Article
Medicine, General & Internal
Lin Liu, Chen-Xi Liang, Xiao-Wei Wang, Ke-Xin Pei, Xin-Di Ma, Chun-Xi Zhang, Jing-Hui Dong, Ming-Ming Gao, Jia-Wei Liao
Summary: This study found that surgical removal of adipose tissue before obesity onset did not effectively prevent hyperlipidemia, insulin resistance, fatty liver, or atherosclerosis in a mouse model.
CHINESE MEDICAL JOURNAL
(2021)
Article
Immunology
Hui Zhou, Xiyan Liao, Qin Zeng, Haowei Zhang, Jianfeng Song, Wanyu Hu, Xiaoxiao Sun, Yujin Ding, Dandan Wang, Yalun Xiao, Tuo Deng
Summary: Accumulation and activation of immunocytes in adipose tissues are important in obesity-induced inflammation and insulin resistance. Chemokines, especially CCL5, play a crucial role in recruiting immunocytes to adipose tissue during obesity. CCL5 deficiency exacerbates adipose inflammation and impairs insulin sensitivity in obese mice. This study provides insights into the role of CCL5 in obesity-induced adipose inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Zheng Li, Qiang Ren, Zongtao Zhou, Zongyu Cai, Bin Wang, Jing Han, Luyong Zhang
Summary: A new dual PPAR δ/γ partial agonist, ZLY06, was identified and showed excellent pharmacokinetic profiles suitable for oral medication, significantly improving glucolipid metabolism without causing weight gain or hepatic steatosis. This study suggests potential benefits of ZLY06 on metabolic syndrome with no adverse effects related to commonly used PPAR γ full agonist.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Abbas Ali Sangouni, Mohammad Alizadeh, Atena Jamalzehi, Karim Parastouei
Summary: Garlic supplementation significantly improves MetS components, insulin resistance, FLI, and appetite.
PHYTOTHERAPY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Gracia Fahed, Laurence Aoun, Morgan Bou Zerdan, Sabine Allam, Maroun Bou Zerdan, Youssef Bouferraa, Hazem I. Assi
Summary: Metabolic syndrome is a cluster of metabolic dysregulations associated with insulin resistance and chronic low-grade inflammation. If left untreated, it significantly increases the risk of developing diabetes and cardiovascular diseases. However, many aspects of Metabolic syndrome are still not completely understood, and many questions remain unanswered. This review provides a comprehensive overview of the historical background, epidemiology, histopathology, pathophysiology, management, and prevention of Metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
Sang Jun Yoon, Seul Ki Kim, Na Young Lee, Ye Rin Choi, Hyeong Seob Kim, Haripriya Gupta, Gi Soo Youn, Hotaik Sung, Min Jea Shin, Ki Tae Suk
Summary: Metabolic syndrome is a cluster of medical conditions including high blood pressure, abdominal obesity, hyperglycemia, and dyslipidemia, related to diseases like obesity and diabetes. Korean Red Ginseng, traditionally associated with various beneficial effects, has been commonly used in traditional medicine to treat metabolic conditions.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Multidisciplinary Sciences
Luis Crisostomo, Ivana Jarak, Luis P. Rato, Joao F. Raposo, Rachel L. Batterham, Pedro F. Oliveira, Marco G. Alves
Summary: The consumption of energy-dense diets has led to an increase in obesity and its associated comorbidities worldwide. Unhealthy feeding habits can start at an early age, leading to early onset of metabolic diseases with potential unknown consequences on reproductive function. Recent evidence suggests intergenerational and transgenerational effects of high-fat diets on sperm parameters and testicular metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Roberta Dourado Cavalcante da Cunha de Sa, Jussara de Jesus Simao, Viviane Simoes da Silva, Talita Mendes de Farias, Maysa Mariana Cruz, Vitor Jaco Antraco, Lucia Armelin-Correa, Maria Isabel Alonso-Vale
Summary: This study found that different ratios of EPA and DHA have different impacts on adipose tissue metabolism, with fish oil rich in EPA instead of DHA effectively reversing changes induced by obesity.
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Chia-Chu Liu, Shu-Pin Huang, Yung-Chin Lee, Cheng-Hsueh Lee, Tsung-Yi Huang, Jiun-Hung Geng, Che-Wei Chang, Chung-Yu Lin, Yung-Shun Juan, Wen-Jeng Wu, Tusty-Jiuan Hsieh
Summary: The study found an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and testosterone deficiency (TD) in aging Taiwanese men, particularly in those without metabolic syndrome (MetS). This suggests that MAFLD could serve as an early predictor of TD, facilitating the identification of high-risk individuals and enabling timely interventions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pediatrics
Diana Paola Cordoba-Rodriguez, Iris Iglesia, Alejandro Gomez-Bruton, Gerardo Rodriguez, Jose Antonio Casajus, Hernan Morales-Devia, Luis A. Moreno
Summary: This study examined the differences in fat-free mass/lean body mass according to insulin sensitivity/insulin resistance/glucose tolerance/metabolic syndrome in children. The results showed lower fat-free mass/lean body mass percentage but higher values in mass units for children with insulin resistance/glucose tolerance/metabolic syndrome. The findings contribute to our understanding of the impact of lean mass on metabolic health in children.
Review
Nutrition & Dietetics
Yuji Xiao, Xue Zhang, Dongxin Yi, Fangyi Qiu, Lei Wu, Yiyong Tang, Ningning Wang
Summary: The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing globally and is an important public health problem. There is currently no consensus on pharmacological treatment for MAFLD, while the Mediterranean diet (MD) is considered to be the cornerstone of MAFLD management due to its antioxidant, anti-inflammatory, and antibacterial properties.
FRONTIERS IN NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Joseph A. M. J. L. Janssen
Summary: Recent data suggests that the onset of metabolic syndrome and related diseases is often preceded by a period of hyperinsulinemia. Hyperinsulinemia may be caused by factors such as diet, over-nutrition, genetic background, and fetal/metabolic programming. The synergistic effects of hyperinsulinemia and functional hypercortisolism may promote abdominal visceral obesity and insulin resistance, which are key components of metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Milian Chen, Ying Cao, Guang Ji, Li Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) has become a common chronic liver disease worldwide. It is commonly associated with obesity, but can also occur in lean individuals, known as lean NAFLD. Lean NAFLD is often accompanied by sarcopenia, progressive loss of muscle mass and quality. The pathological features of lean NAFLD contribute to the development of sarcopenia, while sarcopenia further exacerbates ectopic fat accumulation and lean NAFLD. In this review, we discuss the association between sarcopenia and lean NAFLD, summarize the underlying pathological mechanisms, and suggest potential strategies to reduce the risks of lean NAFLD and sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Christine Torris, Milada Cvancarova Smastuen, Marianne Molin
Article
Health Care Sciences & Services
Christine Hillestad Hestevik, Marianne Molin, Jonas Debesay, Astrid Bergland, Asta Bye
BMC HEALTH SERVICES RESEARCH
(2019)
Article
Geriatrics & Gerontology
Christine Hillestad Hestevik, Marianne Molin, Jonas Debesay, Astrid Bergland, Asta Bye
Article
Nutrition & Dietetics
C. H. Hestevik, M. Molin, J. Debesay, A. Bergland, A. Bye
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2020)
Review
Nutrition & Dietetics
Ellisiv Laerum-Onsager, Marianne Molin, Cecilie Fromholt Olsen, Asta Bye, Jonas Debesay, Christine Hillestad Hestevik, Maria Bjerk, Are Hugo Pripp
Summary: This study found that in the elderly population, nutritional support can significantly reduce the risk of hospital readmission, while physical exercise interventions did not have the same effect.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2021)
Article
Nutrition & Dietetics
Linda Aimee Hartford Kvael, Ida Lochting, Marianne Molin
Summary: This study investigated the use of dietary supplements (DS) among individuals living with Fibromyalgia syndrome (FMS) and found that DS users tended to have higher education levels, self-reported knowledge about DS, but overall lower knowledge of health claims. Users of DS marketed for muscles/joints appeared to spend more money on DS. The findings highlight the importance of interventions to ensure informed decision-making about DS in light of their increasing availability and aggressive advertising through health claims in the media.
Article
Nutrition & Dietetics
Greta Heim, Ruth Olaug Thuestad, Marianne Molin, Asgeir Brevik
Summary: The introduction of free school meals in a small municipality in Norway has been found to have a positive impact on students' educational health and the learning environment. It led to increased social interactions, reduced absenteeism during lunchtime, and a more peaceful atmosphere at lunchtime.
Article
Public, Environmental & Occupational Health
Marie Michaelsen Bjontegaard, Marianne Molin, Marit Kolby, Liv Elin Torheim
Summary: This study aimed to investigate the share of ultra-processed foods in Norway and the change in expenditure on such foods from 2013. The results showed that in 2019, the highest expenditure was on ultra-processed foods (46.5%) and minimally or unprocessed foods (36.3%). The study also found a slight increase in the processing degree of certain food groups between 2013 and 2019. In conclusion, there is a high share of expenditure on ultra-processed foods in Norway, indicating a potentially high consumption of these foods.
PUBLIC HEALTH NUTRITION
(2023)
Article
Health Care Sciences & Services
Ida -Kristin Orjasaeter Elvsaas, Lisa Garnweidner-Holme, Laurence Habib, Marianne Molin
Summary: This study aims to develop a serious game application that promotes critical thinking about health claims by incorporating user insights and input. Through a mixed methods evaluation, it was found that the game was perceived as both educational and fun by users. Future research can focus on assessing the impact of the serious game on learning outcomes and health choices.
JMIR FORMATIVE RESEARCH
(2023)
Article
Education & Educational Research
Christine Torris, Mona Elisabeth Meyer, Ida Hellum Sandbekken, Hedvig Halvorsrud, Marianne Molin
Summary: The COVID-19 pandemic led to a shift towards online education, prompting a study on students' perceived learning outcomes in a digital learning environment and their association with grades. The research found a significant linear relationship between overall perceived learning outcomes and grades achieved. Attending digital seminars, participating in voluntary colloquium groups, and having motivation to learn were predictors of higher grades, while high extrinsic motivation was associated with lower grades.
EDUCATION SCIENCES
(2022)
Article
Nutrition & Dietetics
Christine Hillestad Hestevik, Marianne Molin, Jonas Debesay, Astrid Bergland, Asta Bye
Article
Geriatrics & Gerontology
Christine Hillestad Hestevik, Ella Heyerdahl, Bjorg Lysne Garaas, Gerd Sylvi Sellevold, Marianne Molin
Article
Environmental Sciences
Inger Aakre, Sigrun Henjum, Elin Lovise Folven Gjengedal, Camilla Risa Haugstad, Marie Vollset, Khalil Moubarak, Tecber Saleh Ahmed, Jan Alexander, Marian Kjellevold, Marianne Molin