Article
Chemistry, Inorganic & Nuclear
Luis Felipe Hernandez-Ayala, Cynthia Sinai Novoa-Ramirez, Miguel Reina, Lena Ruiz-Azuara
Summary: This study presents the synthesis, characterization, electrochemical studies, DFT calculations, and in vitro evaluation of four novel direct bonded ruthenium-selenium compounds, revealing the impact of intermediate properties and compound structure on cytotoxic activity, with 2c demonstrating the best inhibitory effect on cell proliferation.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Andre Ferrarini, Rafael Natan Soek, Rafaella Rebecchi Rios, Francielli Sousa Santana, Renan Borsoi Campos, Roberto Santana da Silva, Fabio Souza Nunes
Summary: Two novel ruthenium-nitrosyl complexes were synthesized and characterized. RuLANO can release chloride ions and dissociate NO upon irradiation, while Ru3LBNO is photo-inactive in a specific wavelength range. These results are consistent with calculations and electrochemical responses.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Cherifa Boulechfar, Hana Ferkous, Sihem Boufas, Malika Berredjem, Amel Delimi, Souad Djellali, Amel Djedouani, Rania Bahadi, Sihem Laamari, Krishna Kumar Yadav, Byong-Hun Jeon, Wahiba Bouchelaghem, Manawwer Alam, Yacine Benguerba
Summary: In this study, experimental and computational investigations were conducted on a Schiff base and its metal complexes. The azote atom coordinates with the metal according to the FT-IR spectra. Powder X-ray Diffraction experiments show that the crystalline nature of metal complexes is responsible for their enhanced crystallinity. X-ray photoelectron spectroscopy shows that the binding energy of the nitrogen atom's 1s electrons is increased in metal complexes due to complexation. Cyclic voltammograms and DPPH radical scavenging assay demonstrate that transition metal complexes are more effective at scavenging DPPH radicals compared to the free ligand. The theoretical analysis of the investigated complexes provides evidence of the metal's bonding potential in the environment.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Sahar Salarieh, Hamid Golchoubian, Golasa Moayyedi, Ehsan Rezaee
Summary: This study presents an experimental and computational investigation of a ligand and its mixed chelate copper(II) complexes, focusing on their properties and solvatochromic behavior. The experimental characterization revealed the effect of ligand protonation and solvent coordination on the structure and color of the complexes. The computational results provided further support for the proposed solvatochromic mechanism.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Tohama B. Abdullah, Reza Behjatmanesh-Ardakani, Ahmed S. Faihan, Hayfa M. Jirjes, Mortaga M. Abou-Krisha, Tarek A. Yousef, Sayed H. Kenawy, Ahmed S. M. Al-Janabi
Summary: Mixed ligand complexes of Pd(II) and Cd(II) with N-picolyl-amine dithiocarbamate (PAC-dtc) as primary ligand and tertiary phosphine ligand as secondary ligands have been synthesized and characterized. The complexes showed significant antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. DFT calculations were performed to investigate the quantum parameters of three complexes and their geometries were optimized.
Article
Chemistry, Physical
Cherifa Boulechfar, Hana Ferkous, Amel Delimi, Malika Berredjem, Abdesalem Kahlouche, Anis Madaci, Souad Djellali, Sihem Boufas, Amel Djedouani, Abdelhamid Errachid, Azmat Ali Khan, Abir Boublia, Tarek Lemaoui, Yacine Benguerba
Summary: In this study, the synthesis, characterization, and anti-corrosion performance of 2-furaldehyde semi-carbazone Schiff base (FSC) complexes of cobalt (II), zinc (II), and manganese (II) on XC38 carbon steel immersed in 1 M HCl solution were investigated. Experimental investigations and quantum chemical simulation approaches were used. The results showed that these compounds are powerful inhibitors with significant adsorption on the steel surface, providing considerable inhibition. SEM analysis revealed that FSC and its complexes formed a barrier between the inhibitors and the vacant d-orbital of iron on the XC38 carbon steel surface.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Sain Singh, Govinda R. Navale, Sonia Agrawal, Haobam Kisan Singh, Labhini Singla, Dhiman Sarkar, Manabendra Sarma, Anghuman Roy Choudhury, Kaushik Ghosh
Summary: Misfolding and aggregation of proteins are associated with neurodegenerative disorders. This study synthesized novel ruthenium complexes and investigated their inhibitory activity against protein aggregation and amyloid formation. The complexes showed significant inhibition of protein aggregation and amyloid fibril formation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Inorganic & Nuclear
Riccardo Pettinari, Fabio Marchetti, Alessia Tombesi, Corrado Di Nicola, Claudio Pettinari, Chuanpan Guo, Zhihong Zhang, Agustin Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: Two new pyrazole ligands with a pyridine moiety were synthesized and fully characterized, and their coordination modes in metal complexes were analyzed. Cytotoxicity studies showed similar activity of these ligands and complexes in cisplatin-sensitive and cisplatin-resistant ovarian carcinoma cells.
INORGANICA CHIMICA ACTA
(2021)
Review
Chemistry, Medicinal
Poul Erik Hansen
Summary: This paper briefly summarizes methods for determining the structure of beta-diketones, with a focus on NMR methods and density functional calculations. It discusses the tautomeric equilibria of beta-diketones in relation to biological effects and relevant physical parameters like acidity and solubility. The structure of a series of biologically active molecules, including usnic acids, tetramic and tetronic acids, o-hydroxydibenzoylmethanes, curcumines, lupulones, and hyperforines, is examined.
Article
Chemistry, Physical
Dawid Zych
Summary: This study focuses on the theoretical investigations of mono- and dinuclear complexes, utilizing density functional theory calculations to understand their optical properties and physical parameters. The results have significant implications for the field of chemistry and materials science.
Article
Chemistry, Inorganic & Nuclear
Hadi Kargar, Muhammad Ashfaq, Mehdi Fallah-Mehrjardi, Reza Behjatmanesh-Ardakani, Khurram Shahzad Munawar, Muhammad Nawaz Tahir
Summary: In this study, three new nickel(II), copper(II), and zinc(II) complexes were synthesized and structurally characterized, with the crystal structure of the nickel(II) complex confirmed. Non-covalent interactions in the complexes were investigated and the enrichment ratio of chemical species was calculated.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Olga Impert, Anna Kozakiewicz-Piekarz, Anna Katafias, Maciej Witwicki, Urszula K. Komarnicka, Katarzyna Kurpiewska, Rudi van Eldik
Summary: Two new ion-pair complexes were synthesized and their properties and purity were characterized using various analytical techniques. The spectral characteristics and redox behavior of these complexes were examined, and their EPR spectra were found to be different from previously reported analogs. The presence of an unpaired electron was confirmed by DFT calculations.
Article
Chemistry, Inorganic & Nuclear
Nimisha Jain, Angelina Mary, Vishesh Manjunath, Rahul Sakla, Rupesh S. Devan, D. Amilan Jose, Abbas Raja Naziruddin
Summary: The synthesis and characterization of heteroleptic ruthenium (II) complexes with donor functionalized phenyl-terpyridine and monocarboxylic groups have shown potential for photovoltaic applications. Excitation of these complexes under visible light results in metal-to-ligand charge transfer transitions, with implications for preventing back electron transfer in oxidized states and a relatively rapid excited-state decay following the energy gap law. These findings suggest promising photosensitizing abilities in these complexes and warrant further investigation for their potential use in photovoltaic devices.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Baoping Ling, Jiarong Wang, Yuxia Liu, Yuan-Ye Jiang, Peng Liu, Jin Feng, Siwei Bi
Summary: Density functional theory calculations were used to explore the Ru-catalyzed decarbonylative annulation reaction, revealing a Ru(II)-Ru(0)-Ru(II) transformation. The oxidative addition of C(carbonyl)-C(carbonyl) bond to Ru(0) was found to be favorable, while the regeneration of the catalyst was predicted to be achieved by the oxidation of air oxygen. This study provides new insights into the decarbonylative annulation.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Rocio Redon, Tania Gonzalez-Garcia, Lorena Espinoza-Flores, Alfonsina Reyes-Mosso, Erika Martin, V. M. Ugalde-Saldivar
Summary: Palladium(0) nanoparticles were synthesized in colloidal suspension using different solvents and reducing methods, resulting in varying nanoparticle sizes that influenced catalysis. The best conversion in C-C Heck catalysis was observed under the minimum reaction conditions at 120 degrees C and 10 h, with N,N-dimethylformamide as solvent and no reducing agent.[dimethylformamide] This system produced the largest nanoparticles in dispersion, highlighting the importance of nanoparticle size in achieving high yields in C-C Heck catalysis.
Article
Biochemistry & Molecular Biology
Mohammed Elhoudi, Rachid Oukhrib, Christian A. Celaya, Daniel G. Araiza, Youness Abdellaoui, Issam Barra, Younes Brahmi, Hassan Bourzi, Miguel Reina, Abdallah Albourine, Hicham Abou Oualid
Summary: In this study, bio-based alginates containing metallic beads were synthesized via an alginate cross-linking method and their properties were studied using experimental techniques combined with theoretical simulations. The thermal properties analysis showed that alginate beads with Ce and Cu behaved differently as a function of temperature, and density functional theory calculations revealed that the reactivity of Ce beads was higher than that of Cu beads.
JOURNAL OF MOLECULAR MODELING
(2022)
Article
Electrochemistry
Fernando Landgrave-Barbosa, Andres F. Marmolejo-Valencia, Alejandro Baray-Calderon, Hailin Hu, Julio Cesar Aguilar-Cordero, Carlos Amador-Bedolla, Victor M. Ugalde-Saldivar
Summary: This study investigates the poly(3-hexylthiophene) (P3HT) thin films deposited on fluorine-doped tin oxide (FTO) glass substrates using the spin-coating process. The results show abnormal spectra in films with thicknesses between 40 and 50 nm, possibly due to the formation of defects. Energy-resolved electrochemical impedance spectroscopy (ER-EIS) experiments reveal a thickness dependence of the lowest unoccupied molecular orbital (LUMO) energy level, while the highest occupied molecular orbital (HOMO) level remains constant.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Hector Garcia-Ortega, Chloe Lhardy, Jesus Gracia-Mora, Armando Marin-Becerra, Miguel Reina, Antonio Reina
Summary: This study presents an educational game called MET-organic, which is used to teach nomenclature and functional group identification in organic chemistry courses. The results show that the game has a positive impact on student learning and engagement.
JOURNAL OF CHEMICAL EDUCATION
(2022)
Article
Plant Sciences
Julio Cesar Carrero, Violeta Curay-Herrera, Lysette Chacon-Nino, Felix Krengel, Silvia-Laura Guzman-Gutierrez, Mayra Silva-Miranda, Luisa-Carolina Gonzalez-Ramirez, Raul J. Bobes, Clara Espitia, Ricardo Reyes-Chilpa, Juan-Pedro Laclette
Summary: This study evaluated the pharmacological activities of Tabernaemontana plant species on Entamoeba histolytica. The alkaloid fraction of T. arborea root bark showed potent anti-amoebic activity, but its effect decreased over time and was unable to limit abscess formation. This research provides a new potential alternative for amoebiasis control.
Article
Chemistry, Multidisciplinary
Miguel Reina, Herve This, Antonio Reina
Summary: Language plays a crucial role in communication, and in chemistry, it is essential for representing the world of phenomena accurately. It is important to differentiate between different chemical objects and their elements, and to have a clear understanding of concepts like elements, atoms, molecules, and compounds. Chemical education should emphasize the distinction between objects and categories, and the understanding of elements and compounds.
JOURNAL OF CHEMICAL EDUCATION
(2022)
Article
Chemistry, Multidisciplinary
Chloe Lhardy, Hector Garcia-Ortega, Jesus Gracia-Mora, Armando Marin-Becerra, Antonio Reina, Miguel Reina
Summary: Unit Kemps is an engaging and easy-to-play educational game that aims to help students learn physical quantities and differentiate between their properties, units, and symbols. Testing in Mexico showed encouraging results in terms of content, playability, and engagement.
JOURNAL OF CHEMICAL EDUCATION
(2022)
Article
Environmental Sciences
Jose Gregorio Prato, Fernando Carlos Millan, Luisa Carolina Gonzalez, Anita Cecilia Rios, Esteban Lopez, Ivan Rios, Siboney Navas, Andres Marquez, Julio Cesar Carrero, Juan Isidro Diaz
Summary: This study evaluated the adsorption of phosphate and nitrate ions from aqueous solutions on calcined adsorbent beds prepared from oxidic lithological material. The findings suggest that the amphoteric iron and aluminum oxides with variable charges present in the material allow for their use as an alternative technique to eliminate phosphates and other ions dissolved in natural water.
Article
Chemistry, Physical
Miguel Reina, Eduardo Gabriel Guzman-Lopez, Annia Galano
Summary: This study presents a set of new rasagiline derivatives that are designed to be antioxidant compounds for treating neurodegenerative disorders. Computational methods were used to produce and evaluate these derivatives, identifying three of them as the most promising with potential for better free radical scavenging and neuroprotective capabilities compared to rasagiline.
INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY
(2023)
Letter
Chemistry, Multidisciplinary
Miguel Reina, Herve This, Antonio Reina
JOURNAL OF CHEMICAL EDUCATION
(2023)
Article
Polymer Science
Rene A. Hauyon, Denis Fuentealba, Nancy Pizarro, Maria C. Ortega-Alfaro, Victor M. Ugalde-Saldivar, Patricio A. Sobarzo, Jean Medina, Luis Garcia, Ignacio A. Jessop, Carmen M. Gonzalez-Henriquez, Alain Tundidor-Camba, Claudio A. Terraza
Summary: A new polymer material, p-TPS-DMAC-TRZ, with high thermal stability and good solubility was successfully synthesized, which maintained the fluorescence properties of DAMC-TRZ while improving thermal stability and morphological properties. The results showed that p-TPS-DMAC-TRZ is a promising candidate for use as a light-emitting layer in OLED devices.
Article
Chemistry, Physical
Eduardo Martinez-Gonzalez, Carlos Amador-Bedolla, Victor M. Ugalde-Saldivar
Summary: Finding water-soluble organic negolytes that can store two electrons is crucial for increasing the charge storage capacity of next-generation flow batteries. In this study, the reduction process of the gallocyanine compound was investigated and found to exhibit a reversible process of adsorption and diffusion pathways. The reversible redox chemistry of the compound was further confirmed through testing a flow cell, which showed excellent battery performance.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Adrian Hernandez-Diazcouder, Cesar Diaz-Godinez, Julio Cesar Carrero
Summary: The COVID-19 pandemic has sparked a rapid race to develop control strategies, including diagnostic methods, therapies, and vaccines. However, existing vaccines do not provide sufficient protection against infection, highlighting the need for more effective vaccines to combat current and future variants. Additionally, the development of new diagnosis and treatment strategies is desirable to address the persistent presence of COVID-19. Recently, there has been interest in utilizing extracellular vesicles (EVs) as natural nanocarriers for delivering molecules and pathogen information. Studies have shown that SARS-CoV-2 infection induces the release of EVs, which can be used for disease prognosis and as carriers for active molecules and drugs. This review summarizes the progress made in using EVs for diagnosis, treatment, and vaccination against SARS-CoV-2 infection over the past three years.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jesus Erubielp Miguel-Gomez, Dennise Salazar, Miguel Reina
Summary: Ludic-didactic material has been proven to enhance teaching and learning processes by reducing student's stress level and promoting team spirit and trust. In chemistry courses, a game called Intermolecular Forces Dominoes has been developed to improve the learning of intermolecular forces. The game aims to help students identify relevant types of intermolecular forces in a fun and competitive environment. Testing the game on a pilot group and later on 51 students showed favorable results in terms of gameplay, content, usefulness, and student involvement. Additionally, the students' knowledge related to the topic improved after playing the game, indicating that Intermolecular Forces Dominoes can effectively reinforce and review basic concepts.
JOURNAL OF CHEMICAL EDUCATION
(2023)
Article
Chemistry, Multidisciplinary
Jesus Alberto Barron-Zambrano, Josue Ordaz-Rivera, Cristian Carrera-Figueiras, Christian A. Celaya, Miguel Reina, Erbin Guillermo Uc-Cayetano, Yamile Perez-Padilla, M. A. Estrella-Gutierrez, Adriana Esparza-Ruiz
Summary: The bis(2phSbz) was characterized and evaluated as a solid chelating adsorbent for lead(II) removal. It showed pH-dependent metal ion sorption and exhibited high adsorption capacities for lead(II), cadmium(II), and zinc(II) ions. It also demonstrated selective removal of lead(II) from multicomponent solutions and high desorption efficiency using EDTA.
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
