Article
Engineering, Biomedical
Anamika Singh, Alok Raghav, Parvaiz Ahmad Shiekh, Ashok Kumar
Summary: This study developed a treatment approach for diabetic peripheral neuropathy (DPN) using a fused exosomal system combined with electrical stimulation, showing normalization of nerve conduction velocity and compound muscle action potential, muscle recovery, and observed paracrine effects in controlling hyperglycemia and tissue damage attenuation. It provides a promising effective treatment for DPN and contributes to cutting-edge therapeutic approaches.
BIOACTIVE MATERIALS
(2021)
Article
Neurosciences
Min You, Haizhu Xing, Ming Yan, Jie Zhang, Jiayi Chen, Yang Chen, Xiaoli Liu, Jing Zhu
Summary: Paclitaxel-induced peripheral neuropathy (PIPN) is a neurological disorder caused by paclitaxel (PTX) treatment in cancer patients. Schwann cell-derived exosomes (SC-EXOs) have been found to effectively improve PIPN both in vitro and in vivo. SC-EXOs alleviate PTX-induced mechanical nociceptive sensitization, ameliorate nerve fiber loss and DRG injury, and protect damaged neurons by upregulating miR-21 to repress the PTEN signaling pathway. These findings provide a novel strategy for the treatment of PIPN.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jiayang Li, Guangzhi Wu, Weiye Li, Xiongyao Zhou, Weizhen Li, Xiong Xu, Ke Xu, Rangjuan Cao, Shusen Cui
Summary: This study found significant differences in miRNA expression between plasma exosomes of DPN and age-matched healthy rats. MiR-20b-3p was enriched in hplasma-exos and both of them alleviated DPN symptoms. MiR-20b-3p regulated autophagy in Schwann cells by targeting Stat3, inhibiting the progression of DPN.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Neurosciences
Baoyan Fan, Michael Chopp, Yi Zhang, Xinli Wang, Amy Kemper, Zheng Gang Zhang, Xian Shuang Liu
Summary: The study found that knockout of the Ago2 gene in PLP lineage Schwann cells (SCs) led to a reduction in nerve conduction velocities and impairments of thermal and mechanical sensitivities. It was also observed that Ago2 knockout induced demyelination and neurodegeneration. These results suggest that Ago2 in SCs is essential for maintaining peripheral nerve function and its loss exacerbates nerve damage in diabetic peripheral neuropathy (DPN).
Article
Neurosciences
Baoyan Fan, Michael Chopp, Zheng Gang Zhang, Xian Shuang Liu
Summary: MSC-derived exosomes loaded with miR-146a exhibit enhanced therapeutic effects on diabetic peripheral neuropathy (DPN) by downregulating inflammation-related genes and improving nerve function recovery. The engineered exosomes show higher loading capacity and better accumulation in peripheral nerve tissues, leading to increased nerve conduction velocity and decreased sensitivity to thermal and mechanical stimuli in diabetic mice with DPN compared to exosomes without miR-146a cargo.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Qingqing Yuan, Xiang Zhang, Wandi Wei, Jialing Zhao, Yuhao Wu, Song Zhao, Lin Zhu, Peiran Wang, Jun Hao
Summary: In this study, lycorine was identified as a potential drug for diabetic peripheral neuropathy. It was found that lycorine promoted autophagy in Schwann cells through AMPK pathway activation and MMP9 downregulation.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Limanjaya Anita, Guo Nan Yin, Soon-Sun Hong, Ju-Hee Kang, Yong Song Gho, Jun-Kyu Suh, Ji-Kan Ryu
Summary: This study found that pericyte-derived extracellular vesicle-mimetic nanovesicles (PC-NVs) can promote penile angiogenesis and neural regeneration under diabetic conditions, thereby improving erectile function. PC-NVs act through multiple signaling pathways under diabetic conditions, inducing endothelial proliferation and migration while suppressing cell apoptosis. In addition, PC-NVs also induce neural regeneration under high-glucose conditions. The findings provide a new treatment strategy for diabetic ED.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell & Tissue Engineering
Xing Zhang, Yihong Jiang, Qun Huang, Zhaoyu Wu, Hongji Pu, Zhijue Xu, Bo Li, Xinwu Lu, Xinrui Yang, Jinbao Qin, Zhiyou Peng
Summary: Exosomes secreted by ADSCs overexpressing GLO-1 promoted endothelial cell protection and angiogenesis in diabetic mice with limb ischemia, showing promising potential for clinical treatment.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Agriculture, Multidisciplinary
Weiyu Hou, Fanrui Zhao, Li Fang, Xiyan Wang, Dan Wu, Chunlei Liu, Yue Leng, Yawen Gao, Junxi Fu, Ji Wang, Weihong Min
Summary: Walnut-derived peptides can improve insulin resistance, lower blood glucose and dyslipidemia by activating the AMPK/mTOR/ULK1 pathway, thus alleviating the symptoms of type 2 diabetes mellitus.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Piyush Gondaliya, Adil Ali Sayyed, Palak Bhat, Mukund Mali, Neha Arya, Amit Khairnar, Kiran Kalia
Summary: Diabetic wounds are a debilitating complication affecting a significant number of patients, and current therapies are unsatisfactory. This study demonstrates the potential of miR-155 inhibitor-loaded MSC-derived exosomes in promoting diabetic wound healing through synergistic effects. The study also suggests a new approach of using MSC-derived exosomes to encapsulate miRNA and antibiotics for improved management of diabetic wounds.
MOLECULAR PHARMACEUTICS
(2022)
Article
Cell & Tissue Engineering
Yinghui Wang, Jiaxi Liu, Honggang Wang, Shasha Lv, Qingzhen Liu, Shan Li, Xue Yang, Gang Liu
Summary: Diabetic kidney disease (DKD) is a major cause of end-stage renal disease worldwide. Exosomes derived from human umbilical cord mesenchymal stem cells (HUC-MSCs) have shown effectiveness in treating DKD, but the mechanisms behind this are not well understood. This study investigated the link between DKD and inflammasome activation, and the therapeutic potential of exosomes in relieving inflammation and repairing damage. The results demonstrated that MSC-derived exosomes, particularly those containing miR-22-3p, protected against inflammation in podocytes and diabetic mice by mediating the NLRP3 inflammasome. This highlights the potential of MSC-derived exosomes as a cell-free therapeutic strategy for DKD.
Article
Cell & Tissue Engineering
Yiming Wang, Lin Jing, Xiao Lei, Zhen Ma, Bei Li, Yuanyuan Shi, Wuyang Zhang, Yuan Li, Hongzhi Zhou, Kaijin Hu, Yang Xue, Yan Jin
Summary: Our study confirmed that local application of umbilical cord-derived apoptotic extracellular vesicles (ApoEVs) from mesenchymal stem cells (MSCs) improved cutaneous wound healing in type 2 diabetes mellitus (T2DM) mice. ApoEVs inhibited macrophage pyroptosis in T2DM mice by reducing oxidative stress levels and regulated the death process.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Plant Sciences
Juanzhen Yang, Yuxi Wei, Tong Zhao, Xiaoqian Li, Xuejian Zhao, Xingnan Ouyang, Lihua Zhou, Xiuqin Zhan, Minyi Qian, Jiaying Wang, Xu Shen
Summary: The study found that magnolol (MG) can improve neurological dysfunctions in diabetic peripheral neuropathy (DPN) mice, promote neurite outgrowth, protect nerve structure, and regulate inflammation and apoptosis processes through multiple pathways. These results reveal the potential of MG as a treatment for DPN and provide further understanding of its mechanism of action.
Article
Pharmacology & Pharmacy
Junya Hanaguri, Noriaki Nagai, Harumasa Yokota, Akifumi Kushiyama, Masahisa Watanabe, Satoru Yamagami, Taiji Nagaoka
Summary: This study found that fenofibrate nano-eyedrops can improve impaired retinal blood flow regulation in type 2 diabetic mice and prevent retinal glial dysfunction via the phosphorylation of PPAR-alpha.
Article
Chemistry, Medicinal
Xiaobao Gong, Zhenwei Gui, Xiaoli Ye, Xuegang Li
Summary: This study discovered that jatrorrhizine, an active constituent of Rhizoma Coptidis, significantly improved diabetic peripheral neuropathy. The findings showed that jatrorrhizine treatment reduced the sensitivity threshold for thermal and mechanical stimuli and increased nerve conduction velocity. Moreover, jatrorrhizine increased the number of nerve fibers and axons, myelin thickness, and axonal diameters. The study also revealed that jatrorrhizine enhanced Schwann cells' myelination by regulating the NRG1-ErbB2-PI3K-AKT pathway.
PHYTOTHERAPY RESEARCH
(2023)