Article
Oncology
Arce Domingo-Relloso, Matthew O. Gribble, Angela L. Riffo-Campos, Karin Haack, Shelley A. Cole, Maria Tellez-Plaza, Jason G. Umans, Amanda M. Fretts, Ying Zhang, M. Daniele Fallin, Ana Navas-Acien, Todd M. Everson
Summary: This study investigated the association between blood DNA methylation and type 2 diabetes. The results suggest that differences in blood DNA methylation are related to markers of glucose metabolism and insulin activity, although no significant associations were found after multiple comparisons correction.
CLINICAL EPIGENETICS
(2022)
Review
Biochemistry & Molecular Biology
Gregory Alexander Raciti, Antonella Desiderio, Michele Longo, Alessia Leone, Federica Zatterale, Immacolata Prevenzano, Claudia Miele, Raffaele Napoli, Francesco Beguinot
Summary: Diabetes poses a serious threat to global health, especially for T2D patients facing severe complications. Improving care for T2D is crucial, and alterations in DNA methylation hold potential for predicting T2D risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Rachel G. Miller, Josyf C. Mychaleckyj, Suna Onengut-Gumuscu, Eleanor Feingold, Trevor J. Orchard, Tina Costacou
Summary: This study explored the potential of DNA methylation as an early marker for cardiovascular disease (CVD) in type 1 diabetes patients and how this association differs based on glycemic exposure. The study found that DNA methylation at loci involved in calcium channel activity and development may contribute to long-term CVD risk in type 1 diabetes patients, especially in individuals with higher glycemic exposure. These findings suggest the need for further research in this area.
CLINICAL EPIGENETICS
(2023)
Article
Genetics & Heredity
Kelsey Dawes, Willem Philibert, Benjamin Darbro, Ronald L. Simons, Robert Philibert
Summary: This study provides a new model for predicting T2D status in African Americans by evaluating the interaction between genes and methylation. The study found that certain gene-methylation interactions are associated with the development and complications of T2D, and correcting for genetic confounding improves the ability to detect T2D.
Article
Genetics & Heredity
Silja Schrader, Alexander Perfilyev, Mats Martinell, Sonia Garcia-Calzon, Charlotte Ling
Summary: The study found an association between statin therapy and epigenetic modifications in patients with type 2 diabetes, identifying differential methylation sites related to cholesterol biosynthesis and immune response through analysis of blood DNA methylation.
Article
Biochemistry & Molecular Biology
Elena Succurro, Francesco Andreozzi, Roberto Carnevale, Angela Sciacqua, Vittoria Cammisotto, Velia Cassano, Gaia C. Mannino, Teresa V. Fiorentino, Daniele Pastori, Pasquale Pignatelli, Giorgio Sesti, Francesco Violi
Summary: The study suggests that redox status imbalance negatively influences vascular outcomes in patients with type 2 diabetes mellitus, with soluble NOX2 and serum albumin levels significantly correlated with the incidence of non-fatal myocardial infarction.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Rupal Dubey, Pranav Kumar Prabhakar, Jeena Gupta
Summary: Diabetes-related delayed wound healing is a multifactorial complication affected by genetic, dietary, and lifestyle factors, with epigenetic modifications recognized as key facilitators of gene-environment interactions. Dysfunctional epigenetic pathways caused by diabetes lead to changed gene expression in target cells, contributing to complications such as cardiomyopathy, nephropathy, and delayed wound healing. The role of epigenetic mechanisms in tissue repair, angiogenesis, and growth factors, as well as altered epigenetic events during diabetic wound healing, are important areas of study.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Cell Biology
Jianxin Deng, Yunxiu Liao, Jianpin Liu, Wenjuan Liu, Dewen Yan
Summary: Diabetic cardiomyopathy is characterized by diastolic relaxation abnormalities in its early stages and clinical heart failure in its later stages, contributing to high mortality and morbidity rates in diabetic populations. Diabetes is a complex condition influenced by genetic and environmental factors, with recent studies highlighting the role of epigenetics in its pathogenesis. Further research on epigenetic mechanisms could lead to novel therapeutic approaches for diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Nutrition & Dietetics
Stavroula A. Paschou, Evanthia Bletsa, Katerina Saltiki, Paraskevi Kazakou, Kanella Kantreva, Paraskevi Katsaounou, Nikoletta Rovina, Georgia Trakada, Petros Bakakos, Charalambos V. Vlachopoulos, Theodora Psaltopoulou
Summary: Obstructive sleep apnea (OSA) is a common and serious public health issue that is associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM). OSA is an independent risk factor for the development and progression of T2DM, as well as T2DM-related cardiovascular complications. OSA may also increase the risk of developing cardiovascular diseases, such as hypertension, coronary artery disease, heart failure, pulmonary hypertension, atrial fibrillation, and stroke. OSA and T2DM share common pathophysiological mechanisms that lead to atherosclerosis. Therefore, clinicians should be aware of the coexistence of OSA and T2DM, as it increases the risk of cardiovascular mortality, and screen for OSA in patients with T2DM. Targeted therapy for both conditions can significantly improve cardiovascular prognosis.
Article
Endocrinology & Metabolism
Diana L. Juvinao-Quintero, Gemma C. Sharp, Eleanor C. M. Sanderson, Caroline L. Relton, Hannah R. Elliott
Summary: This study aimed to provide evidence for a causal relationship between DNA methylation (DNAm) and type 2 diabetes. The researchers used bidirectional two-sample Mendelian randomisation (2SMR) to evaluate the causality at 58 CpG sites. The results showed a strong causal effect of DNAm at cg25536676 (DHCR24) on the risk of type 2 diabetes.
Review
Endocrinology & Metabolism
Emma K. Rautenberg, Yassin Hamzaoui, Dawn K. Coletta
Summary: Type 2 diabetes (T2D) and obesity present major challenges in public health. Understanding the molecular mechanisms contributing to these metabolic disorders, particularly insulin resistance, is crucial. Impaired mitochondria structure and function are common features in insulin-resistant individuals with T2D or obesity, potentially due to epigenetic regulation of mitochondrial and nuclear-encoded genes. Investigating mitochondrial abnormalities is important for gaining insights into the pathogenesis of diabetes and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Nadia Di Pietrantonio, Pamela Di Tomo, Domitilla Mandatori, Gloria Formoso, Assunta Pandolfi
Summary: Diabetes accelerates vascular senescence, leading to chronic inflammation and oxidative stress, which in turn cause endothelial dysfunction and related cardiovascular complications. The acetyltransferase p300 has been suggested to play a crucial role in diabetes-associated inflammation and oxidative stress, potentially contributing to the development of vascular senescence. Understanding the mechanisms of p300 in diabetic vascular dysfunction could aid in finding new therapeutic strategies for cardiovascular diseases related to diabetes.
Article
Biochemistry & Molecular Biology
Francisco Canet, Francesca Iannantuoni, Aranzazu Martinez de Maranon, Pedro Diaz-Pozo, Sandra Lopez-Domenech, Teresa Vezza, Blanca Navarro, Eva Sola, Rosa Falcon, Celia Banuls, Carlos Morillas, Milagros Rocha, Victor M. Victor
Summary: This study demonstrated that empagliflozin treatment led to reductions in body weight, BMI, HbA1C levels, waist circumference, and glucose levels, as well as improvements in leukocyte-endothelium interactions, adhesion molecules, ROS production, and NFkB-p65 expression. These findings suggest that the anti-inflammatory and antioxidant properties of empagliflozin may contribute to its beneficial cardiovascular effects in patients with type 2 diabetes.
Review
Biochemistry & Molecular Biology
Grzegorz K. Jakubiak, Grzegorz Cieslar, Agata Stanek
Summary: Diabetes mellitus is closely associated with cardiovascular diseases, and the nitration of lipoproteins, especially high-density lipoprotein, may play an important role in the development of cardiovascular dysfunction. However, further research is needed to fully understand this relationship.
Article
Biochemistry & Molecular Biology
Xingren Chen, Xiaobo Zhu, Jian Dong, Fang Chen, Qi Gao, Lijun Zhang, Dawei Cai, Hui Dong, Binjia Ruan, Yongxiang Wang, Qing Jiang, Wangsen Cao
Summary: The study demonstrates that diacerein has a significant protective effect on cartilage damage in OA mice, by inhibiting the upregulation of DNMT1/3a, promoter hypermethylation of PPAR gamma, and reversing the expression of antioxidant enzymes and inflammatory cytokines.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Surgery
Stefan Wallen, Gustaf Bruze, Johan Ottosson, Claude Marcus, Johan Sundstrom, Eva Szabo, Torsten Olbers, Maria Palmetun-Ekback, Ingmar Naslund, Martin Neovius
Summary: This study aimed to compare the use of opioids in patients with obesity who underwent bariatric surgery versus those who underwent intensive lifestyle modification. The results showed that patients who underwent bariatric surgery had a higher proportion of opioid users and a larger total opioid dose, especially in those who received additional surgery during follow-up.
Letter
Allergy
Andrei Malinovschi, Xingwu Zhou, Christer Janson, Johan Sundstrom, Per Wollmer, Jenny Hallberg
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Endocrinology & Metabolism
Shafqat Ahmad, Ulf Hammar, Beatrice Kennedy, Samira Salihovic, Andrea Ganna, Lars Lind, Johan Sundstroem, Johan Arnlov, Christian Berne, Ulf Riserus, Patrik K. E. Magnusson, Susanna C. Larsson, Tove Fall
Summary: This study investigated the association between obesity and circulating metabolites and used Mendelian randomization to address causality. The findings suggest that obesity is associated with variations in several metabolites.
Article
Public, Environmental & Occupational Health
Maria-Pia Hergens, Max Bell, Per Haglund, Johan Sundstrom, Erik Lampa, Joanna Nederby-Ohd, Maria Rotzen Ostlund, Thomas Cars
Summary: This observational study based on the real-time Covid-19 monitoring framework provides insights into the risk factors associated with mortality, hospitalization, and ICU admission in Covid-19 infections. Kidney failure, diabetes, obesity, heart failure, and ischemic heart disease increase the risk of mortality and hospitalization, while atrial fibrillation and hypertension do not. The study also suggests that triage processes affect the ICU admission risk, as certain comorbid conditions are associated with lower ICU admission.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Liam Gaziano, Luanluan Sun, Matthew Arnold, Steven Bell, Kelly Cho, Stephen K. Kaptoge, Rebecca J. Song, Stephen Burgess, Daniel C. Posner, Katja Mosconi, Cassianne Robinson Cohen, Amy M. Mason, Thomas R. Bolton, Ran Tao, Elias Allara, Petra Schubert, Lingyan Chen, James R. Staley, Natalie Staplin, Servet Altay, Pilar Amiano, Phar Volker Arndt, Johan Arnlov, Elizabeth L. M. Barr, Cecilia Bjorkelund, Jolanda M. A. Boer, Hermann Brenner, Edoardo Casiglia, Paolo Chiodini, Jackie A. Cooper, Josef Coresh, Mary Cushman, Rachel Dankner, Karina W. Davidson, Renate T. de Jongh, Chiara Donfrancesco, Gunnar Engstrom, Heinz Freisling, Agustin Gomez de la Camara, Vilmundur Gudnason, Graeme J. Hankey, PerOlof Hansson, Alicia K. Heath, Ewout J. Hoorn, Hironori Imano, Simerjot K. Jassal, Rudolf Kaaks, Verena Katzke, Jussi Kauhanen, Stefan Kiechl, Wolfgang Koenig, Richard A. Kronmal, Cecilie Kyro, Deborah A. Lawlor, Borje Ljungberg, Conor MacDonald, Giovanna Masala, Christa Meisinger, Olle Melander, Conchi Moreno Iribas, Toshiharu Ninomiya, Dorothea Nitsch, Borge G. Nordestgaard, Charlotte OnlandMoret, Luigi Palmieri, Dafina Petrova, Jose Ramon Quiros Garcia, Annika Rosengren, Carlotta Sacerdote, Masaru Sakurai, Carmen Santiuste, Matthias B. Schulze, Sabina Sieri, Johan Sundstrom, Valerie Tikhonoff, Anne Tjonneland, Tammy Tong, Rosario Tumino, Ioanna Tzoulaki, Yvonne T. van der Schouw, W. M. Monique Verschuren, Henry Volzke, Robert B. Wallace, S. Goya Wannamethee, Elisabete Weiderpass, Peter Willeit, Mark Woodward, Kazumasa Yamagishi, Raul ZamoraRos, Elvis A. Akwo, Saiju Pyarajan, David R. Gagnon, Philip S. Tsao, Sumitra Muralidhar, Todd L. Edwards, Scott M. Damrauer, Jacob Joseph, Lisa Pennells, Peter W. F. Wilson, Seamus Harrison, Thomas A. Gaziano, Michael Inouye, Colin Baigent, Juan P. Casas, Claudia Langenberg, Nick Wareham, Elio Riboli, J. Michael Gaziano, John Danesh, Adriana M. Hung, Adam S. Butterworth, Angela M. Wood, Emanuele Di Angelantonio
Summary: The study results suggest that mild-to-moderate kidney dysfunction is causally related to the risk of coronary heart disease in people without manifest cardiovascular disease or diabetes.
Article
Multidisciplinary Sciences
Lars Lind, Johan Sundstrom, Solve Elmstahl, Koen F. Dekkers, J. Gustav Smith, Gunnar Engstrom, Tove Fall, Johan Arnlov
Summary: A complex metabolic profile related to all components of metabolic syndrome was identified using metabolomics. This profile represented various metabolic classes and was associated with insulin sensitivity, suggesting the importance of insulin sensitivity in the clustering of cardiovascular risk factors.
Article
Genetics & Heredity
K. Alaine Broadaway, Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P. Wilson, Anne H. Moxley, Swarooparani Vadlamudi, Arushi Varshney, Anne U. Jackson, Vasudha Ahuja, Stefan R. Bornstein, Laura J. Corbin, Graciela E. Delgado, Om P. Dwivedi, Lilian Fernandes Silva, Timothy M. Frayling, Harald Grallert, Stefan Gustafsson, Liisa Hakaste, Ulf Hammar, Christian Herder, Sandra Herrmann, Kurt Hojlund, David A. Hughes, Marcus E. Kleber, Cecilia M. Lindgren, Ching-Ti Liu, Jian'an Luan, Anni Malmberg, Angela P. Moissl, Andrew P. Morris, Nikolaos Perakakis, Annette Peters, John R. Petrie, Michael Roden, Peter E. H. Schwarz, Sapna Sharma, Angela Silveira, Rona J. Strawbridge, Tiinamaija Tuomi, Andrew R. Wood, Peitao Wu, Bjorn Zethelius, Damiano Baldassarre, Johan G. Eriksson, Tove Fall, Jose C. Florez, Andreas Fritsche, Bruna Gigante, Anders Hamsten, Eero Kajantie, Markku Laakso, Jari Lahti, Deborah A. Lawlor, Lars Lind, Winfried Maerz, James B. Meigs, Johan Sundstrom, Nicholas J. Timpson, Robert Wagner, Mark Walker, Nicholas J. Wareham, Hugh Watkins, Ines Barroso, Stephen O'Rahilly, Niels Grarup, Stephen CJ. Parker, Michael Boehnke, Claudia Langenberg, Eleanor Wheeler, Karen L. Mohlke
Summary: Insufficient insulin secretion and increased proinsulin levels indicate beta-cell stress and insulin resistance. A meta-analysis of European-ancestry individuals identified 36 independent signals at 30 loci associated with fasting proinsulin. These loci are involved in various mechanisms that affect insulin processing and beta-cell function. Colocalization analysis provided potential candidate genes and regulatory mechanisms for proinsulin production and glucose regulation. This study highlights the importance of genetic studies for understanding disease predisposition.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Tracey G. Simon, Bjorn Roelstraete, Naim Alkhouri, Hannes Hagstrom, Johan Sundstrom, Jonas F. Ludvigsson
Summary: This study found that children and young adults with biopsy-proven NAFLD had significantly higher rates of incident MACE, including ischaemic heart disease and congestive heart failure, compared to matched population controls.
Article
Public, Environmental & Occupational Health
Sara Higueras-Fresnillo, Angel Herraiz-Adillo, Viktor H. Ahlqvist, Daniel Berglind, Cecilia Lenander, Bledar Daka, Maria Braennholm Syrjala, Johan Sundstrom, Carl Johan Ostgren, Karin Radholm, Pontus Henriksson
Summary: The aim of this study was to examine the prevalence of ideal cardiovascular health (iCVH) in the middle-aged population of Sweden. Data from a large population-based study were analyzed and a total iCVH score was calculated based on seven components. Results showed that only 18.2% of the population reached ideal status, while 51.9% were classified as intermediate status and 29.9% as poor status of iCVH. Women had a higher prevalence of iCVH status and a lower prevalence of poor iCVH status. These findings can be used as benchmarks for future comparisons and efforts to promote cardiovascular health.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Lars Lind, Tove Fall, Johan Arnlov, Solve Elmstahl, Johan Sundstrom
Summary: This study explored the relationship between a wide range of circulating metabolites and future cardiovascular disease (CVD) as well as subclinical markers of CVD in the general population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Troels Yndigegn, Bertil Lindahl, Joakim Alfredsson, Jocelyne Benatar, Lisa Brandin, David Erlinge, Urban Haaga, Claes Held, Pelle Johansson, Patric Karlstrom, Thomas Kellerth, Toomas Marandi, Katarina Mars, Annica Ravn-Fischer, Johan Sundstrom, Ollie Ostlund, Robin Hofmann, Tomas Jernberg
Summary: This article introduces a trial called REDUCE-AMI, which aims to evaluate the effect of long-term beta-blocker treatment on death and recurrent myocardial infarction in patients with acute MI. The study will involve 5000 patients and observe both primary and secondary endpoints. The results will have important implications for guidelines and clinical practice.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Norhammar, Johan Bodegard, Marc Vanderheyden, Navdeep Tangri, Avraham Karasik, Aldo Pietro Maggioni, Kari Anne Sveen, Tiago Taveira-Gomes, Manuel Botana, Lukas Hunziker, Marcus Thuresson, Amitava Banerjee, Johan Sundstrom, Andreas Bollmann
Summary: The CaReMe HF study collected individual level data from digital healthcare systems in 11 countries to estimate the prevalence, clinical outcomes, and costs of HF. The study found that 1-2% of the contemporary adult population has HF, and these individuals are at significant risk of adverse outcomes and associated costs.
Article
Cardiac & Cardiovascular Systems
Joel Ohm, Ralf Kuja-Halkola, Anna Warnqvist, Henrike Haebel, Per H. Skoglund, Johan Sundstroem, Kristina Hambraeus, Tomas Jernberg, Per Svensson
Summary: Low socioeconomic status is associated with worse prognosis after myocardial infarction. This study identified nonparticipation in cardiac rehabilitation, cardiometabolic risk profile, and persistent smoking as mediating factors in the relationship between low income and post-MI recurrent atherosclerotic cardiovascular disease events.
Article
Psychiatry
Eric Clapham, Johan Reutfors, Marie Linder, Lena Brandt, Johan Sundstrom, Robert Boden
Summary: The risk of cardiac adverse events following the use of clozapine is debated; however, its risk for chemically related antipsychotics olanzapine and quetiapine is unknown. A Swedish study used registers to analyze the risk of perimyocarditis and heart failure in patients receiving these antipsychotics. The study found that clozapine use was associated with a significantly increased short-term risk of perimyocarditis and an increased long-term risk of heart failure. Olanzapine and quetiapine use did not show an increased risk compared to no antipsychotic treatment.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.