Review
Microbiology
Qingru Jiang, Tian Li, Wei Chen, Yingfang Huo, Xiangyu Mou, Wenjing Zhao
Summary: The microbiota, especially the maternal-associated microbial metabolites, play a crucial role in individuals' early and long-term health. However, the relationship between maternal-associated microbial metabolites and offspring diseases is still poorly understood. This review aims to summarize current knowledge on these metabolites and their links to the development of various offspring diseases.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Lin Xiao, Qin Liu, Mei Luo, Lishou Xiong
Summary: Research has identified the significant roles that microbiota-derived metabolites play in the development of IBS symptoms in patients, shedding light on the complex interplay between gut microbiota and IBS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xin Liang, Xue Li, Yu Jin, Yi Wang, Changling Wei, Zhicheng Zhu
Summary: This study aimed to investigate the changes in intestinal homeostasis and metabolism in mice after MA administration and exercise intervention. The composition of gut microbiota, levels of SCFAs and amino acids were assessed. The results showed that exercise intervention modulated changes induced by MA administration, with differences observed in dominant microbiota, amino acids and SCFAs.
Article
Food Science & Technology
Mateus Kawata Salgaco, Natalia Partis Perina, Thais Moreno Tome, Elaine Martins Bento Mosquera, Tamara Lazarini, Adilson Sartoratto, Katia Sivieri
Summary: This study evaluated the impact of an infant cereal with probiotics on infants' gut microbiota by simulating human gastrointestinal conditions. The results showed that the cereal can stimulate the growth of beneficial Lactobacillus strains, reduce NH4+ production, and increase the production of short chain fatty acids, especially butyric acid.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Yao Peng, Yugiang Nie, Jun Yu, Chi Chun Wong
Summary: Colorectal cancer is a leading cause of cancer-related deaths worldwide, and its pathogenesis is closely related to microbial metabolites from the gut microbiota. Some of these metabolites can act as oncogenic factors for CRC by influencing host physiology. Through metabolomics technology, the study of microbiota-derived metabolites has accelerated our understanding of host-microbiota interactions in CRC.
Article
Environmental Sciences
Xi Fu, Zheyuan Ou, Mei Zhang, Yi Meng, Yanling Li, Qingmei Chen, Jun Jiang, Xin Zhang, Dan Norback, Zhuohui Zhao, Yu Sun
Summary: The study found that students in urban schools in Shanxi province were more likely to experience SBS symptoms, while microbial diversity was higher in rural schools. Certain bacterial species were associated with SBS symptoms, with some microbial metabolic pathways showing a negative correlation with symptom occurrence.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Agronomy
Siyu Yi, Md. Abul Kalam Azad, Yujiao Ji, Yang Liu, Mengying Dou, Xiangfeng Kong
Summary: The study evaluated the nutritional values of Mao-tai lees and its fermented products and explored their effects on in vitro intestinal fermentation. The results showed that the fermented products had higher contents of fiber, protein, and vitamins, as well as more micronutrients. Additionally, the fermented lees had higher levels of free amino acids and bioamines, while having lower levels of hydrolyzed amino acids and other organic acids. Overall, using fermented lees as feedstuff alternatives can alter their nutritional composition and promote protein utilization.
Article
Immunology
Chia-Wei Liou, Sin-Jhong Cheng, Tzu-Ting Lai, Yu-Hsuan Tsai, Che-Wei Chien, Yu-Lun Kuo, Shih-Hsuan Chou, Cheng-Chih Hsu, Wei-Li Wu
Summary: Social novelty, a cognitive process crucial for strategic interaction among animals based on prior experiences, is modulated by the commensal microbiome in the gut through various routes, including microbe-derived metabolite signaling. Short-chain fatty acids (SCFAs), metabolites produced by bacterial fermentation in the gastrointestinal tract, have been found to affect host behavior. This study demonstrates that the direct delivery of SCFAs into the brain disrupts social novelty through specific neuronal populations, specifically the CaMKII-labeled neurons in the BNST.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biology
Masato Hirota, Miho Tamai, Sachie Yukawa, Naoyuki Taira, Melissa M. Matthews, Takeshi Toma, Yu Seto, Makiko Yoshida, Sakura Toguchi, Mio Miyagi, Tomoari Mori, Hiroaki Tomori, Osamu Tamai, Mitsuo Kina, Eishin Sakihara, Chiaki Yamashiro, Masatake Miyagi, Kentaro Tamaki, Matthias Wolf, Mary K. Collins, Hiroaki Kitano, Hiroki Ishikawa
Summary: COVID-19 mRNA vaccines elicit adaptive immunity against SARS-CoV-2, but the levels of vaccine-induced responses vary among individuals. A systems biology study using multi-omics analyses of human samples identified factors associated with these immune responses. The study found that the expression of activation protein 1 (AP-1) transcription factors, influenced by commensal microbial activity, is negatively correlated with the effectiveness of the BNT162b2 vaccine in inducing T-cell responses.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tae Woong Whon, Hyun Sik Kim, Na-Ri Shin, Eun Sung Jung, Euon Jung Tak, Hojun Sung, Mi-Ja Jung, Yun-Seok Jeong, Dong-Wook Hyun, Pil Soo Kim, Yu Kyung Jang, Choong Hwan Lee, Jin-Woo Bae
Summary: Castrated male cattle have distinct intestinal microbiota and amino acid profiles, leading to increased muscle fat storage, and experimental evidence confirms that alterations in the gut microbiota are a key contributor to obesity in these animals. Targeting the gut microbiota may be a potential therapeutic strategy for hypogonadism and obesity.
Article
Immunology
Jing Xie, Ying Wang, Qi Zhong, Shun-jie Bai, Chan-juan Zhou, Tian Tian, Jian-jun Chen
Summary: This study investigated the relationships between microbial metabolites in feces and neurotransmitters in the prefrontal cortex of depressed mice using targeted metabolomics. The results identified differential microbial metabolites and neurotransmitters and found significant correlations between them. The study suggests that disturbances in microbial metabolites, especially amino acids, may affect neurotransmitter levels and contribute to the onset of depression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Sage E. Foley, Michael J. Dente, Xuqiu Lei, Benjamin F. Sallis, Ethan B. Loew, Mario Meza-Segura, Katherine A. Fitzgerald, Beth A. McCormick
Summary: Preventing aberrant inflammation is crucial for maintaining homeostasis in the mammalian intestine. This study uncovers a sophisticated signaling network directed by intestinal microbial metabolites that regulate the expression of P-glycoprotein (P-gp), a key component in protecting the intestinal epithelium. The findings highlight the important role of histone deacetylases (HDAC) inhibition, nuclear receptor activation, and the involvement of new signaling pathways and transcription factors in P-gp induction.
Article
Food Science & Technology
Xingjiang Li, Ying He, Wei Yang, Dongdong Mu, Min Zhang, Yilong Dai, Zhi Zheng, Shaotong Jiang, Xuefeng Wu
Summary: This study investigated three types of sufu prepared through natural fermentation: NF, SF, and MF, revealing differences in microbial species and nutritional quality among them. While NF sufu had the highest number of microbial species, SF sufu had the lowest. Tetragonococcus, Bacillus, Acinetobacter, and Staphylococcus were identified as the main bacteria in sufu, with NF sufu containing a large number of harmful bacteria. NF and MF sufu had higher protein and soy isoflavone contents, indicating their superior nutritional value.
FOOD SCIENCE & NUTRITION
(2021)
Article
Environmental Sciences
Boyuan Bi, Kun Wang, He Zhang, Yu Wang, Hongyan Fei, Ruopeng Pan, Fengpeng Han
Summary: Specific metabolites and secondary metabolites released by plants under drought stress play critical roles in shaping soil microbial community structures, suggesting that plant-mediated rhizosphere metabolism is a key factor affecting underground ecological processes.
LAND DEGRADATION & DEVELOPMENT
(2021)
Article
Agricultural Engineering
Manupati Hemalatha, S. Venkata Mohan
Summary: This study investigated the potential of Duckweed in treating dairy wastewater and its utilization as nutritional biomass. The results showed that Duckweed had good treatment efficiency in removing organic carbon, nitrates, and phosphates from wastewater. It also exhibited potential as a nutritional supplement for livestock and poultry industries, as well as a feedstock for biorefinery.
BIORESOURCE TECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Yuxia Chen, Dan Shen, Lilan Zhang, Ruqing Zhong, Zhengqun Liu, Lei Liu, Liang Chen, Hongfu Zhang
Article
Agriculture, Dairy & Animal Science
Zhengqun Liu, Ruqing Zhong, Liang Chen, Fei Xie, Kai Li, Lei Liu, Hongfu Zhang
Article
Agriculture, Dairy & Animal Science
Zhengqun Liu, Kai Li, Ruqing Zhong, Liang Chen, Bifeng Zhang, Lei Liu, Hongfu Zhang
Summary: The time-based total fecal collection method accurately estimated energy values and nutrient digestibility coefficients, while the index method with acid-insoluble ash underestimated the energy values and nutrient digestibility coefficients of some fiber-rich diets.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Endocrinology & Metabolism
Shumin Zhang, Jingwen Zhao, Fei Xie, Hengxun He, Lee J. Johnston, Xiaofeng Dai, Chaodong Wu, Xi Ma
Summary: This review summarizes the crosstalk between short chain fatty acids (SCFAs) and host metabolism in relation to NAFLD pathophysiology, focusing on recent advances. It highlights the roles of SCFAs in gut generation and absorption, maintenance of gut barrier, alleviation of hepatic inflammatory responses, and regulation of hepatic energy balance, with involvement of G-protein-coupled receptors (GPRs) in these metabolic processes. The review aims to provide new insights into the potential therapeutic targeting of SCFAs in the management of liver diseases.
Article
Agriculture, Dairy & Animal Science
Zhengqun Liu, Zeqing Li, Zi Zheng, Ning Li, Shuqin Mu, Yong Ma, Zhijiang Zhou, Jun Yan, Chunlian Lu, Wenjie Wang, Hongfu Zhang
Summary: This study investigated the protective effects of L-theanine supplementation on diquat-challenged weaned piglets. The results showed that L-theanine could reduce diarrhea rates and mortality, improve growth rate and villus height, and alleviate oxidative stress in piglets.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaobin Wen, Ruqing Zhong, Guoqi Dang, Bing Xia, Weida Wu, Shanlong Tang, Lixin Tang, Lei Liu, Zhengqun Liu, Liang Chen, Hongfu Zhang
Summary: The study suggests that pectin enhances intestinal integrity and barrier function by altering intestinal microbiota composition and their metabolites, which subsequently alleviates intestinal injury and improves the growth performance of piglets.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Zhonghao Liu, Ning Li, Zi Zheng, Chunhua Zhang, Zhengqun Liu, Chunling Song, Jun Yan, Shuqin Mu
Summary: This study evaluated the effects of crude extracts from Lonicera japonica and Radix Puerariae as feed additives on finishing pigs. The results showed that these extracts improved growth performance, fecal microbiota, and nutrient digestibility in finishing pigs. The study suggests that Lonicera japonica and Radix Puerariae crude extracts could be beneficial feed additives for finishing pig diets.
Article
Biochemistry & Molecular Biology
Yanrong Liu, Zhengqun Liu, Qiang Luo, Zhuwen Sun, Ning Li, Zi Zheng, Shuqin Mu, Xiaoqiao Zhou, Jun Yan, Chao Sun, Hongfu Zhang
Summary: Based on our previous research, we investigated the effects of cinnamaldehyde on lipid droplet generation and development in adipogenic differentiated C2C12 cells. The results showed that cinnamaldehyde promoted the decomposition and autophagy of lipid droplets while inhibiting their fusion. These findings suggest that cinnamaldehyde may have potential for regulating lipid metabolism.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Zhengqun Liu, Ning Li, Xiaoqiao Zhou, Zi Zheng, Chunhua Zhang, Shiyue Liang, Yuanming Li, Jun Yan, Qianjun Li, Shuqin Mu
Summary: This study examined the effects of fermented bamboo powder as a new feed ingredient on the growth performance, serum biochemical parameters, immunoglobulins and inflammatory cytokines, and fecal microbial composition of growing-finishing pigs. The results showed that the inclusion of fermented bamboo powder in the diet had no negative effects on growth performance and had beneficial effects on promoting serum biochemical and immune indices and modulating the fecal microbiota of pigs. Therefore, fermented bamboo powder could be a potential fiber-rich ingredient for growing-finishing pigs.
Article
Agriculture, Dairy & Animal Science
Zhonghao Liu, Jun Yan, Ning Li, Zi Zheng, Chunhua Zhang, Zhengqun Liu, Chunling Song, Shuqin Mu
Summary: This study aimed to investigate the influence of adding Lonicera japonica and Radix Puerariae crude extracts, and their mixture to the diet of finishing pigs on their growth performance, antioxidant capacity, and immunological functions. The results showed that adding these extracts improved feed intake, feed to gain ratio, red blood cell count, cholesterol content, antioxidant capacity, and immunological functions of the pigs. In summary, adding Lonicera japonica and Radix Puerariae crude extracts to the diet can enhance the growth performance of finishing pigs.
Article
Agriculture, Dairy & Animal Science
Zi Zheng, Zhengqun Liu, Ning Li, Shuqin Mu, Shiyue Liang, Zhonghao Liu, Chunhua Zhang, Yuanming Li, Jun Yan, Qianjun Li
Summary: The addition of fermented bamboo powder (FBP) in growing-finishing pigs' diet showed positive effects on growth performance and meat quality, by improving feed digestibility, enhancing meat appearance, and meeting Chinese consumers' preferences. However, excessive FBP usage resulted in negative effects, such as reduced feed efficiency and compromised taste of pork.
Article
Agriculture, Dairy & Animal Science
Qingtao Gao, Zhengqun Liu, Kai Li, Guosong Bai, Lei Liu, Ruqing Zhong, Liang Chen, Hongfu Zhang
Summary: This study investigated the time-course effects of different types of dietary fiber on energy values, fecal microbiota, and short-chain fatty acid concentration in growing pigs. The results showed that fiber inclusion decreased the energy values of the diet and that the gut microbiota of pigs needed more time to adapt to a high fiber diet.
Article
Agriculture, Dairy & Animal Science
Zhengqun Liu, Kai Li, Ruqing Zhong, Liang Chen, Lei Liu, Hongfu Zhang
Summary: This study investigated the effects of dietary fibre and types of indigestible markers on the digestibility of nutrients in diets fed to growing pigs. The results showed that the type of dietary fibre significantly affected the recovery rate of indigestible markers, and it is recommended to use acid-insoluble ash as a marker when determining the digestibility of nutrients in pig diets.
ARCHIVES OF ANIMAL NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Zhengqun Liu, Ruqing Zhong, Kai Li, Liang Chen, Bifeng Zhang, Lei Liu, Hongfu Zhang
Summary: This study aimed to compare the energy values of high-fiber dietary ingredients with different solubility in growing pigs using the difference and regression methods. Results showed that the regression method was a robust indirect method to evaluate the energy values for high-fiber ingredients with different solubility, while the difference method with a moderate inclusion level could be applied as a substitute if the number of experimental animals was limited.
