Article
Chemistry, Physical
Wenxing Lv, Ziwei Han, Shaokun Dong, Yanjuan Huang, Jinqi Deng, Chao Liu, Qiang Feng, Jiashu Sun
Summary: An all-aqueous microfluidic reactor was used to synthesize protein-loaded ZIF-8 nanoparticles in a one-step, rapid, and highly controlled manner at room temperature. The ZIF-8 nanoparticles with protein encapsulation efficiency over 97% were achieved by pre-mixing proteins with 2-MIM. The 25 nm ZIF-8 nanoparticles showed the best performance in promoting cellular uptake of protein payload and enhancing cytosolic protein delivery.
Review
Anatomy & Morphology
Vahid Hoseinpour, Zahra Shariatinia
Summary: There is limited research on the usage of zeolitic imidazolate framework-8 (ZIF-8) in bone tissue engineering, with this review focusing on its application and synthesis methods, biocompatibility, and medical applications. The literature review covers previous applications of ZIF-8 in bone tissue engineering, discussing its use in bone scaffolds and drug delivery systems, as well as highlighting future perspectives.
Review
Engineering, Chemical
Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang
Summary: ZIF-8, composed of Zn ions and imidazolate ligands, is a metal-organic framework with high porous property, loading capacity, and thermal/chemical stability. Recent research has focused on synthesis methods and potential applications in drug delivery, while also summarizing the potential risks of using ZIF-8 for this purpose.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Yingying Liu, Ying Huo, Qing Fan, Mei Li, Hongbin Liu, Bin Li, Youming Li
Summary: The novel PDA@ZIF-8/CNFs composite hydrogel with a packaging structure enables on-demand drug release and exhibits significant pH-dependent release behavior. The drug release mechanism is mainly driven by anomalous transport. NIR light radiation can accelerate drug delivery in this composite hydrogel.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Analytical
Zhuo Sun, Juan Lu, Xin Zhang, Xiangyu Shan, Qian Wu, Yingjie Zhao, Li Tian
Summary: This study demonstrates the use of ZIF-8 NF as an ECL accelerator for the detection of terbutaline residual and fabricates a novel ECL sensor based on ZIF-8 NF. The method shows high sensitivity, good stability, and applicability to actual samples.
Article
Chemistry, Physical
Yonghang Zhou, Kang Zhang, Tian-shun Song, Jingjing Xie
Summary: In this study, the performance of microbial electrosynthesis (MES) was improved by modifying the cathode with ZIF-8 particles of different pore sizes. The ZIF-8 modified electrode achieved a higher acetate production rate and concentration compared to the bare cathode. The high CO2 adsorption capacity of ZIF-8 and its beneficial effects on biofilm formation and bacteria enrichment contributed to the improved performance of MES.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Chemistry, Multidisciplinary
Yue Zhang, Rong Deng, Ling Yuan, Chaoqi Zhang, Jing Wang, Chao Liu
Summary: This work reports the construction of zinc-based zeolite imidazole framework (ZIF-8) microrings through an anisotropic growth-etching route. The method involves the deposition of ZIF-8 crystals on the edges of leaf-like ZIF-L nanosheets with coordinatively unsaturated Zn2+ and subsequent selective etching of alkaline unstable ZIF-L. Additionally, functional carbon materials with a ring-like structure can be prepared by pyrolysis of ZIF-8 microrings, exhibiting improved performance in oxygen reduction reaction. These findings may pave the way for the design of MOFs with sophisticated micro/nanostructures.
Article
Green & Sustainable Science & Technology
Wenhao Xia, Siew Kei Lau, Wai Fen Yong
Summary: This study investigated the environmental impacts of different synthesis methods for ZIF-8 through life cycle assessment (LCA), with a focus on the contribution of solvents. The findings showed that replacing the solvent DMF with methanol could significantly reduce the impact on human health, ecosystem, and resources. The mechanochemical method had the least environmental impact due to its simplicity and fewer production steps.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Biophysics
Yaping Shen, Yonggang Lv
Summary: Despite various treatment strategies, it is difficult to cure tumor bone metastasis. In this study, a bone and tumor dual targeted nanocarrier was developed by loading NF-KB inhibitor into ZIF-8 and coating it with HA/ALN. The dual targeted nanoparticle effectively inhibited breast cancer cells growth and osteoclastogenesis in vitro, and improved bone resorption and tumor progress in vivo.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Applied
Nadhem Missaoui, Mohamed Bouzid, Amani Chrouda, Hamza Kahri, Houcine Barhoumi, Ai Ling Pang, Mohsen Ahmadipour
Summary: The aim of this study was to investigate CO2 adsorption on the highly porous ZIF-8. Characterization of ZIF-8 was done through techniques such as X-ray diffraction, scanning electron microscopy, TGA analysis, and N2 adsorption-desorption isotherms. Adsorption isotherms were obtained at different temperatures (273 K, 298 K, 323 K, and 353 K). A new model based on multilayer with saturation was simulated and interpreted. Physicochemical parameters describing the CO2 adsorption process and thermodynamic functions governing the adsorption process were determined. The results showed that CO2 adsorption on ZIF-8 was spontaneous and exothermic.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Xiao Mi, Juan Lu, Mingran Dong, Yang Lou, Xia Zhan, Xi Chen
Summary: Dihydromyricetin (DHM) holds potential as an antitumor agent, but its low bioavailability limits its clinical application. In this study, DHM@ZIF-8 nanoparticles were developed using ZIF-8 as a carrier to enhance its antitumor activity. The nanoparticles exhibited a regular morphology with a suitable particle size and a high drug release rate in a simulated tumor micro acid environment. Compared to the prodrug, DHM@ZIF-8 showed increased killing effect on HepG2 cells, along with enhanced removal of ROS, promotion of apoptosis, and significant modulation of apoptosis-related proteins within tumor cells.
Article
Biophysics
Haokang He, Lin Li, Yongsheng Wu, Daohui Zhao, Jie Liu, Jian Zhou
Summary: This study investigates the adsorption behavior of enzymes on ZIF-8 surfaces and its impact on catalytic activity using simulation methods. The results demonstrate that charged ZIF-8 surfaces can achieve ordered adsorption for enhanced catalytic activity, with ZIF-8-NH2 being a promising candidate for immobilization.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Fatima Guerrero, Victoria Pulido, Said Hamad, Pedro Aljama, Alejandro Martin-Malo, Carolina Carrillo-Carrion
Summary: This study demonstrates the potential of zeolitic-imidazolate framework-8 nanoparticles to be incorporated within a renal scaffold while still retaining their ability to remove hydrophobic uremic toxins like p-cresol under flow conditions. This could lead to the development of novel adsorbents for dialysis and/or artificial kidneys in the future.
Article
Biophysics
Xinyi Li, Shengxin Hou, Jiucun Chen, Cai-E He, Yong-E Gao, Yi Lu, Die Jia, Xianbin Ma, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: A pH-responsive nanoplatform based on silk sericin-zeolitic imidazolate framework-8 was designed for the delivery of chemotherapeutic drugs, which showed better stability and biocompatibility in tumor microenvironment. The nanoplatform achieved efficient drug uptake and significant tumor permeability, realizing targeted and enhanced chemotherapy. Overall, this silk sericin-based nanosystem represents a promising strategy to improve the treatment effect of chemotherapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yu-Chun Chiang, Wei-Ting Chin
Summary: In this study, PAN-based activated nanofiber composites embedded inside ZIF-8 crystals or ZDC-850 were fabricated as CO2 adsorbents. The material properties were affected by the timing of ligand decomposition in ZIF-8 and the degree of crystallinity of ZDC-850 changed compared to ZIF-8. The ZIF-8/PAN exhibited the highest CO2 adsorption capacity.
Article
Chemistry, Multidisciplinary
Jiating Xu, Ruipeng Shi, Guanying Chen, Shuming Dong, Piaoping Yang, Zhiyong Zhang, Na Niu, Shili Gai, Fei He, Yujie Fu, Jun Lin
Review
Chemistry, Inorganic & Nuclear
Jiating Xu, Jiajia Zhou, Yinghui Chen, Piaoping Yang, Jun Lin
COORDINATION CHEMISTRY REVIEWS
(2020)
Article
Nanoscience & Nanotechnology
Qianqian Sun, Bin Liu, Ruoxi Zhao, Lili Feng, Zhao Wang, Shuming Dong, Yushan Dong, Shili Gai, He Ding, Piaoping Yang
Summary: Mitochondria play a crucial role in cell function by maintaining Ca2+ homeostasis and disrupting this balance can lead to tumor cell death. Calcium overload in tumor cells and tissue calcification inhibit tumor growth and can be used as contrast agents for computed tomography imaging.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Jiating Xu, Jun Wang, Jin Ye, Jiao Jiao, Zhiguo Liu, Chunjian Zhao, Bin Li, Yujie Fu
Summary: Metal-coordinated supramolecular nanoassemblies have unique physicochemical properties that bridge the boundary between traditional inorganic and organic materials, making them promising for cancer theranostics. By tailoring the structural components, multifunctional theranostic nanomedicines can be constructed to modulate the tumor microenvironment and enhance tumor accumulation. The advancements in design and fabrication, as well as the prospects and challenges of metal-coordinated supramolecular self-assemblies for technical advances and clinical translation, are discussed.
Article
Engineering, Environmental
Qianqian Sun, Bin Liu, Zhao Wang, Lili Feng, Ruoxi Zhao, Shuming Dong, Yushan Dong, Lei Zhong, Shili Gai, Piaoping Yang
Summary: The study designed a Ca2+ nanogenerator that reshapes the tumor microenvironment through heat generation of indocyanine green and production of copper ions, enabling photodynamic therapy, chemodynamic therapy, and calcium overload. The generation of Ca(OH)2 during the reaction significantly improves the acidic environment of TME and promotes the oxidation of GSH.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Inorganic & Nuclear
Qianqian Sun, Zhao Wang, Bin Liu, Fei He, Shili Gai, Piaoping Yang, Dan Yang, Chunxia Li, Jun Lin
Summary: This review article presents the latest research progress on enhancing CDT antitumor effects through the amplification strategy of oxidative stress triggered by endogenous/exogenous stimuli, categorizing enhanced CDT nanomaterials into three major groups. Representative examples in each category are dissected and discussed in terms of rational design, mechanism of action, and potential medical applications. The challenges and bottlenecks in current CDT development are summarized, along with preliminary directions for future development in order to maximize the potential power of biology and chemistry coordination.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Agricultural Engineering
Hongyi Pan, Siming Nie, Zelin Wang, Liang Yu, Zhiguo Liu, Jiating Xu, Yujie Fu
Summary: This study developed a green and efficient process for simultaneous extraction and enrichment of phytochemicals from plant waste using a novel CO2-responsive surfactant (CRS) aqueous with ultrasound assistance. The optimal conditions were determined as ultrasound time of 120 min, R(S/L) of 20 mg/mL and CRS concentration of 54 mmol/L, leading to an increased extraction yield for target compounds compared to other surfactants. The method showed promise as a nontoxic, lower cost, and sustainable alternative for extracting valuable components from plant materials.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Nanoscience & Nanotechnology
Wubin Lv, Jin Ye, Qiang Wang, Chunsheng Li, Jun Wang, Zhiyong Zhang, Na Niu, Zhiguo Liu, Jiating Xu, Yujie Fu
Summary: This study proposes a type of UCNPs with tunable biodegradation rate, achieved by a core-shell structure and varying Zr4+ doping content. The degradation rate of these UCNPs can be easily modulated by changing the Zr4+ doping content in the shell, and is pH-responsive for tumor acidity-triggered degradation. In addition, the coordination cross-linking effect between UCNPs and SA molecules improves the tumor retention of the nanosystems.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Jun Wang, Jin Ye, Wubin Lv, Shuang Liu, Zhiyong Zhang, Jiating Xu, Miaojun Xu, Chunjian Zhao, Piaoping Yang, Yujie Fu
Summary: This study develops a novel hybrid biomimetic nanozyme by combining polydopamine-decorated CuO with the natural enzyme glucose oxidase (GOD), enabling multiple therapeutic strategies including relieving tumor hypoxia, starvation therapy, chemodynamic therapy, and photothermal therapy in the tumor microenvironment. This research provides insights for the further development of nanozymes in multimodal cancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Chunsheng Li, Jin Ye, Xing Yang, Shuang Liu, Zhiyong Zhang, Jun Wang, Kefen Zhang, Jiating Xu, Yujie Fu, Piaoping Yang
Summary: Lanthanide-doped nanoparticles coated with Fe/Mn bimetal-doped ZIF-8 were developed for second near-infrared imaging-guided synergistic photodynamic/chemodynamic therapy. The nanoparticles showed excellent upconversion and downconversion emission properties for optical imaging and photodynamic therapy. Additionally, the decreased bandgap of the ZIF-8 photosensitizer enabled photocatalytic-driven photodynamic therapy and responsive release of ions for chemodynamic therapy in the tumor microenvironment.
Article
Chemistry, Multidisciplinary
Jin Ye, Wubin Lv, Chunsheng Li, Shuang Liu, Xing Yang, Jiangwei Zhang, Chen Wang, Jiating Xu, Guanqiao Jin, Bin Li, Yujie Fu, Xinqiang Liang
Summary: Single-atom nanozymes have great potential to replace natural enzymes by mimicking their metal active centers at the atomic level. A PEGylated mesoporous Mn-based single-atom nanozyme has been designed, exhibiting excellent enzymatic performance and photothermal conversion efficiency. It can effectively kill cancer cells through catalytic and photothermal therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jikun Wang, Chunsheng Li, Yujie Cui, Qiang Wang, Jin Ye, Jie Yang, Zhongyuan Liu, Su Zhang, Yujie Fu, Jiating Xu
Summary: A near-infrared fluorescent nanoprobe for plant imaging was developed, which exhibited dual-mode emission of red upconversion and near-infrared downconversion. The nanoprobe showed ideal near-infrared emissive capabilities and was used to study the uptake and transport of nanoparticles in plants.
Article
Chemistry, Physical
Jin Ye, Yuanyuan Zhang, Juan Wang, Shuang Liu, Yuanhang Chang, Xiuping Xu, Chunte Feng, Jian Xu, Li Guo, Jiating Xu, Yujie Fu
Summary: Using calcination and solvothermal methods, FeS2/Bi2WO6 heterojunctions were prepared and used as photo-Fenton catalysts. The catalysts exhibited enhanced catalytic activity due to the synergistic effect between photocatalytic oxidation and Fenton oxidation, as well as the introduction of oxygen vacancies.
CATALYSIS SCIENCE & TECHNOLOGY
(2022)
Article
Materials Science, Biomaterials
Qiang Wang, Jin Ye, Jikun Wang, Mengting Liu, Chunsheng Li, Wubin Lv, Shuang Liu, Na Niu, Jiating Xu, Yujie Fu
Summary: In this study, a multifunctional nanomedicine was developed for imaging-guided therapy. The nanomedicine showed exceptional optical imaging capabilities and enabled both photodynamic therapy and chemodynamic therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Physical
Jin Ye, Jiating Xu, Chunsheng Li, Di Tian, Xiaohan Zhao, Qiang Wang, Wubin Lv, Jun Wang, Haijiao Xie, Yudong Li, Zhiguo Liu, Yujie Fu
Summary: Utilizing semiconductors to improve nitrogen conversion efficiency, the formation of multiple heterojunctions has significantly enhanced the rate of nitrogen fixation.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
