NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization

(2019) Pedro Antas et al.   Cell Reports

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

(2017) Kelley S. Yan et al.   NATURE

E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling

(2017) Carmen Dominguez-Brauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

(2017) Zhen Qi et al.   Nature Communications

USP7 Is a Tumor-Specific WNT Activator for APC -Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination

(2017) Laura Novellasdemunt et al.   Cell Reports

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

(2016) Carmen Dominguez-Brauer et al.   Cell Stem Cell

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation

(2016) Helen H N Yan et al.   GUT

Intestinal knockout of Nedd4 enhances growth of Apcmin tumors

(2016) C Lu et al.   ONCOGENE

Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms

(2015) Laura Novellasdemunt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling

(2014) Z Huang et al.   ONCOGENE

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth

(2014) H.-E. Hsia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

(2014) Taoling Zeng et al.   Cell Reports

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

(2013) Ciara Metcalfe et al.   Cell Stem Cell

HECT Domain-containing E3 Ubiquitin Ligase NEDD4L Negatively Regulates Wnt Signaling by Targeting Dishevelled for Proteasomal Degradation

(2013) Yi Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEDD4L Is Downregulated in Colorectal Cancer and Inhibits Canonical WNT Signaling

(2013) Jarred P. Tanksley et al.   PLoS One

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway

(2012) Peter W. Eide et al.   CELLULAR SIGNALLING

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

(2012) Jurian Schuijers et al.   EMBO JOURNAL

The role of ubiquitylation in receptor endocytosis and endosomal sorting

(2012) K. Haglund et al.   JOURNAL OF CELL SCIENCE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Identification of Nedd4 E3 Ubiquitin Ligase as a Binding Partner and Regulator of MAK-V Protein Kinase

(2012) Svetlana V. Kalinichenko et al.   PLoS One

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function

(2011) Avinash Persaud et al.   EMBO JOURNAL

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

(2011) H Nikki March et al.   NATURE GENETICS

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development

(2010) Hiroshi Kawabe et al.   NEURON

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression of NEDD-1, a PTEN regulator, in gastric and colorectal carcinomas 

(2008) SUNG SOO KIM et al.   APMIS

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

(2008) Viljar Jaks et al.   NATURE GENETICS