The double dealing of cyclin D1

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

(2019) Shuo Qie et al.   Nature Communications

Cyclin D1 integrates G9a-mediated histone methylation

(2019) Zhiping Li et al.   ONCOGENE

Cytoplasmic cyclin D1 regulates glioblastoma dissemination

(2019) Tània Cemeli et al.   JOURNAL OF PATHOLOGY

A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation

(2019) Gozde Korkmaz et al.   NUCLEIC ACIDS RESEARCH

Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence

(2018) Phatthamon Laphanuwat et al.   JOURNAL OF CELL SCIENCE

Prognostic and clinicopathological significance of cyclin D1 expression in oral squamous cell carcinoma: A systematic review and meta-analysis

(2018) Pablo Ramos-García et al.   ORAL ONCOLOGY

Genetic alterations in main candidate genes during melanoma progression

(2018) Maria Cristina Sini et al.   Oncotarget

Regulation of the master regulator FOXM1 in cancer

(2018) Guo-Bin Liao et al.   Cell Communication and Signaling

Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms

(2018) Robert Albero et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells

(2018) Victoria J. Gennaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer

(2017) Martha L. Slattery et al.   GENES CHROMOSOMES & CANCER

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

CDK4/6 inhibition triggers anti-tumour immunity

(2017) Shom Goel et al.   NATURE

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival

(2017) Haizhen Wang et al.   NATURE

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research

(2017) Denise N Slenter et al.   NUCLEIC ACIDS RESEARCH

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells

(2017) Simon Body et al.   Scientific Reports

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models

(2016) Mindy I. Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin D1, cancer progression, and opportunities in cancer treatment

(2016) Shuo Qie et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The molecular pathogenesis of mantle cell lymphoma

(2016) Niklas Vogt et al.   LEUKEMIA & LYMPHOMA

Treating cancer with selective CDK4/6 inhibitors

(2016) Ben O'Leary et al.   Nature Reviews Clinical Oncology

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases

(2016) Per Hydbring et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin

(2016) Noel P. Fusté et al.   Nature Communications

Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer

(2016) Noel P. Fusté et al.   Oncotarget

CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma

(2016) Atish Mohanty et al.   Oncotarget

Cyclin D1 represses peroxisome proliferator-activated receptor alpha and inhibits fatty acid oxidation

(2016) Sushama Kamarajugadda et al.   Oncotarget

Cyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathway

(2015) Sophie Bustany et al.   BMC CANCER

Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors

(2015) Nawal Bendris et al.   CELL CYCLE

Consequence of the tumor-associated conversion to cyclin D1b

(2015) M. A. Augello et al.   EMBO Molecular Medicine

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Cyclin D1 promotes BRCA2-Rad51 interaction by restricting cyclin A/B-dependent BRCA2 phosphorylation

(2015) C Chalermrujinanant et al.   ONCOGENE

Targeting CDK4 and CDK6: From Discovery to Therapy

(2015) C. J. Sherr et al.   Cancer Discovery

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis

(2015) Mathew C. Casimiro et al.   Oncotarget

Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling

(2014) Z. Li et al.   CANCER RESEARCH

The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis

(2014) Siwanon Jirawatnotai et al.   CELL CYCLE

Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1 

(2014) K. Bhalla et al.   DIABETES

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression

(2014) Yoonjin Lee et al.   NATURE

Cooperation between Dmp1 Loss and Cyclin D1 Overexpression in Breast Cancer

(2013) Sinan Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

New Roles of Cyclin D1

(2013) Richard G. Pestell   AMERICAN JOURNAL OF PATHOLOGY

Female-specific rectal carcinogenesis in cyclin D1b transgenic mice

(2013) Chul Jang Kim et al.   CARCINOGENESIS

Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells

(2013) Tsutomu Shimura et al.   CELL CYCLE

ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis

(2013) L P Vaites et al.   ONCOGENE

Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer

(2013) Zuoren Yu et al.   Nature Communications

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium

(2012) N. E. Brown et al.   CANCER RESEARCH

Proteomic Identification of a Direct Role for Cyclin D1 in DNA Damage Repair

(2012) S. Jirawatnotai et al.   CANCER RESEARCH

Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α

(2012) Eric A. Hanse et al.   CELL CYCLE

Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes

(2012) Michael A. Augello et al.   JOURNAL OF CLINICAL INVESTIGATION

ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice

(2012) Mathew C. Casimiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular pathology and genetics of pancreatic endocrine tumours

(2012) Gabriele Capurso et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Cyclin D1 Inhibits Mitochondrial Activity in B Cells

(2011) G. Tchakarska et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

3’UTR mediated regulation of the cyclin D1 proto-oncogene

(2011) Anagha Deshpande et al.   CELL CYCLE

PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b

(2011) Hui Meng et al.   CELL CYCLE

High-level cytoplasmic cyclin D1 expression in lymph node metastases from prostate cancer independently predicts early biochemical failure and death in surgically treated patients

(2011) Achim Fleischmann et al.   HISTOPATHOLOGY

The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation

(2011) L. P. Vaites et al.   MOLECULAR AND CELLULAR BIOLOGY

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

(2011) Siwanon Jirawatnotai et al.   NATURE

Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility

(2011) R M H Fernández et al.   ONCOGENE

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

(2010) Priya Aggarwal et al.   CANCER CELL

Identification of ASF/SF2 as a Critical, Allele-Specific Effector of the Cyclin D1b Oncogene

(2010) N. A. Olshavsky et al.   CANCER RESEARCH

Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage Response

(2010) Z. Li et al.   CANCER RESEARCH

Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

(2010) Z. Zhong et al.   CANCER RESEARCH

Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen

(2010) Frédéric Bienvenu et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2

(2010) X Zeng et al.   ONCOGENE

Alternative Splicing of the Cyclin D1 Proto-Oncogene Is Regulated by the RNA-Binding Protein Sam68

(2009) M. P. Paronetto et al.   CANCER RESEARCH

Cyclin D1 Splice Variants: Polymorphism, Risk, and Isoform-Specific Regulation in Prostate Cancer

(2009) C. E.S. Comstock et al.   CLINICAL CANCER RESEARCH

Suppression of Cancer Cell Growth by Promoting Cyclin D1 Degradation

(2009) Jing Shan et al.   MOLECULAR CELL

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

(2009) Manas K. Santra et al.   NATURE

Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome

(2009) E K A Millar et al.   ONCOGENE

Mutations in Fbx4 Inhibit Dimerization of the SCFFbx4 Ligase and Contribute to Cyclin D1 Overexpression in Human Cancer

(2008) Olena Barbash et al.   CANCER CELL

ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover

(2008) Ruth M. Densham et al.   CELLULAR SIGNALLING

Association between CCND1 G/A870 Polymorphism, Allele-Specific Amplification, Cyclin D1 Expression, and Survival in Esophageal and Lung Carcinoma

(2008) V. K. Gupta et al.   CLINICAL CANCER RESEARCH

Alternate Cyclin D1 mRNA Splicing Modulates p27KIP1Binding and Cell Migration

(2008) Zhiping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation

(2008) Zuoren Yu et al.   JOURNAL OF CELL BIOLOGY

Genotoxic Stress-Induced Cyclin D1 Phosphorylation and Proteolysis Are Required for Genomic Stability

(2008) L. L. Pontano et al.   MOLECULAR AND CELLULAR BIOLOGY