Article
Biochemistry & Molecular Biology
Theresa Strauss, Burkhard Greve, Michael Gabriel, Nurjannah Achmad, Dhanusha Schwan, Nancy Adriana Espinoza-Sanchez, Antonio Simone Lagana, Ludwig Kiesel, Matti Poutanen, Martin Goette, Sebastian Daniel Schaefer
Summary: This study found that the silencing of Musashi-1 and Musashi-2 increased cell apoptosis and necrosis, and reduced the expression of stem cell genes and cell proliferation in endometriosis. Additionally, the Musashi genes had an impact on the expression of the cell cycle regulator p21. These findings suggest the therapeutic potential of targeting the Musashi-Notch axis in the treatment of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Fang-Shin Nian, Pei-Shan Hou
Summary: This review introduces the role of the Notch signaling pathway in neocortical formation, discussing its regulatory mechanisms and interactions with other signaling pathways. Finally, the discussion also explores how modifications to the Notch signaling pathway can drive the evolution of the neocortex.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Junchen Chen, Xiaoxue Dong, Xuejun Cheng, Qiang Zhu, Jinyu Zhang, Qian Li, Xiaoli Huang, Min Wang, Liping Li, Weixiang Guo, Binggui Sun, Qiang Shu, Wen Yi, Xuekun Li
Summary: Ogt deficiency in adult neural stem/progenitor cells leads to a decrease in the aNSPC pool, abnormal neurogenesis, and impaired cognitive function in adult mice. Mechanistic studies reveal that Ogt catalyzes the O-GlcNAc modification of the Notch TM/ICD fragment, which in turn affects neurogenic defects induced by Ogt deficiency.
Article
Multidisciplinary Sciences
Tobias Troost, Udi Binshtok, David Sprinzak, Thomas Klein
Summary: The selection of a single sensory organ precursor (SOP) from a large group of cells in Drosophila is controlled by cis-inhibition (CI), where the ligand Delta inhibits the Notch receptor in the same cell. The mammalian ligand Dl-like 1 does not exhibit cis-inhibition in Drosophila. A mathematical model and experiments show that Mindbomb1 induces basal Notch activity, which is suppressed by CI, highlighting the trade-off between basal Notch activity and CI for SOP selection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Neurosciences
Aikaterini Lampada, Verdon Taylor
Summary: Neurogenesis stops in most areas of the mammalian brain before or shortly after birth, but in certain brain regions, the production of new neurons continues into adulthood. Neural stem cells in these neurogenic zones are situated within niches that govern their activity and fate. Majority of adult brain stem cells are mitotically inactive and can remain dormant for extended periods. The molecular mechanisms regulating neural stem cell maintenance and differentiation are of great interest, with Notch signaling identified as a critical regulator in various tissues, including the nervous system. This review examines the roles of Notch signaling, as well as the functions of different Notch receptors and ligands, in the regulation of adult neurogenesis in mice.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Immunology
Fang Zhao, Yini He, Zhihao Zhao, Jiarong He, Hong Huang, Kelong Ai, Liang Liu, Xiong Cai
Summary: This review discusses the role of Notch signaling in rheumatoid arthritis (RA) and its relationship with angiogenesis. It also explores potential strategies targeting the Notch signaling to improve the treatment outcomes of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Anatomy & Morphology
Nan Hu, Linqing Zou
Summary: HES proteins are bHLH transcription factors that regulate the proliferation and differentiation of stem cells, critically involved in nervous system development. Their oscillatory expression levels allow for complex regulation of downstream genes, while acting as hubs for molecular crosstalk among signaling pathways.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Review
Endocrinology & Metabolism
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke, a common and undertreated cerebral disease with high mortality and disability rate, involves various intrinsic and extrinsic factors that regulate the progression. Astrocytes, as an integral part of the neuronal glia system, play crucial roles in neuronal survival after ischemic stroke. The RhoA/ROCK signaling pathway and astrocytes have significant impact on neurological function and tissue repair after brain injury caused by ischemic stroke.
METABOLIC BRAIN DISEASE
(2021)
Article
Physics, Fluids & Plasmas
Chandrashekar Kuyyamudi, Shakti N. Menon, Sitabhra Sinha
Summary: We demonstrate that heterogeneity in cell shapes and sizes, in the context of contact-mediated interactions, can result in qualitatively different collective behavior in tissues. When lateral inhibition is implemented through intercellular coupling, these disorder-driven transitions can significantly alter the ultimate differentiation pattern of cells by modifying their fate choice through changes in neighborhood geometry. Furthermore, when contact-induced signals affect inherent cellular oscillations, disorder can lead to the emergence of partially-ordered dynamical states that are functionally relevant.
Article
Cell Biology
Carla Belmonte-Mateos, Lydvina Meister, Cristina Pujades
Summary: Tissue growth and morphogenesis are tightly coordinated processes that determine cell fates and stem cell capacities. Studying the neurogenic commitment in the zebrafish embryonic brainstem, researchers discovered temporal and spatial differences in progenitor capacities and the decreased proliferative capacity of cells within center areas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Engineering, Environmental
Zhihua Ren, Tingting Ku, Yurou Gao, Xiaoxi Yang, Lingyi Meng, Qian S. Liu, Jiefeng Liang, Hanqing Xu, Chunyang Liao, Qunfang Zhou, Francesco Faiola, Guibin Jiang
Summary: This study investigated the effects of two PFIs on neural differentiation of mouse embryonic stem cells (mESCs). The results showed that PFIs increased ectodermal differentiation and promoted neurogenesis. The study also found that PFIs regulated the Notch-Hes signaling pathway through mmumiRNA-34a-5p to influence the commitment of mESCs to the neural lineage. These findings provide new insights into the potential neurodevelopmental toxicities of PFIs and can contribute to the health risk assessment of these emerging chemicals.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Oncology
Franciele C. Kipper, Mark W. Kieran, Ajith Thomas, Dipak Panigrahy
Summary: Glioblastoma, the most malignant form of glioma, is associated with Notch signaling, which plays a role in tumor cell differentiation and tumor normalization. In vitro studies suggest that inhibiting Notch expression can induce tumor cell differentiation and improve treatment outcomes. However, Notch also functions as a receptor in the vasculature and promotes tumor normalization.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Tingkui Zhao, Fujin He, Keqing Zhao, Lin Yuxia, Huanyu Li, Xingru Liu, Juan Cen, Shaofeng Duan
Summary: Changes in the cerebral microenvironment after acute ischemic stroke-reperfusion hinder neurological function recovery and contribute to stroke recurrence. A triple-targeted self-assembled nanodelivery system was developed, incorporating the neuroprotective drug rutin and hyaluronic acid, along with SS-31 peptide to target mitochondria. This system effectively enhanced plasticity, reduced neurological damage, and promoted neuroinflammation maintenance, penumbra angiogenesis, and neovascularization.
ACS CENTRAL SCIENCE
(2023)
Review
Cell Biology
Abdellah Akil, Ana K. Gutierrez-Garcia, Rachael Guenter, J. Bart Rose, Adam W. Beck, Herbert Chen, Bin Ren
Summary: The Notch signaling pathway is crucial in determining the fate of vascular endothelial cells, angiogenesis, and tumor progression, particularly in the development of CSCs and therapeutic resistance. Cross-talk between Notch pathway and other signaling pathways plays a vital role in promoting various aspects of tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Lucas M. Jozwick, Ashok P. Bidwai
Summary: The effects of Notch signaling in metazoan animals are mediated by the Enhancer of Split (E(spl)/HES) basic Helix-Loop-Helix-Orange (bHLH-O) repressors. This study explores the phosphorylation of these repressors and its impact on their function. It identifies E(spl)-M gamma as a new target of CK2 and reveals that the phosphorylation site is juxtaposed to the WRPW motif. The distinct positioning of CK2 and MAPK sites suggests that phosphorylation may contribute to the functional diversity of bHLH-O proteins.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Meeting Abstract
Oncology
Dongya Jia, Mohit Kumar Jolly, Marcelo Boareto, Princy Parsana, Steven Mooney, Kenneth J. Pienta, Herbert Levine, Eshel Ben-Jacob
Article
Biochemical Research Methods
Marcelo Boareto, Jonatas Cesar, Vitor B. P. Leite, Nestor Caticha
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2015)
Article
Multidisciplinary Sciences
Marcelo Boareto, Mohit Kumar Jolly, Aaron Goldman, Mika Pietila, Sendurai A. Mani, Shiladitya Sengupta, Eshel Ben-Jacob, Herbert Levine, Jose N. Onuchic
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2016)
Article
Multidisciplinary Sciences
Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Biochemistry & Molecular Biology
Tomas Tomka, Dagmar Iber, Marcelo Boareto
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Federico Bocci, Larisa Gearhart-Serna, Marcelo Boareto, Mariana Ribeiro, Eshel Ben-Jacob, Gayathri R. Devi, Herbert Levine, Jose Nelson Onuchic, Mohit Kumar Jolly
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biology
Anna Stopka, Marcelo Boareto
JOURNAL OF THEORETICAL BIOLOGY
(2019)
Article
Cell Biology
Runrui Zhang, Marcelo Boareto, Anna Engler, Angeliki Louvi, Claudio Giachino, Dagmar Iber, Verdon Taylor
Article
Multidisciplinary Sciences
Jose M. Dias, Zhanna Alekseenko, Ashwini Jeggari, Marcelo Boareto, Jannik Vollmer, Mariya Kozhevnikova, Hui Wang, Michael P. Matise, Andrey Alexeyenko, Dagmar Iber, Johan Ericson
Article
Biochemistry & Molecular Biology
Tanzila Mukhtar, Jeremie Breda, Manal A. Adam, Marcelo Boareto, Pascal Grobecker, Zahra Karimaddini, Alice Grison, Katja Eschbach, Ramakrishnan Chandrasekhar, Swen Vermeul, Michal Okoniewski, Mikhail Pachkov, Corey C. Harwell, Suzana Atanasoski, Christian Beisel, Dagmar Iber, Erik van Nimwegen, Verdon Taylor
Summary: The study reveals dynamic transcriptional changes and heterogeneity within murine embryonic NSCs, BPs, and NBNs. Signature hallmarks of NSC, BP, and NBN clusters were identified, along with predicted active transcriptional nodes and networks contributing to neural fate specification. Expression of receptors, ligands, and downstream pathway components showed highly dynamic changes over time and throughout the lineage, indicating differential responsiveness to signals.
Correction
Multidisciplinary Sciences
Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Developmental Biology
Marcelo Boareto, Dagmar Iber, Verdon Taylor
Review
Oncology
Mohit Kumar Jolly, Marcelo Boareto, Bisrat G. Debeb, Nicola Aceto, Mary C. Farach-Carson, Wendy A. Woodward, Herbert Levine
Article
Biochemistry & Molecular Biology
Dongya Jia, Mohit Kumar Jolly, William Harrison, Marcelo Boareto, Eshel Ben-Jacob, Herbert Levine
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)
