Recent synthesis of functionalized s-tetrazines and their application in ligation reactions under physiological conditions: a concise overview

Installation of Minimal Tetrazines through Silver-Mediated Liebeskind–Srogl Coupling with Arylboronic Acids

(2019) William D. Lambert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Free Synthetic Approach to 3-Monosubstituted Unsymmetrical 1,2,4,5-Tetrazines Useful for Bio-orthogonal Reactions

(2018) Pierre Audebert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo

(2018) Julian Tu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic and Scalable Syntheses of Unsymmetrical 1,2,4,5-Tetrazines by Thiol-Containing Promotors

(2018) Wuyu Mao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells

(2017) Carlo P. Ramil et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation of Unsymmetrical 1,2,4,5-Tetrazines via a Mild Suzuki Cross-Coupling Reaction

(2017) Aaron M. Bender et al.   ORGANIC LETTERS

Green- to far-red-emitting fluorogenic tetrazine probes – synthetic access and no-wash protein imaging inside living cells

(2017) Achim Wieczorek et al.   Chemical Science

Triggered Drug Release from an Antibody–Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice

(2016) Raffaella Rossin et al.   BIOCONJUGATE CHEMISTRY

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Development and application of bond cleavage reactions in bioorthogonal chemistry

(2016) Jie Li et al.   Nature Chemical Biology

Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes

(2015) Fabian Ehret et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal Reactions for Labeling Proteins

(2014) Kathrin Lang et al.   ACS Chemical Biology

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

In Situ Synthesis of Alkenyl Tetrazines for Highly Fluorogenic Bioorthogonal Live-Cell Imaging Probes

(2014) Haoxing Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Current Approaches for RNA Labeling in Vitro and in Cells Based on Click Reactions

(2014) Daniela Schulz et al.   CHEMBIOCHEM

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

(2014) Craig S. McKay et al.   CHEMISTRY & BIOLOGY

“Minimalist” Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling

(2014) Zhengqiu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET

(2014) Kaihang Wang et al.   Nature Chemistry

Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels–Alder Ligation

(2014) Sander B. Engelsma et al.   ORGANIC LETTERS

An efficient and mild oxidant for the synthesis of s-tetrazines

(2014) Ramajeyam Selvaraj et al.   TETRAHEDRON LETTERS

The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals

(2013) D. Zeng et al.   JOURNAL OF NUCLEAR MEDICINE

Metal-Catalyzed One-Pot Synthesis of Tetrazines Directly from Aliphatic Nitriles and Hydrazine

(2012) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

(2012) David M. Patterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Mild and Efficient Synthesis of 3-Hetarylamino-s-Tetrazines

(2012) Aleksei B. Sheremetev et al.   MENDELEEV COMMUNICATIONS

Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction

(2012) Kathrin Lang et al.   Nature Chemistry

Bioorthogonal Chemical Reporters for Analyzing Protein Lipidation and Lipid Trafficking

(2011) Howard C. Hang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biomedical Applications of Tetrazine Cycloadditions

(2011) Neal K. Devaraj et al.   ACCOUNTS OF CHEMICAL RESEARCH

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Bioorthogonal chemistry: recent progress and future directions

(2010) Reyna K. V. Lim et al.   CHEMICAL COMMUNICATIONS

s-Tetrazines as Building Blocks for New Functional Molecules and Molecular Materials

(2010) Gilles Clavier et al.   CHEMICAL REVIEWS

A Photochemical Synthesis of Functionalizedtrans-Cyclooctenes Driven by Metal Complexation

(2008) Maksim Royzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY