Article
Biochemistry & Molecular Biology
Carolin Seifert, Ellen Balz, Susann Herzog, Anna Korolev, Sebastian Gassmann, Heiko Paland, Matthias A. Fink, Markus Grube, Sascha Marx, Gabriele Jedlitschky, Mladen Tzvetkov, Bernhard H. Rauch, Henry W. S. Schroeder, Sandra Bien-Moeller
Summary: Research has shown that PIM1 kinase plays a significant role in the behavior of glioblastoma stem cells, and its inhibition can lead to the death of these stem-like cells, suggesting a potential approach for glioblastoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kun Liu, Jun Pu, Zhi Nie, Yulin Shi, Liping Jiang, Qisheng Wu, Yongbin Chen, Cuiping Yang
Summary: Research has shown that ivacaftor, commonly used for cystic fibrosis therapy, acts as a potent inhibitor of GSCs maintenance in glioblastoma, promoting cellular apoptosis, suppressing patient-derived xenograft tumor growth, and reducing stemness marker gene expressions of GSCs like CD133, CD44, and Sox2, ultimately inhibiting glioblastoma progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Sumitra Tatapudy, Jobelle Peralta, Todd Nystul
Summary: In Drosophila ovarian epithelial follicle stem cells, the E2 ubiquitin ligase, Bendless, plays multiple roles in JNK signaling, differentiation, proliferation, and niche competition, with a relationship to hedgehog signaling pathway regulation.
Article
Biochemistry & Molecular Biology
Miaomiao Ge, Jianyun Zhu, Kefan Yi, Yue Chen, Wanshuang Cao, Menghuan Wang, Chunfeng Xie, Xiaoting Li, Shanshan Geng, Jieshu Wu, Caiyun Zhong, Hui Cao, Zhiwei Jiang, Hongyu Han
Summary: Gastric cancer is a deadly malignant tumor often characterized by recurrences or metastasis even after eradication therapy. Cancer stem cells (CSCs) play a crucial role in this process, and the sonic hedgehog (SHH) pathway is important in maintaining CSC characteristics. The role of p63 proteins in regulating CSCs is not well understood. Dietary diallyl trisulfide (DATS) has been shown to have preventive effects against gastric cancer, but its effect on targeting gastric CSCs is poorly understood. This study investigates the role of ?Np63/SHH pathway in gastric CSCs and the inhibitory effect of DATS on gastric CSCs.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Raphael Luis Rocha Nogueira, Tais Bacelar Sacramento de Araujo, Ludmila Faro Valverde, Viviane Aline Oliveira Silva, Bruno Raphael Ribeiro Cavalcante, Erik Aranha Rossi, Kyan James Allahdadi, Mitermayer Galvao dos Reis, Thiago Almeida Pereira, Ricardo D. Coletta, Daniel Pereira Bezerra, Bruno Solano de Freitas Souza, Rosane Borges Dias, Clarissa A. Gurgel Rocha
Summary: The present study evaluated the therapeutic potential of Arsenic Trioxide (ATO) in treating Oral Squamous Cell Carcinoma (OSCC). The results showed that ATO has antitumoral effects and inhibits the Hedgehog (HH) pathway. Furthermore, ATO also induced changes in cell morphology and cell cycle in oral cancer cells.
Article
Biochemistry & Molecular Biology
Arianna Casciati, Mirella Tanori, Isabella Gianlorenzi, Elena Rampazzo, Luca Persano, Giampietro Viola, Alice Cani, Silvia Bresolin, Carmela Marino, Mariateresa Mancuso, Caterina Merla
Summary: Glioblastoma multiforme (GBM) is the most common brain cancer in adults, and current therapies have limited effectiveness. Research has shown that high intensity ultra-short pulsed electric fields (PEFs) can affect the growth and differentiation of GBM cells and neurospheres, potentially providing a promising treatment option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Meng-Hang Yang, Bing Li, Ke-Jie Chang
Summary: This study found that arsenic trioxide (As2O3) has a remarkable inhibitory effect on tumor initiating cells (TICs) of small cell lung cancer (SCLC) both in vitro and in vivo. This inhibitory effect may be achieved by down-regulation of the Notch pathway.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Joana Peixoto, Sudha Janaki-Raman, Lisa Schlicker, Werner Schmitz, Susanne Walz, Alina M. Winkelkotte, Christel Herold-Mende, Paula Soares, Almut Schulze, Jorge Lima
Summary: Spheres and monolayers of glioblastoma cell lines exhibit significant metabolic and gene regulation differences, with arginine biosynthesis identified as a key metabolic pathway in supporting neurosphere metabolism. The study suggests the potential for new therapeutic strategies through targeting metabolic vulnerabilities in different glioblastoma subpopulations. The integration of transcriptome and metabolome data highlights the importance of arginine biosynthesis in regulating stem-like features in glioblastoma.
Article
Cell & Tissue Engineering
Shuai Li, Huifang Zhao, Xiaobo Han, Bin Ni, Lang He, Omar Mukama, Jean de Dieu Habimana, Zuoxian Lin, Rongqi Huang, Hualin Huang, Chao Tian, Feng Tang, Zhiyuan Li
Summary: Researchers successfully generated hiNSCs/neurospheres from urine cells using a virus-free technique, providing a convenient method for storing and transporting NSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Mia C. Borlongan, Hongbin Wang
Summary: Tumorigenic cancer stem cells (CSCs) are a subset of cells within tumors that have distinct genetic and phenotypic profiles and signaling pathways compared to other tumor cells. Targeting the unique self-renewal and differentiation properties of CSCs could revolutionize cancer therapy. Understanding the signaling mechanisms of CSCs will improve our knowledge of cancer pathology and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Ji-Zhong Yin, Xiao-Qian Shi, Ming-Dong Wang, He Du, Xue-Wei Zhao, Bing Li, Meng-Hang Yang
Summary: The study found that arsenic trioxide (ATO) can inhibit the polarization of tumor-associated macrophages (TAMs) in lung adenocarcinoma (LUAD), thus inhibiting tumor growth and metastasis. ATO disrupts the positive feedback loop between LUAD and TAMs by inhibiting the expression of Jagged1 and Notch1 in LUAD and down-regulating the secretion of CCL2 and IL1 beta, leading to the suppression of M2 polarization.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Muhammad G. Kibriya, Farzana Jasmine, Aaron Munoz, Tariqul Islam, Alauddin Ahmed, Lin Tong, Muhammad Rakibuz-Zaman, Mohammad Shahriar, Mohammed Kamal, Christopher R. Shea, Joseph H. Graziano, Maria Argos, Habibul Ahsan
Summary: This study is the first to examine the gene expression of basal cell carcinoma in the context of arsenic exposure. It found that high arsenic exposure is associated with impaired DNA replication, cellular response to DNA damage repair, and immune response. The study also suggests a lower chance of platinum drug resistance in basal cell carcinoma patients with high arsenic exposure.
Article
Biochemistry & Molecular Biology
Ganesh Shenoy, Sina Kheirabadi, Zaman Ataie, Aurosman Pappus Sahu, Kondaiah Palsa, Quinn Wade, Chachrit Khunsriraksakul, Vladimir Khristov, Becky Slagle-Webb, Justin D. Lathia, Hong-Gang Wang, Amir Sheikhi, James R. Connor
Summary: This study found that increasing cellular iron content decreased migratory capacity of human glioblastoma cells, and cells with higher iron levels exhibited reduced motility. Cells at the tumor periphery had a gene signature consistent with lower levels of cellular iron.
Article
Biochemistry & Molecular Biology
Ganesh Shenoy, Sina Kheirabadi, Zaman Ataie, Aurosman Pappus Sahu, Kondaiah Palsa, Quinn Wade, Chachrit Khunsriraksakul, Vladimir Khristov, Becky Slagle-Webb, Justin D. Lathia, Hong-Gang Wang, Amir Sheikhi, James R. Connor
Summary: Cellular iron content has an impact on the migratory capacity of glioblastoma cells, with higher iron levels leading to reduced motility. This finding is crucial for understanding the migration and invasion mechanisms of glioblastoma.
Article
Oncology
Silvia Matteoni, Paola Matarrese, Barbara Ascione, Mariachiara Buccarelli, Lucia Ricci-Vitiani, Roberto Pallini, Veronica Villani, Andrea Pace, Marco G. Paggi, Claudia Abbruzzese
Summary: Chlorpromazine, a medication used for psychiatric disorders for decades, has shown potential in treating glioblastoma by inhibiting cell viability, reducing cloning efficiency, decreasing stemness gene expression, and synergizing with temozolomide. The promising results have led researchers to initiate a Phase II clinical trial to evaluate the efficacy of adding chlorpromazine to the standard treatment protocol for GBM patients.
FRONTIERS IN ONCOLOGY
(2021)