Article
Biochemistry & Molecular Biology
Aysun Ozdemir, Burcin Ibisoglu, Yaprak Dilber Simay Demir, Elifnur Benhur, Farzaneh Valipour, Mustafa Ark
Summary: It was found that caspase 2 directly truncates ROCK 1 in cell death, generating a 130kDa active fragment that is responsible for membrane bleb formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Michael Killinger, Barbora Vesela, Marketa Prochazkova, Eva Matalova, Karel Kleparnik
Summary: Protein heterogeneity at the single-cell level is crucial for understanding animal development processes, with low-copy-number proteins playing key roles in proliferation, differentiation, and apoptosis. The study on bone-related cells demonstrated a gradual increase in caspase-3/7 activation from proliferation to differentiation, and then to apoptosis, supporting the role of pro-apoptotic caspases in non-apoptotic functions through fine-tuning of their activation levels.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Asif Ahmad Bhat, Riya Thapa, Obaid Afzal, Neetu Agrawal, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Abdulmalik Saleh Alfawaz Altamimi, Parteek Prasher, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Summary: Cytotoxic drugs kill cancer cells through apoptosis, but recent research has found that pyroptosis can inhibit cell proliferation and shrink tumors. Pyroptosis and apoptosis are caspase-dependent programmed cell death processes. Inflammasomes activate caspase-1 and latent cytokines, including IL-1 beta and IL-18, to induce pyroptosis by cleaving gasdermin E (GSDME). Understanding the cellular and molecular mechanisms of caspase-3 and GSDME-mediated programmed cell death, specifically pyroptosis, may lead to potential targets for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Farzaneh Ghazavi, Jelle Huysentruyt, Jordy De Coninck, Stephanie Kourula, Sofie Martens, Behrouz Hassannia, Tim Wartewig, Tatyana Divert, Ria Roelandt, Bastian Popper, Andreas Hiergeist, Peter Tougaard, Tom Vanden Berghe, Marie Joossens, Geert Berx, Nozomi Takahashi, Adam Wahida, Peter Vandenabeele
Summary: Apoptosis is not essential for turnover of intestinal epithelial cells, maintenance of barrier function, microbiome, and immune cell composition during homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Summya Rashid, Adil Farooq Wali, Shahzada Mudasir Rashid, Rana M. Alsaffar, Ajaz Ahmad, Basit L. Jan, Bilal Ahmad Paray, Saeed M. A. Alqahtani, Azher Arafah, Muneeb U. Rehman
Summary: The study reveals that zingerone has neuroprotective effects by inhibiting cognitive impairment, neural damage, and inflammation induced by seizures.
Article
Chemistry, Inorganic & Nuclear
Sreelakshmi Ajay, Jayanthy S. Panicker, K. A. Manjumol, Parameswaran P. Subramanian
Summary: In this study, silver nanoparticles were synthesized using the leaf extract of Coleus Vettiveroids, providing a simple, safe and eco-friendly method. The nanoparticles were formed by reducing aqueous silver nitrate solution during UV exposure. The biogenic silver nanoparticles exhibited small particle size and excellent photocatalytic activity in degrading textile dyes under sunlight.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Environmental Sciences
Guangzhe Zheng, Jie Zhang, Xuan Zhang, Zhihong Zhang, Sijin Liu, Shuping Zhang, Changwen Zhang
Summary: Metal nanoparticles (NPs) have unique physicochemical properties that make them widely used in daily life and commercial activities. This study investigated the effects of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) on macrophages, and found that AgNPs induced non-apoptotic programmed cell death (PCD), called ferroptosis, accompanied by lipid peroxidation and iron homeostasis disorders. Moreover, smaller AgNPs had a greater ferroptotic effect on macrophages than larger ones, and ferroptosis in AgNP-treated macrophages was mainly triggered by AgNPs per se rather than Ag ions.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Genetics & Heredity
Shijun Yang, Caixia Tan, Xuerong Sun, Xiong Tang, Xiao Huang, Fan Yan, Guangxiang Zhu, Qin Wang
Summary: This study investigates the mechanisms of metamorphosis in the Chinese giant salamander, focusing on the role of caspase genes and the effect of thyroid hormone treatment. The results show that caspase genes play a key role in the loss of external gills, and thyroid hormone treatment can accelerate this process.
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marialucia Gallorini, Cristina Antonetti Lamorgese Passeri, Amelia Cataldi, Anna Concetta Berardi, Leonardo Osti
Summary: This study establishes a cell model to investigate the effects of hyaluronic acid (HA) on rotator cuff tendinopathy (RCT). The results show that HA with low molecular weight can reduce cell apoptosis, reverse the activation of caspase 3 and 7, and counteract the oxidative stress (OS) induced by RCT. Additionally, HA with higher molecular weight improves the expression of collagen 1. These findings enhance our understanding of the mechanisms of HA in the treatment of RCT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Mohammed Salah Ayoup, Ahmed Farag Mansour, Hamida Abdel-Hamid, Marwa M. Abu-Serie, Salma M. Mohyeldin, Mohamed Teleb
Summary: The development of novel therapeutics promoting selective tumor elimination is critical in clinical oncology. In this study, the authors have identified caspase-3 activation as a personalized anticancer strategy and synthesized a series of isoindole-based compounds that show promising antiproliferative activities against cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Kakali Bhadra
Summary: This article reviews the alternative pathways of cancer cell death targeted by anticancer drug molecules, providing a molecular basis for new strategies in cancer treatment. Many drugs can effectively induce cell death through targeting the caspase-independent cell death pathway, which is significant for cancer therapy.
Article
Materials Science, Biomaterials
Jingbo Lin, Jiaxin Zhang, Kuang Wang, Shengdi Guo, Wuli Yang
Summary: Ferroptosis, an alternative form of cell death, holds great promise for non-apoptotic cancer treatment. This study focused on the use of iron-based nanomaterials coated with zwitterionic polymers to enhance the effect of ferroptosis in colon cancer treatment. The results showed good biocompatibility and excellent tumor inhibitory effect in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Environmental Sciences
Jiangyan Li, Xiaoru Chang, Mengting Shang, Shuyan Niu, Wenli Zhang, Bangyong Zhang, Wenyan Huang, Tianshu Wu, Ting Zhang, Meng Tang, Yuying Xue
Summary: The study showed that the cytotoxicity of silver nanoparticles on A549 cells led to apoptosis and mitochondrial injury, triggering autophagy and mitophagy, and also causing lysosomal damage and oxidative/antioxidant imbalance.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Toxicology
A. Yusuf, A. Brophy, B. Gorey, A. Casey
JOURNAL OF APPLIED TOXICOLOGY
(2018)
Article
Materials Science, Biomaterials
Azeez Yusuf, Alan Casey
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2020)
Article
Toxicology
Azeez Yusuf, Alan Casey
TOXICOLOGY IN VITRO
(2019)
Review
Biochemistry & Molecular Biology
Michael E. O'Brien, Grace Murray, Debananda Gogoi, Azeez Yusuf, Cormac McCarthy, Mark R. Wormald, Michelle Casey, Claudie Gabillard-Lefort, Noel G. McElvaney, Emer P. Reeves
Summary: AAT is a serine protease inhibitor that modulates innate immune mechanisms through anti-inflammatory activities, involving interactions with a wide range of proteins, cytokines, and cell surfaces. Recent research has highlighted the immunomodulatory role of AAT, particularly in lipid or protein-protein interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Azeez Yusuf, Awatif Rashed Z. Almotairy, Hanan Henidi, Ohoud Y. Alshehri, Mohammed S. Aldughaim
Summary: Nanotechnology has experienced rapid development in the past four decades and has revolutionized various aspects of everyday life. It has had significant impacts on fields like medicine and food industry, leading to improvements in shelf life of food, drug delivery, and development of specific therapeutics.
Review
Chemistry, Analytical
Azeez Yusuf, Dylan O'Flynn, Blanaid White, Linda Holland, Anne Parle-McDermott, Jenny Lawler, Thomas McCloughlin, Denise Harold, Belinda Huerta, Fiona Regan
Summary: Global water scarcity is a growing concern primarily due to the changing climate conditions and increasing population growth leading to higher water consumption. The production and consumption of pharmaceuticals and organic chemicals are causing increased pollution in fresh water sources, posing a potential threat to aquatic organisms. International monitoring networks are emerging with a focus on evaluating the threat of chemical pollutants in aquatic ecosystems using specific bioassay batteries.
ANALYTICAL METHODS
(2021)
Article
Pharmacology & Pharmacy
Hani Alothaid, Mohammed S. Aldughaim, Azeez Oriyomi Yusuf, Umama Yezdani, Alaa Alhazmi, Mahmoud M. Habibullah, Mohammad Gayoor Khan
Summary: The study developed a supersaturated self-nanoemulsifying drug delivery system (S-SNEDDS) to improve the oral bioavailability of Albendazole (ABZ). By selecting the appropriate formulation and solidification technique, the S-SNEDDS was successfully transformed into solid supersaturated self-nanoemulsifying drug delivery systems (SS-SNEDDS). This system, characterized by small globule size and excellent dispersion properties, can be used for proper clinical application of ABZ.
Review
Chemistry, Analytical
Dylan O'Flynn, Jenny Lawler, Azeez Yusuf, Anne Parle-McDermott, Denise Harold, Thomas Mc Cloughlin, Linda Holland, Fiona Regan, Blanaid White
Summary: Active pharmaceutical ingredients (APIs) are increasingly recognized as contaminants of emerging concern (CECs), with potential ecological and human health impacts. This review focuses on six pharmaceuticals heavily consumed globally, with poor removal rates in wastewater treatment plants, and their persistence in the aquatic environment. The research covers a period of 10 years, examining over 100 published studies, highlighting the severe risk pharmaceuticals can pose to surface water environments and the importance of education and proper waste management to reduce pharmaceutical occurrence in surface waters.
ANALYTICAL METHODS
(2021)
