Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells

Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes

(2019) Shinsuke Sakai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Widely-targeted quantitative lipidomics method by supercritical fluid chromatography triple quadrupole mass spectrometry

(2018) Hiroaki Takeda et al.   JOURNAL OF LIPID RESEARCH

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

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Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule

(2016) Takeshi Yamamoto et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

(2016) Takeshi Yamamoto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB

(2016) Xuesong Li et al.   Cell Death & Disease

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Rubicon Deficiency Enhances Cardiac Autophagy and Protects Mice From Lipopolysaccharide-induced Lethality and Reduction in Stroke Volume

(2015) Zhenguo Zi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

Cellular Cholesterol Transport Proteins in Diabetic Nephropathy

(2014) Joseph G. S. Tsun et al.   PLoS One

Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity

(2013) Albert Herms et al.   CURRENT BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy Guards Against Cisplatin-Induced Acute Kidney Injury

(2012) Atsushi Takahashi et al.   AMERICAN JOURNAL OF PATHOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

(2011) T. Kimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

DNA damage and autophagy

(2011) Humberto Rodriguez-Rocha et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Renal lipid metabolism and lipotoxicity

(2010) Ion Alexandru Bobulescu   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain

(2010) Keisuke Tabata et al.   MOLECULAR BIOLOGY OF THE CELL

Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys

(2009) Chongren Tang et al.   JOURNAL OF LIPID RESEARCH

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE