placebo-controlled study
- (2018) Messoud Ashina et al. CEPHALALGIA
- A phase 1 study to assess the pharmacokinetics, safety, and tolerability of fremanezumab doses (225 mg, 675 mg and 900 mg) in Japanese and Caucasian healthy subjects
- (2018) Orit Cohen-Barak et al. CEPHALALGIA
- Sustained reductions in migraine days, moderate-to-severe headache days and days with acute medication use for HFEM and CM patients taking fremanezumab: Post-hoc analyses from phase 2 trials
- (2018) Rashmi B Halker Singh et al. CEPHALALGIA
- Molecular studies of CGRP and the CGRP family of peptides in the central nervous system
- (2018) Erica R Hendrikse et al. CEPHALALGIA
- Safety of galcanezumab in patients with episodic migraine: A randomized placebo-controlled dose-ranging Phase 2b study
- (2018) Tina Marie Myers Oakes et al. CEPHALALGIA
- ARISE: A Phase 3 randomized trial of erenumab for episodic migraine
- (2018) David W Dodick et al. CEPHALALGIA
- A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Erenumab on Exercise Time During a Treadmill Test in Patients With Stable Angina
- (2018) Christophe Depre et al. HEADACHE
- The Prevalence and Impact of Migraine and Severe Headache in the United States: Figures and Trends From Government Health Studies
- (2018) Rebecca Burch et al. HEADACHE
- Effect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine
- (2018) David W. Dodick et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system
- (2018) Karl Messlinger JOURNAL OF HEADACHE AND PAIN
- PACAP and its role in primary headaches
- (2018) Lars Edvinsson et al. JOURNAL OF HEADACHE AND PAIN
- CGRP as the target of new migraine therapies — successful translation from bench to clinic
- (2018) Lars Edvinsson et al. Nature Reviews Neurology
- The serum level of inflammatory markers in chronic and episodic migraine: a case-control study
- (2018) Fahimeh Martami et al. NEUROLOGICAL SCIENCES
- Peripherally Administered CGRP Induces Spontaneous Pain in Mice
- (2018) Brandon J. Rea et al. PAIN
- The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm
- (2018) Richard D. Palmiter TRENDS IN NEUROSCIENCES
- Evaluation of Galcanezumab for the Prevention of Episodic Migraine
- (2018) Virginia L. Stauffer et al. JAMA Neurology
- Effect of Different Doses of Galcanezumab vs Placebo for Episodic Migraine Prevention
- (2018) Vladimir Skljarevski et al. JAMA Neurology
- Encoding of danger by parabrachial CGRP neurons
- (2018) Carlos A. Campos et al. NATURE
- Migraine induction with calcitonin gene-related peptide in patients from erenumab trials
- (2018) Casper Emil Christensen et al. JOURNAL OF HEADACHE AND PAIN
- Overview of Neuropeptides: Awakening the Senses?
- (2017) Andrew F. Russo HEADACHE
- Fremanezumab as Add-On Treatment for Patients Treated With Other Migraine Preventive Medicines
- (2017) Joshua M. Cohen et al. HEADACHE
- CGRP and its receptors
- (2017) Debbie L. Hay et al. HEADACHE
- Functional and structural alterations in the migraine cerebellum
- (2017) Jan Mehnert et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2017) Theo Vos et al. LANCET
- Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial
- (2017) Stewart Tepper et al. LANCET NEUROLOGY
- A craniofacial-specific monosynaptic circuit enables heightened affective pain
- (2017) Erica Rodriguez et al. NATURE NEUROSCIENCE
- Activity and connectivity of the cerebellum in trigeminal nociception
- (2017) Jan Mehnert et al. NEUROIMAGE
- Erenumab (AMG 334) in episodic migraine
- (2017) Messoud Ashina et al. NEUROLOGY
- Fremanezumab for the Preventive Treatment of Chronic Migraine
- (2017) Stephen D. Silberstein et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Controlled Trial of Erenumab for Episodic Migraine
- (2017) Peter J. Goadsby et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pathophysiology of Migraine: A Disorder of Sensory Processing
- (2017) Peter J. Goadsby et al. PHYSIOLOGICAL REVIEWS
- Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission
- (2017) Rebecca E. Yarwood et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the CGRP Binding Monoclonal Antibody LY2951742 (Galcanezumab) in Healthy Volunteers
- (2017) David Monteith et al. Frontiers in Pharmacology
- Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis
- (2016) Robin M van Dongen et al. CEPHALALGIA
- A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine
- (2016) Tiffini Voss et al. CEPHALALGIA
- Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms
- (2016) Bianca N. Mason et al. JOURNAL OF NEUROSCIENCE
- Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomised, double-blind, placebo-controlled, phase 2 trial
- (2016) Hong Sun et al. LANCET NEUROLOGY
- TEV-48125 for the preventive treatment of chronic migraine
- (2016) Marcelo E. Bigal et al. NEUROLOGY
- Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine
- (2016) Song Guo et al. PAIN
- Wiping Out CGRP: Potential Cardiovascular Risks
- (2016) Antoinette MaassenVanDenBrink et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Calcitonin Gene-Related Peptide (CGRP): A New Target for Migraine
- (2015) Andrew F. Russo Annual Review of Pharmacology and Toxicology
- CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment
- (2015) Lars Edvinsson BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Randomized controlled trial of the CGRP receptor antagonist telcagepant for prevention of headache in women with perimenstrual migraine
- (2015) Tony W Ho et al. CEPHALALGIA
- Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study
- (2015) Marcelo E Bigal et al. LANCET NEUROLOGY
- Role of PACAP in migraine headaches
- (2014) László Vécsei et al. BRAIN
- Safety and efficacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study
- (2014) David W Dodick et al. LANCET NEUROLOGY
- Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial
- (2014) David W Dodick et al. LANCET NEUROLOGY
- Altered processing of sensory stimuli in patients with migraine
- (2014) Marina de Tommaso et al. Nature Reviews Neurology
- Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention
- (2014) T. W. Ho et al. NEUROLOGY
- Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
- (2014) F. A. Russell et al. PHYSIOLOGICAL REVIEWS
- The role of the blood–brain barrier in the development and treatment of migraine and other pain disorders
- (2014) Marcos F. DosSantos et al. Frontiers in Cellular Neuroscience
- Migraine and the Risk for Stroke and Cardiovascular Disease
- (2014) Simona Sacco et al. Current Cardiology Reports
- Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program
- (2013) Marcelo E Bigal et al. CEPHALALGIA
- The effect of sodium nitroprusside on cerebral hemodynamics and headache in healthy subjects
- (2013) Song Guo et al. CEPHALALGIA
- The International Classification of Headache Disorders, 3rd edition (beta version)
- (2013) CEPHALALGIA
- BMS-927711 for the acute treatment of migraine: A double-blind, randomized, placebo controlled, dose-ranging trial
- (2013) Ronald Marcus et al. CEPHALALGIA
- Unanswered Questions in Headache: So What Is Photophobia, Anyway?
- (2013) Andrew F. Russo et al. HEADACHE
- Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine
- (2013) E. Cernuda-Morollon et al. NEUROLOGY
- CGRP and migraine: Could PACAP play a role too?
- (2013) Eric A. Kaiser et al. NEUROPEPTIDES
- Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level
- (2012) Sajedeh Eftekhari et al. BMC NEUROSCIENCE
- The Evolution of a Migraine Attack - A Review of Recent Evidence
- (2012) Andrew Charles HEADACHE
- Modulation of CGRP-Induced Light Aversion in Wild-Type Mice by a 5-HT1B/D Agonist
- (2012) E. A. Kaiser et al. JOURNAL OF NEUROSCIENCE
- Light Evokes Melanopsin-Dependent Vocalization and Neural Activation Associated with Aversive Experience in Neonatal Mice
- (2012) Anton Delwig et al. PLoS One
- Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers
- (2011) Faisal Mohammad Amin et al. CEPHALALGIA
- Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine
- (2011) David J Hewitt et al. CEPHALALGIA
- Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation
- (2011) Ann C. Raddant et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Randomized Controlled Study of Telcagepant Plus Ibuprofen or Acetaminophen in Migraine
- (2011) David J. Hewitt et al. HEADACHE
- Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine
- (2011) Ertugrul Uzar et al. JOURNAL OF HEADACHE AND PAIN
- Evidence for a vascular factor in migraine
- (2010) Mohammad S. Asghar et al. ANNALS OF NEUROLOGY
- Modulation of nocioceptive transmission with calcitonin gene-related peptide receptor antagonists in the thalamus
- (2010) O. Summ et al. BRAIN
- BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study
- (2010) Hans-Christoph Diener et al. CEPHALALGIA
- Randomized, controlled trial of telcagepant over four migraine attacks
- (2010) Andrew P Ho et al. CEPHALALGIA
- Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura
- (2010) Jakob Møller Hansen et al. CEPHALALGIA
- Long-Term Tolerability of Telcagepant for Acute Treatment of Migraine in a Randomized Trial
- (2010) Kathryn M. Connor et al. HEADACHE
- Characterization of the Calcitonin Gene-Related Peptide Receptor Antagonist Telcagepant (MK-0974) in Human Isolated Coronary Arteries
- (2010) K. Y. Chan et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Cerebellar distribution of calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) in rat
- (2010) Lars Edvinsson et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Coding of facial expressions of pain in the laboratory mouse
- (2010) Dale J Langford et al. NATURE METHODS
- A neural mechanism for exacerbation of headache by light
- (2010) Rodrigo Noseda et al. NATURE NEUROSCIENCE
- Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion
- (2010) S. Eftekhari et al. NEUROSCIENCE
- CGRP receptor antagonism and migraine
- (2010) Lars Edvinsson et al. Neurotherapeutics
- Regulation of signal transduction by calcitonin gene-related peptide receptors
- (2010) Christopher S Walker et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Elevated Saliva Calcitonin Gene-Related Peptide Levels During Acute Migraine Predict Therapeutic Response to Rizatriptan
- (2009) Roger K. Cady et al. HEADACHE
- Role of Calcitonin Gene-Related Peptide in Light-Aversive Behavior: Implications for Migraine
- (2009) A. Recober et al. JOURNAL OF NEUROSCIENCE
- Genetic Enhancement of Calcitonin Gene-Related Peptide-Induced Central Sensitization to Mechanical Stimuli in Mice
- (2009) Blanca Marquez de Prado et al. JOURNAL OF PAIN
- Randomized, controlled trial of telcagepant for the acute treatment of migraine
- (2009) K. M. Connor et al. NEUROLOGY
- Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP
- (2009) Ana Recober et al. NEUROPHARMACOLOGY
- The Blood-Brain Barrier in Migraine Treatment
- (2008) L Edvinsson et al. CEPHALALGIA
- Vasoactive Intestinal Peptide Causes Marked Cephalic Vasodilation, but does not Induce Migraine
- (2008) A Rahmann et al. CEPHALALGIA
- Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial
- (2008) Tony W Ho et al. LANCET
- Inhibitory effect of BIBN4096BS, CGRP8-37, a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery
- (2007) L Edvinsson et al. BRITISH JOURNAL OF PHARMACOLOGY
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