期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 9, 期 11, 页码 1615-1621出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERN.09.86
关键词
Alzheimer's disease; cell cycle; oxidative stress; retinoic acid; therapeutics
资金
- National Institutes of Health [R01 AG026151]
Retinoic acid, an essential factor derived from vitamin A, has been shown to have a variety of functions including roles as an antioxidant and in cellular differentiation. Since oxidative stress and dedifferentiation of neurons appear to be common pathological elements of a number of neurodegenerative disorders, we speculated that retinoic acid may offer therapeutic promise. In this vein, recent compelling evidence indicates a role of retinoic acid in cognitive activities and anti-amyloidogenic properties. Here, we review the actions of retinoic acid that indicate that it may have therapeutic properties ideally served for the treatment of neurodegenerative diseases such as Alzheimer's disease.
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