Nature-inspired new isoindole-based Passerini adducts as efficient tumor-selective apoptotic inducers via caspase-3/7 activation

Morpho‐functional analyses reveal that changes in the chemical structure of a marine bisindole alkaloid alter the cytotoxic effect of its derivatives

(2022) Sabrina Burattini et al.   MICROSCOPY RESEARCH AND TECHNIQUE

A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer

(2022) Pierina Cetraro et al.   Cancers

The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis

(2021) Mahshid Ghasemi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Two decades of recent advances of Passerini reactions: synthetic and potential pharmaceutical applications

(2021) Yasmin Wahby et al.   NEW JOURNAL OF CHEMISTRY

Stochastic fluctuations in apoptotic threshold of tumour cells can enhance apoptosis and combat fractional killing

(2020) Baohua Qiu et al.   Royal Society Open Science

Future Therapeutic Directions for Smac-Mimetics

(2020) Emma Morrish et al.   Cells

Targeting apoptosis in cancer therapy

(2020) Benedito A. Carneiro et al.   Nature Reviews Clinical Oncology

Targeting apoptotic caspases in cancer

(2020) Ashley Boice et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Repurposing of quinoline alkaloids identifies their ability to induce sub G0/G1 phase cell cycle arrest and enhance doxorubicin‐induced apoptosis in cervical and hepatocellular carcinoma cells

(2020) Mohamed El‐Mesery et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

1-Isoindolinone scaffold-based natural products with a promising diverse bioactivity

(2020) Sunil P. Upadhyay et al.   FITOTERAPIA

An Updated Review of Smac Mimetics, LCL161, Birinapant, and GDC-0152 in Cancer Treatment

(2020) Yung-Chieh Chang et al.   Applied Sciences-Basel

A Facile and Eco-Friendly Method for the Synthesis of Sulfonamide and Sulfonate Carboxylic Acid Derivatives—X-ray Structure, Hirshfeld Analysis and Spectroscopic Characterizations

(2019) Zainab Almarhoon et al.   Crystals

Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives

(2019) Hui Cong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel α-acyloxy carboxamides via Passerini reaction as caspase 3/7 activators

(2019) Mohammed Salah Ayoup et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential

(2019) Matthew W. Boudreau et al.   ACS Chemical Biology

Cancer Metabolism and the Evasion of Apoptotic Cell Death

(2019) Aditi Sharma et al.   Cancers

ProTox-II: a webserver for the prediction of toxicity of chemicals

(2018) Priyanka Banerjee et al.   NUCLEIC ACIDS RESEARCH

A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl)-2-[(2R,5R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)

(2018) Christopher N. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of some novel sulfonamide derivatives as apoptosis inducers

(2017) Khaled O. Mohamed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Isolation and identification of aromatic compounds in Lion’s Mane Mushroom and their anticancer activities

(2015) Wei Li et al.   FOOD CHEMISTRY

Apoptotic activity of 5-fluorouracil in breast cancer cells transformed by low doses of ionizing α-particle radiation

(2015) RICHARD PONCE-CUSI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Total Synthesis of a Reported Fluorometabolite from Streptomyces sp. TC1 Indicates an Incorrect Assignment. The Isolated Compound Did Not Contain Fluorine

(2014) Mohammed Salah Ayoup et al.   JOURNAL OF NATURAL PRODUCTS

Small-molecule SMAC mimetics as new cancer therapeutics

(2014) Longchuan Bai et al.   PHARMACOLOGY & THERAPEUTICS

5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-δ

(2014) NIZAR M. MHAIDAT et al.   Oncology Letters

Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain

(2013) Robert F. Kester et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Applications of Passerini Reaction

(2012) Ali Reza Kazemizadeh et al.   CURRENT ORGANIC CHEMISTRY

Structure–Activity Relationships, Ligand Efficiency, and Lipophilic Efficiency Profiles of Benzophenone-Type Inhibitors of the Multidrug Transporter P-Glycoprotein

(2012) Ishrat Jabeen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Measuring and Modeling Apoptosis in Single Cells

(2011) Sabrina L. Spencer et al.   CELL

Caspases and cancer

(2011) M Olsson et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interconversion Study in 1,4-Substituted Six-Membered Cyclohexane-Type Rings. Structure and Dynamics oftrans-1,4-Dibromo-1,4-dicyanocyclohexane

(2011) Alex D. Bain et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles

(2010) Noha I. Ziedan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents

(2009) William Kemnitzer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme

(2009) Bo Wang et al.   DRUG METABOLISM REVIEWS

Heavy Halogen Atom Effect on13C NMR Chemical Shifts in Monohalo Derivatives of Cyclohexane and Pyran. Experimental and Theoretical Study

(2009) Alvaro Cunha Neto et al.   Journal of Chemical Theory and Computation

The influence of lead discovery strategies on the properties of drug candidates

(2009) György M. Keserü et al.   NATURE REVIEWS DRUG DISCOVERY

Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics

(2008) Haiying Sun et al.   ACCOUNTS OF CHEMICAL RESEARCH

Targeting Cell Death in Tumors by Activating Caspases

(2008) A. Clark et al.   CURRENT CANCER DRUG TARGETS

Cytotoxic activity screening of some indigenous Thai plants

(2008) P. Prayong et al.   FITOTERAPIA

Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP)†

(2008) Haiying Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand Binding Efficiency: Trends, Physical Basis, and Implications

(2008) Charles H. Reynolds et al.   JOURNAL OF MEDICINAL CHEMISTRY