Article
Medicine, General & Internal
Wei Yan, Yingchun Shen, Jinny Huang, Ling Lu, Qian Zhang
Summary: MCC950 shows significant hepatoprotective effects in CCl4-induced ALI by enhancing M2 macrophage and MDSC function at different time points, suggesting a potential new therapeutic strategy.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Sara A. Vayrynen, Jinming Zhang, Chen Yuan, Juha P. Vayrynen, Andressa Dias Costa, Hannah Williams, Vicente Morales-Oyarvide, Mai Chan Lau, Douglas A. Rubinson, Richard F. Dunne, Margaret M. Kozak, Wenjia Wang, Diana Agostini-Vulaj, Michael G. Drage, Lauren Brais, Emma Reilly, Osama Rahma, Thomas Clancy, Jiping Wang, David C. Linehan, Andrew J. Aguirre, Charles S. Fuchs, Lisa M. Coussens, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, Shuji Ogino, Jonathan A. Nowak, Brian M. Wolpin
Summary: The study revealed a diverse set of myeloid cells within the PDAC tumor microenvironment, which are distributed heterogeneously across patient tumors. Beyond cell density, the spatial locations of immune cells are also associated with patient outcomes, underscoring the potential role of spatially resolved myeloid cell subtypes as quantitative biomarkers for PDAC prognosis and therapy.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Galina Gabriely, Duanduan Ma, Shafiuddin Siddiqui, Linqing Sun, Nathaniel P. Skillin, Hadi Abou-El-Hassan, Thais G. Moreira, Dustin Donnelly, Andre P. da Cunha, Mai Fujiwara, Lena R. Walton, Amee Patel, Rajesh Krishnan, Stuart S. Levine, Brian C. Healy, Rafael M. Rezende, Gopal Murugaiyan, Howard L. Weiner
Summary: Myeloid suppressor cells expressing LAP on their surface promote tumor growth by stimulating Tregs and inhibiting effector T cells. Blocking TGF-beta can reduce the tolerogenic ability of these cells, leading to slower cancer progression. Additionally, single-cell RNA-Seq analysis reveals distinct immunosuppressive cell subsets with high levels of MHCII and PD-L1 genes. This study provides new insights into the role of LAP(Hi) MCs in tumor growth and potential therapeutic targets for cancer treatment.
Review
Oncology
Zhaonian Hao, Ruyuan Li, Yuanyuan Wang, Shuangying Li, Zhenya Hong, Zhiqiang Han
Summary: MDSC play vital roles in cancer microenvironment, influencing the responses to immunotherapies and prognosis of cancer patients. Therefore, proposing MDSC-inhibiting strategies becomes crucial in the field of cancer immunotherapies.
BIOMARKER RESEARCH
(2021)
Article
Immunology
Tianju Liu, Francina Gonzalez De Los Santos, Andrew E. Rinke, Chuling Fang, Kevin R. Flaherty, Sem H. Phan
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease without effective therapy. This study investigated the role of myeloid-derived suppressor cells (MDSCs) expressing B7H3 in IPF. The expansion of MDSCs correlated with disease severity in IPF patients. B7H3-mediated MDSCs activated lung fibroblasts and myofibroblast differentiation, and also suppressed T-cell proliferation. Inhibition of MDSC recruitment with anti-B7H3 antibodies reduced inflammation and fibrosis in a mouse model of pulmonary fibrosis. These findings suggest that MDSCs and B7H3 may play a significant role in the progression of IPF and could be potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Rou Xie, Shaobo Ruan, Jiaqi Liu, Lin Qin, Chuanyao Yang, Fan Tong, Ting Lei, Maxim Shevtsov, Huile Gao, Yi Qin
Summary: The study developed a furin-responsive aggregated nanoplatform to address the challenges of insufficient drug accumulation and chemoresistance in cancer chemotherapy. By loading doxorubicin and hydroxychloroquine, the platform enhanced tumor cell sensitivity to chemotherapy drugs and exerted anti-tumor effects through macrophage polarization.
Review
Immunology
Dandan Xu, Cheng Li, Yushan Xu, Mingyue Huang, Dawei Cui, Jue Xie
Summary: Myeloid-derived suppressor cells (MDSCs) are a group of immature cells derived from bone marrow that play critical immunosuppressive functions in autoimmune diseases. Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNA regulation, have been shown to regulate the differentiation and development of MDSCs and their suppressive functions. Further research is needed to better understand the biological and epigenetic regulation of MDSCs in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Chenyuan Song, Yufei Ji, Wenzhi Wang, Ning Tao
Summary: This study investigates the biological effect of ginger polysaccharide on myeloid-derived suppressor cells (MDSCs) in tumor microenvironment. Ginger polysaccharide promotes apoptosis of MDSCs by regulating lipid metabolism, inhibiting fatty acid synthesis and lipid droplet accumulation.
PHYTOTHERAPY RESEARCH
(2023)
Review
Immunology
Alexandra Neaga, Cristina Bagacean, Adrian Tempescul, Laura Jimbu, Oana Mesaros, Cristina Blag, Ciprian Tomuleasa, Corina Bocsan, Mihaela Gaman, Mihnea Zdrenghea
Summary: Research suggests that miRNAs play a role as tumor suppressors in favorably impacting AML outcomes, with macrophages increasingly being deciphered for their role in this process. miRNAs are not only proposed as diagnostic and prognostic biomarkers for AML, but are also seen as potential therapeutic approaches for various cancers, including AML.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Norman Fultang, Xinyuan Li, Ting Li, Youhai H. Chen
Summary: MDSCs are a crucial sub-population of leukocytes in carcinogenesis and cancer immunotherapy. Despite the involvement of various transcription factors in regulating MDSC differentiation, none of them are specifically expressed in MDSCs. The recent discovery of the c-Rel-C/EBP beta enhanceosome in MDSCs may provide insights into how transcription factors regulate MDSC differentiation in a lineage-specific manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Kristin C. Hicks, Yulia Y. Tyurina, Valerian E. Kagan, Dmitry I. Gabrilovich
Summary: Immunosuppressive myeloid cells generate oxidized lipids, which play a role in immune suppression in cancer.
Review
Pharmacology & Pharmacy
Shweta Joshi, Andrew Sharabi
Summary: This review discusses the role of MDSCs in tumor growth, their interaction with NK cells, and the impact on NK cell-based immunotherapies, presenting strategies to enhance NK cell cytotoxicity.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Cell Biology
Vaishali Bhardwaj, Stephen M. M. Ansell
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells composed of pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections. They exhibit distinct characteristics and exert strong immunosuppressive effects on T-cells and other immune cells, making them a major obstacle to cancer immunotherapies. However, the clinical outcomes of targeting MDSCs in hematological malignancies, particularly B-cell malignancies, still require further exploration. This review provides a comprehensive summary of the complex biology and immunosuppressive pathways of MDSCs, with a focus on their role in modulating T-cell function in hematological malignancies, and discusses the challenges, therapeutic strategies, and clinical relevance of targeting MDSCs in these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Maryam Moradi-Chaleshtori, Samaneh Shojaei, Samira Mohammadi-Yeganeh, Seyed Mahmoud Hashemi
Summary: The study demonstrated that repolarization of M2 macrophages to M1 phenotype using tumor-derived exosomes loaded with miR-130 led to a reduction in migration and invasion abilities of breast cancer cells. The findings suggest a therapeutic potential in targeting tumor invasion and metastasis in breast cancer through this approach.
Article
Chemistry, Multidisciplinary
Xiaotu Ma, Meinan Yao, Yu Gao, Yale Yue, Yao Li, Tianjiao Zhang, Guangjun Nie, Xiao Zhao, Xiaolong Liang
Summary: Immune cell-derived exosomes have been engineered as radiotherapy sensitizers in order to enhance the efficacy of radiotherapy by modifying the immune microenvironment and increasing DNA damage repair inhibition.
Article
Nanoscience & Nanotechnology
Meng Yu, Fang Guo, Jinping Wang, Fengping Tan, Nan Li
ACS APPLIED MATERIALS & INTERFACES
(2015)
Article
Chemistry, Multidisciplinary
Meng Yu, Fang Guo, Fengping Tan, Nan Li
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Engineering, Biomedical
Meng Yu, Fang Guo, Jinping Wang, Fengping Tan, Nan Li
Article
Engineering, Biomedical
Meng Yu, Xiaolin Xu, Yujun Cai, Lingyun Zou, Xintao Shuai
Article
Pharmacology & Pharmacy
Meng Yu, Huixian Ma, Mingzhu Lei, Nan Li, Fengping Tan
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2014)
Article
Chemistry, Multidisciplinary
Meng Yu, Xiaohui Duan, Yujun Cai, Fang Zhang, Shuqi Jiang, Shisong Han, Jun Shen, Xintao Shuai
Article
Engineering, Biomedical
Wen Ma, Sui-Nan Sha, Pei-Ling Chen, Meng Yu, Jian-Jun Chen, Chao-Bo Huang, Bin Yu, Yun Liu, Li-Han Liu, Zhi-Qiang Yu
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Gui Chen, Yuanyuan Yang, Qing Xu, Mingjian Ling, Huimin Lin, Wen Ma, Rui Sun, Yuchun Xu, Xiqiang Liu, Nan Li, Zhiqiang Yu, Meng Yu
Article
Engineering, Biomedical
Yuanyuan Yang, Xin Liu, Wen Ma, Qing Xu, Gui Chen, Yufei Wang, Haihua Xiao, Nan Li, Xing-Jie Liang, Meng Yu, Zhiqiang Yu
Summary: A multifunctional light-activatable liposome has been engineered for repetitive on-demand drug release under discontinuous light irradiation, allowing for chemo-photodynamic therapy and immunopotentiation in hypoxic tumors. This system effectively remodels the redox balance in tumors, alleviating hypoxia and enhancing PDT efficacy, reversing cisplatin resistance, and polarizing tumor-associated macrophages to the immunocompetent M1 phenotype.
Article
Pharmacology & Pharmacy
Ling Yu, Zhenjie Wang, Zhuomao Mo, Binhua Zou, Yuanyuan Yang, Rui Sun, Wen Ma, Meng Yu, Shijun Zhang, Zhiqiang Yu
Summary: A photo-activatable liposome incorporating both photosensitizer Ce6 and chemotherapeutic drug TP was designed for controlled drug release and synergistic photodynamic therapy in treating HCC. This novel approach showed improved therapeutic effects with reduced side effects, making it a potential treatment option for HCC.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Physical
Huimin Lin, Shanwei Shi, Xinyue Lan, Xiaolong Quan, Qinqin Xu, Guangyu Yao, Jia Liu, Xintao Shuai, Chong Wang, Xiang Li, Meng Yu
Summary: A bifunctional scaffold 3D-printed from nanoink containing metallic polydopamine nanoparticles (FeMg-NPs) is developed to eliminate tumor cells and repair bone defects associated with bone metastasis in breast cancer patients. This approach combines chemodynamic therapy with photothermal therapy to efficiently eradicate bone-metastatic tumors while promoting new bone formation.
Article
Chemistry, Multidisciplinary
Gui Chen, Qing Xu, Zhenzhen Feng, Qinqin Xu, Xuhui Zhang, Yuanyuan Yang, Yuxuan Zhang, Xing-Jie Liang, Zhiqiang Yu, Meng Yu
Summary: Electrodynamic therapy combined with nanotechnology was used to generate highly cytotoxic oxidative radicals for tumor destruction. However, single EDT treatment faces challenges in long-term tumor suppression in an immunosuppressive environment. In this study, a combination therapy of EDT and immunotherapy was designed using a nanocarrier loaded with a glutamine antagonist, which stimulated a protective immune response and demonstrated great therapeutic efficacy in primary and metastatic tumor models.
Article
Engineering, Biomedical
Yuehua Wang, Zhenjie Wang, Fei Jia, Qing Xu, Zhilin Shu, Junlin Deng, Aimin Li, Meng Yu, Zhiqiang Yu
Summary: By constructing a multi-functional oxygen delivery nanoplatform PFH@LSLP, which can simultaneously deliver sorafenib and CSF1/CSF1R inhibitor PLX3397, this study aims to overcome sorafenib resistance in HCC. The nanoplatform exhibits synergistic effects of hypoxia attenuation, resistance-related gene regulation, and immune-microenvironment modification, showing promising antitumor performance.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Siyu Wang, Qing You, Jinping Wang, Yilin Song, Yu Cheng, Yidan Wang, Shan Yang, Lifang Yang, Peishan Li, Qianglan Lu, Meng Yu, Nan Li
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
