Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres

The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells

(2015) Seung Woo Lee et al.   CANCER LETTERS

Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway

(2015) Bao-quan Song et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Interference of Notch1 inhibits the growth of glioma cancer cells by inducing cell autophagy and down-regulation of Notch1–Hes-1 signaling pathway

(2015) Junchao Yao et al.   MEDICAL ONCOLOGY

Therapeutic targeting of autophagy in cancer. Part II: Pharmacological modulation of treatment-induced autophagy

(2015) Anika Nagelkerke et al.   SEMINARS IN CANCER BIOLOGY

Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib

(2014) Megan L Goodall et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells

(2014) Shingo Tanaka et al.   JOURNAL OF NEURO-ONCOLOGY

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

How to Take Autophagy and Endocytosis Up a Notch

(2014) Julia M. I. Barth et al.   Biomed Research International

Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres

(2014) Dacheng Ding et al.   Acta Neuropathologica Communications

A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)

(2013) S Sahebjam et al.   BRITISH JOURNAL OF CANCER

New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

(2013) Eric C. Hales et al.   CELLULAR SIGNALLING

Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth following In Vivo Notch Blockade

(2013) Q. Chu et al.   CLINICAL CANCER RESEARCH

A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors

(2013) Ivan Diaz-Padilla et al.   INVESTIGATIONAL NEW DRUGS

A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)

(2013) Suzanne Richter et al.   INVESTIGATIONAL NEW DRUGS

A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor-Initiating Cells

(2013) Norihiko Saito et al.   STEM CELLS

Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors

(2012) Ian Krop et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

(2012) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in Brain Tumors: A New Target for Therapeutic Intervention

(2011) Niroop Kaza et al.   BRAIN PATHOLOGY

Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy

(2011) Chien-Ju Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of autophagy in temozolomide treated malignant gliomas

(2011) Manabu Natsumeda et al.   NEUROPATHOLOGY

The therapeutic promise of the cancer stem cell concept

(2010) Natasha Y. Frank et al.   JOURNAL OF CLINICAL INVESTIGATION

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis

(2008) Christine E. Eyler et al.   JOURNAL OF CLINICAL ONCOLOGY