Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance

Mitochondrial ROS generated at the complex-II matrix or intermembrane space microdomain have distinct effects on redox signaling and stress sensitivity in C. elegans.

(2019) Adam J Trewin et al.   ANTIOXIDANTS & REDOX SIGNALING

Precisely control mitochondria with light to manipulate cell fate decision

(2019) Patrick Ernst et al.   BIOPHYSICAL JOURNAL

Fndc-1 contributes to paternal mitochondria elimination in C. elegans

(2019) Yunki Lim et al.   DEVELOPMENTAL BIOLOGY

Mos1 Element-Mediated CRISPR Integration of Transgenes in Caenorhabditis elegans

(2019) Nicholas S. Philip et al.   G3-Genes Genomes Genetics

Cardioprotection by the mitochondrial unfolded protein response requires ATF5

(2019) Yves T. Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt

(2019) Stéphane G. Rolland et al.   Cell Reports

Light-induced oxidant production by fluorescent proteins

(2018) Adam J. Trewin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species

(2018) Brandon J. Berry et al.   JOURNAL OF MOLECULAR BIOLOGY

Visible light reduces C. elegans longevity

(2018) C. Daniel De Magalhaes Filho et al.   Nature Communications

Power Grid Protection of the Muscle Mitochondrial Reticulum

(2018) Brian Glancy et al.   Cell Reports

Diverse roles of mitochondria in ischemic stroke

(2018) Jenq-Lin Yang et al.   Redox Biology

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans

(2017) Alexandre Paix et al.   METHODS

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Optical silencing of body wall muscles induces pumping inhibition in Caenorhabditis elegans

(2017) Megumi Takahashi et al.   PLoS Genetics

Auto-regulation in the powerhouse

(2017) Helena M Viola et al.   eLife

Mitochondrial flashes regulate ATP homeostasis in the heart

(2017) Xianhua Wang et al.   eLife

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans

(2016) Salvador Peña et al.   PLoS One

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

(2016) Liang Zhang et al.   Scientific Reports

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Mitochondrial reticulum for cellular energy distribution in muscle

(2015) Brian Glancy et al.   NATURE

Optogenetic acidification of synaptic vesicles and lysosomes

(2015) Benjamin R Rost et al.   NATURE NEUROSCIENCE

Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension

(2015) Susan Chalmers et al.   Scientific Reports

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Loss of a Neural AMP-Activated Kinase Mimics the Effects of Elevated Serotonin on Fat, Movement, and Hormonal Secretions

(2014) Katherine A. Cunningham et al.   PLoS Genetics

Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning

(2013) Cevher Ozcan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange

(2013) Jaime Santo-Domingo et al.   EMBO JOURNAL

Construction of photoenergetic mitochondria in cultured mammalian cells

(2013) Kiyotaka Y. Hara et al.   Scientific Reports

Anoxia-Reoxygenation Regulates Mitochondrial Dynamics through the Hypoxia Response Pathway, SKN-1/Nrf, and Stomatin-Like Protein STL-1/SLP-2

(2013) Piya Ghose et al.   PLoS Genetics

A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel

(2013) Andrew P. Wojtovich et al.   PeerJ

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

(2013) Sebastian Schmeisser et al.   Molecular Metabolism

Mitochondrial (‘mild’) uncoupling and ROS production: physiologically relevant or not?

(2012) Irina G. Shabalina et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

Suspended animation, diapause and quiescence

(2012) Pamela A. Padilla et al.   CELL CYCLE

Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit inCaenorhabditis elegans

(2012) Andrew P. Wojtovich et al.   FEBS LETTERS

Antioxidant potential of all-transretinoic acid (ATRA) and enhanced activity of liposome encapsulated ATRA against inflammation and tumor-directed angiogenesis

(2012) Siddikuzzaman et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation

(2012) Thomas H. Sanderson et al.   MOLECULAR NEUROBIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An optogenetic application of proton pump ArchT to C. elegans cells

(2012) Ayako Okazaki et al.   NEUROSCIENCE RESEARCH

Microbial Light-Activatable Proton Pumps as Neuronal Inhibitors to Functionally Dissect Neuronal Networks in C. elegans

(2012) Steven J. Husson et al.   PLoS One

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Ischemic preconditioning: The role of mitochondria and aging

(2011) Andrew P. Wojtovich et al.   EXPERIMENTAL GERONTOLOGY

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Regulation of Anoxic Death in Caenorhabditis elegans by Mammalian Apoptosis Signal-Regulating Kinase (ASK) Family Proteins

(2011) T. Hayakawa et al.   GENETICS

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

(2011) Susan Chalmers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening

(2010) Mohammed Aldakkak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypoxia and mitochondrial oxidative metabolism

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse

(2010) Lindsey R. Fischer et al.   BRAIN

Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism

(2010) Jeffrey A. Butler et al.   FASEB JOURNAL

High-performance genetically targetable optical neural silencing by light-driven proton pumps

(2010) Brian Y. Chow et al.   NATURE

Volatile Anesthetic Preconditioning Present in the Invertebrate Caenorhabditis elegans

(2009) Baosen Jia et al.   ANESTHESIOLOGY

All-transretinoic acid as a novel therapeutic strategy for Alzheimer’s disease

(2009) Hyun-Pil Lee et al.   Expert Review of Neurotherapeutics

Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans

(2009) Stephen Dingley et al.   MITOCHONDRION

TheCaenorhabditis elegansAMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for Resistance to Oxidative Stress and for Normal Motility and Foraging Behavior

(2008) Hyojin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY